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| 1 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 2 | Treatment of phenol wastewater by microwave-induced CIO_2-CuO_x/Al_2O_3 catalytic oxidation process显示文摘CuOx/Al2O3 的催化剂被剧降沉积方法作为一个支持者用γ - Al2O3 准备。CuO 和 Cu2O 在 Al2O3 的表面上被装载,由 X 光检查衍射(XRD ) 和 X 光检查光电子光谱学(XPS ) 描绘了。面对 CuOx/Al2O3,导致微波的氯二氧化物(ClO2 ) 催化氧化过程为包含 100 mg/L 酚的合成废水的处理被进行。影响酚移动的因素被调查,结果证明那个导致微波的 ClO2-CuOx/Al2O3 过程能有效地降级在有低氧化剂剂量的一短反应时间的沾染物,广泛的 pH 范围。在一个给定的条件下面(ClO2 集中 80 mg/L,微波力量 50 W,接触时间 5 min,催化剂剂量 50 g/L, pH 9 ) ,酚移动百分比接近了 92.24% ,相应于 79.13% CODCr 移动。由导致微波的 ClO2-CuOx/Al2O3 催化氧化过程的酚的移动是复杂非同类的固体 / 水的反应,它由动力学适合伪 first-order。与传统的 ClO2 氧化, ClO2 催化氧化和导致微波的 ClO2 氧化相比,导致微波的 ClO2 催化氧化系统能显著地提高降级效率。它为酚废水的移动提供一种有效技术。 | BI Xiao-yi WANG Peng JIANG Hong XU Huan-yan SHI Shu-jie HUANG Jun-li | 2007 | Journal of Environmental Sciences2007，19，12： | 28 |
| 3 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 4 | The Molecular Mechanism of HDAC Inhibitors in Anticancer Effects显示文摘HDAC 和帽子是哪个的二种酶 catalyse deacetylation 和在优核质的 histone 的 acetylation,其动态平衡在 DNA 为基因抄写和优核质的基因表示有精确规定水平。他们的 Disbalance 能在正常房间带增长和区别的混乱,然后导致肿瘤的开始。他们的异常功能是直接与各种各样的肿瘤的开始和前进有关例如 promyelocytic 白血病, Hodgkin 淋巴瘤,结肠的癌症和 gastral 癌症。HDAC 的禁止者被用于肿瘤的治疗。他们能制止 HDAC 的活动并且堵住 deacetylation 的混乱引起的基因表示的抑制。它的主要生物效果在导致肿瘤房间的区别躺着,逮捕在 G0/G1 的房间圆,激活房间 apoptosis 基因,提高化学治疗和放射性的治疗的敏感。到目前为止 HDAC 是在 anticancer 药 research.Cellular 与分子的免疫学的重要目标酶。2006; 3 (4 ): 285-290。 | Gaofeng Bi Guosheng Jiang | 2006 | Cellular & Molecular Immunology2006，3，4： | 20 |
| 5 | Groundwater Contamination with NO_3-N in a Wheat-Corn Cropping System in the North China Plain显示文摘The North China Plain,where summer corn(Zea mays L.)and winter wheat(Triticum aestivum L.)are the major crops grown,is a major agricultural area in China.Permeable soils make the region susceptible to groundwater pollution by NO_3-N,which is applied to fields in large amounts of more than 400 kg NO_3-N ha^(-1)as fertilizer.A field experiment was established in 2002 to examine the relationship among N fertilization rate,soil NO_3-N,and NO_3-N groundwater contamination.Two adjacent fields were fertilized with local farmers' N fertilization rate(LN)and double the normal application rate(HN),respectively,and managed under otherwise identical conditions.The fields were under a traditional summer corn/winter wheat rotation.Over a 22-month period,we monitored NO_3-N concentrations in both bulk soil and soil pore water in 20-40 cm increments up to 180 cm depth.We also monitored NO_3-N concentrations in groundwater and the depth of the groundwater table.No significant differences in soil NO_3-N were observed between the LN and HN treatment.We identified NO_3-N plumes moving downward through the soil profile.The HN treatment resulted in significantly higher groundwater NO_3-N,relative to the LN treatment,with groundwater NO_3-N consistently exceeding the maximum safe level of 10 mg L^(-1),but groundwater NO_3-N above the maximum safe level was also observed in the LN treatment after heavy rain.Heavy rain in June,July,and August 2003 caused increased NO_3-N leaching through the soil and elevated NO_3-N concentrations in the groundwater.Concurrent rise of the groundwater table into NO_3-N- rich soil layers also contributed to the increased NO_3-N concentrations in the groundwater.Our results indicate that under conditions of average rainfall,soil NO_3-N was accumulated in the soil profile.The subsequent significantly higher- than-average rainfalls continuously flushed the soil NO_3-N into deeper layers and raised the groundwater table,which caused continuous groundwater contamination with NO_3-N.The results suggest that under common farming practices in the North China Plain,groundwater contamination with NO_3-N was likely,especially during heavy rainfalls,and the degree of groundwater contamination appeared to be proportional to the N application rates.Decreasing fertilization rates, splitting fertilizer inputs,and optimizing irrigation scheduling had potential to reduce groundwater NO_3-N contamination. | ZHAO Bing-Zi ZHANG Jia-Bao M. FLURY ZHU An-Ning JIANG Qi-Ao BI Jin-Wei | 2007 | Pedosphere2007，17，6： | 20 |
