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| 1 | Prediction of permafrost changes in Northeastern China under a changing climate显示文摘Northeastern China has the second largest expanse of permafrost in China,primarily known as Xing'an-Baikal permafrost.Located on the southeastern edges of the Eurasian cryolithozone,the permafrost is thermally unstable and ecologically sensitive to external changes.The combined impacts of climatic,environmental,and anthropogenic changes cause 3-dimensional degradation of the permafrost.To predict these changes on the southern limit and ground temperature of permafrost in Northeastern China,an equivalent latitude model (ELM) for the mean annual ground surface temperature (MAGSTs) was proposed,and further improved to take into account of the influences of vegetation and snow-cover based on observational data and using the SHAW model.Using the finite element method and assuming a climate warming rate of 0.048°C a-1,the ELM was combined with the unsteady-state heat conduction model to simulate permafrost temperatures at present,and to predict those after 50 and 100 a.The results indicate that at present,sporadic permafrost occurs in the zones with MAGSTs of 1.5°C or colder,and there would still be a significant presence of permafrost in the zones with the present MAGSTs of 0.5°C or colder after 50 a,and in those of-0.5°C or colder after 100 a.Furthermore,the total areal extent of permafrost would decrease from 2.57×105 km2 at present to 1.84×105 km2 after 50 a and to 1.29×105 km2 after 100 a,i.e.,a reduction of 28.4% and 49.8% in the permafrost area,respectively.Also the permafrost would degrade more substantially in the east than in the west.Regional warming and thinning of permafrost would also occur.The area of stable permafrost (mean annual ground temperature,or MAGT≤-1.0°C) would decrease from present 1.07×105 to 8.8×104 km2 after 50 a,and further decrease to 5.6×104 km2 after 100 a.As a result,the unstable permafrost and seasonally frozen ground would expand,and the southern limit of permafrost would shift significantly northwards.The changes in the permafrost environment may adversely affect on ecological environments and engineering infrastructures in cold regions.Avoidance of unnecessary anthropogenic changes in permafrost conditions is a practical approach to protect the permafrost environment. | WEI Zhi JIN HuiJun ZHANG JianMing YU ShaoPeng HAN XuJun JI YanJun HE RuiXia CHANG XiaoLi | 2011 | Science China Earth Sciences2011，54，6： | 15 |
| 2 | Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 ex-pression in a rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong decoction(LD) on expression of matrix metalloproteinase-2(MMP-2) and metalloproteinase-2(TIMP-2) in a rat model of uterine leiomyoma(UL).METHODS:UL was induced in rats using exogenous estrogen and progesterone.LD was administered(p.o.) for 4 weeks,and mifepristone(RU-486)used as a control.To observe the effect of LD on the uterine coefficient and uterine transverse diameter,a radioimmunoassay method was used to detect serum levels of sex hormones.Light microscopic analyses of pathologic changes in the tissues of UL rats were evaluated.Expression of the proteins of matrix metalloproteinases(MMPs) and tissue inhibitors of metalloproteinases(TIMPs) in uterine tissues was assessed by immunohistochemical staining and western blotting.RESULTS:A UL model in rats was established successfully.LD reduced uterine weight,uterine coefficient,and uterine transverse diameter compared with untreated controls.LD reduced levels of estradiol,progesterone,follicle-stimulating hormone,and luteinizing hormone in our UL models.LD improved the pathologic condition of uterine muscle.Expression of MMP-2 protein decreased to varying extents in LD-treated groups,but TIMP-2 levels were enhanced.LD appears to reduce MMP-2 expression and increase TIMP-2 expression in UL tissue.CONCLUSION:These data suggest that the mechanism of action of LD on ULs may involve reduction of MMP-2 expression and increase in TIMP-2 expression in rats. | Wang Yasong Li Donghua Xu Xin Qian Ruiya Zhang Yalan Huang Yuhua Geng Jianguo Zou Xiaoli Han Hon-gjuan Zhang Wufang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 12 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Effect of Lichong Decoction on expression of IGF-I and proliferating cell nuclear antigen mRNA in rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong Decoction(Lichong Decoction for strengthening anti-pathogenic Qi and eliminating blood stasis) on the expression of insulin-like growth factor-I(IGF-I) and proliferating cell nuclear antigen(PCNA) mRNA in a rat model of uterine leiomyoma.METHODS:Fifty female Wistar rats were randomized into a normal control group,model group,Lichong Decoction group,Guizhifuling Capsule(Capsule containing Cassia Twig and Poria) group,and Mifepristone