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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | Functional analysis of the larval serum protein gene promoter from silkworm,Bombyx mori.显示文摘The regulation region of larval serum protein gene, Bombyx mori. (BmLSP), consisting of the first intron, the first exon, the central promoter region and 5′-upstream region, is cloned from genomic DNA from the silkworm va-riety of Suju譓inghu. Using PCR and restriction endonu-clease methods, a series of luciferase reporter plasmids, driven by different length of BmLSP promoters, are con-structed. Via the transient expression system in BmN cells, the effects of the regulation elements and foreign insect hor-mones on the BmLSP promoter activity are investigated. The results demonstrate that the promoter activity of BmLSP is 5.8- or 4.4-fold higher than that of BmLSPs whose first in-tron or the element in 5′-upstream region harboring the homologous sequence with the first intron of light-chain fib-roin gene (EHIF) is deleted, respectively, suggesting that both the first intron and EHIF contain the main positive cis-acting elements. However, the inactive mariner transposable ele-ment (MTE) in 5′-upstream region presents a negative effect. Furthermore, the effects of juvenile hormone analogue (JHA) on the BmLSP promoter activity show a typical dose-dependent manner, that is, low concentration treat-ments increase the BmLSP promoter activity and high con-centration treatments decrease it. Meanwhile, insect ecdy-sone (MH) treatments present no significant effect. | TANG Shunming, YI Yongzhu, SHEN Xingjia, ZHANG Zhifang, LI Yiren & HE Jialu Key Laboratory of Silkworm Biotechnology, Ministry of Agriculture, Sericultural Research Institute, Chinese Academy of Agricultural Sci-ences, Zhenjiang 212018, China Correspondence should be addressed to Zhang Zhifang (e-mail: zjsbsri@ public.zj.js.cn) | 2003 | Chinese Science Bulletin2003，48，23： | 13 |
| 3 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome显示文摘PRKAG2 心脏的症候群正染色体的主导的继承疾病在编码 γ 的 PRKAG2 基因从变化被结果;激活安培的蛋白质 kinase 的 2 规章的子单元。影响病人通常开发室的 tachyarrhythmia 并且经历对医疗倔强并且要求心脏的移植的进步的心失败。在这研究,我们与家庭 Wolff-Parkinson-White 症候群从病人在 PRKAG2 识别一个 H530R 变化。由产生转基因的 H530R PRKAG2 和敲门在里面老鼠,我们证明两个模型包括心脏的肥大和肝糖存储概括人的症状,证实 H530R 变化是有原因地与 PRKAG2 有关心脏的症候群。我们进一步联合联系 adeno 的 virus-9 (AAV9 ) 和 CRISPR/Cas9 编辑基因的系统当让野类型的等位基因未经触动时,破坏编码 H530R 的变异的 PRKAG2 等位基因。在出生后的白天的 AAV9-Cas9/sgRNA 的单个全身的注射 4 或白天 42 实质地在转基因的 H530R PRKAG2 和敲门在里面鼠标恢复心的形态学和函数。一起,我们的工作建议在 vivo CRISPR/Cas9,染色体编辑由有选择地破坏引起疾病的变化是在 PRKAG2 心脏的症候群和另外的主导的继承心脏病的治疗的一个有效工具。 | Chang Xie Ya-Ping Zhang Lu Song Jie Luo Wei Qi Jialu Hu Danbo Lu Zhen Yang Jian Zhang Jian Xiao Bin Zhou Jiu-Lin Du Naihe Jing Yong Liu Yan Wang Bo-Liang Li Bao-Liang Song Yan Yan | 2016 | Cell Research2016，26，10： | 12 |
| 4 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 5 | Synergistic effect of Pt nanoparticles and micro-mesoporous ZSM-5 in VOCs low-temperature removal显示文摘Micro-mesoporous ZSM-5 zeolites were obtained by the post-treatment of tetrahydroxy ammonium hydroxide(TPAOH) solution with different concentration.The hierarchical pore structure formed during the desilication process facilitates the dispersion of Pt nanoparticles and Pt/ZSM-5 catalysts exhibit rather high catalytic activity for the deep oxidation of various VOCs at low temperature.The catalyst treated with TPAOH of 0.1 mol/L(Pt/ZSM-5(0.1)) shows the lowest degradation temperature(T90%) of 128 and 142℃, respectively for benzene and n-hexane.Compared with the untreated Pt/ZSM-5 catalyst, the abundant mesopores, small Pt particle size and finely dispersed Pt contribute to the superior catalytic activity and stability of the Pt/ZSM-5 catalysts for VOCs removal.More importantly, the existence of H_(2)O in the feed gases hardly affected the activity of Pt/ZSM-5(0.1) catalyst at the low reaction temperature of 128℃, which is very important for VOCs low-temperature removal in the future practical applications. | Jialu Wang Xiaolin Guo Yijun Shi Renxian Zhou | 2021 | Journal of Environmental Sciences2021，33，9： | 6 |
