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| 1 | 植物表型组学:发展、现状与挑战显示文摘随着遥感、机器人技术、计算机视觉和人工智能的发展,植物表型组学研究已经步入了快速成长阶段。本文首先介绍了植物表型组学的发展简史,包括其理论核心、研究方法、在生物研究中的应用以及国际上最新的研究动向。然后,针对各类表型技术载体平台如手持、人载、车载、田间实时监控、大型室内外自动化平台和航空机载等,分析这些技术手段在室内、外植物研究中的应用情况和实际问题。为了对表型研究中产生的巨量图像和传感器数据进行量化分析,把大数据转化为有实际意义的性状信息和生物学知识,本文着重讨论了后期表型数据解析和相应的研发过程。最后,提出表型组学的应用前景与未来展望,以期为中国的表型研究提供指导和建议。 | 周济 Francois Tardieu Tony Pridmore John Doonan Daniel Reynolds Neil Hall Simon Griffiths 程涛 朱艳 王秀娥 姜东 丁艳锋 | 2018 | 南京农业大学学报2018，41，4： | 64 |
| 2 | High-risk corneal allografts: A therapeutic challenge显示文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in 'low-risk' settings. Furthermore, although corneal graft survival in 'lowrisk' recipients is favourable, the prognosis in 'high-risk' recipients for corneal graft is poor. In 'high-risk' grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of 'high-risk' recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in 'high-risk' recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both 'low-risk' and 'high-risk' hosts. | Tian Yu Vijayalakshmi Rajendran May Griffith John V Forrester Lucia Kuffová | 2016 | World Journal of Transplantation2016，6，1： | 7 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 4 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 5 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 6 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 7 | 甲醇自发点火特性研究显示文摘从实验和数值模拟两方面探讨了甲醇的热点火特性。实验中应用快速压缩机得到了温度与点火延迟期的关系。计算中采用了基元化学反应动力学模型,给出了压力、温度、产物及主要中间反应体的变化历程。对助燃剂二叔丁基过氧化物的活化作用进行了理论分析。 | 焦清介 Griffiths John F | 1994 | 北京理工大学学报1994，14，4： | 3 |
| 8 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 9 | The application of the QSSA via reaction lumping for the reduction of complex hydrocarbon oxidation mechanisms显示文摘 | Kevin J. Hughes Mike Fairweather John F. Griffiths Richard Porter Alison S. Tomlin | 2009 | Proceedings of the Combustion Institute2009，，1： | 2 |
| 10 | 提高西藏黄奶牛生产性能研究显示文摘该项目是中澳国际联合的其中一个,根据发展奶业,促进农区畜牧业发展,提高农村生活水平的需要在西藏河谷流域农牧交错带开展调研。三年来在四个不同的区域进行随机抽样设点,了解项目区奶牛发展现状,系统收集分析当前农户饲养奶牛的饲料结构,营养水平、繁殖成活能力以及管理模式。同时引进澳方饲养奶牛的先进技术、管理措施和发展理念,有效利用西藏现有的作物秸秆,研发优良饲草、饲喂技术,进一步研究牛在一个生长周期中的饲料平衡、生长模式及量化营养等生产性能的对应关系,加大引创结合、重点突破,提高项目区奶牛生产性能,增加农户现金收入。 | 尼玛扎西 色珠 参木友 奥斯曼 洛桑强白 平措占堆 巴桑珠扎 次仁罗布 韩建成 王莉 顿珠坚参 姬秋梅 曲广鹏 向巴卓玛 鲍宇 红秀花 张强 John Wilkins Colin Griffiths John Piltz Amanda | 2008 | 西藏科技2008，，6： | 2 |
| 11 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology显示文摘 | Geoffrey C. Nguyen Charles N. Bernstein Alain Bitton Anthony K. Chan Anne M. Griffiths Grigorios I. Leontiadis William Geerts Brian Bressler J. Decker Butzner Marc Carrier Nilesh Chande John K. Marshall Chadwick Williams Clive Kearon | 2014 | Gastroenterology2014，，3： | 2 |
| 12 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 13 | Waist-to-Hip Ratio, Body Mass Index, and Subsequent Kidney Disease and Death显示文摘 | Essam F. Elsayed Mark J. Sarnak Hocine Tighiouart John L. Griffith Tobias Kurth Deeb N. Salem Andrew S. Levey Daniel E. Weiner | 2008 | American Journal of Kidney Diseases2008，，1： | 1 |
| 14 | CEO ownership, corporate control, and bank performance显示文摘 | John M. Griffith Lawrence Fogelberg H. Shelton Weeks | 2002 | Journal of Economics and Finance2002，，2： | 1 |
| 15 | Do R&D Tax Credits Work? Evidence From A Panel of Countries 1979 - 1997显示文摘 | BLOOM NICK RACHEL GRIFFITH JOHN VAN REENEN | 2002 | Journal of Public Economics2002，85，1： | 1 |
