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| 1 | Tectonic thermal history and its significance on the formation of oil and gas accumulation and mineral deposit in Ordos Basin显示文摘The analyzing data on stratigraphic temperature measurement , thermal conductivity of the strata and radioactive heat production rate show that the present average geothermal gradient in the Ordos Basin is 2.93℃/100 m, and the average heat flow value is 61.78 mW/m2, which belongs to the mesothermal basin, and the value of the present geothermal gradient and heat flow in the east is higher than that in the west. The sandstone radioactive heat production rate of Zhiluo Group in Dongsheng Uranium deposits of Yimeng uplift is obviously higher in the mudstone, indicating that there exists a uranium anomaly. Based on studies of the present thermal field of the basin, the late-Mesozoic paleotemperature and paleogeothermal gradient are determined by using different kinds of paleotemperature methods. According to the anomaly of the late-Mesozoic paleotemperature gradient and magmatic event age, there was a tectonic thermal event in the early Cretaceous epoch of late-Mesozoic. This article rebuilds tectonic thermal history of different tectonic units by thermal history simulation using basin simulating software. The evolution of oil-gas and coal, and accumulation (mineralization) of mineral uranium are all controlled by the tectonic thermal history in the Ordos basin, especially by the tectonic thermal event that happened in the late Mesozoic. For both the gas source rocks of upper Paleozoic group and lower paleozoic group, the gas was largely generated in the early Cretaceous epoch of the late Mesozoic. The main petroleum generation period for Yanchang Group in Triassic system is the early Cretaceous epoch too, and the highest thermal maturity of the coal of Permo-Carboniferous, Triassic, and Jurassic reaches is the early Cretaceous epoch also. Early Cretaceous epoch is still one of the most important mineralizing periods of uranium. | REN ZhanLi ZHANG Sheng GAO ShengLi CUI JunPing XIAO YuanYuan XIAO Hui | 2007 | Science China Earth Sciences2007，50，z2： | 44 |
| 2 | Mapping the hotspots and coldspots of ecosystem services in conservation priority setting显示文摘空间明确地热点和 coldspots 印射是在将保存放为生态系统服务(ES ) 的优先级的一个重要连接。然而,很少研究都没识别并且测试了他们的 ES 热点和 coldspots 的紧密和效率,它可以削弱生态的保存的有效性。在这学习,基于 RUSLE 模型和 Getis-Ord 官方补给 * 统计,我们确定了年度土壤保存服务(SC ) 的变化并且从 2000 ~ 2013 在中国的 Shaanxi 省识别了统计上重要的热点和 coldspots。结果显示那, 1 ) 有高 SC 的区域也介绍了一个显著地增加的趋势,当有低 SC 的区域仅仅稍微变化了时;2 ) SC 热点和 coldspots 证明热点主要是的明显的空间 differentiationthe 空间地在南部的 Shaanxi 聚集了,当 coldspots 主要在 Guanzhong 盆和沙多风的高原被散布时;并且 3 ) 识别热点有提供 SC 的最高的能力,与提供的 29.6% 全部的区域, 59.7% 总数满足。相反, coldspots 占据了 46.3% 全部的区域,但是仅仅提供了 17.2% 全部的 SC。除了保存单个 ES, Getis-Ord 官方补给 * 统计方法能也帮助为保存多重 ES 和生物多样性识别多功能的优先级区域。 | LI Yingjie ZHANG Liwei YAN Junping WANG Pengtao HU Ningke CHENG Wei FU Bojie | 2017 | Journal of Geographical Sciences2017，27，6： | 19 |
| 3 | Cenozoic Stratigraphy Deformation History in the Central and Eastern of Qaidam Basin by the Balance Section Restoration and its Implication显示文摘Qaidam 盆,在 Qinghai 西藏高原的北边缘定位了,是大中生代新生代盆,和熊巨大的厚新生代阶层。自从 ∼55 妈,印第安人欧亚的板板碰撞的地质的事件是记录的井。在高分辨率的地层学基于最近的进步,平衡的节的一种技术被用于六东北西南地质的地震侧面在 Qaidam 盆中央、东方重建外壳的弄短变丑历史在新生代碰撞期间。结果证明 Qaidam 盆开始弄短对早碰撞将近同步的变丑,作为弱压缩表明,变丑在中间期间并且晚显著地增加了始新世,然后稍微变弱并且开始后来很快加速了晚中新世,特别第四级,反映这强大的有压缩性的变丑并且快速在 Qaidam 盆附近北西藏的高原高举。 | LIU Dongliang FANG Xiaomin GAO Junping WANG Yadong ZHANG Weilin MIAO Yunfa LIU Yongqian ZHANG Yuezhong | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 16 |
