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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | 青年人群单纯收缩期或舒张期高血压的心血管病风险显示文摘根据2017年美国心脏病学院/美国心脏协会高血压指南定义,在1级高血压青年人群中,关于单纯收缩期高血压(isolated systolic hypertension,ISH)、单纯舒张期高血压(isolated diastolic hypertension,IDH)或收缩期和舒张期高血压(systolic and diastolic hypertension,SDH)相关的健康预后知之甚少。方法:在全国健康筛查数据库中. | 刘青(译) 刘莉(校) Lee H Yano Y Cho SMJ Park JH Park S Lloyd-Jones DM Kim HC | 2020 | 中华高血压杂志2020，28，8： | 3 |
| 3 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 4 | Mycoplasma pneumoniae and Legionella pneumophila in community-acquired lower respiratory tract infections among hospitalized children:diagnosis by real time PCR显示文摘 | Maltezou HC La-Scola B Aatm H | 2004 | Scand J Infect Dis2004，36，9： | 1 |
| 5 | The role of overdiagnosis and reclassification in the maked increase of esophageal adenocarcinoma incidence显示文摘 | Pohl H Welch HC | 2005 | J Natl Cancer Inst2005，97，： | 1 |
| 6 | Enhancement of transport critical current densities in (Bi,Pb)2Sr2Ca2Cu3O10/Ag tapes at 77K following fast neutron irradiation显示文摘 | HC Q Y WEBER H W SAUERZOPF F M | 1994 | Appl Phys Lett1994，65，4： | 1 |
| 7 | Risk of spontaneous hemorrhage after diagnosis of cerebral arteriovenous malformation显示文摘 | Mast H Young WL Koennecke HC | 1997 | Lancet1997，350，9084： | 1 |
| 8 | Cerebral tumor staging in patients with bronchial carcinona by computed tomography显示文摘 | Sallbeck R Grau HC Artmenn H | 1990 | Cancer1990，66，： | 1 |
| 9 | Serotypes of Pasteurella anatipestifer isolates from ducks in Singapore:a proposal of new serotypes显示文摘 | Loh H Teo T P Tan HC | 1992 | Avian Pathology1992，21，： | 1 |
| 10 | Overview of neurobrucellosis: a pooled analysis of 187 cases显示文摘 | Gul HC Erdem H Bek S | 2009 | Int J Infect Dis2009，13，： | 1 |
| 11 | Comparison of short- and long-term outcomes after extralevator abdominoperineal excision and standard abdominoperineal excision for rectal cancer: a systematic review and recta-analysis 显示文摘 | Yu HC Peng H He XS | 2014 | Int J Colorectal Dis2014，29，2： | 1 |
| 12 | Serotypes of 'Pasteurella' anatipestifer isolates from ducks in Singapore: a proposal of new serotypes显示文摘 | Lob H Teo TP Tan HC | 1992 | Avian Pathology1992，21，3： | 1 |
| 13 | Kinetics of thermal and oxidative decomposition of printed circuit boards显示文摘 | CHENK S CHEN HC WUC H | 1999 | Journal of Environmental Engineering1999，125，3： | 1 |
| 14 | Overexpression of GRP78 and GRP94 arc markers for aggressiver behavior anti poor prognosis in gastric carcinomas 显示文摘 | Zheng HC Takahashi H Li XH | 2008 | Hum Pathol2008，39，7： | 1 |
| 15 | Recombinant gene products of two natural variants of the human cytidine deaminase gene confer different deamination rates of cytarabine in vit ro显示文摘 | KIBCH HC SCHRODER J HOPPE H | 1998 | Exper Hematol1998，26，： | 1 |
| 16 | Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia 显示文摘 | Kawamoto A Gwon HC Iwaguro H | 2001 | Circulation2001，103，： | 1 |
| 17 | Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia显示文摘 | Kawamoto A Gwon HC Iwaguro H | 2001 | Circulation2001，103，5： | 1 |
| 18 | Electric current-induced detachment of staphylococcus epidermidis biofilms from surgical stainless steel 显示文摘 | van der Borden A J van der Werf H van der Mei HC | 2004 | Appl Environ Microbiol2004，70，11： | 1 |
| 19 | Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas 显示文摘 | Zheng HC Takahashi H Li XH | 2008 | Hum Patho12008，39，7： | 1 |
| 20 | Use of twist-drill craniostomy with drain in evacuation of chronic subdural hematomas:independent predictors of recurrence 显示文摘 | Escosa Ba6 M Wessling H Salca HC | 2011 | Acta Neurochir(Wien)2011，153，5： | 1 |
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