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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 3 | Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis显示文摘BACKGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing population.AIM To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee OA.The visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(KOOS),and adverse events were analyzed.Analysis was performed on the R-platform using OpenMeta(Analyst)software.Twenty-one studies,involving 936 patients,were included.Only one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was performed.RESULTS At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(P<0.001,P=0.539),and AD-MSCs outperformed BM-MSCs compared to controls in measures such as WOMAC(P<0.001,P=0.541),Lysholm scores(P=0.006;P=0.933),and KOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional outcomes.Future trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA. | Sathish Muthu Sandesh C Patil Naveen Jeyaraman Madhan Jeyaraman Prakash Gangadaran Ramya Lakshmi Rajendran Eun Jung Oh Manish Khanna Ho Yun Chung Byeong-Cheol Ahn | 2023 | World Journal of Orthopedics2023，14，1： | 2 |
| 4 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 5 | Anti-CD16/CD30 bispecific antibody treatment for Hodgkin's disease: role of infusion schedule and costimulation with cytokines 显示文摘 | Hartmann F Renner C Jung W ET aI | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 6 | A novel electrochemically active and Fe (Ⅲ)-reducing bacterium phylogenetically related to Aeromonas hydrophila, isolated from a microbial fuel cell 显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiol Lett2003，223，： | 1 |
| 7 | Effects of complex carbide fraction on high-temperature wear properties of hardfacing alloys reinforced with complex carbides显示文摘 | Kim C K Lee S h Jung J Y | 2003 | Materials Science and Engineering A2003，349，1： | 1 |
| 8 | Efficient multilevel successive elimination algorithms for block matching motion estimation 显示文摘 | Shin S C Baik H | 2002 | Vision Image and Signal Processing IEE Proc2002，149，2： | 1 |
| 9 | Capillary tube selection for HCFC22 alternatives 显示文摘 | Jung D Park C Park B | 1999 | International Journal of Refrigeration1999，22，8： | 1 |
| 10 | A novel electrochemically active and Fe (Ⅲ)-reducing bacterium phylogenetieally related to Aeromonas hydrophila, isolated from a microbial fuel cell显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiology Letters2003，223，： | 1 |
| 11 | Transparent amorphous In-Ga-Zn-O thin film as function of various gas flows for TFT applications 显示文摘 | JUNG C H KIM D J KANG Y K | 2009 | Thin Solid Films2009，517，14： | 1 |
| 12 | Surface Status and Size Influences of Nickel Nanoparticles on Sulfur Compound Adsorption 显示文摘 | Chang H K Jung G P Ji C P | 2007 | Applied Surface Science2007，253，13： | 1 |
| 13 | Chromosome 9 monosomy by fluorescence in situ hybridization of bladder irrigation specimens is predictive of tumor recurrence显示文摘 | Jung I Reeder JE Cox C | 1999 | J Urol1999，162，6： | 1 |
| 14 | Low pressure sintering of Sialon using different sintering additives 显示文摘 | Jung H J Aim K Y Choi C | 2008 | Journal of the Ceramic Society of Japan2008，116，1： | 1 |
| 15 | Prediction of collapse in femoral head osteonecrosis:a modified Kerboul method with use of magnetic resonance images显示文摘 | HA Y C JUNG W H KIM J R | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 16 | A Novel Electrochemically Active and Fe (Ⅲ)- reducing Bacterium Aeromonas Hydrophoila Related to Clostridium Butyricum Isolated from a Microbial Fuel Cell 显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiol Lett2003，223，： | 1 |
| 17 | Force tracking impedance control of robot manipulators trader unknown environment 显示文摘 | JUNG S HSIA T C BONITZ R G | 2004 | IEEE Transactions on Control Systems Technology2004，12，3： | 1 |
| 18 | Processes responsible for the trace content in precipitation 显示文摘 | Junge C E | 1977 | IASH-AISH publ1977，118，： | 1 |
| 19 | Low expression of p27 (Kipl) in advanced mucoepidermoid carcinomas of head and neck显示文摘 | Choi C S Choi G Jung K Y | 2001 | Head Neck2001，23，4： | 1 |
| 20 | A Novel Synthetic Route to TiO2-pillared Layered Titanate with Enhanced Photocatalytic Activity显示文摘 | Choy J H Lee H C Jung H Huang S J | 2001 | Journal of Materials Chemistry2001，11，： | 1 |
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