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| 1 | Extreme drought changes in Southwest China from 1960 to 2009显示文摘从 1960 ~ 2009 在西南中国基于温度的每日的数据和 108 个气象学的车站的降水,我们计算每月、每年的表面潮湿的索引,以及极端干旱频率。根据数据,极端干旱频率在的时间、空间的特征内部年度,内部十,夏天季风时期和冬季季风时期被分析。结果如下被显示。(1 ) 一般来说,西南的四川盆,南部的 Hengduan 山, Guangxi 的南部的海岸和北贵州是极端干旱频率显著地在过去的 50 年里增加了的区域。至于十的变化,从 1960 年代,到 1980 年代,极端干旱频率介绍了一个减少的趋势,当 1990 年代是最湿的十年,整个区域正在变得湿时。在 2000 年代,极端干旱频率快速升起,但是地区性的差别还原剂。(2 ) 在夏天季风时期期间,干旱频率正在成长的极端,通常在四川盆附近发生在高山,最在云南 Guangxi 和塑造扫帚的山分开。高度在极端干旱频率上有影响,是不同的;在冬季季风时期期间,区域是相对湿的,极端干旱频率正在减少。(3 ) 在夏天季风时期期间,突然的变化在 2003 被观察,而突然的变化在冬季季风时期期间在 1989。年度极端干旱频率变化在夏天季风和冬季季风时期期间是突然的变化的重叠。年度极端干旱频率的离开顺序颤动是 quasi-5 年和 quasi-12 年。 | ZHANG Mingjun HE Jinyun WANG Baolong WANG Shengjie LI Shanshan LIU Wenli MA Xuening | 2013 | Journal of Geographical Sciences2013，23，1： | 43 |
| 2 | The role of magmatism in the thinning and breakup of the South China Sea continental margin显示文摘INTRODUCTION Magmatism plays a key role in the process of continental margin breakup and ocean formation.Even in the extremely magma-poor Iberia and Newfoundland margin,studies of field outcrops have shown that syn-rift magmatism had participated in rifting from a very early stage and contributed directly to the rifting process.The final transition from exhumed continental mantle to the ocean formation is also triggered by the accumulation and eruption of magma[1]. | Zhen Sun Jian Lin Ning Qiu Zhimin Jian PinXian Wang Xiong Pang Jinyun Zheng Benduo Zhu | 2019 | National Science Review2019，6，5： | 34 |
| 3 | Analysis of ionospheric anomaly preceding the Mw7.3 Yutian earthquake显示文摘On February 12,2014,a large Mw7. 3 earthquake occurred in Yutian of Xijiang Province,China.We processed the global ionosphere maps provided by CODE( the Center for Orbit Determination in Europe)and the foF2( the critical frequency of F2-layer) data of Chongqing ionosonde station to analyze the preearthquake ionospheric anomalies. Solar activities and magnetic storm were checked by the sliding inter quartile range method to remove their effects on the ionosphere. A positive ionospheric anomaly with the large amplitude of 20 TECU was observed near the epicenter on February 3( 10th day before the earthquake). In addition,the foF2 at Chongqing station had an unusual increase of more than 40% on the day,which was consistent with the TEC( Total Electron Content) anomaly. The global disturbance represents that the peak of TEC anomaly didn't coincide with the vertical projection of epicenter. The TEC anomalous area was closer to the equator,and it mainly occurred from local time 16 ∶ 00 to 20 ∶ 00. An enhancement of TEC with the small amplitude also appeared in the magnetically conjugated region. | Li Wang Guo Jinyun Yu Xuemin Yu Hongjuan | 2014 | Geodesy and Geodynamics2014，5，2： | 15 |
| 4 | Improved threshold retracker for satellite altimeter waveform retracking over coastal sea显示文摘数据质量是为到测地学和海洋学的卫星的申请的一个关键因素。因为高度表波形被地形学和环境污染严重污染,测高法的精确性在沿海的区域被限制。那么波形沤飘动被需要为更好的精确性计算地球物理的数据记录(GDR ) 的范围修正。在这篇论文,新波形沤 racker 说出改进阀值沤 racker (国际互联网广播台) 被提出。ret racker 首先基于在波形检测的前缘造亚波形,然后决定每前缘的中点计算折磨范围修正的ret ,最后从一个海洋潮模式从一个本地 geopotential 模型和潮高度根据大地水准面波动计算引用的海表面高度,并且把它与所有作比较沤折磨范围决定最好的。作为测试, Geosat 美国通用汽车公司的高度表波形是沤在台湾沿海的区域附近飘动。结果比 -5-pa-rameter 功能试穿方法和阀值方法的更好证明国际互联网广播台方法的那精确性是 two times,并且三比 GDR 的更好预定。国际互联网广播台能高效地改进沿海的海区域的测高法精确性。 | GUO Jinyun HWANG Cheiway CHANG Xiaotao LIU Yuting | 2006 | Progress in Natural Science:Materials International2006，16，7： | 14 |