| 6 | Coupled BEM-FEM Analysis of the Large-Diameter Cylinder Structure System显示文摘A method of coupled BEM-FEM analysis for the elastic spatial structure system is presented. It can be applied to the calculation of the stress and deformation of the large-diamater cylinder structure system and it is suitable for symmetric or non-symmetric structures under the distributed or concentrated load. Numerical examples show that the proposed method and computer program BEFEM are quite efficient in the analysis of the large-diameter cylinder structure problems in ocean engineering. | Zhou Xireng, Duan Xudong, Sang Xuezhu Zhang Rui and Dai Jialu 1 Professor, Tianjin University, Tianjin2 Engineer, Xiamen Port Office, Fujian3 Lecturer, Tianjin University, Tianjin4 Senior Engineer, Tianjin Port Office, Tianjin | 1992 | China Ocean Engineering1992，7，2： | 6 |
| 7 | High activity of CeO2-TiO2 composites for deep oxidation of 1,2-dichloroethane显示文摘CeO2-TiO2 catalysts prepared by different methods were investigated for deep oxidation of 1,2-dichloroethane(DCE),as a typical representative of the chlorinated volatile organic compounds(CVOCs).Characterization analysis reveals that CeO2-TiO2 catalysts prepared by sol-gel and coprecipitation methods exhibit higher specific area,CeO2 and TiO2 particles are highly dispersed into each other and the reducibility and mobility of active oxygen species are obviously promoted due to the strong interaction between the two catalysts CeO2 and TiO2,resulting in higher catalytic activity for DCE oxidation to and less chlorinated byproduct.The high calcination temperature would lead to the formation of a new monoclinic phase Ce0.3Ti0.7O2 and sintering,which is the main reason for the catalytic activity for DCE oxidation markedly decreases. | Jialu Wang Zhinan Shi Renxian Zhou | 2020 | Journal of Rare Earths2020，38，8： | 5 |
| 8 | Experimental study of chemical concentration variation of ASP flooding显示文摘A physical modeling system of long slim tube was established. Several pressure measuring and sampling points were laid out at different positions along the tube. Through real-time measurements of pressures and chemical concentrations at different points, the mass transfer and chemical concentration of ASP flooding in porous media are studied. The concentration of chemicals declines gradually during the fluid flow from the inlet to the outlet of the model. The concentration increases in the front edge of the slug faster than the concentration decreases in the rear edge of the slug. The concentration variation of the chemicals is an asymmetrical and offset process. The order of motion velocities of the chemicals from fast to slow is polymer, alkali and surfactant. The motion lag and comprehensive diffusion are strong in the vicinity of the inlet, the motion velocities of the chemicals are high, the difference of flow velocities among the three chemicals is significant and the chromatographic separation of the chemicals is obvious. In the area near the outlet, the comprehensive diffusion and motion lag become weak, the concentrations of the chemicals decrease, the motion velocities of the chemicals are slow, the difference among the motion velocities of the chemicals becomes small, the chromatographic separation is not obvious, the adsorption and retention of chemicals gradually increase as the chemical slug moves further along the tube, the adsorption and retention of polymer is the most serious. | WANG JiaLu YUAN ShiYi SHI FaShun JIA Xu | 2009 | Science China(Technological Sciences)2009，52，7： | 4 |
| 9 | Comparative study of gel-based separated arcdischarge, HiPCO, and CoMoCAT carbon nanotubes for macroelectronic applications显示文摘由于他们有房间温度免职 / 出版处理的优秀电的性质和相容性,为 macroelectronic 应用程序例如的高纯净的围单人赛的半导体的碳 nanotubes 抓住伟人潜力在薄电影的晶体管和显示器背面板电子学。然而,亲戚有利并且为 macroelectronics 遗体的各种各样的 nanotubes 的劣势一个开的问题,尽管有大意义。这里在这糊,我们报导三种主流的碳 nanotubes 的比较、系统的研究(弧分泌物, HiPCO , CoMoCAT )为薄电影的晶体管应用使用便宜基于胶化的专栏层析分开,并且高效晶体管--它为在活跃矩阵使用的晶体管满足要求器官的轻射出的二极管显示有完成。我们观察在取决于 nanotube 直径的晶体管活动性和开/关比率之间的一宗交易。当时有更大的直径的弧分泌物 nanotubes 导致高设备活动性, HiPCO 和 CoMoCAT 有更小的直径的 nanotubes 能提供高开/关比率(> 106 ) 为有可比较的尺寸的晶体管。而且,我们也把基于胶化的分开的 nanotubes 与 nanotubes 用密度坡度超离心机(DGU ) 分开了作比较方法,并且发现分开胶化的 nanotubes 能像分开 DGU 的 nanotubes 一样提供纯净和薄电影的晶体管性能。我们的途径能为未来碳用作批评基础基于 nanotube 的薄电影的 macroelectronics。 | Jialu Zhang Hui Gui Bilu Liu Jia Liu Chongwu Zhou | 2013 | Nano Research2013，6，12： | 3 |
