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| 1 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 2 | 自然保护区、恢复力和动态景观显示文摘在这个日益被人类活动所改变的世界里,保护生物多样性对于维持有恢复力的生态系统和确保生态系统产品的可持续流动以及对社会的服务是至关重要的。但是,现有的自然保护区和国家公园不大可能结合生态系统的长期和大尺度的动态。因此,保护策略必须包括大面积的人类利用经营的土地。为了能使生态系统在大规模的自然和人为干扰之后得以重组,以生态存储形式出现的空间恢复力是必备的前提。生态存储包括那些能使生态系统得以重组的物种、相互作用和结构,它的组成部分可能出现在干扰斑块中,也可能出现在周围的景观中。现有的静态自然保护区应该由动态自然保护区加以补充,例如生态休闲地和动态演替保护区,这些都是在景观尺度上模拟自然干扰状况,进行生态系统经营的组成部分。 | Janne Bengtsson Per Angelstam Thomas Elmqvist Urban Emanuelsson Carl Folke Margareta Ihse Fredrik Moberg Magnus Nystrm 王胜 | 2003 | AMBIO-人类环境杂志2003，32，6： | 11 |
| 3 | Rivastigmine, a new-generation cholinesterase inhibitor for the treatnent of Alzheimer's disease 显示文摘 | Jann M W | 2000 | Pharmacotherapy2000，20，1： | 1 |
| 4 | Transgenic bioreactors显示文摘 | Janne J Alhonen L Hyttinen J M | 1998 | Biotecbnol Annu Rev1998，56，4： | 1 |
| 5 | Templating Organic Semi- conductors via Self-assembly of Polymer Colloids显示文摘 | Raffaele M Janne R Glenn H | 2003 | Sci- ence2003，299，： | 1 |
| 6 | Theta burst TMS increas- es cerebral blood flow in the primary motor cortex during motor performance as assessed by arterial spin labeling (ASL) 显示文摘 | Orosz A Jann K Wirth M | 2012 | Neuroimage2012，61，3： | 1 |
| 7 | Complete amino acid sequence of human placental protein 14: a progesterone- regulated uterine protein homologous to β-lactoglobulins 显示文摘 | Julkunen M Seppala M Janne O | 2006 | Proc Natl Acadsci USA2006，104，12： | 1 |
| 8 | Relationship between promoter strength and tronsformation frequencies using mannose selection for the production of transgenic sugar bee显示文摘 | Joersbo M Jorn D M Janne B | 2000 | Molecular Breeding2000，，6： | 1 |
| 9 | Templating Organic Semiconductors via Self-assembly of Polymer Colloids显示文摘 | Raffaele M Janne R Glenn H | 2003 | Science2003，，299： | 1 |
| 10 | Semantic memory involvement in the default mode network: a functional neuroimaging study using independent component analysis 显示文摘 | Wirth M Jann K Dierks T | 2011 | Neuroimage2011，54，4： | 1 |
| 11 | Transgenic animals as bio- producers of therapeutic proteins 显示文摘 | Janne J Hyttinen J M Peura T | 1992 | Annals of Internal Medicine1992，24，： | 1 |
| 12 | High polymorphism in the k-casein (CSN3) gene from wild and domestic eaprine species revealed by DNA sequencing显示文摘 | Jann O Prinzenberg E M Luikart G | 2004 | J Dairy Res2004，71，： | 1 |
| 13 | Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit 显示文摘 | Medyouf H Mossner M Jann JC | 2014 | Cell Stem Cell2014，14，6： | 1 |
| 14 | Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma显示文摘 | Allen AM Czerminska M Janne PA | 2006 | Int Badiat Oncol Biol Phys2006，65，： | 1 |
| 15 | Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats:A microdialysis study in an animal model of depression显示文摘 | Janne G Eldbjorg F Robert M | 2007 | Behavioural Brain Research2007，181，1： | 1 |
| 16 | MET increased gene copy number and primary resistance to gefitinib therapy in non-small- cell lung cancer patients 显示文摘 | Cappuzzo F Janne PA Skokan M | 2009 | Ann Oncol2009，20，2： | 1 |
| 17 | ROS1 rearrangements in lung cancer: a newgenomic subset of lung adenocarcinoma显示文摘 | Janne PA Meyerson M | 2012 | J Clin Oncol2012，30，8： | 1 |
| 18 | The structure of the capsular polysaccharide (K5 antigen) of urinary-tract-infective Eschericbia coil O 10 : K5 : H4 A polymer similar to desulfo-heparin 显示文摘 | Vann W F Schmidt M A Jann B | 1981 | European Journal of Biochemistry1981，116，2： | 1 |
| 19 | Long-term survival after lung transplantation depends on development and severity of branchiolitis obliterans syndrome显示文摘 | Christopher MB Jorn C Jann M | 2007 | J Heart Lung Transplant2007，26，7： | 1 |
| 20 | Genetic approaches to the cellular functions of polyamines in mammals显示文摘 | Janne J Alhonen L Pietila M | 2004 | Eur J Biochem2004，271，5： | 1 |
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