| 5 | Seasonal and inter-annual variations of length of day and polar motion observed by SLR in 1993―2006显示文摘A time series of length of the day (LOD) and polar motion (PM) were estimated from the range data measured by the satellite laser ranging technique (SLR) to LAGEOS 1/2 through 1993 to 2006. Com-pared with EOPC04 released by the International Earth Rotation and Reference Systems Service (IERS),the root mean squares errors for LOD,X and Y of PM are 0.0067 milliseconds (ms),0.18 milli-arc-sec-onds (mas) and 0.20 mas,respectively. Then the time series are analyzed with the wavelet transforma-tion and least squares method. Wavelet analysis shows that there are the obvious seasonal and inter-annual variations of LOD and PM,but the annual variation cannot be distinguished from the Chandler variation because these two frequencies are very close. The trends and periodic variations of LOD and PM are given in the least squares sense. LOD changes with the annual and semiannual periods. The annual and Chandler variations for PM are also detected,but the semiannual motion for PM is not found. The trend rate of the LOD change in 1993―2006 is ?0.18 ms per year,and the difference from the well-known 1.7 ms per century showed that the trend rate is diverse in different periods possibly. The trend rates of PM in the X and Y directions are 2.25 and 1.67 mas per year respectively,and the North Pole moves to 36.5°E relative to the crust,which is different from the direction of Greenland. | GUO JinYun HAN YanBen | 2009 | Chinese Science Bulletin2009，54，1： | 9 |
| 6 | The synchronicity and difference in the change of suspended sediment concentration in the Yangtze River Estuary显示文摘从长江盆的沉积分泌物在最近的年里有一个逐步的减少趋势。扣押三座峡水库加重了这个减少的趋势并且通过传播效果在长江河口影响了推迟的沉积集中(SSC ) 的变化。长江河口的 SSC 数据在 19592012 期间显示出那:(1 ) 在南方的 SSC 在河口并且在长江分叉近海海区域显示了减少的趋势并且向海少些减少了。同时,在在 SSC 和沉积分泌物之间的减少的大小的差别向海变得更大。(2 ) 为北方布朗奇,优先的流动没很变化,但是 SSC 趋于减少,它被 SSC 的减少主要在南方布朗奇和中国东方海引起。( 3 )由于减少的流量和相对加强的潮,在在 20032012 的浅节移动了的酒吧中的 SSC 的山峰区域为在 19842002 与那相比联合起来的大约 1/6 经度里面,并且里面动人的距离在洪水季节的顺序>年度一般水准>旱季。(4 ) 在南方经过的入口,因为增加由暂停引起了,岸沟交换是, SSC 主要减少了不到减少在盆和海区域由锋利的 SSC 减少引起了。颠倒在中间的节是真的,在 SSC 显示出一个增加的趋势的地方。(5 ) 在北方经过的入口在减少的流动裂口和沉积裂口比率的联合影响下面,在盆和海区域和暂停的减少的数量的减少的 SSC, SSC 显示了一个减少的趋势。在中间的节,因为增加的数量由沉积引起了,温习塘是多于减少的数量由外部环境引起了,显著地, SSC 趋于增加。整体地,在沉积分泌物的锋利的减少在长江河口引起了同步 SSC 减少。但是在 SSC 从盆在沉积分泌物在对锋利的减少的 SSC 的反应显示了增加的趋势,显示的 synchronicity 和差别的地方,仍然有区域。 | YANG Yunping DENG Jinyun ZHANG Mingjin LI Yitian LIU Wanli | 2015 | Journal of Geographical Sciences2015，25，4： | 8 |
| 7 | Identification of autophagy signaling network that contributes to stroke in the ischemic rodent brain via gene expression显示文摘Autophagy plays a vital role in cerebral ischemia and may be a potential target for developing novel therapy for stroke. In this study, we constructed an autophagy-related pathway network by analyzing the genes related to autophagy and ischemic stroke, and the risk genes were screened. Two autophagy-related modules were significantly up-regulated and clustered to influence cerebral ischemia. Besides, three key modular genes(NFKB1, RELA, and STAT3) were revealed. With 5-fold cross validation, the ROC curves of NFKB1, RELA, and STAT3 were 0.8256, 0.8462, and 0.8923. They formed a complex module and competitively mediated the activation of autophagy in cerebral ischemia. In conclusion, a module containing NFKB1, RELA, and STAT3 mediates autophagy, serving as a potential biomarker for the diagnosis and therapy of ischemic stroke. | Kun Liang Lei Zhu Jinyun Tan Weihao Shi Qing He Bo Yu | 2015 | Neuroscience Bulletin2015，31，4： | 7 |
| 8 | Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress显示文摘Background: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress(HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation(PA).Results: Supplementation with resveratrol(2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione(GSH)level, reducing reactive oxygen species(ROS) and up-regulating the expression of Sirtuin 1(SIRT1). It was also found that melatonin(10^(-7)mol/L) and the combination of resveratrol(2.0 μmol/L) plus melatonin(10^(-7)mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under HS.Conclusions: This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. | Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang Yukun Song Pingli He Guoshi Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 7 |
