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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy显示文摘BACKGROUND Left ventricular hypertrophy(LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic(ECG) diagnosis have limited accuracy.AIM To investigate findings associated with LVH on ECG and developed an improved system for the diagnosis of LVH.METHODS A cohort study comparing ECG data acquired within 30 days of transthoracic echocardiography(TTE) was performed. Multivariate regression analysis identified ECG findings associated with increased LV mass and mass index. A scoring system was derived and performance compared to established criteria for LVH.RESULTS Data from 5486 outpatients with TTEs and corresponding ECGs were included in the derivation cohort, 333(6.1%) of whom had LVH by TTE. In the primary regression analysis, findings associated with LVH were amplitudes of Q in V3, R in V6, S in V3, T in V6, P' in V1, P in V6, as well as R and T-axis discordance, R peak time in V6, QRS duration, weight, height, sex, and age. From this we derived a score consisting of 5 criteria, and validated it in an independent cohort of 910 patients. With a threshold of 1.5 points, sensitivity and specificity were67.9% and 81.4%, and 62.5% and 83.2% in the derivation and validation cohorts,respectively. With a threshold of 2 points, sensitivity and specificity were 42.3% and 93.0%, and 37.5% and 93.4% in these cohorts.CONCLUSIONS This score had superior sensitivity for detection of LVH by ECG while making a modest sacrifice in specificity compared to conventional criteria. | Eric D Braunstein Lori B Croft Jonathan L Halperin Steve L Liao | 2019 | World Journal of Cardiology2019，11，3： | 2 |
| 3 | Plant pathogens and integrated defenee responses to infection显示文摘 | Jonathan D G Jones Jeflbry L Dangl | 2001 | Nature2001，411，： | 1 |
| 4 | Intensive chemotherapy and radicaf resections for primary nonse minomatous mediastinaf germ ceff tumors显示文摘 | Garret L W Grant D T Jonathan C N | 2000 | Ann Thorac Surg2000，69，： | 1 |
| 5 | Plant pathogens and integrated defence responses to infection显示文摘 | JEFFERY L D JONATHAN D G J | 2001 | Nature2001，411，： | 1 |
| 6 | Using CALPUFF to evaluate the impacts of power plant emissions in illinois:model sensitivity and implications 显示文摘 | JONATHAN I L JOHN D S DENNIS H D | 2002 | Atmospheric Environment2002，36，： | 1 |
| 7 | Effect of antenna separation on the capacity of BLAST in correlated channels 显示文摘 | Chizhik D Farrokhi R F Jonathan L | 2000 | IEEE Communications Letters2000，4，11： | 1 |
| 8 | The epithelial-mesenchymal transition:new insights in signaling,development,and disease显示文摘 | Jonathan M L Shoukat D Raghu K Erik W T | 2006 | JCB2006，172，7： | 1 |
| 9 | The un-predictable nature of internal tides on continental shelves显示文摘 | Nash Jonathan D Kelly Samuel M Shroyer Emily L | | 0，，： | 1 |
| 10 | A plant DNA minipreparation: version II 显示文摘 | Stephen L D Jonathan W James B H | 1983 | Plant Molecular Biology Reporter1983，1，4： | 1 |
| 11 | A Within Firm Analysis of Current and Expected Future Audit Lag Determinants显示文摘 | Behn K B Searcy D L Jonathan B W | 2006 | Joural of Information Systems2006，20，1： | 1 |
| 12 | Understorey plant community structure in lower montane and subalpine forests, Grand Canyon National Park, USA 显示文摘 | Daniel C L Jonathan D B Peer Z F | 2005 | Journal of Biogeography2005，32，12： | 1 |
| 13 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 14 | The plant immune system显示文摘 | Jonathan D G J Jeffery L D | 2006 | Nature2006，444，： | 1 |
| 15 | Carbide-derived carbons:A comparative study of porosity based on small-angle scattering and adsorption isotherms显示文摘 | GIOVANNA L RANJAN K D JONATHAN P S | 2006 | Langmuir2006，22，21： | 1 |
| 16 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 17 | Fast Quantum Gates for Cold Trapped Ions显示文摘 | JONATHAN D PLENIO M B KNIGHT P L | 2000 | Phys Rev A2000，62，04： | 1 |
| 18 | SimRoot : Modelling and Visualization of Root Systems 显示文摘 | Jonathan P Lynch Kai L Nielsen Robert D Davis | 1997 | Plant and Soil1997，188，： | 1 |
| 19 | Study of Plant-Air Transfer of PCBs from an Evergreen Shrub: Implications for Mechanisms and Modeling 显示文摘 | Jonathan L B Gareth O T Gerha D | 2003 | Environ Sci Technol2003，37，： | 1 |
| 20 | Probiotics in prevetion of antibiotic associated diarrher:meta-analysis显示文摘 | ALOYISUS L D'SOUZA CHAKRAVARTHI R JONATHAN C | 2002 | BMJ2002，324，6： | 1 |
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