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| 1 | 飞秒激光烧蚀氟化钙晶体表面特性显示文摘采用飞秒激光对氟化钙晶体表面进行加工。通过调控激光参数,采用静止聚焦和动态扫描两种方式在晶体表面加工出一系列微结构(烧蚀孔和烧蚀线)。分别对两种加工方式烧蚀后的氟化钙晶体表面微结构进行系统研究,包括参数依赖关系、材料表面烧蚀阈值等。计算结果表明:在静止聚焦情况下,累积因子为0.0033;在动态扫描情况下,当扫描方向与激光偏振方向垂直或平行时,累积因子分别为0.0043和0.0052。飞秒激光加工过程中的脉冲累积效应能够对晶体的烧蚀产生重要影响。 | 郭太勇 张立木 任莹莹 蔡阳健 Carolina Romero Javier R.Vázquez de Aldana | 2019 | 光学学报2019，39，1： | 8 |
| 2 | Q-switching of waveguide lasers based on graphene/WS_2 van der Waals heterostructure显示文摘We report on the operation of passively Q-switched waveguide lasers at 1 μm wavelength based on a graphene∕WS_2 heterostructure as a saturable absorber(SA). The gain medium is a crystalline Nd:YVO_4 cladding waveguide produced by femtosecond laser writing. The nanosecond waveguide laser operation at 1064 nm has been realized with the maximum average output power of 275 m W and slope efficiency of 37%. In comparison with the systems based on single WS_2 or graphene SA, the lasing Q-switched by a graphene∕WS_2 heterostructure SA possesses advantages of a higher pulse energy and enhanced slope efficiency, indicating the promisingapplications of van der Waals heterostructures for ultrafast photonic devices. | ZIQI LI CHEN CHENG NINGNING DONG CAROLINA ROMERO QINGMING LU JUN WANG JAVIER RODRíGUEZ VáZQUEZ DE ALDANA YANG TAN FENG CHEN | 2017 | Photonics Research2017，5，5： | 7 |
| 3 | Clinical significance of occult hepatitis B virus infection显示文摘Occult hepatitis B virus(HBV) infection(OBI) is defined as the presence of HBV DNA in the liver(with or without detectable HBV DNA in serum) for individuals testing HBV surface antigen negative.Until recently,the clinical effect of OBI was unclear on the progression of liver disease;on the development of hepatocellular carcinoma;and on the risk for reactivation or transmission of HBV infection.Several studies suggest a high prevalence of OBI among patients with cryptogenic chronic liver disease,but its role in the progression to cirrhosis remains unclear.Although OBI has been well documented in human immunodeficiency virus(HIV) -positive patients,especially among those coinfected with hepatitis C virus,further studies are needed to determine its current clinical impact in HIV setting. | Miriam Romero Antonio Madejón Conrado Fernández-Rodríguez Javier García-Samaniego | 2011 | World Journal of Gastroenterology2011，17，12： | 6 |
| 4 | Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses显示文摘最普遍的三部件的阴茎修复术模型是 700CX 和泰坦 ? 。在第一植入以后,我们的目的是估计病人和搭挡满足。这是 multicenter,回顾,满足了在 2009 和 2013 之间的包括标准的所有病人在被包括的 nonrandomized 学习。总共, 248 个病人同意参与。评估耐心的满足,一张验证,但是修改的 11 问题问询表被完成(编辑) ;并且二条款的问询表被给搭挡的 nonvalidated。统计分析使用了一个顺序的逻辑回归模型。248 个病人(194 与 700CX 对 54 与泰坦 ?) 和 207 对夫妇完成了问询表(165 与 700CX 对 42 与泰坦 ?) 。全面满足高。为有优先的期望的性交和高依从的两个都显示出的大可靠性。大多数病人能在 6 个月以内正确地管理阴茎修复术。手术后的阴茎弄短在 42% 盒子和 46% 中导致了一些不满(700CX /Titan ?) 。重要差别在病人问询表的三个问题被发现。有更多的病人,对 700CX 满意(P = 0.0001 ) 。有泰坦 ? 的没有病人植入比 6 个月长带了去最佳的管理。仅仅,有 700CX 的 4% 病人植入与泰坦 ? 与放气被不满足,与 24% 相对照(P = 0.0031 ) 。二个搭挡问题,一个人显示出统计上重要的差别(P = 0.0026 ) 。看起来,组 700CX 将推荐到重新植入有一个更大的趋势的修复术。全面满足为两 prostheses 很高。最后的方面树立,松驰的阴茎是令人满意的,但是两个组与它的最后的尺寸显示出重要不满。搭挡外套满足高。 | Javier Romero Otero Cesar Rojas Cruz Borja Garcia Gomez Joaquim Sarquella Geli lose Medina Polo Eduard Ruiz Castane Alfredo Rodriguez Antolin | 2017 | Asian Journal of Andrology2017，19，3： | 3 |
| 5 | Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C显示文摘AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration (< 400 000 vs ≥ 400 000), genotype (1/4 vs 3/4), cirrhotic status and ribavirin dose (800/1000/1200 mg/d).RESULTS: A total of 1014 patients were included in the study. Mean age of the patients was 44.3 ± 9.8 years, 70% were male, and 97% were Caucasian. The main sources of HCV infection were intravenous drug abuse (25%) and blood transfusion (23%). Seventyeight percent were infected with HCV genotype 1/4 (68% had genotype 1) and 22% with genotypes 2/3. The HCV-RNA level was > 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%). The planned treatment duration was 48 wk for 92% of patients with genotype 2/3 and 24 wk for 97% of those with genotype 1/4 (P < 0.001). Seven percent of patients experienced at least one reduction in