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| 1 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | A ASLD guidelines for treatment of chronic hepatitis B显示文摘 | Norah A. Terrault Natalie H. Bzowej Kyong‐Mi Chang Jessica P. Hwang Maureen M. Jonas M. Hassan Murad | 2016 | Hepatology2016，，： | 6 |
| 3 | Gastrointestinal stromal tumors: CT and MRI findings显示文摘 | Kumaresan Sandrasegaran Arumugam Rajesh Daniel A. Rushing Jonas Rydberg Fatih M. Akisik John D. Henley | 2005 | European Radiology2005，，7： | 3 |
| 4 | Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution显示文摘 | Camille L. Hancock Friesen David Zurakowski Ravi R. Thiagarajan Joseph M. Forbess Pedro J. del Nido John E. Mayer Richard A. Jonas | 2005 | The Annals of Thoracic Surgery2005，，2： | 2 |
| 5 | The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C显示文摘 | Kathleen B. Schwarz Regino P. Gonzalez–Peralta Karen F. Murray Jean P. Molleston Barbara A. Haber Maureen M. Jonas Philip Rosenthal Parvathi Mohan William F. Balistreri Michael R. Narkewicz Lesley Smith Steven J. Lobritto Stephen Rossi Alexandra Valsamaki | 2011 | Gastroenterology2011，，2： | 2 |
| 6 | Strain-induced nucleation of MnS in electrical steels显示文摘 | W. P. Sun M. Militzer J. J. Jonas | 1992 | Metallurgical Transactions A1992，，3： | 2 |
| 7 | Liver resection for hepatocellular carcinoma in patients without cirrhosis显示文摘 | A. Thelen C. Benckert H.‐M. Tautenhahn H.‐M. Hau M. Bartels J. Linnemann J. Bertolini M. Moche C. Wittekind S. Jonas | 2012 | Br J Surg2012，，1： | 2 |
| 8 | Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression显示文摘 | Theodore H. Lindsay Beth M. Jonas Molly A. Sevcik Kazufumi Kubota Kyle G. Halvorson Joseph R. Ghilardi Michael A. Kuskowski Edward B. Stelow Pinku Mukherjee Sandra J. Gendler Gilbert Y. Wong Patrick W. Mantyh | 2006 | Pain2006，，1： | 2 |
| 9 | Isolation and Hepatocyte Differentiation of Mesenchymal Stem Cells From Porcine Bone Marrow—“Surgical Waste” as a Novel MSC Source显示文摘 | S. Brückner H.-M. Tautenhahn S. Winkler P. Stock S. Jonas M. Dollinger B. Christ | 2013 | Transplantation Proceedings2013，，5： | 2 |
| 10 | Assessment of Value and Applications of In Vitro Testing of Topical Dermatological Drug Products显示文摘 | Gordon L. Flynn Vinod P. Shah Srinivas N. Tenjarla Michael Corbo David DeMagistris Terry G. Feldman Thomas J. Franz Deborah R. Miran David M. Pearce Joel A. Sequeira James Swarbrick Jonas C. T. Wang Avaraham Yacobi Joel L. Zatz | 1999 | Pharmaceutical Research1999，，9： | 2 |
| 11 | Feature sensitive re-sampling of point set surfaces with Gaussian spheres显示文摘Feature sensitive simplification and re-sampling of point set surfaces is an important and challenging issue for many computer graphics and geometric modeling applications.Based on the regular sampling of the Gaussian sphere and the surface normals mapping onto the Gaussian sphere,an adaptive re-sampling framework for point set surfaces is presented in this paper,which includes a naive sampling step by index propagation and a novel cluster optimization step by normalized rectification.Our proposed re-sampling scheme can generate non-uniformly distributed discrete sample points for the underlying point sets in a feature sensitive manner.The intrinsic geometric features of the underlying point set surfaces can be preserved efficiently due to our adaptive re-sampling scheme.A novel splat rendering technique is adopted to illustrate the efficiency of our re-sampling scheme.Moreover,a numerical error statistics and surface reconstruction for simplified models are also given to demonstrate the effectiveness of our algorithm in term of the simplified quality of the point set surfaces. | MIAO YongWei BOSCH Jonas PAJAROLA Renato GOPI M. FENG JieQing | 2012 | Science China(Information Sciences)2012，55，9： | 2 |
| 12 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 13 | Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non‐interventional, multicenter study ( LOBSTER )显示文摘 | Hans J. Schlitt Sven Jonas Tom M. Ganten Gerrit Grannas Christian Moench Falk Rauchfuss Aiman Obed Giuseppe Tisone Antonio D. Pinna Giorgio E. Gerunda Susanne Beckebaum | 2013 | Clin Transplant2013，，3： | 1 |
| 14 | Refractive Errors and Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis显示文摘 | Chen-Wei Pan M. Kamran Ikram Carol Y. Cheung Hyung-Won Choi Chiu-Ming Gemmy Cheung Jost B. Jonas Seang-Mei Saw Tien-Yin Wong | 2013 | Ophthalmology2013，，： | 1 |
| 15 | Effect of molybdenum, niobium, and vanadium on static recovery and recrystallization and on solute strengthening in microalloyed steels显示文摘 | H. L. Andrade M. G. Akben J. J. Jonas | 1983 | Metallurgical Transactions A1983，，10： | 1 |
| 16 | Strain-induced nucleation of MnS in electrical steels显示文摘 | W. P. Sun M. Militzer J. J. Jonas | 1992 | Metallurgical Transactions A1992，，3： | 1 |
| 17 | Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs显示文摘 | Astrid A.M. Van der Veldt Mark Lubberink Idris Bahce Maudy Walraven Michiel P. de Boer Henri N.J.M. Greuter N. Harry Hendrikse Jonas Eriksson Albert D. Windhorst Pieter E. Postmus Henk M. Verheul Erik H. Serné Adriaan A. Lammertsma Egbert F. Smit | 2012 | Cancer Cell2012，，： | 1 |
| 18 | Strain-induced nucleation of MnS in electrical steels显示文摘 | W. P. Sun M. Militzer J. J. Jonas | 1992 | Metallurgical Transactions A1992，，3： | 1 |
| 19 | Definition of subtypes in the European genotype of porcine reproductive and respiratory syndrome virus: nucleocapsid characteristics and geographical distribution in Europe显示文摘 | Tomasz Stadejek Martin B. Oleksiewicz Alexei V. Scherbakov Anna M. Timina Jonas S. Krabbe Katarzyna Chabros Denis Potapchuk | 2008 | Archives of Virology2008，，8： | 1 |
| 20 | Influence of microstructure on the flow behavior of duplex stainless steels at high temperatures显示文摘 | O. Balancin W. A. M. Hoffmann J. J. Jonas | 2000 | Metallurgical and Materials Transactions A2000，，5： | 1 |
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