| 9 | On the McKay quivers and m-Cartan matrices Dedicated to Professor LIU ShaoXue on the occasion of his 80th birthday显示文摘In this paper, we introduce the m-Cartan matrix and observe that some properties of the quadratic form associated to the Cartan matrix of an Euclidean diagram can be generalized to the m-Cartan matrix of a McKay quiver. We also describe the McKay quiver for a finite abelian subgroup of a special linear group. | GUO JinYun School of Mathematics and Computational Sciences, Xiangtan University, Xiangtan 411105, China | 2009 | Science China Mathematics2009，52，3： | 6 |
| 10 | 土霉素对柑橘黄龙病的防治效果及对柑橘产量和品质的影响显示文摘为有效防控柑橘黄龙病,于2017年在佛罗里达大学柑橘研究与教育中心的奥本代尔市柑橘试验场进行田间试验筛选黄龙病的防治药剂及其浓度,测定注射土霉素后叶片中柑橘黄龙病菌亚洲种Cadidatus Liberibacter asiaticus、土霉素、淀粉含量、柑橘产量、出汁率、可溶性固形物含量和酸度,显微镜下观察注射土霉素后淀粉粒的分布。结果表明,浓度为1.6 g/株土霉素处理180 d后柑橘叶片中黄龙病菌亚洲种含量减少幅度最大,为91.78%;注射浓度为1.6 g/株土霉素后7 d,叶片中土霉素含量达142.2μg/kg,注射后11 d叶片中土霉素含量达到最大,为239.8μg/kg,注射后45 d叶片中土霉素含量低至99.6μg/kg以下;注射后7~90 d,叶片中黄龙病菌亚洲种含量呈波浪形变化,注射90 d后叶片中黄龙病菌亚洲种含量一直处于增长趋势,叶片中黄龙病菌亚洲种含量总体随着土霉素含量的升高而降低;注射浓度为1.6 g/株土霉素后,叶片中淀粉含量大幅度下降,60 d时达到最低值,为3.3μg/mm2,90 d时达到峰值,为14.5μg/mm2;单株产量为16.7 kg,与注射浓度为0.8 g/株土霉素处理差异不显著,但均显著高于其它2个处理;柑橘出汁率、可溶性固形物和酸度均与清水对照差异不显著。表明土霉素可有效抑制黄龙病菌亚洲种,减少柑橘叶片内淀粉含量,增加柑橘产量,但对果实品质未产生显著影响。 | 姚廷山 周彦 ACHOR Diann LI Jinyun WANG Nian 周常勇 | 2020 | 植物保护学报2020，47，6： | 6 |
| 11 | On temporal-spatial distribution of backscatter coefficients over China determined by TOPEX/Poseidon mission显示文摘This paper deals with the backscatter coefficients known as sigma0 at Ku band and C band based on the GDR-M (Merged Geophysical Data Record) of TOPEX/Poseidon (T/P) through Jan.1993 to Dec.2004 over land surface of China.After smoothing and interpolating the backscatter coefficients for both bands, we achieve the 5′×5′ grid data and the time series of backscatter coefficients in 12 years.The spatial distribution of sigma0 over typical areas (wetland, desert, mountainous area, agriculture base, etc.) of Chinese territory is analyzed and discussed.The fast Fourier transformation (FFT) is used to detect the cycles of seasonal variations of sigma0 time series and gives that the annual period is the major cycle.Meanwhile a semiannual period is also found in some places.We use the least squares method on both periods and find that the amplitude of annual period is obviously greater than that of semi-annual period.The relationship among the anomalousness of time series, variations of environment and climate change, and the serious natural calamity (flood, drought) is also discussed.Data of topography slope extracted from SRTM are used to do correlation analysis with the backscatter coefficients in parts of China to quantify the impact of slope on backscatter coefficients in Ku and C bands, and the results show that they all have a negative correlation but the magnitudes are different in different places with different coverages.Such as the area of Liaoning and Jilin has the maximum correlation -0.56, the Taklimakan Desert has the minimum correlation -0.11, and the other places commonly have correlations in (-0.3, -0.5). | GUO JinYun YANG Lei LIU Xin HWANG CheinWay YANG Hong | 2012 | Science China Earth Sciences2012，55，12： | 6 |
| 12 | Influence of higher-order ionospheric delay correction on GPS precise orbit determination and precise positioning显示文摘At present, Global Navigation Satellite Systems(GNSS) users usually eliminate the influence of ionospheric delay of the first order items by dual-frequency ionosphere-free combination. But there is still residual ionospheric delay error of higher order term. The influence of the higher-order ionospheric corrections on both GPS precision orbit determination and static Precise Point Positioning(PPP) are studied in this paper. The influence of higher-order corrections on GPS precision