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| 1 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 2 | Pancreatic enzymes and abdominal adipose tissue distribution in new-onset prediabetes/diabetes after acute pancreatitis显示文摘BACKGROUND New-onset prediabetes/diabetes after acute pancreatitis(NODAP)is the most common sequela of pancreatitis,and it differs from type 2 prediabetes/diabetes mellitus(T2DM).AIM To study the associations between circulating levels of pancreatic amylase,pancreatic lipase,chymotrypsin and fat phenotypes in NODAP,T2DM,and health.METHODS Individuals with NODAP(n=30),T2DM(n=30),and sex-matched healthy individuals(n=30)were included.Five fat phenotypes(intra-pancreatic fat,liver fat,skeletal muscle fat,visceral fat,and subcutaneous fat)were determined using the same magnetic resonance imaging protocol and scanner magnet strength for all participants.One-way analysis of covariance,linear regression analysis,and relative importance analysis were conducted.RESULTS Intra-pancreatic fat deposition(IPFD)was higher in NODAP(9.4%±1.8%)and T2DM(9.8%±1.1%)compared with healthy controls(7.8%±1.9%)after adjusting for covariates(P=0.003).Similar findings were observed in regards to visceral fat volume(P=0.005),but not subcutaneous fat volume,liver fat,or skeletal muscle fat.Both IPFD(β=-2.201,P=0.023)and visceral fat volume(β=-0.004,P=0.028)were significantly associated with circulating levels of pancreatic amylase in NODAP,but not in T2DM or healthy individuals.Of the five fat phenotypes,IPFD explained the highest amount of variance in pancreatic amylase concentration(R2=15.3%out of 41.2%).None of the phenotypes contributed meaningfully to the variance in pancreatic lipase or chymotrypsin.CONCLUSION Both NODAP and T2DM are characterized by increased IPFD and visceral fat volume.However,only NODAP is characterized by significant inverse associations between the two fat phenotypes and pancreatic amylase. | Juyeon Ko Loren Skudder-Hill Jaelim Cho Sakina H Bharmal Maxim S Petrov | 2021 | World Journal of Gastroenterology2021，27，23： | 5 |
| 3 | 德国北部挪威云杉林可持续经营中期计划的实例分析显示文摘可持续森林经营理论为中期林业计划和收获调整提供了丰富的模型选择,其不同的方法可应用于各种特定的场合和不同经营类型。本文简要回顾了传统的森林计划方法,一种称为“多林分发展”的概念可以用于任意的经营系统,这个概念把森林看作由一系列林分组成,在每一个林分中可以预先制定多种经营措施的选项,每种选项都可以通过木材或其它产品以及消耗的资源计算出一个目标值。这种简单的概念可以应用到大量的不同森林经营场合,它为森林经营者制定切实可行的森林措施和评价森林经营计划提供方法。在本研究中,以德国北部一片包括21个小班的挪威云杉林班的一个中期计划为例,说明“多林分发展”这一经营系统在实际生产中的应用。每个小班具有不同的初始状态,每个小班预设了若干经营选项,根据小班的初始状态、生长模型为各种选项计算各时期的木材产出。在林班的水平上,经营目标方程包括两个组成部分:净现值和均衡木材收获值。用模拟退火的方法来优化总体目标方程值。优化的总体解决方案在为每个小班选定合适的经营选项的同时,在全林的水平上获得最优的经济和均衡产出组合。 | 陈伯望 Klaus.von Gadow Frantiek Vilko Sofía Sánchez Orois | 2006 | 林业科学研究2006，19，5： | 4 |
| 4 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 5 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 6 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 7 | An efficient simulation algorithm for the model parameters of robotic manipulations显示文摘 | Ha I J Ko M S Kwon S K | 1989 | IEEE Trans on Robotics and Automation1989，5，： | 2 |
| 8 | The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation显示文摘 | Dupont E Ko Y S Rothery S | 2001 | Circulation2001，103，6： | 2 |
| 9 | Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress显示文摘 | Sangman Lee Jae s Moon Tae-Seok Ko | 2003 | Plant Physiology2003，131，： | 1 |
| 10 | Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in P53 stabilization显示文摘 | KO J LEE Y H HWANG S Y | 2003 | Oncogene2003，22，： | 1 |
| 11 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 12 | On the Complete Convergence for Weighted Sums of Dependent Random Variables under Condition of Weighted Integrability 显示文摘 | Baek J I Ko M H Kim T S | 2008 | J Korean Math Soc2008，45，1： | 1 |
| 13 | A cytochrome P450 gene is differentially expressed in compa-ible and incompatible interactions between pepper(Capsicum annuum)and the anthracnose fungus,Colletotrichum gloeosp-orioides显示文摘 | Ko M K Kim Y S | 1999 | Mol Plant-microbe Interaction1999，12，： | 1 |
| 14 | Improved enzymatic hydrolysis yield of rice straw using electron beam irradiation pretreatment显示文摘 | Bak J S Ko J K Han Y H | 2009 | Bioresource Technology2009，100，： | 1 |
| 15 | Effect of Modified Atmosphere Packaging on the Shelf-life of Coated, Whole and Sliced Mushrooms显示文摘 | KIM K M KO J A LEE J S | 2006 | Lebensmittel- wissenschaft und Technologie2006，39，4： | 1 |
| 16 | Structure-borne noise reduction for an infinite,elastic cylindrical shell显示文摘 | KO S H SEONG W PYO S | 2001 | Journal of the Acoustical Society of America2001，109，4： | 1 |
| 17 | Agenetie algorithm approach to developing the multi - echelon reverse logistics network for product returns显示文摘 | Min H Ko H J Ko C S | 2006 | Omega2006，34，： | 1 |
| 18 | Novel molecular drug carrier:Encapsulation of oxaliplatin in cucurbit uril and its effects on stability and reactivity of the drug显示文摘 | JEON Y J KIM S Y KO Y H | 2005 | Org Biomol Chem2005，3，11： | 1 |
| 19 | Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress 显示文摘 | Lee S Moon J S Ko T S | 2003 | Plant Physio12003，131，2： | 1 |
| 20 | Digital image stabilizing algorithms based on bit-plane matching 显示文摘 | Ko S J Lee S H Lee K H | 1998 | IEEE Transactions on Consumer Electronics1998，44，3： | 1 |
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