group.The uterine leiomyoma model was established by peritoneal injections of exogenous estrogen and progesterone hormone.The ultrastructural changes in cells of rat uterine tissues were observed with transmission electron microscopy,and the expression of IGF-I and PCNA mRNA was detected by real-time fluorescent quantitative PCR.RESULTS:Following treatment,cells in the Lichong Decoction group appeared to be arranged normally,the cellular morphology were almost in a normal state,hyperplasia and hypertrophy of the chondriosome was reduced,collagen fibers were arranged in a regular manner,without obvious hyperplasia,and the expression of IGF-I and PCNA mRNA was significantly decreased compared with the model group(P<0.01).CONCLUSIONS:The effect of Lichong Decoction on uterine leiomyoma is related to its function in reducing the expression of IGF-I and PCNA mRNA. | Donghua Li Yalan Zhang Hongjuan Han Jianguo Geng Xiaolei Xie Jiubo Zheng Yasong Wang Xiaoli Zou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 5 | Multiscale hierarchical analysis of rock mass and prediction of its mechanical and hydraulic properties显示文摘Engineering geological and hydro-geological characteristics of foundation rock and surrounding rock mass are the main factors that affect the stability of underground engineering. This paper presents the concept of multiscale hierarchical digital rock mass models to describe the rock mass, including its structures in different scales and corresponding scale dependence. Four scales including regional scale,engineering scale, laboratory scale and microscale are determined, and the corresponding scaledependent geological structures and their characterization methods are provided. Image analysis and processing method, geostatistics and Monte Carlo simulation technique are used to establish the multiscale hierarchical digital rock mass models, in which the main micro-and macro-structures of rock mass in different geological units and scales are reflected and connected. A computer code is developed for numerically analyzing the strength, fracture behavior and hydraulic conductivity of rock mass using the multiscale hierarchical digital models. Using the models and methods provided in this paper, the geological information of rock mass in different geological units and scales can be considered sufficiently,and the influence of downscale characteristics(such as meso-scale) on the upscale characteristics(such as engineering scale) can be calculated by considering the discrete geological structures in the downscale model as equivalent continuous media in the upscale model. Thus the mechanical and hydraulic properties of rock mass may be evaluated rationally and precisely. The multiscale hierarchical digital rock mass models and the corresponding methods proposed in this paper provide a unified and simple solution for determining the mechanical and hydraulic properties of rock mass in different scales. | Xiaoli Liu Guofeng Han Enzhi Wang Sijing Wang Kumar Nawnit | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，4： | 8 |
| 6 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 7 | Effect of Cooling Rate and Vanadium Content on the Microstructure and Hardness of Medium Carbon Forging Steel显示文摘This paper reports the effect of cooling rate on the microstructure and hardness of a kind of medium carbon steel microalloyed with two levels of V content(0.15%and 0.28%)after hot deformation by using single compression tests on a Gleeble-3800 thermal simulator.The results show that cooling rate has a significant effect on the microstructure and hardness of the tested steels.Both the fraction of pearlite and hardness increase with increasing cooling rate,whereas a further increase of the cooling rate above a critical value promotes the formation of acicular ferrite(AF),and thus leads to a decrease of hardness mainly owing to the decrease of pearlite fraction and replacing it by AF and the less effective precipitation strengthening.Increasing V content results in a significant increase of hardness,and this tendency enhances with increasing cooling rate until the formation of AF.Furthermore,increasing V content also significantly enhances the formation of AF structure at a lower cooling rate.The results also suggest that by controlling microstructure,especially the precipitation of fine V(C,N)particles through adjusting postforging cooling,the strengthening and gradient function in one hot-forging part could be obtained. | Weijun Hui Yongjian Zhang Chengwei Shao Silian Chen Xiaoli Zhao Han Dong | 2016 | Journal of Materials Science & Technology2016，32，6： | 7 |
