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| 1 | Bowel preparation with split-dose polyethylene glycol before colonoscopy: a meta-analysis of randomized controlled trials显示文摘 | Todd W. Kilgore Abdillahi A. Abdinoor Nicholas M. Szary Samuel W. Schowengerdt Jamie B. Yust Abhishek Choudhary Michelle L. Matteson Srinivas R. Puli John B. Marshall Matthew L. Bechtold | 2011 | Gastrointestinal Endoscopy2011，，6： | 6 |
| 2 | Development of time series stacks of Landsat images for reconstructing forest disturbance history显示文摘Forest dynamics is highly relevant to a broad range of earth science studies,many of which have geographic coverage ranging from regional to global scales.While the temporally dense Landsat acquisitions available in many regions provide a unique opportunity for understanding forest disturbance history dating back to 1972,large quantities of Landsat images will need to be analysed for studies at regional to global scales.This will not only require effective change detection algorithms,but also highly automated,high level preprocessing capabilities to produce images with subpixel geolocation accuracies and best achievable radiometric consistency,a status called imagery-ready-to-use(IRU).This paper describes a streamlined approach for producing IRU quality Landsat time series stacks(LTSS).This approach consists of an image selection protocol,high level preprocessing algorithms and IRU quality verification procedures.The high level preprocessing algorithms include updated radiometric calibration and atmospheric correction for calculating surface reflectance and precision registration and orthorectification routines for improving geolocation accuracy.These automated routines have been implemented in the Landsat Ecosystem Disturbance Adaptive System(LEDAPS)designed for processing large quantities of Landsat images.Some characteristics of the LTSS developed using this approach are discussed. | Chengquan Huang Samuel N.Goward Jeffrey G.Masek Feng Gao Eric F.Vermote Nancy Thomas Karen Schleeweis Robert E.Kennedy Zhiliang Zhu Jeffery C.Eidenshink John R.G.Townshend | 2009 | International Journal of Digital Earth2009，2，3： | 5 |
| 3 | Computational fluid dynamics simulation on the longwall gob breathing显示文摘In longwall mines, atmospheric pressure fluctuations can disturb the pressure balance between the gob and the ventilated working area, resulting in a phenomenon known as ‘‘gob breathing'. Gob breathing triggers gas flows across the gob and the working areas and may result in a condition where an oxygen deficient mixture or a methane accumulation in the gob flows into the face area. Computational Fluid Dynamics(CFDs) modeling was carried out to analyze this phenomenon and its impact on the development of an explosive mixture in a bleeder-ventilated panel scheme. Simulation results indicate that the outgassing and ingassing across the gob and the formation of Explosive Gas Zones(EGZs) are directly affected by atmospheric pressure changes. In the location where methane zones interface with mine air, EGZ fringes may form along the face and in the bleeder entries. These findings help assess the methane ignition and explosion risks associated with fluctuating atmospheric pressures. | Samuel A.Lolon Jürgen F.Brune Gregory E.Bogin Jr. John W.Grubb Saqib A.Saki Aditya Juganda | 2017 | International Journal of Mining Science and Technology2017，27，2： | 5 |
| 4 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 5 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 6 | In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis显示文摘The present study evaluated the in vitro activity and in vivo efficacy of diminazene combined with chloroquine as a potential drug against Leishmania donovani.Amphotericin B was used as a positive control drug.In vitro activity involved incubation of various drug concentrations with promastigotes or vero cells in culture before determination of parasite growth inhibition or cell death while in vivo evaluations involved infection of various mice groups with virulent L.donovani parasites and treatment with test drug compounds following disease establishment.Weight changes in experimental mice were also evaluated before infection and throughout the