| 16 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 17 | Vascular calcification does not predict anastomotic leak or conduit necrosis following oesophagectomy显示文摘BACKGROUND Anastomotic leaks(AL)and gastric conduit necrosis(CN)are serious complications following oesophagectomy.Some studies have suggested that vascular calcification may be associated with an increased AL rate,but this has not been validated in a United Kingdom population.AIM To investigate whether vascular calcification identified on the pre-operative computed tomography(CT)scan is predictive of AL or CN.METHODS Routine pre-operative CT scans of 414 patients who underwent oesophagectomy for malignancy with oesophagogastric anastomosis at the Queen Elizabeth Hospital Birmingham between 2006 and 2018 were retrospectively analysed.Calcification of the proximal aorta,distal aorta,coeliac trunk and branches of the coeliac trunk was scored by two reviewers.The relationship between these calcification scores and occurrence of AL and CN was then analysed.The Esophagectomy Complications Consensus Group definition of AL and CN was used.RESULTS Complication data were available in n=411 patients,of whom 16.7%developed either AL(15.8%)or CN(3.4%).Rates of AL were significantly higher in female patients,at 23.0%,compared to 13.9%in males(P=0.047).CN was significantly more common in females,(8.0%vs 2.2%,P=0.014),patients with diabetes(10.6%vs 2.5%,P=0.014),a history of smoking(10.3%vs 2.3%,P=0.008),and a higher American Society of Anaesthesiologists grade(P=0.024).Out of the 14 conduit necroses,only 4 occurred without a concomitant AL.No statistically significant association was found between calcification of any of the vessels studied and either of these outcomes.Multivariable analyses were then performed to identify whether a combination of the calcification scores could be identified that would be significantly predictive of any of the outcomes.However,the stepwise approach did not select any factors for inclusion in the final models.The analysis was repeated for composite outcomes of those patients with either AL or CN(n=69,16.7%)and for those with both AL and CN(n=10,2.4%)and again,no significant associations were detected.In the subset of patients that developed these outcomes,no significant associations were detected between calcification and the severity of the complication.CONCLUSION Calcification scoring was not significantly associated with Anastomotic Leak or CN in our study,therefore should not be used to identify patients who are high risk for these complications. | Benjamin J Jefferies Emily Evans James Bundred James Hodson John L Whiting Colm Forde Ewen A Griffiths | 2019 | World Journal of Gastrointestinal Surgery2019，11，7： | 1 |
| 18 | Large scale analysis of virulence genes in Escherichia coli strains isolated from Avalon Bay, CA显示文摘 | Matthew J. Hamilton Asbah Z. Hadi John F. Griffith Satoshi Ishii Michael J. Sadowsky | 2010 | Water Research2010，，18： | 1 |
| 19 | Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers显示文摘 | Ramaswamy Govindan Li Ding Malachi Griffith Janakiraman Subramanian Nathan D. Dees Krishna L. Kanchi Christopher A. Maher Robert Fulton Lucinda Fulton John Wallis Ken Chen Jason Walker Sandra McDonald Ron Bose David Ornitz Donghai Xiong Ming You David J. | 2012 | Cell2012，，： | 1 |
| 20 | Mapping the Two Faces of R&D:Productivity Growth in A Panel of OECD Industries显示文摘 | Rachel Griffith Stephen Redding John Van Reenen | 2004 | The Review of Economics and Statistics2004，86，4： | 1 |
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