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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 3 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 4 | Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein 13 Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis显示文摘 | Hongli Lian Pengbo Xu Shengbo He Jun Wu Jian Pan Wenxiu Wang Feng Xu Sheng Wang Junsong Pan Jirong Huang Hong-Quan Yang | 2018 | Molecular Plant2018，11，10： | 10 |
| 5 | Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release显示文摘Thermosensitive 药交货系统(DDS ) 面对主要挑战,例如遥远、可重复的控制在 vivo 温度,尽管这些能增加药的治疗学的功效。处理这个问题,我们涂在红外线附近(NIR ) photothermal Cu 1.75 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ,与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4, 37 吗? | Sheng Huang Jing Liu Qian He Hongli Chen Jiabin Cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang | 2015 | Nano Research2015，8，12： | 7 |
| 6 | Improvement of short-term forecasting in the northwest Pacific through assimilating Argo data into initial fields显示文摘在温度和咸度的短期的预报精确性上吸收南船座数据进起始的域的影响是使用西方的诺思太平洋的一个预报系统估计的份量上,在有一个概括坐标系统(POMgcs ) 的普林斯顿海洋模型的库上。这个系统使用顺序的 multigrid 三维变化(3DVAR ) 吸收观察数据的分析计划。二个数字实验在吸收数据进起始的域的进程除常规温度和海表面温度(SST ) 以外有或没有南船座温度和咸度侧面数据被进行。预报错误被在预报时期期间使用独立温度和咸度侧面估计,包括水平地平均的根均方差( H-RMSEs )的垂直分布和垂直地平均的吝啬的错误( MEs )和空间地平均的根均方差( S-RMSEs )的时间的变化的水平分布。在二个实验之间的比较证明南船座数据的吸收显著地改进预报精确性,与为温度,和咸度最大的 H-RMSE 的 24% 减小预报更显然被改进,平均深入地比 300 m 浅的为 H-RMSEs 50% 落下。如此的改进被温度和咸度的相对一致的采样在时空从南船座流浪者引起。 | FU Hongli CHU Peter C HAN Guijun HE Zhongjie LI Wei ZHANG Xuefeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 2 |
| 7 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 8 | Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘 | Tianyan Chen Yingli He Xiaojing Liu Zhi Yan Ke Wang Hongli Liu Shuling Zhang Yingren Zhao | 2012 | Clinical and Experimental Medicine2012，，3： | 2 |
| 9 | Lipopo1ysaccharideregulates toll-like receptor 4 expression in human aortic smooth muscle cells显示文摘 | Hongli Li Ying He Jianjun Zhang et a1 | 2007 | Cell Bio Int2007，31，8： | 1 |
| 10 | Breeding of a New Clubroot-resistant Chinese Cabbage Variety, CCR11242显示文摘In this study,using Japanese radish cytoplasmic sterile line ' Half Green Cabbage'( HGC) and clubroot-resistant South Korean cabbage variety ' CR Cabbage King'( CCK) as experimental materials,self-incompatible DH lines were obtained by microspore culture.Through five generations of backcross,CCR11239,a clubroot-resistant radish cytoplasmic sterile line,was obtained.Through six generations of self-crossing,CCR11240,the maintainer line of CCR11239,was bred.After the cross of CCK and Luchunbai 1( 83- 1) and five generations of self-crossing,self-compatible line CCR11241 was obtained.Through crossing CCR11240 with CCR11241,the new cabbage variety CCR11242 was obtained.After variety comparison test,provincial regional test and production demonstration test,the new variety was registered in 2012.The average yield of CCR11242 reached 60 975 kg / hm2,which was improved by 142% compared with Luchunbai 1( 83- 1).The disease index of CCR11242 was 5.63,which was 88.13 lower than the control,indicating high resistance( HR) to clubroot. | Xuezhong XU Zhimei TIAN Hongli YANG Jingfeng HU Liqin ZHANG Mei LAN Hongju DUAN Jiangming HE | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
| 11 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 12 | Nuclear EPL-HAM complex is essential for the development of chloroplasts显示文摘Chloroplasts most likely originated from the endosymbiosis of cyanobacterial ancestors,entering the eukaryotic lineage about 1.0-1.5 billion years ago(Parfrey et al.,2011;Archibald,2015).Consequently,their biogenesis depends on genetic information from both the nuclear and chloroplast genomes.Photosynthetic housekeeping genes of core components in photosystemsⅠandⅡ(PSI and PSII)are encoded by the plastid genome。 | Bo Ding Hongli Xie Kangning Zhang He Li Yushi Gao Jing Zhang Bin Xu Lianwei Peng Guofeng Yang Guo-Liang Wang Upinder Gill Zeng-Yu Wang Maofeng Chai | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 13 | On the Cultural"Other"and"Self"of Chinese Culture Going Abroad显示文摘Under the conditions of globalization,it is a m ission in the new era for C hinese culture going abroad.H ow ever,during the period of post-colonialism,w estern scholars have studied C hinese culture based on the w estern culture and values.As a result,C hinese culture has becom e cultural 'other '. T hrough analyzing the cultural 'other ' and'self',the demonstration of Chinese culture from the perspective of post-colonialism proves not to be true.It is an inevitable choice for C hina's developm ent to m ake the C hinese culture go abroad and m ake an equal dialogue betw een C hinese and w estern cultures. | He Hongli Liu Wenyuan | 2017 | 学术界2017，，9： | 1 |