| 10 | A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis显示文摘Under stress,the endomembrane system undergoes reorganization to support autophagosome biogenesis,which is a central step in autophagy.How the endomembrane system remodels has been poorly understood.Here we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment(ERGIC)and the ER-exit site(ERES)in the ER-Golgi system,which is essential for promoting autophagosome biogenesis induced by different stress stimuli.The ERGIC-ERES contact is established by the interaction between TMED9 and SEC12 which generates a short distance opposition(as close as 2-5 nm)between the two compartments.The tight membrane contact allows the ERES-located SEC12 to transactivate COPII assembly on the ERGIC.In addition,a portion of SEC12 also relocates to the ERGIC.Through both mechanisms,the ERGIC-ERES contact promotes formation of the ERGIC-derived COPII vesicle,a membrane precursor of the autophagosome.The ERGIC-ERES contact is physically and functionally different from the TFG-mediated ERGIC-ERES adjunction involved in secretory protein transport,and therefore defines a unique endomembrane structure generated upon stress conditions for autophagic membrane formation. | Shulin Li Rui Yan Jialu Xu Shiqun Zhao Xinyu Ma Qiming Sun Min Zhang Ying Li Jun-Jie Gogo Liu Liangyi Chen Sai Li Ke Xu Liang Ge | 2022 | Cell Research2022，32，2： | 3 |
| 11 | Robust adaptive NN-based output feedback control for a dynamic positioning ship using DSC approach显示文摘A robust adaptive NN-based output feedback control scheme is presented for a dynamic positioning ship with uncertainties and unknown external disturbances. We tackle the problem that velocity vector of a ship is not available by employing a high-gain observer, and develop the proposed control approach by combing vectorial backstepping with dynamic surface control approach, which is simpler and easier to implement in engineering practice. The neural network(NN) approximation technique is used to compensate for the uncertainties and unknown external disturbances, and it removes the requirement for the prior knowledge about the vessel parameters and external disturbances. Also, it is demonstrated that the proposed control strategy can force the position and yaw angle of a dynamic positioning ship to approach the desired point while guaranteeing all singles of the designed closed-loop dynamic positioning system semi-globally uniformly ultimately bounded by means of the Lyapunov function. Simulation results of a supply ship illustrate the effectiveness of the proposed scheme. | YANG Yang GUO Chen DU JiaLu | 2014 | Science China(Information Sciences)2014，57，10： | 3 |
| 12 | Synthesis and Device Applications of High-Density Aligned Carbon Nanotubes Using Low-Pressure Chemical Vapor Deposition and Stacked Multiple Transfer显示文摘For nanotube-based electronics to become a viable alternative to silicon technology,high-density aligned carbon nanotubes are essential.In this paper,we report the combined use of low-pressure chemical vapor deposition and stacked multiple transfer to achieve high-density aligned nanotubes.By using an optimized nanotube synthesis recipe,we have achieved high-density aligned carbon nanotubes with density as high as 30 tubes/μm.In addition,a facile stacked multiple transfer technique has been developed to further increase the nanotube density to 55 tubes/μm.Furthermore,high-performance submicron carbon nanotube field-effect transistors have been fabricated on the high-density aligned nanotubes.Before removing the metallic nanotubes by electrical breakdown,the devices exhibit on-current density of 92.4μA/μm and normalized transconductance of 13.3μS/μm.Moreover,benchmarking with the aligned carbon nanotube transistors in the literature indicates that our devices exhibit the best performance so far,which is attributed to both the increased nanotube density and scaling down of channel length.This study shows the great potential of using such high-density aligned nanotubes for high performance nanoelectronics and analog/RF applications. | Chuan Wang Koungmin Ryu Lewis Gomez De Arco Alexander Badmaev Jialu Zhang Xue Lin Yuchi Che Chongwu Zhou | 2010 | Nano Research2010，3，12： | 3 |
