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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang W X Yang R Lai Y C Kovanis V Harrison M A F | 2011 | EPL2011，94，48： | 1 |
| 3 | Technology, standards, and real- world deployments of the EPC network 显示文摘 | Thieseh F Floerkemeier C Harrison M | 2009 | IEEE Internet Computing2009，13，2： | 1 |
| 4 | Effect of spacing and age on nitrogen and phosphorus distribution in biomass of Eucalyptus camaldulensis,Eucalyptus pellita and Eucalyptus urophylla plantations in southeastern Brazil显示文摘 | Harrison R B Reis G G Reis M D G F | 2000 | Forest Ecology and Management2000，133，3： | 1 |
| 5 | Removal of domestic airborne dust particles by naturally charged liquid sprays 显示文摘 | Gaunt L F Hughes J F Harrison N M | 2003 | Journal of Electrostatics2003，58，15： | 1 |
| 6 | Origin of methane inthe Elk Valley coalfield,southeastern British Columbia显示文摘 | Aravena R Harrison S M Barker J F | 2003 | Chemical Geology2003，195，1： | 1 |
| 7 | The effect of CO2 availability on the growth, iron oxidation and CO,-fixation rates of pure cultures of Leptospirillum Jerriphilum and Acidithiobacillus Jerrooxidans 显示文摘 | BRYAN C G DAVIS-BELMAR C S van WYK N FRASER M K DEW D RAUTENBACH G F HARRISON | 2012 | Biotechnology and Bioengineering2012，109，7： | 1 |
| 8 | Response of two sweet potato cultivars to weed interference显示文摘 | HARRISON H F JR JACKSON D M | 2011 | Crop protection2011，30，10： | 1 |
| 9 | A randomized prospective assessor-blind evaluation of luteinizing hormone dosage and in vitro fertilization outcome显示文摘 | Gordon U D Harrison R F Fawxy M | 2001 | Fertil Steril2001，75，2： | 1 |
| 10 | Structure of SARS coronavirus spike receptor-binding domain complexed with receptor 显示文摘 | Li F Li W Farzan M Harrison SC | 2005 | Science2005，309，5742： | 1 |
| 11 | Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung 显示文摘 | HARRISON F E BEST J L MEREDITH M E | 2012 | PLoS ONE2012，7，35： | 1 |
| 12 | Tertiary structural evolution of the Gangdese thrust system in southern Tibet显示文摘 | Yin A Harrison T M Reyerson F J | 1994 | Journal of Geophysical Research1994，99，18： | 1 |
| 13 | Proximal gastric cancers resected via a transabdominal-only approach显示文摘 | KARPEH M S BRENNAN M F | 1997 | Ann Surg1997，225，6： | 1 |
| 14 | Particle Size Distribution from a Modem Heavy Duty Diesel Engine显示文摘 | Shi J P Harrison R M Brear F | 1999 | The Science of the Total Environment1999，235，1： | 1 |
| 15 | Raising Tibet显示文摘 | Harrison T M Copeland P Kidd W S F | 1992 | Science1992，255，： | 1 |
| 16 | A new method for sparsity control in support vector classification and regression显示文摘 | Drezet P M L Harrison R F | 2001 | Pattern Recognition2001，34，1： | 1 |
| 17 | Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy显示文摘 | GURUDU S R RAMIREZ F C HARRISON M E | 2012 | Gastrointest Endosc2012，76，3： | 1 |
| 18 | Raising Tibet 显示文摘 | Harrison T M Copeland P Kidd W S F Yin A | 1992 | Science1992，255，5052： | 1 |
| 19 | Investigation of high temperature blackbody BB3200显示文摘 | Metzdorf J Harrison N J Fox N P Khlevnoy B B Khromtchenko V B Mekhontsev S N Shapoval V I Zelener M F Sapritsky V I | 1998 | Metrologia1998，35，： | 1 |
| 20 | Total gastrectomy is not necessary for p roximal gastric cancer显示文摘 | Harrison L E Karpeh M S Brennan M F | 1998 | Surgery1998，123，2： | 1 |
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