| 4 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 5 | High-accuracy primary and transfer standards for radiometric calibration显示文摘The first research and experimental results obtained in China of high-accuracy radiometric calibration based on cryogenic radiometer are reported. Uncertainties of cryogenic radiometer and trap detectors at 7 wavelengths in the visible spectrum (488-786 nm) were less than 0.023% and 0.035% respectively, which proved the reasonability and possibility of establishing and transferring high-accuracy radiometric standards based on detectors. | Xiaobing Zheng Haoyu Wu Junping Zhang Yucheng Liu Wei Zhou Leyi Wang Yanli Qiao | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 6 | Molecular simulation of oligomer inhibitors for calcite scale显示文摘Molecular simulation was performed to study the interaction between CaCO3 crystal and several oligomer inhibitors, by using the equilibrium morphology method to calculate the growth morphology of CaCO3 without inhibitors. The calculated morphology agreed well with SEM photographs. Then, a double-layer model was built to investigate the interaction between calcite crystal and oligomer inhibitors containing maleic anhydride (MA) and acrylic acid (AA). Interaction energy per gram of an oligomer inhibitor was introduced as a scale of inhibition efficiency of different monomers. The results indicated that, for calcite scale inhibition, acrylamide (AM) and vinyl phosphonic acid (VPA) were the most efficient monomers, while allylsulfonic acid (AS) was the poorest. Increasing proportion of AM in dimer inhibitor molecule would improve the inhibition efficiency of MA, though, for a trimer, such as MA-AA-AM, certain sequence of monomers in the inhibitor molecule was necessary besides higher proportion of AM. | Qiuyu Zhang Hua Ren Wenwen Wang Junping Zhang Hepeng Zhang | 2012 | Particuology2012，10，3： | 11 |
| 7 | Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease显示文摘Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future. | Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 9 |
| 8 | Developing a bacteriophage cocktail for biocontrol of potato bacterial wilt显示文摘Bacterial wilt is a devastating disease of potato and can cause an 80% production loss. To control wilt using bacteriophage therapy, we isolated and characterized twelve lytic bacteriophages from different water sources in Kenya and China. Based on the lytic curves of the phages with the pathogen Ralstonia solanacearum, one optimal bacteriophage cocktail, P1, containing six phage isolations was formulated and used for studying wilt prevention and treatment efficiency in potato plants growing in pots. The preliminary tests showed that the phage cocktail was very effective in preventing potato bacterial wilt by injection of the phages into the plants or decontamination of sterilized soil spiked with R. solanacearum. Eighty percent of potato plants could be protected from the bacterial wilt(caused by R. solanacearum reference strain GIM1.74 and field isolates), and the P1 cocktail could kill 98% of live bacteria spiked in the sterilized soil at one week after spraying.However, the treatment efficiencies of P1 depended on the timing of application of the phages, the susceptibility of the plants to the bacterial wilt, as well as the virulence of the bacteria infected,suggesting that it is important to apply the phage therapy as soon as possible once there are early signs of the bacterial wilt. These results provide the basis for the development of bacteriophagebased biocontrol of potato bacterial wilt as an alternative to the use of antibiotics. | Cuihua Wei Junli Liu Alice Nyarnbura Maina Francis B Mwaura Junping Yu Chenghui Yan Ruofang Zhang Hongping Wei | 2017 | Virologica Sinica2017，32，6： | 8 |
| 9 | RNA interference targeting CD147 inhibits metastasis and invasion of human breast cancer MCF-7 cells by downregulating MIVIP-9/VEGF expression显示文摘 | Fang Li Junping Zhang Jiqiang Guo Yuan Jia Yaping Han Zhuanhua Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 7 |
