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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Endocrine regulation of menstruation 显示文摘 | Jabbour H N Kelly R W Fraser H M | 2006 | Endocr Rew2006，27，1： | 1 |
| 3 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 4 | Mechanical properties of nanocrystalline nickel produced by electrodeposition显示文摘 | Ebrahimi F Bourne G R Kelly M S | 1999 | Nanostructured Materials1999，11，3： | 1 |
| 5 | Use and impact of satellite atmospheric motion winds on ECMWF analyses and forecasts显示文摘 | Tomassini M Kelly G Saunders R | 1999 | Monthly Weather Review1999，127，6： | 1 |
| 6 | Stability and post-buckling behav- ior in nonbolted elastomeric isolators显示文摘 | Kelly J M Marsico M R | 2010 | Seism Isolation Protect Syst2010，1，1： | 1 |
| 7 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 8 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 9 | Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immtmogenic 显示文摘 | Curtiss R Kelly S M | 1987 | Infect Immun1987，55，12： | 1 |
| 10 | Later Life Leisure: How They Play in Peoria显示文摘 | KELLY J R STEINKAMP M W | 1986 | The Gerontologist1986，26，5： | 1 |
| 11 | Accuracy of finite difference modeling of acoustic wave equation显示文摘 | Alford R M Kelly K R Boore D M | 1974 | Geophysics1974，39，6： | 1 |
| 12 | High resolution characterization of the asian monsoon between 146 0013 and 99 0013 years B P from Dongge Cave, China and global correlation of events surrounding Termination Ⅱ 显示文摘 | Kelly M J Edwards L R Cheng H | 2006 | Palaeogeography Palaeeclimatology Palaeoecology 20062006，236，： | 1 |
| 13 | Accuracy of finite- difference modeling of the acoustic wave equation 显示文摘 | Alford R M Kelly K R Boore D M | 1974 | Geophysics1974，39，： | 1 |
| 14 | Mechanisms of energy absorption in special devices for use in earthquake resistant structures显示文摘 | Kelly J M Skinner R I Heine A J | 1972 | Bulletin of New Zealand National Society for Earthquake Engineering1972，5，3： | 1 |
| 15 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Stable computed torque control of robot manipulators via fuzzy self-tuning 显示文摘 | Llama M A Kelly R Santibaiez V | 2000 | IEEE Trans on Systems Man and Cybernetics --Part B: Cybernetics2000，30，1： | 1 |
| 17 | Dispersion of cerussite-rich tailings and plant uptake of heavy metals at historical lead mines near Newtownards,Northern Ireland显示文摘 | Moles N R Smyth D Mather C E Beattie E H Kelly M | 2004 | Applied Earth Science2004，113，： | 1 |
| 18 | Growth of well- defined ZnO mieropartieles by hydroxide ion hydrolysis of zinc salts显示文摘 | Mcbride R A Kelly J M Mecormaek D E | 2003 | J Mater Chem2003，13，5： | 1 |
| 19 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | | 0，，11： | 1 |
| 20 | Indicators of ecosystem response and recovery显示文摘 | Kelly J R Harwell M A | | 0，，05： | 1 |
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