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| 1 | Effect of ginger Effect of ginger on gastric motility and symptoms of functional dyspepsiaon gastric motility and symptoms of functional dyspepsia显示文摘AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides. | Ming-Luen Hu Christophan K Rayner Keng-Liang Wu Seng-Kee Chuah Wei-Chen Tai Yeh-Pin Chou Yi-Chun Chiu King-Wah Chiu Tsung-Hui Hu | 2011 | World Journal of Gastroenterology2011，17，1： | 19 |
| 2 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 3 | Concentration and chemical composition of PM 2.5 in Shanghai for a 1-year period显示文摘 | Boming Ye Xueli Ji Haizhen Yang Xiaohong Yao Chak K Chan Steven H Cadle Tai Chan Patricia A Mulawa | 2002 | Atmospheric Environment2002，，4： | 2 |
| 4 | Handle- aware isolines for scalable shape editing显示文摘 | Au O K C Fu H B Tai C L | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 5 | Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics显示文摘 | Tai M H Olson L K Madhukar B V et ai | 2003 | Pancreas2003，26，： | 1 |
| 6 | Bioavailability of a series of novel acylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as an ascorbic acid supplement in rats and guinea pigs 显示文摘 | Tai A Fujinami Y Matsumoto K | 2002 | Biosci Biotechnol Biochem2002，66，8： | 1 |
| 7 | An Information Retrieval Model Based on Vector Space Method by Supervised Learning显示文摘 | Tai Xiaoying Ren Fuji Kenji K | 2002 | Information Processing and Management2002，38，6： | 1 |
| 8 | Topology optimization of piezoelectric sensors/actuators for torsional vibration control of composite plates显示文摘 | WANG S Y TAI K QUEK S T | 2006 | Smart Materials and Structures2006，15，2： | 1 |
| 9 | Fabrication and mechanical properties of multi walled carbon nanotubes/epoxy nano composites 显示文摘 | Yeh M K Hsieh T H Tai N | 2008 | Mater Sci Eng A2008，483，484： | 1 |
| 10 | Graph representation for structural topology optimization using genetic algorithms 显示文摘 | Wang S Y Tai K | 2004 | Computers & Structures2004，82，： | 1 |
| 11 | Elevated Serum Arginase Activity Levels in Patients with Breast Cancer显示文摘 | Muhammet Fevz? Polat Sey?than Tays? Sev?n? Polat Abdullah B?yük Ebubek?r Bakan | 2003 | Surgery Today2003，，9： | 1 |
| 12 | Touching a teddy bear mitigates neg- ative effects of social exclusion to increase prosocial behavior 显示文摘 | Tai K Zheng X Narayanan J | 2011 | So Psychol Pets Scl2011，2，6： | 1 |
| 13 | Adverse effects of arecoline and nicotine on human periodontal ligament fibroblasts in vitro 显示文摘 | CHANG Y C LII C K TAI K W | 2001 | J Clin Periodontol2001，28，3： | 1 |
| 14 | Randomized clinical trial of the effect of open versus laparoscopically assisted colectomy on systemic immunity in patients with colorectal cancer显示文摘 | TANG C L EU K W TAI B C | 2001 | Br J Surg2001，88，6： | 1 |
| 15 | Functional reconstruction of swallowing and articulation after total glossectomy without laryngectomy: money pouch-like reconstruction method using rectus abdominis myocutaneous flap显示文摘 | Kiyokawa K Tai Y Inoue Y | 1999 | Plast Reconstr Surg1999，104，： | 1 |
| 16 | Trends in the incidence and mortality of coronary heart disease in asian pacific region 显示文摘 | MENG K C TAI E | 2013 | Journal of Atherosclerosis and Thrombosis2013，21，： | 1 |
| 17 | Detection of machine failure:hidden Markov model approach显示文摘 | TAI A H CHING W K CHAN L Y | 2009 | Computers and Industrial Engineering2009，57，2： | 1 |
| 18 | Parametric representation of a surfacepencil with a common spatial geodesic显示文摘 | Wang G J Tang K Tai C L | 2004 | Computer-Aided Design2004，36，5： | 1 |
| 19 | An evolutionary algorithm for multiobjective optimization 显示文摘 | Ray T Tai K Scow K C | 2001 | Engineering Optimization2001，33，3： | 1 |
| 20 | Structural studies of two ovalbumin glycopeptides in relation to the endo - beta - N - acetylglucosaminidase specificity显示文摘 | Tai T Yamashita K Ogata- Arakawa M | 1975 | The Journal of Biological Chemistry1975，250，21： | 1 |
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