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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | Advances in laparoscopy for acute care surgery and trauma显示文摘The greatest advantages of laparoscopy when compared to open surgery include the faster recovery times, shorter hospital stays, decreased postoperative pain, earlier return to work and resumption of normal daily activity as well as cosmetic benefits. Laparoscopy today is considered the gold standard of care in the treatment of cholecystitis and appendicitis worldwide. Laparoscopy has even been adopted in colorectal surgery with good results. The technological improvements in this surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its utilization in operations with fully intracorporeal anastomoses. Further progress in laparoscopy has included single-incision laparoscopic surgery and natural orifice trans-luminal endoscopic surgery. Nevertheless, laparoscopy for emergency surgery is still considered challenging and is usually not recommended due to the lack of adequate experience in this area. The technical difficulties of operating in the presence of diffuse peritonitis or large purulent collections and diffuse adhesions are also given as reasons. However, the potential advantages of laparoscopy, both in terms of diagnosis and therapy, are clear. Major advantages may be observed in cases with diffuse peritonitis secondary to perforated peptic ulcers,for example, where laparoscopy allows the confirmation of the diagnosis, the identification of the position of the ulcer and a laparoscopic repair with effective peritoneal washout. Laparoscopy has also revolutionized the approach to complicated diverticulitis even when intestinal perforation is present. Many other emergency conditions can be effectively managed laparoscopically, including trauma in select hemodynamically-stable patients. We have therefore reviewed the most recent scientific literature on advances in laparoscopy for acute care surgery and trauma in order to demonstrate the current indications and outcomes associated with a laparoscopic approach to the treatment of the most common emergency surgical conditions. | Matteo Mandrioli Kenji Inaba Alice Piccinini Andrea Biscardi Massimo Sartelli Ferdinando Agresta Fausto Catena Roberto Cirocchi Elio Jovine Gregorio Tugnoli Salomone Di Saverio | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 3 | High concentration of calcium ions in Golgi apparatus显示文摘The interphase NIH3T3 cells were vitally fluorescentstained with calcium indicator fluo-3 and Glogi probe C6NBD-ceramide, and then the single cells were examined by laser scanning confocal microscopy (LSCFM) for subcellular distributions of Ca2+ and the location of Golgi apparatus. In these cells, the intracellular Ca2+ were found to be highly concentrated in the Golgi apparatus. The changes of distribution of cytosolic high Ca2+ region and the Golgi apparatus coincided with the cell cycle phase.In calcium free medium, when the plasma membrane of the cells which had been loaded with fluo-3/AM were permeated by digitonin, the fluorescence of the Golgi region decreased far less than that of the cytosol. Our results indicated that the Glogi lumen retained significantly high concentration of free calcium. | XUE SHAOBAI M. RoBERT NICOUD JIE CUI D.J.ARNDT JOVIN(Depariment of Biology, Beijing Normal University, Beijing 100875, China)(Max-Planck-Institute fur Biophysikalische Chemie,Gottingen, Germany) | 1994 | Cell Research1994，4，1： | 3 |
| 4 | Hepatitis B and C virus infections as possible risk factor for pancreatic adenocarcinoma显示文摘 | S. Fiorino S. Lorenzini M. Masetti G. Deleonardi A.G. Grondona T. Silvestri E. Chili P. Del Prete L. Bacchi-Reggiani A. Cuppini E. Jovine | 2012 | Medical Hypotheses2012，，5： | 2 |