| 13 | Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding显示文摘The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/ Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layer, and fluid changes the flow direction toward the low and the middle permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency. | WANG Jialu SHEN Pingping CHEN Yongzhong ZHANG Zubo JIA Xu TIAN Yuling | 2005 | Science China(Technological Sciences)2005，48，4： | 3 |
| 14 | A theoretic study of a distance-based regression model显示文摘The distance-based regression model has many applications in analysis of multivariate response regression in various ?elds, such as ecology, genomics, genetics, human microbiomics, and neuroimaging. It yields a pseudo F test statistic that assesses the relation between the distance(dissimilarity) of the subjects and the predictors of interest. Despite its popularity in recent decades, the statistical properties of the pseudo F test statistic have not been revealed to our knowledge. This study derives the asymptotic properties of the pseudo F test statistic using spectral decomposition under the matrix normal assumption, when the utilized dissimilarity measure is the Euclidean or Mahalanobis distance. The pseudo F test statistic with the Euclidean distance has the same distribution as the quotient of two Chi-squared-type mixtures. The denominator and numerator of the quotient are approximated using a random variable of the form ξχ_d^2+ η, and the approximate error bound is given. The pseudo F test statistic with the Mahalanobis distance follows an F distribution.In simulation studies, the approximated distribution well matched the 'exact' distribution obtained by the permutation procedure. The obtained distribution was further validated on H1N1 in?uenza data, aging human brain data, and embryonic imprint data. | Jialu Li Wei Zhang Sanguo Zhang Qizhai Li | 2019 | Science China Mathematics2019，62，5： | 2 |
| 15 | Construction of Ecological City from the Perspective of Ecological Progress—A Case Study of Liaocheng City显示文摘Ecological progress is a new stage in the development of human civilization and ecological city is a new city development model under the concept of ecological progress. In this paper, favorable conditions and constraints for constructing an ecological city are analyzed and construction concepts are put forward. It contributes to the construction of Liaocheng into an ecological city and has a referential value for other cities. | LIU Kai WANG Chengxin SHI Jialu SUN Xue | 2013 | Journal of Landscape Research2013，5，3： | 2 |
| 16 | Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates显示文摘Emerging SARS-CoV-2 variants and the gradually decreasing neutralizing antibodies over time post vaccination have led to an increase in incidents of breakthrough infection across the world.To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain(RBD)(PS-RBD)and whole inactivated virus particle vaccine(IV)against the variant strains,in this study,rhesus macaques were immunized with PS-RBD or IV vaccine,followed by a Beta variant(B.1.351)challenge.Although neutralizing activity against the Beta variant was reduced compared with that against the prototype,the decreased viral load in both upper and lower respiratory tracts,milder pathological changes,and downregulated inflammatory cytokine levels in lung tissues after challenge demonstrated that PS-RBD and IV still provided effective protection against the Beta variant in the macaque model.Furthermore,PS-RBD-induced macaque sera possessed general binding and neutralizing activity to Alpha,Beta,Delta,and Omicron variants in our study,though the neutralizing antibody(NAb)titers declined by varying degrees,demonstrating potential protection of