orbit determination, GPS observations and static PPP are analyzed by neglecting or considering the higher-order ionospheric corrections by using a globally distributed network which is composed of International GNSS Service(IGS) tracking stations. Numerical experimental results show that, the root mean square(RMS) in three dimensions of satellite orbit is 36.6 mme35.5 mm. The maximal second-order ionospheric correction is 9 cm, and the maximal third-order ionospheric correction is 1 cm. Higher-order corrections are influenced by latitude and station distribution. PPP is within 3 mm in the directions of east and up. Furthermore, the impact is mainly visible in the direction of north, showing a southward migration trend, especially at the lower latitudes where the influence value is likely to be bigger than 3 mm. | Zhimin Liu Yangyang Li Jinyun Guo Fei Li | 2016 | Geodesy and Geodynamics2016，7，5： | 5 |
| 13 | A New Species of the Genus Rhacophorus (Anura: Rhacophoridae) from Dabie Mountains in East China显示文摘A new species of rhacophorid of the genus Rhacophorus is described from the Dabie Mountains of west Anhui,east China.The new species,Rhacophorus zhoukaiyae sp.nov.is distinguished from its congeners by a combination of the following characters: 1) the ventral surface and front-and-rear of the femur is paler yellowish and decorated with irregular grayish blotching,and without obvious spots on the dorsum of the hand and foot webbing; 2) the outer metatarsal tubercle is small; 3) outer fingers are half-webbed and outer toes two third webbed; 4) the skin on the dorsum is smooth and without compressed warts; 5) the throat,chest and belly are pure paler yellowish; 6) the dorsal part of the fingers and toes are grayish-white; 7) the iris is golden-yellow.In addition,the phylogenetic tree showed that all the individuals of R.zhoukaiyae sp.nov.clustered into one distinct clade which suggested the validity of this species.This results could also be used to the support of species delimitation.Currently,this species is known only from mid-elevation montane evergreen forest in the Dabie Mountains of west Anhui,China. | Tao PAN Yanan ZHANG Hui WANG Jun WU Xing KANG Lifu QIAN Kai LI Yu ZHANG Jinyun CHEN Dingqi RAO Jianping JIANG Baowei ZHANG | 2017 | Asian Herpetological Research2017，18，1： | 5 |
| 14 | Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells显示文摘Vascular calcification(VC)is a common characteristic of aging,diabetes,chronic renal failure,and atherosclerosis.The basic component of VC is hydroxyapatite(HAp).Nano-sized HAp(nHAp)has been identified to play an essential role in the development of pathological calcification of vasculature.However,whether nHAp can induce calcification in vivo and the mechanism of nHAp in the progression of VC remains unclear.We discovered that nHAp existed both in vascular smooth muscle cells(VSMCs)and their extracellular matrix(ECM)in the calcified arteries from patients.Synthetic nHAp had similar morphological and chemical properties as natural nHAp recovered from calcified artery.nHAp stimulated osteogenic differentiation and accelerated mineralization of VSMCs in vitro.Synthetic nHAp could also directly induce VC in vivo.Mechanistically,nHAp was internalized into lysosome,which impaired lysosome vacuolar H+-ATPase for its acidification,therefore blocked autophagic flux in VSMCs.Lysosomal re-acidification by cyclic-3′,5′-adenosine monophosphate(cAMP)significantly enhanced autophagic degradation and attenuated nHAp-induced calcification.The accumulated autophagosomes and autolysosomes were converted into calcium-containing exosomes which were secreted into ECM and accelerated vascular calcium deposit.Inhibition of exosome release in VSMCs decreased calcium deposition.Altogether,our results demonstrated a repressive effect of nHAp on lysosomal acidification,which inhibited autophagic degradation and promoted a conversion of the accumulated autophagic vacuoles into exosomes that were loaded with undissolved nHAp,Ca^(2+),Pi and ALP.These exosomes bud off the plasma membrane,deposit within ECM,and form calcium nodules.Vascular calcification was thus accelerated by nHAP through blockage of autophagic flux in VSMCs. | Qi Liu Yi Luo Yun Zhao Pingping Xiang Jinyun Zhu Wangwei Jing Wenjing Jin Mingyao Chen Ruikang Tang Hong Yu | 2022 | Bioactive Materials2022，7，2： | 5 |
