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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Effect of particulate materials and osmoprotectants on very-high-gravity ethanolic fermentation by Saccharomyces cerevisiae显示文摘 | Thomas K C Hynes S H Ingledew W M | 1994 | Applied and EnvironmentalMicrobiology1994，60，5： | 1 |
| 3 | Amphibians and agricultural chemicals:Review of the risks in a cmplex environment 显示文摘 | MANN R M HYNE R V CHOUNG C B | 2009 | Environ Pollut2009，157，11： | 1 |
| 4 | Induction of midbrain dopaminergic neurons by Sonic hedgehog显示文摘 | Porter JA Chiang C | 1995 | Neuron1995，15，： | 1 |
| 5 | Dynamic external fixation for pilon tractures of the interphalangeal joints显示文摘 | HYNES M C GIDDINS G E | 2001 | J Hand Surg Br2001，26，2： | 1 |
| 6 | Quantifying the value of multi-sectoral marine commercial activity in Ireland显示文摘 | Morrissey K Donoghue O C Hynes S | | 0，，05： | 1 |
| 7 | Amphibians and Agricultural Chemicals: Review of the Risks in a Complex Environment显示文摘 | Mann R M Hyne R V Choung C B | 2009 | Environmental Pollution2009，157，11： | 1 |
| 8 | Facial emotion processing in schizophrenia:a non-specific neuropsycholocal deficit Psychol Med显示文摘 | Clotet EP Hynes F Ashwin C | 2010 | Schizophr Res2010，40，6： | 1 |
| 9 | Effect of particulate materials and osmoprotectants on very high gravity ethanlic fermentation 显示文摘 | THOMAS K C HYNES S H INGLEDEW W M | 1994 | Applied and Environmental Microbiology1994，，5： | 1 |
| 10 | Foliar application of fungal biocontrol agents for the control of white mold of dry beans caused by Sclerotinia sclerotiorum 显示文摘 | Huang H C Bremer E Hynes R K | 2000 | Biological Control2000，18，： | 1 |
| 11 | Multivariate analy-sis of proteolysis patterns differentiated the impact of six strains of probiotic bacteria on a semi-hard cheese显示文摘 | Bergamini C V Hynes E R Candioti M C | | 0，，06： | 1 |
| 12 | Development of highnutrient-dense, low-pollution diets and prediction of aquaculture wastes using biological approaches 显示文摘 | Cho C Y Hynes J D Wood K R | 1994 | Aquaculture1994，124，： | 1 |
| 13 | Shock-tube study of the pyrolysis of the halon replacement molecule CF3CHFCF3显示文摘 | HYNES R G MACKIE J C MASRI A R | 1999 | Journal of Physical Chemistry A1999，103，1： | 1 |
| 14 | A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo显示文摘 | Bertram J P Hynes S R | 2006 | Proc Natl Acad Sci USA2006，103，8： | 1 |
| 15 | Silver nanoparticle formation:Predictions and verification of the aggregative growth model显示文摘 | Van Hyning D L Klemperer W G Zukoski C F | | 0，，11： | 1 |
| 16 | Waves follicle devel- opment during the estrous cycle in sheep 显示文摘 | EVANS A C DUFFY P HYNES N | 2000 | Theriogenol2000，53，3： | 1 |
| 17 | Alopecia and dalteparin:a previously unreported association显示文摘 | Barnes C Deidun D Hynes K | 2000 | Blood2000，96，4： | 1 |
| 18 | Development of high-nu- trient- dense, low-pollution diets and prediction of aquaculture wastes using biological approaches 显示文摘 | Cho C Y Hynes J D Wood K R | 1994 | Aquaculture1994，124，： | 1 |
| 19 | Production of fuel alcohol from wheat by VHG technology:effect of sugar concentration and temperature显示文摘 | Thomas K C Hynes S H Ingledew W M | 1993 | Appl Biochem and Biotechnol1993，43，： | 1 |
| 20 | A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo 显示文摘 | Ford M C Bertram J P Hynes S R | 2006 | Proc Natl Acad Sci USA2006，103，8： | 1 |
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