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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Method for rapid on-site identification of VOCs显示文摘Rapid on-site identification of volatile organic compounds (VOCs) in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid (< 3 min) sampling and identification of VOCs typically found at contaminated sites at the low ppbv level. | Justin D Fair William F Bailey Robert A Felty Amy E Gifford Benjamin Shultes Leslie H Volles | 2009 | Journal of Environmental Sciences2009，21，7： | 8 |
| 3 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 4 | Distinguishing between parenchymal and anastomotic leakage at duct-to-mucosa pancreatic reconstruction in pancreaticoduodenectomy显示文摘瞄准:在胰腺的残余的 duct-to-mucosa 重建把吻合与实质的漏区分开来。方法:我们考察了与 end-to-side duct-to-mucosa pancreatojejunostomy (PJ ) 在 5/2000 和 12/2005 之间执行的 68 pancreaticod-uodenectomies 的图表。pancreatography 的结果,以及仙子胰腺的排水管体积,和淀粉酶层次被分析。结果:68 pancreatojejunostomies, 48 没由 pancreatography 有漏缝并且有低排水管的淀粉酶(正常) ;八没让 pancreatographic 漏,但是提高了排水管淀粉酶(实质的漏缝) ;并且 12 让 pancreatographic 漏并且提高了排水管淀粉酶(吻合漏缝) 。尽管在实质的排水管体积漏,组显著地在手术后的白天(邮政部门) 被提高 4,没有差别在邮政部门 7 点被发现。排水管淀粉酶水平不在邮政部门 4 点是显著地不同的。在邮政部门 7 点,相反, anastomotic 漏缝组显著地与正常和 parenchymal 漏缝组相比提高了排水管淀粉酶水平(14158 +/- 24083 IU/L 对 89 +/- 139 IU/L 和 1707 +/- 1515 IU/L,分别地 P = 0.012 ) 。结论:为在 pancreaticoduodenectomy 以后的胰腺的残余重建,胰腺的排水管淀粉酶铺平的 pancreatogram 和仙子的联合能被用来在胰腺的残余重建在实质的和吻合漏之间区分。 | Justin H Nguyen | 2008 | World Journal of Gastroenterology2008，14，43： | 7 |
| 5 | Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C显示文摘Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications. | Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli C Burcin Taner Rolland C Dickson | 2009 | World Journal of Gastroenterology2009，15，40： | 5 |
| 6 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 7 | Situs inversus abdominus and malrotation in an adult with Ladd's band formation leading to intestinal ischaemia显示文摘地点在对有肠的旋转异例的 abdominus 是一个极其稀罕的条件。尽管肠的旋转不良在婴儿和孩子作为阻塞的一个原因被认出了并且可能由肠的 ischaemia 复杂,它在成年人是很稀罕的。当它发生在成年病人时,它可以作为含糊的断断续续的腹的疼痛作为肠阻塞或肠的 ischaemia 或长期地尖锐地介绍。此处,我们在场与 Ladd 在 32 岁女人导致肠的梗塞的乐队一起的地点在对 abdominus 和肠的旋转不良的一个案例的一个尖锐演讲。 | Ismail H Mallick Rizwan Iqbal Justin B Davies | 2006 | World Journal of Gastroenterology2006，12，25： | 3 |
| 8 | Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice显示文摘AIM:To investigate the effect of matrix metalloproteinase-9(MMP-9) on the remnant liver after massive hepatectomy in the mouse.METHODS:Age-matched,C57BL/6 wild-type(WT),MMP-9(-/-),and tissue inhibitors of metalloproteinases(TIMP)-1(-/-) mice were used.The mice received 80%-partial hepatectomy(PH).Samples were obtained at 6 h after 80%-PH,and we used histology,immunohistochemical staining,western blotting analysis and zymography to investigate the effect of PH on MMP-9.The role of MMP-9 after PH was investigated using a monoclonal antibody and MMP inhibitor.RESULTS:We examined the remnant liver 6 h after 80%-PH and found that MMP-9 deficiency attenuated the formation of hemorrhage and necrosis.There were significantly fewer and smaller hemorrhagic and necrotic lesions in MMP-9(-/-) remnant livers compared with WT and TIMP-1(-/-) livers(P < 0.01),with no difference between WT and TIMP-1(-/-) mice.Serum alanine aminotransaminase levels were significantly lower in