experiment.The results indicated that the diminazene-chloroquine combination was at least nine times more efficacious than individual drugs in killing promastigotes in culture.The diminazene-chloroquine combination was safer(Ld_(50)=0.03±0.04) than Amphotericin B(Ld_(50)=0.02±0.01).Body weight in infected mice increased significantly(P=0.0007) from day7 to day 37 following infection(P=0.026).However,body weight remained comparable in all mice groups during treatment(P=0.16).The diminazene-chloroquine combination significantly reduced splenic parasite numbers as compared to individual drug therapies(P=0.0001) although Amphotericin B was still more efficacious than any other treatment(P=0.0001).Amongst the test compounds,the diminazene-chloroquine combination showed the lowest level of IgG antibody responses with results indicating significant negative correlation between antileishmanial antibody responses and protection against disease.These findings demonstrate the positive advantage and the potential use of a combined therapy of diminazene-chloroquine over the constituent drugs.Further evaluation is recommended to determine the most efficacious combination ratio of the two compounds. | Samuel W.Mwololo Joshua M.Mutiso John C.Macharia Alain J.Bourdichon Michael M.Gicheru | 2015 | The Journal of Biomedical Research2015，29，3： | 3 |
| 7 | Gastric sarcoidosis mimicking irritable bowel syndrome-Cause not association?显示文摘肉状瘤是可以在身体影响任何机关的未知原因论的系统病。胃肠道仅仅很少然而在肝外面被影响。症状可能是非特定的。急躁的肠症候群(IBS ) 是普通诊断。IBS 的识别被罗马 II 标准的使用帮助 - 当器质性病不在时。我们与胃的肉状瘤描述一个病人的第一个盒子与 IBS 介绍了症状,但是随后对抑制免疫力的治疗作出回应。 | John Samuel Leeds Mark Edward McAlindon Eleanor Lorenz Asha Kumari Dube David Surendran Sanders | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 8 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 9 | Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients With Recurrent HCV Infection Treated With Pegylated Interferon显示文摘 | Josh Levitsky Maria Isabel Fiel John P. Norvell Edward Wang Kymberly D. Watt Michael P. Curry Sumeet Tewani Timothy M. McCashland Maarouf A. Hoteit Abraham Shaked Samuel Saab Amanda C. Chi Amy Tien Thomas D. Schiano | 2012 | Gastroenterology2012，，5： | 3 |
| 10 | 北美铁路降低轮轨接触应力新进展显示文摘介绍了北美铁路在降低轮轨接触应力和轮轨作用力方面的研究成果。 | John Samuels 李亨利(译) 刘宏友(校) | 2007 | 国外铁道车辆2007，44，5： | 3 |
| 11 | GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation显示文摘 | Jian Xu Thomas R. Kimball John N. Lorenz David A. Brown Asne R. Bauskin Raisa Klevitsky Timothy E. Hewett Samuel N. Breit Jeffery D. Molkentin | 2006 | Circulation Research2006，，3： | 3 |
| 12 | Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘AIM: To investigate the survival impact of common pharmaceuticals, which target stromal interactions, following a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. METHODS: Data was collected retrospectively for 164 patients who underwent a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma(PDAC). Survival analysis was performed on patients receiving the following medications: angiotensin-converting enzyme inhibitors(ACEI)/angiotensin Ⅱ receptor blockers(ARB), calcium channel blockers(CCB), aspirin, and statins. Statistical analysis included Kaplan-meier survival estimates and cox multivariate regression; the latter of which allowed for any differences in a range of prognostic indicators between groups. Medications showing a significant survival benefit were investigated in combination with other medications to evaluate synergistic effects.RESULTS: No survival benefit was observed with respect to ACEI/ARB(n = 41), aspirin or statins on individual drug analysis(n = 39). However, the entire CCB group(n = 26) showed a significant survival benefit on multivariate cox regression; hazard ratio(HR) of 0.475(CI = 0.250-0.902, P = 0.023). Further analysis revealed that this was influenced by a group of patients who were taking aspirin in combination with CCB; median survival was significantly higher in the CCB + aspirin group(n = 15) compared with the group taking neither drug(n = 98); 1414 d vs 601 d(P = 0.029, logrank test). Multivariate cox regression revealed neither aspirin nor CCB had a statistically significant impact on survival when given alone, however in combination the survival benefit was significant; HR = 0.332(CI = 0.126-0.870, P = 0.025). None of the other medications showed a survival benefit in any combination.CONCLUSION: Aspirin + CCB in combination appears to increase survival in patients with PDAC, highlighting the potential clinical use of combination therapy to target stromal interactions in pancreatic cancer. | Samuel J Tingle John A Moir Steven A White | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 2 |