| 15 | Digital zenith telescope prototype of China显示文摘Classical optical astronomy measures the direction of the local plumb line on the stellar background,and is influenced by variations of the earth gravity field.Therefore,classical optical astrometry can be used to measure and study variations of plumb line.This endows classical optical astrometric technologies special significance for the interdisciplinary researches of astronomy and geoscience,and makes them irreplaceable by technologies like very long baseline interferometry,satellite laser ranging.However,classical astrometric instruments have a major drawback of low efficiency,such as the low automaticity,more operating observers,and even operative error which makes it very difficult to reduce the random observation error in some visual instruments.To overcome this drawback,we have successfully developed the digital zenith telescope prototype(DZT-1)with the aperture of200 mm,using charge coupled device and other advanced technologies and new equipments.As proved by test observations,DZT-1 can observe thousands of stars over one night,which significantly reduces the random observation error and increases the observation accuracy.In addition,DZT-1 has a high degree of automation,even allowing unattended observation by remote control.Besides,DZT-1 has a small-size and is easy to move,making it convenient for mobile measurement of the deflection of the vertical.In summary,DZT can be widely used in the geoscience and astronomy fields. | Lili Tian Jinyun Guo Yanben Han Xiushan Lu Weidong Liu Zheng Wang Bo Wang Zhiqiang Yin Hongqi Wang | 2014 | Chinese Science Bulletin2014，59，17： | 4 |
| 16 | A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82显示文摘Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including tumorigenesis.In contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged behind.Here,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients.Then,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients.We also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC progression.Results:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC progression.CircGNG7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 cells.Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients.Consistent with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor growth.Mechanistically,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic signaling.Downregulation of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor progression.Conclusions:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. | Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo Guoxin Ren | 2021 | Cancer Communications2021，41，11： | 4 |
| 17 | Structural,Functional,and Molecular Imaging of Autism Spectrum Disorder显示文摘Autism spectrum disorder(ASD)is a heterogeneous neurodevelopmental disorder associated with both genetic and environmental risks.Neuroimaging approaches have been widely employed to parse the neurophysiological mechanisms underlying ASD,and provide critical insights into the anatomical,functional,and neurochemical changes.We reviewed recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging(MRI),positron emission tomography(PET),or single-positron emission tomography(SPECT).Longitudinal structural MRI has delineated an abnormal developmental trajectory of ASD that is associated with