| 6 | Preservation of the continence function after intersphincteric resection using a prolapsing technique in the patients with low rectal cancer and its clinical prognosis显示文摘肿瘤的 intersphincteric 切除术的技术与 coloanal 吻合相结合的背景被用来为病人避免永久结肠开口术,直肠的癌症定位了 < 从肛门边缘的 5 厘米。针对用 prolapsing technique.Methods 在 intersphincteric 切除术以后与更低的直肠的癌症估计剩余直肠和病人的临床的预后的克制功能的保藏的这研究这研究与下列包括标准包括了病人:(1 ) 在远侧的边缘以内的直肠的癌症和肿瘤的病理学的证据由外科手术前的内视镜的检查从肛门定位了 5 厘米或更少;(2 ) 不由也的渗入的 MRI 证实外部括约肌, puborectalis 或提肌肌肉;(3 ) 病人与与 well-to-moderate 区别显示出肿瘤的外科手术前的活体检视为 intersphincteric 切除术和更低的 coloanal 吻合是合格的。从 2000 年 1 月,到 6 月 2004,23 日,有低直肠的癌症的病人在这研究被包括。我们使用了标准 abdominoperineal 途径与内部括约肌的 mesorectum 和总数或部分的切除执行肿瘤的激进的切除术。病人为对剩余直肠的功能的评价被跟随,在 operations.Results 以后的癌症复发,从肛门边缘的中部的肿瘤距离是 4.5 (范围 3.5-5.0 ) 厘米和吝啬的远侧的外科的边缘 1.6 (范围 1.0-2.0 ) 厘米。癌症被分类进舞台我(30.4%) ,舞台(47.8%) ,和舞台(21.7%) 根据 TNM 分类。在外科的切除术和 2 个病人(8.7%) 在 coloanal 吻合的地点开发了 anastomotic 苛评的以后的阶段以后,二个病人开发了 anastomotic 管。中部的后续时期是 31.5 个月(范围 12-54 ) , 2 个病人(8.7%) 开发了本地复发。三死亡与远侧的机关转移被联系。二十个病人(87.0%) 维持了胜任在外科以后控制固体或液体凳子和屁克制的能力。在这些病人之中, 2 个病人能控制稳固的凳子并且偶尔失去液体凳子的克制。并且仅仅 1 个病人(4.4%) 在手术以后与稳固的凳子然而并非液体的好克制保留了部分直肠功能。在外科是 13.1,4.7,3.1,2.9,和 3.2 时间 / 天以后,每 3, 6, 12, 24 和 36 个月的天平均澄清的时间。在 intersphincteric 切除术和这个变化在后续的时期期间留下了以后,肛门压力计大小在休息时间期间显示出压力的减少。最大值挤压压力在外科以后在起始的减少以后被改进。在外科以后的更多的剩余直肠功能可以被低直肠癌症的 intersphincteric 切除术保存的结论。同时这种技术在外科以后与很少手术后的复杂并发症和低肿瘤复发是安全的。 | DAI Yong JIANG Jin-bo BI Dong-song JIN Zu-tao SUN Jing-zhong HU San-yuan | 2008 | Chinese Medical Journal2008，，20： | 16 |
| 7 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 8 | Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis显示文摘AIM:To investigate the expression and clinical significance of Wnt member 5a (Wnt5a) and receptor tyrosine kinase-like orphan receptor 2 (Ror2) in hepatocellular carcinoma (HCC).METHODS:In HCC tissues obtained from 85 patients,the protein expressions of Wnt5a,Ror2,β-catenin,and Ki-67 via immunohistochemical staining using the Envision Plus System.The antibody binding was visualized with 3,3'-diaminobenzidine tetrahydrochloride (DAB) before brief counterstaining with Mayer's hematoxylin.The degree of immunohistochemical staining was recorded using a semiquantitative and subjective grading system.The mRNA expression of Ror2 was examined by real-time reverse transcription polymerase chain reaction,including nineteen of the 85 HCC and three normal liver tissues.The ratios of Ror2 to the housekeeping gene GAPDH represented the normalized relative levels of Ror2 expression.To determine the prognostic factor,the outcome of the 82 patients was determined by reviewing their medical charts.The overall and disease-free survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test.The prognostic analysis was carried out with univariate and multivariate Cox regressions models.RESULTS:Compared to nontumorous (hepatitis or cirrhotic) tissues,Ror2 mRNA expression was clearly decreased in HCC.Ror2 and Wnt5a protein expressions in the majority of HCC patients (63% and 77%,respectively) was significantly less in tumor tissues,as compared to adjacent nontumorous tissues,and this reduction was correlated with increasing serum α-fetoprotein and tumor stage.In 68% (58/85) of the HCC cases,the expression of β-catenin in tumor tissues was either downregulated in the cellular membrane,upregulated in the cytoplasm,or both.Survival analysis indicated that Wnt5a and Ror2 protein expressions could be regarded as independent prognostic factors for HCC;HCC patients with decreased Wnt5a or Ror2 protein expression had a poorer prognosis than those with elevated Wnt5a and Ror2 expression (P=0.016,P=0.007,respectively).CONCLUSION:Wnt5a and Ror2 may serve as tumor suppressor genes in the development of HCC,and may serve as clinicopathologic biomarkers for prognosis in HCC patients. | Ming Geng Yong-Cheng Cao Ying-Jian Chen Hui Jiang Li-Quan Bi Xiao-Hong Liu | 2012 | World Journal of Gastroenterology2012，18，12： | 12 |
