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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | SMARCA4缺失型鼻窦癌:10例SWI/SNF驱动的鼻窦恶性肿瘤遗传学谱系的扩展显示文摘低分化鼻窦癌的分子发病机制近年来备受关注。在鼻窦未分化癌的形态学谱系中,几种未分类的癌被重新归类为具有独特遗传学特征的变异体或实体,包括NUT重排性癌和SMARCB1缺失型癌。作者进一步描述了一种罕见的鼻腔未分化癌样肿瘤,其特征是通过免疫组化染色可检测到SWI/SNF构建体SMARCA4(BRG1)的失活。 | Agaimy A Jain D Uddin N 魏建国(摘译) 袁晓露(审校) | 2020 | 临床与实验病理学杂志2020，36，5： | 8 |
| 3 | Surgical strategies for giant medial sphenoid wing meningiomas: a new scoring system for predicting extent of resection显示文摘BACKGROUND: Surgical management of giant medial sphenoid meningiomas (> or =5 cm in maximum dimension) is ex-tremely challenging due to their intimate relationship with vital neural structures like the optic nerve, cranial nerves of | Behari S Giri PJ Shukla D Jain VK Banerji D | 2008 | 中国神经肿瘤杂志2008，6，3： | 7 |
| 4 | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples显示文摘A rapid,sensitive,selective and validated reverse phase high-performance liquid chromatography(RP-HPLC)method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells was performed in this study.The mobile phase consisted of an optimized mixture of methanol:water:trifluroacetic acid(80:20:0.1,v/v/v).Column elution at a flow rate of 1 mL/minute with UV detection at 225 nm at room temperature was used.The RP-HPLC method was successfully applied for the determination of paclitaxel in plasma samples and in culture of cancer cells with nano-quantity of estimation.The validation studies were performed in accordance with the International Conference on Harmonization(ICH)guidelines.The intra-and inter-day precision showed that the coefficients of variation ranged from 1.07%to 4.27%at different levels of concentrations.To the best of our knowledge,this study also reported for the first time the optimization of different solvents for effective extraction of paclitaxel wherein tert.-butyl methyl ether(TBME):diethyl ether(DEE)in 50:50 v/v composition was found most efficient with extraction efficiency ranging between 77.99%and 91.74%and between 76.14 and 93.66%in the plasma and cell culture,respectively.This proposed method was successfully applied to study the pharmacokinetics of paclitaxel and the influence of verapamil and all-trans retinoic acid(atRA)on paclitaxel pharmacokinetics in rat models.This proposed method might emerge as a valuable aid in the laboratory monitoring of paclitaxel in a variety of in vitro as well as in vivo scenarios. | Rakesh Kumar Tekade Antony D'Emanuele Abdelbary Elhissi Ashish Agrawal Anurekha Jain Basel Tawfiq Arafat Narendra Kumar Jain | 2013 | The Journal of Biomedical Research2013，27，5： | 5 |
| 5 | Role of interstitial cells of Cajal in motility disorders of the bowel显示文摘 | Jain D Moussa K Tandon M | 2003 | Am J Gastroenterol2003，98，3： | 2 |
| 6 | Diffraction of elastic P waves by two equal co-axial circular rigid strips显示文摘 | Verma S K Jain D L | 1992 | European Journal of Mechanics A/Solids1992，11，2： | 2 |
| 7 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 8 | Melatonin loaded ethanolie liposomes: Physico- chemical characterization and enhanced transdermal delivery 显示文摘 | Dubey V Mishra D Jain NK | 2007 | European Journal of Pharmaceutics atut Biopharmaceutics2007，67，： | 1 |
| 9 | Timing, quantification and tectonic modelling of Pliocene-Quartenary movements in the NW Himalaya:evidence from fission track dating显示文摘 | Kumar D Singh S | 2000 | Earth and Planetary Science Letters2000，179，43： | 1 |
| 10 | Why the bass model fits without decision variables显示文摘 | Bass F M Kvishnan T V Jain D C | 1994 | Marketing Science1994，13，3： | 1 |
| 11 | Evaluation of p53 and bcl-2 expression as prognostic markers in invasive cervical carcinoma stage Ⅱ b/Ⅲ patients treated by radiotherapy 显示文摘 | Jain D Srinivasan R Patel FD | 2003 | Gynecol Oncol2003，88，1： | 1 |
| 12 | Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus显示文摘 | Jain A Brody D Hamad D | 2000 | Transplantation2000，69，1： | 1 |
| 13 | The D-domain of Sp3modulates its protein levels and activation of the p21CIP1/WAF1promoter显示文摘 | Hammill D Jain N Armstrong S | 2005 | Biochem Biophys Res Commun2005，335，： | 1 |
| 14 | Congestion Control With Explicit Rate Indication显示文摘 | Charny A Clark D Jain R | 1995 | IEEE1995，，： | 1 |
| 15 | Photodynamic therpy for cancer显示文摘 | Dolmans D E Fukumura D Jain R K | 2003 | Nat Rev Cancer2003，3，5： | 1 |
| 16 | Influence of recessshape on the performance of a capillary compen- sated circular thrust pad hydrostatic bearing 显示文摘 | SHARMA S C JAIN S C BHARUKA D K | 2002 | Tribol- ogy International2002，35，6： | 1 |
| 17 | Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis显示文摘 | Nagula S Jain D Groszmann R J | 2006 | J Hepatol2006，44，1： | 1 |
| 18 | Seizure and radiological outcomes in children with solitary cysticercous granulomas with and without albendazole therapy :a retrospective case record analysis显示文摘 | Gulati S Jain P Sachan D | 2014 | Epilepsy Research2014，108，7： | 1 |
| 19 | Comparison of low doses of intrathecal bupivacaine in combined spinal epidural anaesthesia with epidural volume extension for caesarean delivery显示文摘 | Jain G Singh D K Bansal P | 2012 | Anesth Essays Res2012，6，1： | 1 |
| 20 | Tuberculosis vaccine: time to look into future 显示文摘 | CHAWLA S GARG D JAIN R B | 2014 | Hum Vaccin Im- munother2014，10，2： | 1 |
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