ribavirin or peginterferon α-2a dose, respectively. Only 2% of patients required a dose reduction of both drugs. Treatment was continued until week 12 in 99% of patients. Treatment compliance was ≥ 80% in 98% of patients. EVR was achieved in 87% of cases (96% vs 83% of patients with genotype 2/3 and 1/4, respectively; P < 0.001). The bivariate analysis showed that patients who failed to achieve EVR were older (P < 0.005), had higher ALT (P < 0.05), AST (P < 0.05), GGT (P < 0.001) and ferritin levels (P < 0.001), a diagnosis of cirrhosis (P < 0.001), and a higher baseline viral load (P < 0.05) than patients reaching an EVR. Age < 40 years [odds ratios (OR): 0.543, 95%CI: 0.373-0.790, P < 0.01], GGT < 85 IU/mL (OR: 3.301, 95%CI: 0.192-0.471, P < 0.001), low ferritin levels (OR: 0.999, 95%CI: 0.998-0.999, P < 0.01) and genotype other than 1/4 (OR: 4.716, 95%CI: 2.010-11.063, P < 0.001) were identified as independent predictors for EVR in the multivariate analysis. CONCLUSION: CHC patients treated with peginterferon-α-2a/ribavirin in clinical practice show high EVR. Older age, genotype 1/4, and high GGT were associated with lack of EVR. | Javier García-Samaniego Miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 6 | Independent Validation of the Secondary Intracerebral Hemorrhage Score With Catheter Angiography and Findings of Emergent Hematoma Evacuation显示文摘 | Josser E. Delgado Almandoz Bharathi D. Jagadeesan Christopher J. Moran DeWitte T. Cross Gregory J. Zipfel Jin-Moo Lee Javier M. Romero Colin P. Derdeyn | 2012 | Neurosurgery2012，，1： | 1 |
| 7 | Thermodynamic analysis of a Brayton cycle and Rankine cycle arranged in series exploiting the cold exergy of LNG显示文摘 | Manuel Romero Gómez Ramón Ferreiro Garcia Javier Romero Gómez José Carbia Carril | 2013 | Energy2013，，： | 1 |
| 8 | Functional Recovery Following Intracoronary Infusion of Autologous Mononuclear Bone Marrow Cells in Patients With Chronic Anterior Myocardial Infarction and Severely Depressed Ventricular Function显示文摘 | José Suárez de Lezo Concepción Herrera Miguel A. Romero Manuel Pan Rosario Jiménez Dolores Carmona José M. Segura Sonia Nogueras Dolores Mesa Javier Suárez de Lezo Djordje Pavlovic Soledad Ojeda Antonio Torres | 2010 | Revista Espa?ola de Cardiología (English Edition)2010，，10： | 1 |
| 9 | Exploring the enzymatic parameters for optimal delignification of eucalypt pulp by laccase-mediator 显示文摘 | David Ibarra Javier Romero | 2006 | Enzyme and Microbial Technology2006，39，6： | 1 |
| 10 | Comparison of Hematoma Shape and Volume Estimates in Warfarin Versus Non-Warfarin-Related Intracerebral Hemorrhage显示文摘 | Kevin N. Sheth Tracy A. Cushing Lauren Wendell Michael H. Lev Javier M. Romero Kristin Schwab Eric E. Smith Steven M. Greenberg Jonathan Rosand Joshua N. Goldstein | 2010 | Neurocritical Care2010，，1： | 1 |
| 11 | Systematic Characterization of the Computed Tomography Angiography Spot Sign in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk for Hematoma Expansion: The Spot Sign Score显示文摘 | Josser E. Delgado Almandoz Albert J. Yoo Michael J. Stone Pamela W. Schaefer Joshua N. Goldstein Jonathan Rosand Alexandra Oleinik Michael H. Lev R Gilberto Gonzalez Javier M. Romero | 2009 | Stroke2009，，： | 1 |
| 12 | Spot sign score predicts rapid bleeding in spontaneous intracerebral hemorrhage显示文摘 | Javier Romero Jeremy Heit Josser Delgado Almandoz Joshua Goldstein Jingjing Lu Elkan Halpern Steven Greenberg Jonathan Rosand R. Gonzalez | 2012 | Emergency Radiology2012，，3： | 1 |
| 13 | Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared显示文摘 | Farid Radmanesh Guido J. Falcone Christopher D. Anderson Thomas W.K. Battey Alison M. Ayres Anastasia Vashkevich Kristen A. McNamara Kristin Schwab Javier M. Romero Anand Viswanathan Steven M. Greenberg Joshua N. Goldstein Jonathan Rosand H. Bart Brouwers | 2014 | Stroke2014，，： | 1 |
| 14 | Anatomic Pattern of Intracerebral Hemorrhage Expansion: Relation to CT Angiography Spot Sign and Hematoma Center显示文摘 | Grégoire Boulouis Andrew Dumas Rebecca A. Betensky H. Bart Brouwers Panagiotis Fotiadis Anastasia Vashkevich Alison Ayres Kristin Schwab Javier M. Romero Eric E. Smith Anand Viswanathan Joshua N. Goldstein Jonathan Rosand M. Edip Gurol Steven M. Greenberg | 2014 | Stroke2014，，： | 1 |