| 9 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 10 | Arbuscular mycorrhizal fungi ameliorate the chemical properties and enzyme activities of rhizosphere soil in reclaimed mining subsidence in northwestern China显示文摘In semi-arid region of northwestern China, underground mining subsidence often results in decreased vegetation coverage, impoverishment of soil fertility and water stress. In addition, the physical-chemical and biological properties of soil also change, resulting in more susceptible to degradation. In particular, subsidence causes disturbance of the symbioses of plant and microbe that can play a beneficial role in the establishment of vegetation communities in degraded ecosystems. The objective of this study was to evaluate the effects of revegetation with exotic arbuscular mycorrhizal fungi(AMF) inoculum on the chemical and biological properties of soil over time in mining subsidence areas. Soils were sampled at a depth up to 30 cm in the adjacent rhizosphere of Amorpha fruticose Linn. from five reclaimed vegetation communities in northwestern China. In August 2015, a field trial was set up with five historical revegetation experiments established in 2008(7-year), 2011(4-year), 2012(3-year), 2013(2-year) and 2014(1-year), respectively. Each reclamation experiment included two treatments, i.e., revegetation with exotic AMF inoculum(AMF) and non-AMF inoculum(the control). Root mycorrhizal colonization, glomalin-related soil protein(GRSP), soil organic carbon(SOC), soil nutrients, and enzyme activities were also assessed. The results showed that mycorrhizal colonization of inoculated plants increased by 33.3%–163.0% compared to that of non-inoculated plants(P<0.05). Revegetation with exotic AMF inoculum also significantly improved total GRSR(T-GRSP) and easily extracted GRSP(EE-GRSP) concentrations compared to control, besides the T-GRSP in 1-year experiment and the EE-GRSP in 2-year experiment. A significant increase in SOC content was only observed in 7-year AMF reclaimed soils compared to non-AMF reclaimed soils. Soil total N(TN), Olsen phosphorus(P) and available potassium(K) were significantly higher in inoculated soil after 1–7 years of reclamation(except for individual cases), and increased with reclamation time(besides soil Olsen P). The exotic AMF inoculum markedly increased the average soil invertase, catalase, urease and alkaline phosphatase by 23.8%, 21.3%, 18.8% and 8.6%, respectively(P<0.01), compared with the control. Root mycorrhizal colonization was positively correlated with soil parameters(SOC, TN and soil available K) and soil enzyme activities(soil invertase, catalase, urease and alkaline phosphatase) in both AMF and non-AMF reclaimed soils(P<0.05), excluding availableK in non-AMF reclaimed soils. T-GRSP(P<0.01) and EE-GRSP(P<0.05) were significantly correlated with the majority of edaphic factors, except for soil Olsen P. The positive correlation between root mycorrhizal colonization and available K was observed in AMF reclaimed soils, indicating that the AMF reclaimed soil with a high root mycorrhizal colonization could potentially accumulate available K in soils. Our findings concluded that revegetation with exotic AMF inoculum influenced soil nutrient availability and enzyme activities in the semi-arid ecosystem, suggesting that inoculating AMF can be an effective method to improve soil fertility and support restoration of vegetation communities under poor conditions like soil nutrient deficiency and drought. | QIU Lang BI Yinli JIANG Bin WANG Zhigang ZHANG Yanxu Yryszhan ZHAKYPBEK | 2019 | Journal of Arid Land2019，11，1： | 11 |