| 14 | Study of micro-trichome (mict) reveals novel connections between transcriptional regulation of multicellular trichome development and specific metabolism in cucumber显示文摘Trichomes that cover the epidermis of aerial plant organs play multiple roles in plant protection.Compared with a unicellular trichome in model plants,the development mechanism of the multicellular trichome is largely unclear.Notably,variations in trichome development are often accompanied by defects in the biosynthesis of cuticle and secondary metabolites;however,major questions about the interactions between developmental differences in trichomes and defects in metabolic pathways remain unanswered.Here,we characterized the glabrous mutant mict/csgl1/cstbh via combined metabolomic and transcriptomic analyses to extend our limited knowledge regarding multicellular trichome development and metabolism in cucumber.Mict was found to be explicitly expressed within trichome cells.Transcriptomic analysis indicated that genes involved in flavonoid and cuticle metabolism are significantly downregulated in mict mutants.Further metabolomic analysis confirmed that flavonoids,lipids,and cuticle compositions are dramatically altered in mict mutants.Additional studies revealed that Mict regulates flavonoid,lipid,and cuticle biosynthesis by likely directly binding to downstream functional genes,such as CsTT4,CsFLS1,CsCER26,and CsMYB36.These findings suggest that specific metabolic pathways(e.g.,flavonoids and cuticle components)are co-regulated by Mict and provide insights into transcriptional regulation mechanisms of multicellular trichome development and its specific metabolism in cucumber. | Jian Pan Leyu Zhang Guanqun Chen Haifan Wen Yue Chen Hui Du Junlong Zhao Huanle He Hongli Lian Huiming Chen Jianxin Shi Run Cai Gang Wang Junsong Pan | 2021 | Horticulture Research2021，8，1： | 1 |
| 15 | Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘 | Tianyan Chen Yingli He Xiaojing Liu Zhi Yan Ke Wang Hongli Liu Shuling Zhang Yingren Zhao | 2012 | Clinical and Experimental Medicine2012，，3： | 1 |
| 16 | Progresses on the pharmacological effects of Astragaloside IV 显示文摘 | ZHANG LIMIN HE YONGGUI YIN HONGLI | 2014 | Journal of Heibei United University2014，16，02： | 1 |
| 17 | Isolated Microspore Culture and Plant Regeneration of Leaf Mustard(Brassica juncea(L.)Czern.et Coss.)显示文摘Isolated microspore culture was carried out with Brassica juncea to study the effects of sterilization methods,culture period of embryos,hormone formula and the concentration of activated carbon on embryogenesis,and the concentration of NAA on induction of roots. The results showed that the embryogenesis on medium subjected to filter sterilization is better than medium subjected to autoclaved sterilization. The embryos cultured for 15 d had the highest plantlet regeneration rate( 52%). NLN-13 liquid medium including 0. 1 mg / L 6-BA and 0. 2 g / L activated carbon significantly improved the plantlet regeneration rate. 1 /2 MS including 0. 3 mg / L NAA had the highest plantlet regeneration rate( 100%). | Hongli YANG Jingfeng HU Xuezhong XU Jiangming HE Shuang SONG 无 | 2016 | Agricultural Biotechnology2016，5，6： | 1 |
| 18 | SVR Recommendation Algorithm of Civil Aviation Auxiliary Service Based on Context-Awareness显示文摘Analysis of the particularity of the civil aviation passenger auxiliary service recommendation scenario.As application of the traditional recommendation algorithm has certain limitation in civil aviation auxiliary services recommendation,a SVR recommendation algorithm of auxiliary service of civil aviation based on context-awareness was proposed.Analysis of the civil aviation passenger travel data,construct the civil aviation passenger preference model,then recommend auxiliary service for passengers.Based on the traditional two-dimensional user-item recommendation,considering the user characteristics,item attributes and user contextual information in the process of recommendation,which can effectively reduce the data sparseness in some degree.In addition,when there is a new user or a new item,whose similar users or items can be found according to the user or item attributes,to some extent,which can solve the problem of cold start.The experimental results show that the algorithm can recommend auxiliary service for passengers more accurately,which can provide convenience for passengers as well as increase the quality of airlines’services. | Haohan Liu Hongli Zhang Kanghua Hui Huaiqing He | 2015 | 国际计算机前沿大会会议论文集2015，，B12： | 0 |
| 19 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 20 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
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