| 10 | Complete genome analysis of Ketogulonigenium sp. WB0104显示文摘Ketogulonigenium sp. may convert L-sorbose into 2-keto-L-gulonic acid, the vitamin C precursor. The genome of Ketogulonigenium sp. WB0104 consists of a circular 2765030 bp chromo- some with 61.69% G+C content and two circular plasmids of 267968 and 242707 bp. The genome contains 2727 open reading frames (ORFs). The systems of replication, transcription, translation, carbohydrate and energy metabolism are intact, but the repair system is incomplete. About 640 predicted ORFs have been found to encode transporter pro- teins, which account for about one fourth of total predicted ORFs, noticeably higher than other docu- mented bacteria. This may be due to the fact that WB0104 adapts to soil circumstance. | YANG Fan JIA Qian XIONG Zhaohui ZHANG Xiaobing WU Hongtao ZHAO Ying YANG Jian ZHU Junping DONG Jie XUE Ying SUN Lilian SHEN Yan JIN Qi | 2006 | Chinese Science Bulletin2006，51，8： | 6 |
| 11 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 12 | Development of small molecule extracellular signal-regulated kinases(ERKs) inhibitors for cancer therapy显示文摘The mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase 1/2(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its dysregulation is associated with the proliferation, invasion, and migration of cancer cells. ERK1/2 is located at the distal end of this pathway and rarely undergoes mutations, making it an attractive target for anticancer drug development. Currently, an increasing number of ERK1/2 inhibitors have been designed and synthesized for antitumor therapy, among which representative compounds have entered clinical trials. When ERK1/2 signal transduction is eliminated, ERK5 may provide a bypass route to rescue proliferation, and weaken the potency of ERK1/2 inhibitors. Therefore, drug research targeting ERK5 or based on the compensatory mechanism of ERK5 for ERK1/2 opens up a new way for oncotherapy. This review provides an overview of the physiological and biological functions of ERKs, focuses on the structure-activity relationships of small molecule inhibitors targeting ERKs, with a view to providing guidance for future drug design and optimization, and discusses the potential therapeutic strategies to overcome drug resistance. | Xiaoli Pan Junping Pei Aoxue Wang Wen Shuai Lu Feng Faqian Bu Yumeng Zhu Lan Zhang Guan Wang Liang Ouyang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 13 | GNSS clock corrections densification at SHAO:from 5 min to 30 s显示文摘High frequency multi-GNSS zero-difference applications like Precise Orbit Determination(POD)for Low Earth Orbiters(LEO)and high frequency kinematic positioning require corresponding high-rate GNSS clock corrections.The determination of the GNSS clocks in the orbit determination process is time consuming,especially in the combined GPS/GLONASS processing.At present,a large number of IGS Analysis Centers(AC)provide clock corrections in 5-min sampling and only a few ACs provide clocks in 30-s sampling for both GPS and GLONASS.In this paper,an efficient epoch-difference GNSS clock determination algorithm is adopted based on the algorithm used by the Center for Orbit Determination in Europe(CODE).The clock determination procedure of the GNSS Analysis Center at Shanghai Astronomical Observatory(SHAO)and the algorithm is described in detail.It is shown that the approach greatly speeds up the processing,and the densified 30-s clocks have the same quality as the 5-min clocks estimated based on a zero-difference solution.Comparing the densified 30-s GNSS clocks provided by SHAO with that of IGS and its ACs,results show that our 30-s GNSS clocks are of the same quality as that of IGS.Allan deviation also gives the same conclusion.Further validation of the SHAO 30-s clock product is performed in kinematic PPP and LEO POD.Results indicate that the positions have the same accuracy when using SHAO 30-s GNSS clocks or IGS(and its AC)finals.The robustness of the algorithm and processing approach ensure its extension to provide clocks in 5-s or even higher frequencies.The implementation of the new approach is simple and it could be delivered as a black-box to the current scientific software packages. | CHEN JunPing ZHANG YiZe ZHOU XuHua PEI Xiao WANG JieXian WU Bin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，1： | 4 |