| 11 | Trace Elements Characteristics of Black Shales from the Ediacaran Doushantuo Formation, Hubei Province, South China: Implications for Redox and Open vs. Restricted Basin Conditions显示文摘In the present study, we carried out trace element analyses of black shales of the Ediacaran Doushantou Formation from two sections(Jiulongwan, Baiguoyuan) in Hubei Province, South China. Mo-U characteristics of black shales from the two sections and compiled Mo-U data of Doushantuo black shales from sections of a variety of sedimentary facies described the temporal/spatial variability in the redox conditions of paleo-seawater during deposition of the Doushantuo Formation. Changes in Mo-U patterns of the Doushantuo Member Ⅱ(DST2) shales of open marine environments are consistent with a shift from a predominately oxic to a predominately anoxic ocean during their deposition. Mo-U patterns of the DST2 black shales from intra-shelf sections reflect basin restriction may have happened in the intra-shelf basin and are compatible with the redox-stratified model of the intra-shelf basin. Mo-U patterns of black shales of the Doushantuo Member IV(DST4) reveal that the shales from intra-shelf sections have more pronounced Mo enrichment and more significant enrichment of Mo over U than the slope shales, indicating the operation of a Mn particulate shuttle in the intra-shelf basin. High Mo/TOC ratios of the DST4 at the intra-shelf sections, in combination with similar Mo-TOC patterns of the DST4 from both intra-shelf and slope sections, indicate the intrashelf basin was well connected to the open ocean during deposition of the DST4. | Bi Zhu Shaoyong Jiang Daohui Pi Lu Ge Jinghong Yang | 2018 | Journal of Earth Science2018，29，2： | 11 |
| 12 | Effect of atmospheric aerosol on surface ozone variation over the Pearl River Delta region显示文摘Our analysis of the surface aerosol and ultraviolet(UV) measurements in Pearl River Delta(PRD) region shows that the sur-face UV radiation is reduced by more than 50% due to high aerosol concentrations.This has important impacts on urban eco-system and photochemistry,especially on ozone photochemical production over the region.The quantitative effect of aerosols on surface ozone is evaluated by analyzing surface observations(including ozone,ultraviolet radiation,aerosol radiative pa-rameters) and by using radiative and chemical models.A case study shows that the aerosol concentrations and UV radiation are significantly correlated with ozone concentrations.The correlation coefficient between the aerosol optical depth(AOD) and the PM10 mass concentration is very high,with a maximum of 0.98,and the AOD and UV radiation/ozone is anti-correlated,with a correlation coefficient of -0.90.The analysis suggests that ozone productivity is significantly decreased due to the reduction of UV radiation.The noon-time ozone maximum is considerably depressed when AOD is 0.6,and is further decreased when AOD is up to 1.2 due to the reduction of ozone photochemical productivity.Because the occurring probability of aerosol optical depth for AOD550 nm≥0.6 and AOD340 nm≥1.0 is 47,and 55% respectively during the dry season(October,November,December,January),this heavy aerosol condition explains the low ozone maximum that often occurs in the dry season over the Guangzhou region.The analysis also suggests that the value of single scattering albedo(SSA) is very sensitive to the aerosol radiative effect when the radiative and chemical models are applied,implying that the value of SSA needs to be carefully studied when the models are used in calculating ozone production. | DENG XueJiao ZHOU XiuJi WU Dui TIE XueXi TAN HaoBo LI Fei BI XueYan DENG Tao JIANG DeHai | 2011 | Science China Earth Sciences2011，54，5： | 10 |