| 13 | Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society显示文摘 | Elizabeth R. Seaquist John Anderson Belinda Childs Philip Cryer Samuel Dagogo-Jack Lisa Fish Simon R. Heller Henry Rodriguez James Rosenzweig Robert Vigersky | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，5： | 2 |
| 14 | Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity显示文摘 | Anbu Jeba Sunilson John Samuel Syam Mohan Dinesh Kumar Chellappan Anandarajagopal Kalusalingam Saraswathi Ariamuthu | 2012 | Journal of Ethnopharmacology2012，，1： | 2 |
| 15 | BIOGENIC MANGANESE OXIDES: Properties and Mechanisms of Formation显示文摘 | Bradley M. Tebo John R. Bargar Brian G. Clement Gregory J. Dick Karen J. Murray Dorothy Parker Rebecca Verity Samuel M. Webb | 2004 | Annual Review of Earth and Planetary Sciences2004，，： | 2 |
| 16 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 17 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 18 | Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer显示文摘Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation.Unfortunately,once metastatic,no available therapy is curative.The vast majority will die despite aggressive systemic combinational androgenablation therapies.Thus,there is an urgent need for effective systemic therapeutics that sterilize the entire microenvironment in metastatic castration-resistant prostate cancer(mCRPC).To accomplish this goal,advantage can be taken of the unique biology of mCRPC cells.Like their normal cell of origin,mCRPCs retain expression of the prostate-specific differentiation protein,prostate-specific antigen(PSA),which they abundantly secrete into their extracellular fluid(ECF).This unique,and essentially universal,secretion of enzymatically active PSA into the ECF by mCRPCs creates an exploitable therapeutic index for activation of systemically delivered highly lipophilic toxins as“molecular grenades”covalently linked to cysteine-34 of human serum albumin(HSA)via a stable maleimide containing PSA cleavable peptide such that PSA-dependent hydrolysis(i.e.,“detonation”)releases the grenades restrictively within the ECF of mCRPC.This approach decreases dose-limiting host toxicity while enhancing plasma half-life from minutes to days(i.e.,pharmacokinetic effect)and increasing the tissue concentration of the maleimide coupled albumin delivery(MAD)in the ECF at sites of cancer due to the enhanced permeability of albumin at these sites(i.e.,enhanced permeability and retention effect).This allows the MAD-PSA detonated grenades to circulate throughout the body in a non-toxic form.Only within sites of mCRPC is there a sufficiently high level of enzymatically active PSA to efficiently“pull the pin”on the grenades releasing their lipophilic cellpenetrant toxins from HSA.Thus,if a sufficient level of“detonation”occurs,this will kill mCRPC cells,and sterilize the entire PSA-rich metastatic sites via a bystander effect.In this review,two examples of such MAD-PSA detonated molecular grenades are presenteddone based upon thapsigagin and the other on niclosamide. | Emmanuel S.Akinboye W.Nathaniel Brennen Samuel R.Denmeade John T.Isaacs | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 19 | Diagnosis and Management of Partial Small Bowel Obstruction after Laparoscopic Antecolic Antegastric Roux-en-Y Gastric Bypass for Morbid Obesity显示文摘 | Minyoung Cho Lester Carrodeguas David Pinto Charles Lascano Flavia Soto Oliver Whipple Richard Gordon Conrad Simpfendorfer John Paul Gonzalvo Samuel Szomstein Raul J. Rosenthal | 2006 | Journal of the American College of Surgeons2006，，2： | 1 |
| 20 | On the relationship of NDVI with leaf area index in a deciduous forest site显示文摘 | Quan Wang Samuel Adiku John Tenhunen André Granier | 2004 | Remote Sensing of Environment2004，，2： | 1 |
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