| 5 | The impact of extent of pancreatic and venous resection on survival for patients with pancreatic cancer显示文摘Background:Borderline resectable pancreatic cancer may require extended resections in order to achieve tumor-free margins,especially in the case of up-front resections,but it is important to know the limits of surgical therapy in this disease.This study aimed to investigate the impact of extent of pancreatic and venous resection on short-and long-term outcomes in patients with pancreatic adenocarcinoma(PDAC).Methods:This was a retrospective study from a prospectively maintained database of pancreatic resections for PDAC.Short-and long-term outcomes were analyzed in patients having borderline resectable PDAC submitted to up-front total pancreatectomy(TP)or pancreaticoduodenectomy(PD)with simultaneous portal vein(PV)and/or superior mesenteric vein(SMV)resection.Venous resections were carried out as tangential venous resection(TVR)or segmental venous resection(SVR).Patients were divided into 4 groups:(1)PD+TVR,(2)PD+SVR,(3)TP+TVR,(4)TP+SVR.Uni-and multivariate Cox regression analysis were performed to identify factors associated with survival.Results:Ninety-nine patients were submitted to simultaneous pancreatic and venous resection for PDAC.Among them,25 were submitted to PD+TVR(25.3%),12 to PD+SVR(12.1%),23 to TP+TVR(23.2%),and 39 to TP+SVR(39.4%).Overall,major morbidity(Clavien-Dindo grade≥IIIA)was 26.3%.Thirty-and 90-day mortality were 3%and 11.1%,respectively.There were no significant differences among groups in terms of short-term outcomes.Median overall survival of patients submitted to PD+TVR was significantly higher than those to TP+SVR(29.5 vs 7.9 months,P=0.001).Multivariate analysis identified TP(HR=2.11;95%CI:1.31–3.44;P=0.002)and SVR(HR=2.01;95%CI:1.27–3.15;P=0.003)as the only independent prognostic factors for overall survival.Conclusions:Up-front TP associated to SVR was predictive of worse survival in borderline resectable PDAC.Perioperative treatments in high-risk surgical groups may improve such poor outcomes. | Matteo Serenari Giorgio Ercolani Alessandro Cucchetti Matteo Zanello Enrico Prosperi Guido Fallani Michele Masetti Raffaele Lombardi Matteo Cescon Elio Jovine | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Inter-relationships between the fibrinolytic system and lipoproteins in the pathogenesis of coronary atherosclerosis 显示文摘 | Jovin i S Muller B G | 2004 | Atherosclerosis2004，174，： | 1 |
| 8 | Endoscopic ultrasound-guided fine needle aspiration with 22- and 25-gauge needles in solid pancreatic masses: A prospective comparative study with randomisation of needle sequence显示文摘 | Carlo Fabbri Anna Maria Polifemo Carmelo Luigiano Vincenzo Cennamo Paola Baccarini Guido Collina Adele Fornelli Sandro Macchia Nicola Zanini Elio Jovine Marta Fiscaletti Angela Alibrandi Nicola D’Imperio | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 9 | Thrombectomy within 8 hours after symptom onset in ischemic stroke显示文摘 | Jovin TG Chamorro A Cobo E | 2015 | N Engl J Med2015，372，： | 1 |
| 10 | Effect of a gib- berellin-biosynthesis inhibitor treatment on the physicochemical properties of sorghum starch 显示文摘 | Enpeng Li Jovin Hasjim Sushil Dhital | 2011 | Journal of Cereal Science2011，53，3： | 1 |
| 11 | Equipoise among recanalization strategies显示文摘 | Tomsick TA Khatri P Jovin T | 2010 | Neurology2010，74，13： | 1 |
| 12 | Quantum dots finally come of age显示文摘 | JOVIN T M | 2003 | Nature Biotechnol2003，21，1： | 1 |
| 13 | Tracking down the ZP domain:From the mammalian zona pellueida to the mol- luscan vitelline envelope显示文摘 | Monne M Han L Jovine L | 2006 | Semin Reprod Med2006，24，4： | 1 |
| 14 | Imaging molecular interactions inliving cells by FRET microscopy 显示文摘 | Jares-Erijman E A Jovin T M | 2006 | Curr Opin Chem Biol2006，10，5： | 1 |
| 15 | Xenon CT cerebral blood flow in acute stroke显示文摘 | Gupta R Jovin TG Yonas H | 2005 | Neuroimaging2005，15，： | 1 |
| 16 | Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor recep- tor (erbB1) and induce apoptosis in erbBl-overexpressing cells 显示文摘 | Nagy P Amdt-Jovin DJ Jovin TM | 2003 | Exp Cell Res2003，285，1： | 1 |
| 17 | Production of resistant starch by extrusion cooking of acid-modified normal-maize starch显示文摘 | Jovin H Jay LJ | 2009 | Jour- nal of Food Science2009，74，7： | 1 |
| 18 | Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis显示文摘 | Scott E. Kasner Marc I. Chimowitz Michael J. Lynn Harriet Howlett-Smith Barney J. Stern Vicki S. Hertzberg Michael R. Frankel Steven R. Levine Seemant Chaturvedi Curtis G. Benesch Cathy A. Sila Tudor G. Jovin Jose G. Romano Harry J. Cloft | 2006 | Circulation2006，，4： | 1 |
| 19 | The scanning force microscopy of DNA in air and in n-propanol using new spreading agents显示文摘 | Starink J P Jovin T M | 1994 | FEBS Lett1994，355，1： | 1 |
| 20 | Mn and other transition metals at low concentration induce the right-to-left helical transformation of poly d(G-C)显示文摘 | Mcintosh IP Jovin TN | 1982 | EMBO J1982，1，： | 1 |
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