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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 3 | Preassembly and ligand-induced restructuring of the chains of the IFN-γ receptor complex: the roles of Jak kinases, Statl and the receptor chains显示文摘 | Christopher D Krause Natasha Lavnikova Junxia Xie Erwen Mei Olga V Mirochnitchenko Yiwei Jia Robin M Hochstrasser Sidney Pestka | 2006 | Cell Research2006，16，1： | 7 |
| 4 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 5 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 6 | 肾髓质癌中SMARCB1蛋白表达缺失的独特机制:20例形态学和分子分析显示文摘肾髓质癌是一种罕见但极具侵袭性的肾癌,其发生在具有镰状红细胞病或罕见具有其他血红蛋白病的患者。SMARCB1是SWI/SNF染色质重塑复合物的核心亚基,该蛋白表达缺失是肾髓质癌的主要诊断特征。然而,SMARCB1蛋白表达缺失的分子机制尚不清楚。作者回顾性分析了两家机构于1996~2017年期间诊断的20例肾髓质癌。所有患者均有镰状红细胞病,所有肿瘤免疫组化显示有SMARCB1蛋白表达缺失。用3色探针荧光原位杂交(FISH)检测SMARCB1位点状态,并用靶向二代测序平台检测SMARCB1在体细胞内结构的变化情况。20例患者的FISH分析显示,11例(55%)同时存在半合子缺失和SMARCB1易位,6例(30%)SMARCB1纯合子缺失,3例(15%)虽然有SMARCB1蛋白缺失却无结构或拷贝数的改变。 | 魏建国(摘译) 袁晓露(审校) Jia L Carlo M I Khan H | 2019 | 临床与实验病理学杂志2019，35，8： | 3 |
| 7 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 8 | Electrically conductive epoxy resin composites containing polyaniline with different morphologies 显示文摘 | JIA Q M LI J B WANG L F | 2007 | Materials Science and Engineering A2007，448，： | 1 |
| 9 | Sol-gel deposition and luminescent properties of LaMgAl11O19:Ce^3+/Tb^3+ phosphor films 显示文摘 | JIA P Y YU M LIN J | 2005 | J Solid State Chem2005，178，9： | 1 |
| 10 | Wide-range stress intensity factors for the ISRM suggested method using CCNBD specimens for rock fracture toughness tests显示文摘 | WANG Q Z JIA X M WU L Z | 2004 | International Journal of Rock Meehanies and Mining Seienees2004，41，： | 1 |
| 11 | Diamond Formation from a System of SiC and a Metal显示文摘 | Hong S M Li W Jia X P | 1993 | Diamond Related Mater1993，2，： | 1 |
| 12 | The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals显示文摘 | Jia Z S Tang M C Wu J M | 1999 | Food Chemistry1999，64，4： | 1 |
| 13 | Identification of metastasis-related microRNAs in hepatocellular carcinoma显示文摘 | Budhu A Jia H L Forgues M | 2008 | Hepatology2008，47，3： | 1 |
| 14 | Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha 1and TIMP- 1显示文摘 | Jia JD Bauer M Cho JJ | 2001 | J Hepatol2001，35，： | 1 |
| 15 | Location of the ground state of Er3+in doped Y2O3 from two-step photoconductivity显示文摘 | Jia D D Meltzer R S Yen W M 2002 | 2002 | Phys Rev B2002，65，23： | 1 |
| 16 | Using induced pluripotent stemcells to investigate cardiac phenotypes in Timothy syndrome 显示文摘 | Yazawa M Hsueh B Jia XL | 2011 | Na-ture2011，471，7337： | 1 |
| 17 | Mixed-integer linear programming model for gasoline blending and distribution scheduling显示文摘 | Jia Z Ierapetritou M | 2003 | Industrial & Engineering Chemistry Research2003，42，4： | 1 |
| 18 | Efficacy and Side Effects of Chinese Herbal Medicine for Menopausal Symptoms; A Criti- cal Review显示文摘 | Xu LW Jia M Salchow R | 2012 | Evid Based Complement Alternat Med2012，2012，56： | 1 |
| 19 | Late Holocene activity and historical earthquakes of the Qiongxi thrust fault system in the southern Longmen Shah fold-and-thrust belt,eastern Tibetan Pla-teau显示文摘 | Wang M M Jia D Lin Aiming | 2013 | Tectonophysics2013，584，： | 1 |
| 20 | Paeonol attenuates high - fat - diet - induced atherosclerosis in rabbits by anti - inflammatory activity 显示文摘 | Li H Dai M Jia W | 2009 | Plan- ta Med2009，75，1： | 1 |
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