cascading neurobiological processes,and functional MRI has pointed to disrupted functional neural networks.Meanwhile,PET and SPECT imaging have revealed that metabolic and neurotransmitter abnormalities may contribute to shaping the aberrant neural circuits of ASD.Future large-scale,multi-center,multimodal investigations are essential to elucidate the neurophysiological underpinnings of ASD,and facilitate the development of novel diagnostic biomarkers and better-targeted therapy. | Xiaoyi Li Kai Zhang Xiao He Jinyun Zhou Chentao Jin Lesang Shen Yuanxue Gao Mei Tian Hong Zhang | 2021 | Neuroscience Bulletin2021，37，7： | 4 |
| 18 | Resveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia显示文摘Hypoxia conditioning could increase the survival of transplanted neuronal progenitor cells(NPCs)in rats with cerebral ischemia but could also hinder neuronal differentiation partly by suppressing mitochondrial metabolism.In this work,the mitochondrial metabolism of hypoxia-conditioned NPCs(hcNPCs)was upregulated via the additional administration of resveratrol,an herbal compound,to resolve the limitation of hypoxia conditioning on neuronal differentiation.Resveratrol was first applied during the in vitro neuronal differentiation of hcNPCs and concurrently promoted the differentiation,synaptogenesis,and functional development of neurons derived from hcNPCs and restored the mitochondrial metabolism.Furthermore,this herbal compound was used as an adjuvant during hcNPC transplantation in a photothrombotic stroke rat model.Resveratrol promoted neuronal differentiation and increased the long-term survival of transplanted hcNPCs.18-fluorine fluorodeoxyglucose positron emission tomography and rotarod test showed that resveratrol and hcNPC transplantation synergistically improved the neurological and metabolic recovery of stroke rats.In conclusion,resveratrol promoted the neuronal differentiation and therapeutic efficiency of hcNPCs in stroke rats via restoring mitochondrial metabolism.This work suggested a novel approach to promote the clinical translation of NPC transplantation therapy. | Yao Yao Rui Zhou Rui Bai Jing Wang Mengjiao Tu Jingjing Shi Xiao He Jinyun Zhou Liu Feng Yuanxue Gao Fahuan Song Feng Lan Xingguo Liu Mei Tian Hong Zhang | 2021 | Frontiers of Medicine2021，15，3： | 3 |
| 19 | THEORETICAL AND EXPERIMENTAL STUDY ON THE PRESSURE AND VACUUM CONTINUOUS CONTROL SYSTEM BASED ON HYBRID PUMP显示文摘一个新奇压力和真空连续控制系统,作为压力和真空来源采用混合的泵,被介绍。系统的数学模型被开发。系统上的理论模拟和分析被实现以便在特征,参数和系统的工作的点之中学习关系。系统特征上的试验性的调查随一个 fuzzy-PID 控制器的采纳被介绍。模拟和试验性的结果显示连续控制系统基于混合的泵有的压力和真空好动态、静态的性能,强壮的坚韧性和令人满意的适应性到各种各样的系统参数。根据结果,系统能成功地获得高精确性和快反应信号。另外,系统的数学模型被试验性的结果也证明。 | LI Jinyun DU Jingmin FU Xiaoyun LI Baoren | 2007 | Chinese Journal of Mechanical Engineering2007，20，6： | 3 |
| 20 | A Subspace Version of the Powell–Yuan Trust-Region Algorithm for Equality Constrained Optimization显示文摘This paper studied subspace properties of the Celis–Dennis–Tapia(CDT)subproblem that arises in some trust-region algorithms for equality constrained optimization.The analysis is an extension of that presented by Wang and Yuan(Numer.Math.104:241–269,2006)for the standard trust-region subproblem.Under suitable conditions,it is shown that the trial step obtained from the CDT subproblem is in the subspace spanned by all the gradient vectors of the objective function and of the constraints computed until the current iteration.Based on this observation,a subspace version of the Powell–Yuan trust-region algorithm is proposed for equality constrained optimization problems where the number of constraints is much lower than the number of variables. The convergence analysis is given and numerical results arealso reported. | Geovani Nunes Grapiglia Jinyun Yuan Ya-xiang Yuan | 2013 | Journal of the Operations Research Society of China2013，1，4： | 3 |
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