| 13 | LC-MS determination and pharmacokinetic study of salidroside in rat plasma after oral administration of suspensions of traditional Chinese medicine Erzhi Wan and Fructus Ligustri lucidi显示文摘A simple,rapid and sensitive liquid chromatography-mass spectrometry(LC-MS)method was developed for the determination of salidroside in rat plasma and study of its pharmacokinetics after oral administration of suspension of Erzhi Wan and Fructus Ligustri lucidi into Wistar rats.Plasma sample of 200 μL was extracted with acetic ether-isopropanol(2∶1)and the extraction was performed on a Kromasil C18 column(150 mm×4.6 mm,5 μm)with the mobile phase of methanol-water(41∶59,v/v)within a run time of 6.0 min.The analyte was monitored with positive electrospray ionization(ESI)by selected ion monitoring(SIM)mode.The target ions were m/z 323.05 for salidroside and m/z 411.05 for internal standard(IS)geniposide.A good linear relationship was obtained over the range of 5.0-500.0 ng/mL and the lower limit of quantification was 5.0 ng/mL.The validated method was successfully applied to the pharmacokinetic study of salidroside in rat plasma after oral administration of suspension of Erzhi Wan and Fructus Ligustri lucidi. | Ze-Yun Li Qing Li Jiang Lu Jun-Hong Ling Xi-Hua Yu Xiao-Hui Chen Kai-Shun Bi | 2011 | Journal of Pharmaceutical Analysis2011，1，1： | 10 |
| 14 | Relationship between linguistic functions and cognitive functions in a clinical study of Chinese patients with post-stroke aphasia显示文摘 | YU Zeng-zhi JIANG Shu-jun BI Sheng LI Jun LEI Di SUN Li-ling | 2013 | Chinese Medical Journal2013，，7： | 10 |
| 15 | Clinical Application of Loewenstein Occupational Therapy Cognitive Assessment Battery-Second Edition in Evaluating of Cognitive Function of Chinese Patients with Post-stroke Aphasia显示文摘Objective To investigate the clinical application value of Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)battery in Chinese patients with post-stroke aphasia.Methods Cognitive functions of 59 Chinese patients with aphasia following a stroke were assessed with the Chinese version of the second edition of LOTCA battery and their linguistic functions were tested with the Western Aphasia Battery(WAB)Scale,respectively.The results of LOTCA were analyzed and compared across different groups,in the light of gender,age,educational background,the length of illness,and the degree of aphasia.Results Neither the score of subtests of the LOTCA nor the overall scores of LOTCA of aphasia patients with different gender and educational background differed(all P>0.05).In different age groups,apart from thinking operation(F=3.373,P=0.016),visuomotor organization(F=3.124,P=0.022),attention(F=3.729,P=0.009)and the total score(F=2.683,P=0.041),there was no difference in terms of the other subtest scores of LOTCA(all P>0.05).In the groups of different length of time with illness,apart from orientation(F=2.982,P=0.039)and attention(F=3.485,P=0.022),the score of other subtests and the total score of LOTCA were not different(all P>0.05).In the groups of different degree of aphasia,apart from attention(F=2.061,P=0.074),both the score of other subtests and the total score of LOTCA differed(all P<0.05).Conclusion LOTCA might be suitable to assessing the cognitive ability of post-stroke Chinese patients with aphasia. | Zeng-zhi Yu Shu-jun Jiang Jun Li Sheng Bi Fei Li Tao Xie Rui Wang Xiao-tan Zhang | 2013 | Chinese Medical Sciences Journal2013，28，3： | 9 |