| 14 | Planted forest is catching up with natural forest in China in terms of carbon density and carbon storage显示文摘Over the last several decades,China has taken multiple measures for afforestation and natural forest protection,including setting the goal of carbon neutrality by the middle of 21th century.In order to support the practice of relevant policies from the scientific perspective,it is essential to precisely estimate the carbon storage of arbor forest,as it plays an important role in the carbon cycle of ecosystems.In this study,we first used the latest four phases of national forest inventory data to investigate the variation of carbon storage for both natural and planted arbor forest in China during the covered period(1999-2018).Then we used machine leaning methods to simulate the carbon density based on various kinds of environmental factors and analyzed the contribution of each influencing factor.Our results demonstrate that the total carbon storage for arbor forest in China kept increasing over the last two decades,but this increment was mainly brought about by the continuous expansion of forest land.The gap of carbon sequestration between natural forest and planted forest showed a significant trend of reduction.Additionally,tree age was identified as the dominant factor for influencing the spatiotemporal variation of carbon density among all the independent variables while the impact of climatic factor was limited.Therefore,the future improvement of carbon sequestration of arbor forest in should mainly rely on additional projects of afforestation,reforestation,green space conservation and reduction of emissions in China.Conclusions of this study have important implications for policy makers and other stakeholders to evaluate the previous achievement of environmental projects and can also help to set future plans and finally realize the goals of carbon neutrality. | Boyi Liang Jia Wang Zheyuan Zhang Jia Zhang Junping Zhang Elizabeth L.Cressey Zong Wang | 2022 | Fundamental Research2022，2，5： | 3 |
| 15 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 16 | Ambulatory blood pressure profile and stroke recurrence显示文摘Objectives To establish a new ambulatory blood pressure(ABP)parameter(24-hour ABP profile)and evaluated its performance on stroke outcome in ischaemic stroke(IS)or transient ischaemic attack(TIA)patients.Methods The prospective cohort consisted of 1996 IS/TIA patients enrolled for ABP monitoring and a 3-month follow-up for stroke recurrence as outcome.Profile groups of systolic blood pressure(SBP)were identified via an advanced functional clustering method,and the associations of the profile groups and conventional ABP parameters with stroke recurrence were examined in a Cox proportional hazards model.Results Three discrete profile groups(n=604,781 and 611 in profiles 1,2 and 3,respectively)in 24-hour ambulatory SBP were identified.Profile 1 resembled most to the normal diurnal blood pressure pattern;profile 2 also dropped at night,but climbed earlier and with higher morning surge;while profile 3 had sustained higher nocturnal SBP without significant nocturnal SBP decline.The incidence of stroke recurrence was 2.9%,3.9%and 5.5%in profiles 1,2 and 3,respectively.After adjustment for covariates,profile 3 was significantly associated with higher risk of stroke recurrence with profile 1 as reference(HR 1.76,95%CI:1.00 to 3.09),while no significant difference was observed between profiles 2 and 1(HR 1.22,95%CI:0.66 to 2.25).None of conventional ABP parameters showed significant associations with the outcome.Conclusions Ambulatory 24-hour SBP profile is associated with short-term stroke recurrence.Profiles of ABP may help improve identification of stroke recurrence by capturing the additive effects of individual ABP parameters. | Jie Xu Fei Jiang Anxin Wang Hui Zhi Yuan Gao Junping Tian Jinglin Mo Zimo Chen An-Ding Xu Benyan Luo Bo Hu Yuqing Zhang Xingquan Zhao Yilong Wang Hao Li Haipeng Shen Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 3 |