| 15 | Prospective Validation of the Computed Tomographic Angiography Spot Sign Score for Intracerebral Hemorrhage显示文摘 | Javier M. Romero H. Bart Brouwers JingJing Lu Josser E. Delgado Almandoz Hillary Kelly Jeremy Heit Joshua Goldstein Jonathan Rosand R. Gilberto Gonzalez | 2013 | Stroke2013，，： | 1 |
| 16 | On Antenna Design and Capacity Analysis for the Forward Link of a Multibeam Power Controlled Satellite CDMA Network显示文摘 | Javier Romero - Garcia Riccardo De Gaudenzi | 2000 | IEEE Journal On Selected Areas In Communications2000，18，7： | 1 |
| 17 | Tolerance to noise in 91 bird species from 27 urban gardens of Iberian Peninsula显示文摘 | Daniel Patón Francisco Romero Javier Cuenca Jose Carlos Escudero | 2011 | Landscape and Urban Planning2011，，： | 1 |
| 18 | Testing linear models on spectral daylight measurements显示文摘 | Javier Hernandez-Angrez Romero J Antonio GarciaBletran | 1998 | Applied Optics1998，37，6： | 1 |
| 19 | Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment显示文摘BACKGROUND Antiviral treatment of patients with chronic hepatitis B(CHB)in the grey zone of treatment comands risk management in order to optimize the health outcome.In this sense,the identification of HBV mutants related with an increased risk of hepatocellular carcinoma(HCC)could be useful to identify subpopulations with potential indication of antiviral treatment.AIM To analyze the prevalence/persistence of hepatitis B virus(HBV)preS and basal core promoter(BCP)/precore/core variants associated to HCC development in CHB patients in the grey zone.METHODS Work was designed as a longitudinal retrospective study,including 106 plasma samples from 31 patients with CHB in the grey zone of treatment:Hepatitis B e antigen negative,HBV-DNA levels between 12-20000 IU/mL,normal or discordant transaminase levels during follow up and mild/moderate necroinflammatory activity in liver biopsy or Fibroscan(up to 9.5 kPa).Serum HBVDNA was tested using the Abbott Real Time HBV Assay and the BCP/precore/core and the hepatitis B surface antigen(HBsAg)coding regions were analyzed in positive samples by PCR/bulk-sequencing to identify the HCCrelated HBV mutants.RESULTS High-risk HCC related mutants were detected in 24(77%)patients:19(61%)in the BCP/precore/core,and 7(23%)in the HBsAg coding region(2 preS1 and 5 preS2 deletions).The prevalence of preS deletions was genotype-dependent:3/5(60%)patients with preS2 deletions and 1/2 with preS1 deletions were infected with the HBV-E genotype.Since HBV-E was the most prevalent in sub-Saharan patients,a correlation between preS deletions and ethnicity was also found:6/8(75%)sub-Saharan vs 1/19(5%)Caucasian patients had preS deletions(P=0.00016).Remarkably,this correlation was maintained in those patients infected with HBV-A,a minor genotype in sub-Saharan patients:2/2 patients infected with HBV-A from West Africa vs 0/6 of Caucasian origin had preS deletions.The HCC related variants were the major strains and persisted over time(up to 48 mo).Patients with preS deletions had a significant higher prevalence of F2 fibrosis stage than the negatives(57%vs 10%,P=0.0078).CONCLUSION HBV genetic analysis of selected populations,like sub-Saharans infected with HBV-E/A genotypes,will allow identification of subpopulations with risk of HCC development due to accumulation of high-risk HBV variants,thus commanding their increased clinical surveillance. | Ana Isabel Gil-García Antonio Madejón Irene Francisco-Recuero Ana López-López Emiliana Villafranca Miriam Romero Araceli García Antonio Olveira Rocío Mena Juan Ramón Larrubia Javier García-Samaniego | 2019 | World Journal of Gastroenterology2019，25，38： | 1 |
| 20 | The Spot Sign Score in Primary Intracerebral Hemorrhage Identifies Patients at Highest Risk of In-Hospital Mortality and Poor Outcome Among Survivors显示文摘 | Josser E. Delgado Almandoz Albert J. Yoo Michael J. Stone Pamela W. Schaefer Alexandra Oleinik H Bart Brouwers Joshua N. Goldstein Jonathan Rosand Michael H. Lev R Gilberto Gonzalez Javier M. Romero | 2010 | Stroke2010，，1： | 1 |
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