MMP-9(-/-) mice compared with those in TIMP-1(-/-) mice(WT:476 ± 83 IU/L,MMP-9(-/-):392 ± 30 IU/L,TIMP-1(-/-):673 ± 73 IU/L,P < 0.01).Western blotting and gelatin zymography demonstrated a lack of MMP-9 expression and activity in MMP-9(-/-) mice,which was in contrast to WT and TIMP-1(-/-) mice.No change in MMP-2 expression was observed in any of the study groups.Similar to MMP-9(-/-) mice,when WT mice were treated with MMP-9 monoclonal antibody or the synthetic inhibitor GM6001,hemorrhagic and necrotic lesions were significantly smaller and fewer than in control mice(P < 0.05).These results suggest that MMP-9 plays an important role in the development of parenchymal hemorrhage and necrosis in the small remnant liver.CONCLUSION:Successful MMP-9 inhibition attenuates the formation of hemorrhage and necrosis and might be a potential therapy to ameliorate liver injury after massive hepatectomy. | Norifumi Ohashi Tomohide Hori Florence Chen Sura Jermanus Christopher B Eckman Akimasa Nakao Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 9 | Full-thickness intraperitoneal excision by transanal endoscopic microsurgery does not increase short-term complications显示文摘 | Justine A Gavagan Mark H Whiteford Lee L Swanstrom | 2004 | The American Journal of Surgery2004，，5： | 2 |
| 10 | Attentional Changes During Im- plicit Learning: Signal Validity Protects a Target Stimulus From the At- tentional Blink显示文摘 | EVAN J L IRINA M H JUSTIN A H | 2009 | Journal of Experimental Psychology2009，35，2： | 1 |
| 11 | Extracellular Ca2+stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblast显示文摘 | Shixia H Veronica M Justin M | | 0，，： | 1 |
| 12 | Single-use,thermally actuated paraffin valves fur microfluidic applications 显示文摘 | Liu R H Justin Bonannol Yang Jianing | 2004 | Sensors and Actuators B2004，，98： | 1 |
| 13 | A large number of novel coding small open reading frames in the intergenic regions of the Arabidopsis thaliana genome are transcribed and/or under purifying selection显示文摘 | KOUSUKE H ZHANG X JUSTIN O B | | 0，，05： | 1 |
| 14 | Algal esterase activity as a biomeasure of environmental degradation in a freshwater creek显示文摘 | Rudi H Regel John M Ferris George G Ganf Justin D Brookes | 2002 | Aquatic Toxicology2002，，3： | 1 |
| 15 | A Competency-Based Perspective on Entrepreneurship Education:Conceptual andEmpirical Insights显示文摘 | Michael H Morris Justin W Webb Jun Fu | 2013 | Journal of Small Business Management2013，51，3： | 1 |
| 16 | Ross managing the interna organization of colleges and universitie显示文摘 | MATTHEW H JUSTIN M | 2010 | Doing More with Less2010，，3： | 1 |
| 17 | Root adaptation to soil water logging显示文摘 | ARMSTRONG W JUSTIN S H F W BECKETT P M | 1991 | Aquatic Botany1991，39，2： | 1 |
| 18 | The compatible-so- lute-binding protein OpuAC from Bacillus subtilis:ligand binding, site--directed mutagenesis, and crystallographic stud- ies显示文摘 | Sander H J Marina H Justin L | 2008 | Journal of Bacteriology2008，190，16： | 1 |
| 19 | Member IEEE,Analysis and design of a novel hydraulic power source for mobile robots显示文摘 | Justin W Raade H Kazerooni | | 0，，1545： | 1 |
| 20 | Reinforcing poly(e-caprolactone) nanoflbers with cellulose nanocrystals显示文摘 | Justin O Z Maria S P Youssef H | 2009 | Applied Materials and Interfaces2009，1，9： | 1 |
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