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| 1 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 10 |
| 2 | 用于干形描述的2个少参数削度函数(英文)显示文摘以修正的Brink函数和Pain函数拟合尾巨桉干形曲线。材料来源于南非暖温带花岗岩低地草原地区桉树工业用材林53块标准地的153株尾巨桉干形测定数据。2个削度方程均能对调查数据进行很好地拟合,只是在不同的相对高度时有小的偏差。参数少的方程具有十分好的应用前景,因为从理论上来说,可以用参数预估的方法建立一个广义的干形模型。参数预估不能运用于修正的Brink函数,但在Pain函数的基础上建立参数预估模型是可能的甚至是必要的,因为Pain函数是把绝对树干直径描述为相对树干高度的函数。为此,对参数预估模型是否能描述的树形差异或者仅仅是大小的差异作了测度评价。应用结果表明,参数预估模型未必能用于描述树形的差异。 | Khalid A. Hussein Matthias Schmidt Heyns Kotze Klaus von Gadow | 2008 | 林业科学2008，44，6： | 4 |
| 3 | Principles and applications of electrochemical capacitors显示文摘 | KOTZ R CARLEN M | 2000 | Electrochim Acta2000，45，： | 2 |
| 4 | Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries显示文摘Heterogeneity in clinical presentation, histological severity, prognosis and therapeutic outcomes characteristic of non-alcoholic fatty liver disease(NAFLD) necessitates the development of scientifically sound classification schemes to assist clinicians in stratifying patients into meaningful prognostic subgroups. The need for replacement of invasive liver biopsies as the standard method whereby NAFLD is diagnosed, graded and staged with biomarkers of histological severity injury led to the development of composite prognostic models as potentially viable surrogate alternatives. In the present article, we review existing scoring systems used to(1) confirm the presence of undiagnosed hepatosteatosis;(2) distinguish between simple steatosis and NASH; and(3) predict advanced hepatic fibrosis, with particular emphasis on the role of NAFLD as an independent cardio-metabolic risk factor. In addition, the incorporation of functional genomic markers and application of emerging imaging technologies are discussed as a means to improve the diagnostic accuracy and predictive performance of promising composite models found to be most appropriate for widespread clinical adoption. | Hilmar K Lückhoff Frederik C Kruger Maritha J Kotze | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 5 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 6 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 7 | The evaluation of morphological characteristics of human spermatozoa according to stricter criteria显示文摘 | Menkveld R Stander FS Kotze TJ | 1990 | Hum Reprod1990，5，5： | 1 |
| 8 | Intestinal paracellular permeation enhancement with quaternised chitosan:in situ and in vitro evaluation 显示文摘 | JONKER C HAMMAN J H KOTZE A F | 2002 | Int J Pharm2002，238，： | 1 |
| 9 | Prevalence of flat foot in preschool-aged children显示文摘 | Pfeiffer M Kotz R Ledl T | 2006 | Pediatrics2006，2，： | 1 |
| 10 | Principles and applications of electrochemical capacitors显示文摘 | Kotz R Carlen M | 2000 | Electrochimica Acta2000，45，1516： | 1 |
| 11 | The efficacyand safety of a nicotine conjugate vaccine(NicVAX(R))orplacebo co-administered with varenicline(Champix(R))forsmoking cessation:study protocol of a phase lib,double blind,randomized,placebo controlled trial 显示文摘 | Hoogsteder P Kotz D Viechtbauer W | 2012 | BMC Public Health2012，12，： | 1 |
| 12 | Predictors of 1-yearmortality at hospital admission for acute exacerbations ofchronic obstructive pulmonary disease 显示文摘 | Slenter RH Spr〇oten RT Kotz D | 2013 | Respiration2013，85，1： | 1 |
| 13 | Principle and application of electrochemical capacitors 显示文摘 | KOTZ R CARLEN M | 2000 | Electrochimica Acta2000，54，1516： | 1 |
| 14 | Prospective cohort study of the effectiveness of varenicline versus nicotine replacement therapy for smoking cessation in the'real world'显示文摘 | Kotz D Brown J West R | 2014 | BMC Public Health2014，14，1： | 1 |
| 15 | The complete se-quence of the mitochondrial genome of the Aincan penguin ( Sphenis-cus demersus) 显示文摘 | Labuschagne C Kotze A Grobler J P | 2014 | Gene2014，534，1： | 1 |
| 16 | Distributional and Inferential Process Capability Indices 显示文摘 | Kotz S Johnson N L | 1992 | Journal of Quality Technology1992，24，4： | 1 |
| 17 | Dependence structure and symmetry of Huang-Kotz FGM distributions and their extensions显示文摘 | Bairamov I Kotz S | 2002 | Metrika2002，56，： | 1 |
| 18 | Obesity and aging显示文摘 | Kotz CM Billington CJ Levine AS | 1999 | Clin Geriatr Med1999，15，2： | 1 |
| 19 | Synthesis and evaluation of the mucoadhesivity of a CD-chitosan derivative 显示文摘 | Venter J P Kotze AF Auzely-Velty R | 2006 | International Journal of Pharmaceutics2006，313，： | 1 |
| 20 | Capacitance limits of high surface area activated carbons for double layer capacitors 显示文摘 | Barbieri O Hahn M Kotz R | 2005 | Carbon2005，43，： | 1 |
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