| 16 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 17 | Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus显示文摘长期的无法预言的温和压力淫液模型是消沉的一个广泛地使用的试验性的模型。在马头鱼尾的怪兽的外长的导致压力的 neuronal 房间死亡仔细与消沉的致病被联系。过多、延长的 endoplasmic 蜂窝胃嗯压力扳机房间死亡。氢硫化物 H 2 S,第三内长的发信号 gasotransmitter,作为 neuromodulator 和 neuroprotectant 在大脑功能起一个重要作用。我们假设了内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力可能涉及导致淫液的像消沉的行为。因此,集中于是否达到高潮的现在的学习扰乱内长的 H 2 S 和起来调整嗯在马头鱼尾的怪兽的应力并且是否外长的 H 2 S 阻止导致淫液的象压抑一样行为。结果证明对待淫液的老鼠展出像消沉的行为并且海马趾嗯包括调整葡萄糖的蛋白质的起来调整的层次的压力回答 78, CCAAT/enhancer 有约束力的蛋白质相应蛋白质,和劈开的 caspase-12 表示,当时 H 2 在马头鱼尾的怪兽的 S 在对待淫液的老鼠被压制。而且,外长的 H 2 S 阻止导致淫液的像消沉的行为。这些数据显示导致淫液的像消沉的行为与内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力并且建议了那内长的 H 2 S 并且嗯应力是消沉的新奇处理目标。 | Huiying Tan Wei Zou Jiamei Jiang Ying Tian Zhifang Xiao Lili Bi Haiying Zeng Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 8 |
| 18 | Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions显示文摘BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2(PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl-N'-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen(PCNA), STAT3,and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liverprecancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression,PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells.Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cells after the intervention for PKM2.CONCLUSION The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells. | Yang-Hui Bi Wen-Qi Han Ruo-Fei Li Yun-Jiao Wang Zun-Shu Du Xue-Jiang Wang Ying Jiang | 2019 | World Journal of Gastroenterology2019，25，16： | 8 |
| 19 | VLW equation of state of detonation products显示文摘Based on the virial theory, we proposed VLW equation of state of detonation products (VLW EOS). Its basic theory and applications were described. The distinct features of the VLW EOS were:First, the detonation performance of the new high energy density materials could be predicted more reliably. Second, it had extensive application. The detonation parameters of both the condensed high energy density materials and the gaseous fuel air explosives could be calculated. Moreover, combustion performance of propellants could also be precisely calculated. The calculation results were satisfactory. | WU Xiong LONG XinPing HE Bi JIANG XiaoHua | 2009 | Science China Chemistry2009，52，5： | 7 |
| 20 | Rh-incompatible hemolytic disease of the newborn in Hefei显示文摘BACKGROUND Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice.Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn(HDN).Unfortunately,regional status of Rh-HDN is unavailable.We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody.AIM To investigate the prevalence of hemolytic disease of the newborn due to Rhisoimmunization in Hefei City.METHODS Retrospective review of data obtained from Children’s Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019.Status of minor blood group antibody was studied in the corresponding mothers.RESULTS Totally 4138 newborns with HDN admitted during the study period and 116(2.8%)received blood exchange transfusion(BET).Eighteen newborns(0.43%)with proven Rh-incompatible HDN were identified.All were not the first-born baby.Thirteen mothers were RhD(+)(72%)and five were RhD(-).The distribution of Rh-related antibodies in mothers was ten anti-E(55%),five anti-D(27%),and for one anti-C,anti-c,and anti-E/c(6%)each.Thirteen(72.2%)were qualified for BET,relative risk for BET was 28.9 as compared to other types of HDN,but only 10 received due to parenteral refusal.All(100%)RhD related HDN received BET which is not significantly different from RhE related HDN(81.8%).CONCLUSION As expected,all Rh-incompatible HDN newborns were not the first-born.Contrary to the Caucasian population,anti-D induced HDN is not the most common etiology.In our region,anti-E(11/18,61%)is the most common cause of Rh-HDN. | Shao-Hua Bi Liang-Liang Jiang Li-Ying Dai Hong Zheng Jian Zhang Li-Li Wang Chao Wang Qiao Jiang Yu Liu Yong-Li Zhang Juan Wang Chao Zhu Guang-Hui Liu Ru-Jeng Teng | 2019 | World Journal of Clinical Cases2019，7，20： | 7 |
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