| 17 | Effects of imidazolium-based ionic liquids on the isobaric vapor–liquid equilibria of methanol+dimethyl carbonate azeotropic systems显示文摘The separation of methanol(MeOH)and dimethyl carbonate(DMC)is important but difficult due to the formation of an azeotropic mixture.In this work,isobaric vapor–liquid equilibrium(VLE)data for the ternary systems containing different imidazolium–based ionic liquids(ILs),i.e.MeOH+DMC+1-butyl-3-methy-limidazolium bis[(trifluoromethyl)sulfonyl]imide([Bmim][Tf2N]),MeOH+DMC+1-ethyl-3-methyl-imidazolium bis[(trifluoromethyl)sulfonyl]imide([Emim][Tf2N]),and MeOH+DMC+1-ethyl-3-methylimidazolium hexafluorophosphate([Emim][PF6])were measured at 101.3 kPa.The mole fraction of IL was varied from0.05 to 0.20.The experimental data were correlated with the NRTL and Wilson equations,respectively.The results show that imidazolium-based ILs were beneficial to improve the relative volatility of MeOH to DMC,and[Bmim][Tf2 N]showed a much more excellent performance on the activity coefficient of MeOH.The interaction energies of system components were calculated using Gaussian program,and the effects of cation and anion on the separation coefficient of the azeotropic system were discussed. | Songsong Chen Li Dong Junping Zhang Weiguo Cheng Feng Huo Qian Su Wei Hua | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 3 |
| 18 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 19 | Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19显示文摘As a respiratory tract virus,SARS-CoV-2 infected people through contacting with the upper respiratory tract first.Previous studies indicated that microbiota could modulate immune response against pathogen infection.In the present study,we performed metagenomic sequencing of pharyngeal swabs from eleven patients with COVID-19 and eleven Non-COVID-19 patients who had similar symptoms such as fever and cough.Through metagenomic analysis of the above two groups and a healthy group from the public data,there are 6502 species identified in the samples.Specifically,the Pielou index indicated a lower evenness of the microbiota in the COVID-19 group than that in the Non-COVID-19 group.Combined with the linear discriminant analysis(LDA)and the generalized linear model,eighty-one bacterial species were found with increased abundance in the COVID-19 group,where 51 species were enriched more than 8 folds.The top three enriched genera were Streptococcus,Prevotella and Campylobacter containing some opportunistic pathogens.More interestingly,through experiments,we found that two Streptococcus strains,S.suis and S.agalactiae,could stimulate the expression of ACE2 of Vero cells in vitro,which may promote SARS-CoV-2 infection.Therefore,these enriched pathogens in the pharynxes of COVID-19 patients may involve in the virus-host interactions to affect SARS-CoV-2 infection and cause potential secondary bacterial infections through changing the expression of the viral receptor ACE2 and/or modulate the host’s immune system. | Dongyan Xiong Caroline Muema Xiaoxu Zhang Xinming Pan Jin Xiong Hang Yang Junping Yu Hongping Wei | 2021 | Virologica Sinica2021，36，5： | 3 |
| 20 | Author correction to'Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TL R4 signaling’[Acta Pharmaceutica Sinica B 12(2022)1198-1212]显示文摘The authors regret that there were some errors or inexact de-scriptions in author afiliation,the section of materials and methods,and the figure caption of Fig.2A owing to the negligence of authors when writing the manuscript,and there was a picture error in Fig.10 and graphical abstract figure owing to the inappropriate selection for the picture of Radix Ophiopogon japonicus.In author afiliation,'Department of Pharmacology of Chinese Material Medica'should be corrected to'Department of Pharmacology of Chinese Materia Medica'.In 2.4. | Yunhao Wu Xiu Yu Yuwei Wang Yalin Huang Jiahui Tang Shuaishuai Gong Siyu Jiang Yuanli Xia Fang Li Boyang Yu Yuanyuan Zhang Junping Kou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
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