PS-RBD against current circulating variants of concern(VOCs).Interestingly,although the IV vaccine-induced extremely low neutralizing antibody titers against the Beta variant,it still showed reduction for viral load and significantly alleviated pathological change.Other correlates of vaccine-induced protection(CoP)like antibody-dependent cellular cytotoxicity(ADCC)and immune memory were both confirmed to be existing in IV vaccinated group and possibly be involved in the protective mechanism. | Qian He Qunying Mao Xiaozhong Peng Zhanlong He Shuaiyao Lu Jialu Zhang Fan Gao Lianlian Bian Chaoqiang An Wenhai Yu Fengmei Yang Yanan Zhou Yun Yang Yanyan Li Yadi Yuan Xujia Yan Jinghuan Yang Xing Wu Weijin Huang Changgui Li Junzhi Wang Zhenglun Liang Miao Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 17 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 18 | Enhanced dechlorination of 2,4-dichlorophenol by recoverable Ni/Fe–Fe_3O_4 nanocomposites显示文摘Ni/Fe-Fe_3O_4 nanocomposites were synthesized for dechlorination of 2,4-dichlorophenol(2,4-DCP). The effects of the Ni content in Ni/Fe-Fe_3O_4 nanocomposites, solution pH, and common dissolved ions on the dechlorination efficiency were investigated, in addition to the reusability of the nanocomposites. The results showed that increasing content of Ni in Ni/Fe–Fe_3O_4 nanocomposites, from 1 to 5 wt.%, greatly increased the dechlorination efficiency; the Ni/Fe–Fe_3O_4 nanocomposites had much higher dechlorination efficiency than bare Ni/Fe nanoparticles. Ni content of 5 wt.% and initial p H below 6.0 was found to be the optimal conditions for the catalytic dechlorination of 2,4-DCP. Both 2,4-DCP and the intermediate product 2-chlorophenol(2-CP) were completely removed, and the concentration of the final product phenol was close to the theoretical phenol production from complete dechlorination of 20 mg/L of 2,4-DCP, after 3 hr reaction at initial p H value of 6.0,3 g/L Ni/Fe-Fe_3O_4 , 5 wt.% Ni content in the composite, and temperature of 22℃. 2,4-DCP dechlorination was enhanced by Cl-and inhibited by NO3-and SO_4^(2-). The nanocomposites were easily separated from the solution by an applied magnetic field. When the catalyst was reused, the removal efficiency of 2,4-DCP was almost 100% for the first seven uses, and gradually decreased to 75% in cycles 8–10. Therefore, the Ni/Fe–Fe_3O_4 nanocomposites can be considered as a potentially effective tool for remediation of pollution by 2,4-DCP. | Cancan Xu Rui Liu Lvjun Chen Jialu Tang | 2016 | Journal of Environmental Sciences2016，28，10： | 2 |
| 19 | Research on the influence of equity pledge on stock price crash risk:based on financial shock of 2015 stock market crisis显示文摘The 2015 Chinese stock market crisis triggered liquidation because of equity pledge so that the leverage effect of the small probability event with severe results got intensive attention from investors.It is found that the effects of equity pledge on stock price crash risk reversed significantly before and after the 2015 stock market crisis.In the mechanism analysis,we further find that the equity pledge influenced the stock price crash risk by longer suspension and greater price fluctuation.The shareholding ratio of institutional investors and information environment also had a significant moderating effect on the influence of equity pledge on stock price crash risk.Alternative interpretation tests excluded the tunnel effect and pressure effect by shareholders and incentive effect by management.This study by analysing empirical data provides evidence on the change of investors’risk recognition,which is caused by financial shock,in the Chinese capital market. | Rong Xu Jialu Chang Conggang Li Wenlan Wang | 2019 | Economic and Political Studies2019，7，4： | 2 |
| 20 | Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair显示文摘The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.Blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation. | Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang | 2021 | Bioactive Materials2021，6，11： | 2 |
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