| 8 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 9 | Geochronology and geochemistry of Permo-Triassic sandstones in eastern Jilin Province(NE China): Implications for final closure of the Paleo-Asian Ocean显示文摘In the eastern part of the Central Asian Orogenic Belt(CAOB) in northeastern(NE) China, scattered outcrops of molasse deposits mark the ending of an orogeny and are crucial for understanding the evolution of the Paleo-Asian Ocean(PAO). However, the timing of tectonic events and the relationships among these strata remain controversial. To better constrain these geologic events, a comprehensive study of the detrital zircon U-Pb geochronology and geochemistry of the sandstones of the Kaishantun(KST) Formation and Kedao(KD) Group in eastern Jilin Province, NE China, was conducted. The KST Formation is traditionally considered a molasse deposit. The sandstones display low CIA, PIA and high ICV values and low Th/U and Rb/Sr ratios, which suggest that the rocks were derived from an immature intermediate-felsic igneous source and experienced a simple sedimentary recycling history with relatively weak chemical weathering. LA-ICP-MS U-Pb dating of detrital zircons from two samples of the KST Formation yields ages of 748-252 Ma, suggesting that the KST Formation was deposited between 254.5 Ma and 252 Ma in Late Permian. The zircons were mainly derived from the continental northern part of the North China Craton(NCC). In contrast, the U-Pb dating of detrital zircons from five samples of the KD Group yields ages of 2611-230 Ma, suggesting that the KD samples were deposited in the Early to Middle Triassic(ca. 248-233 Ma). The detrital zircon ages for the KD samples can be divided into groups with peaks at 2.5 Ga, 1.8 Ga, 800-1000 Ma, 500 Ma and 440-360 Ma, which suggest that the samples were derived from bidirectional provenances in the Jiamusi-Khanka Block and the NCC. These new data,combined with previously published results, suggest that at least three orogenic events occurred in central-eastern Jilin Province during the Early Permian(270-262 Ma), Early Triassic(254-248 Ma) and Middle-Late Triassic(242-227 Ma). The final closure of the PAO occurred during 242-227 Ma in the Middle-Late Triassic along the Changchun-Yanji suture zone. The detrital zircon geochronological data clearly record plate convergence and the scissor-like closure of the PAO in the eastern CAOB. | Qingxiang Du Zuozhen Han Xiaoli Shen Chao Han Zhigang Song Lihua Gao Mei Han Wenjian Zhong | 2019 | Geoscience Frontiers2019，10，2： | 6 |
| 10 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 11 | Development of Bionic Polymers显示文摘 | Xu Jian Xie Qiongdan Guo Xinlin Feng Lin Jiang Lei Tang Wenghong Luo Xiandong Zhang Xiaoli Han Charles C. | 2004 | 合成化学2004，12，z1： | 5 |
| 12 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 13 | New Evidence of Detrital Zircon Ages for the Final Closure Time of the Paleo-Asian Ocean in the Eastern Central Asian Orogenic Belt(NE China)显示文摘Objective The NE China is located in the eastern segment of the Central Asian Orogenic Belt(CAOB),which is a large accretionary orogen between the Siberian Craton and the North China Craton(NCC).Many researches have discussed about the evolution of the Paleo-Asian Ocean(PAO)in the eastern CAOB.However,the timing of | DU Qingxiang HAN Zuozhen SHEN Xiaoli HAN Chao SONG Zhigang GAO Lihua HAN Mei ZHONG Wenjian YAN Junlei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 14 | Dendritic Growth Pattern and Dendritic Network Distortion in the Platform of a Ni-based Superalloy显示文摘The pattern of dendritic growth and distortion of dendritic network in the platform have been investigated by one mold casting with different platform length during directional solidification. As the platform length elongates, the symmetry of dendritic growth along left and right edges gradually worsens in platform base. While the platform length reaches 14 mm, the distortion of dendritic network is first observed in outward platform. It is found that the distortion of dendritic network along platform inside is more serious than that along platform edges. Both[001] deviation and accumulated misorientation along platform inside, up to 9 and 16.3, respectively, are far greater than those along lefte outwarde right edges. The deformation of dendritic network in a platform may be caused by the asymmetry of the solidification front at the mush zone. | Xiaoli Zhang Yizhou Zhou Yanyun Han Tao Jin Xiaofeng Sun | 2014 | Journal of Materials Science & Technology2014，30，3： | 4 |
| 15 | Rumen-protected glucose supplementation in transition dairy cows shifts fermentation patterns and enhances mucosal immunity显示文摘Manipulation of perinatal diets,such as supplementing feed with rumen-protected glucose(RPG),has been positively regarded as a strategy to improve milking performance.This study was conducted to assess the effects of RPG on the fermentation profiles,resident microbiota and mucosal immunity in the cecum.Ten Holstein dairy cows were randomly assigned to either a 25 g/kg RPG diet(DM basis)or a 11 g/kg coating fat diet(control,CON).Compared with the CON group,the acetate-to-propionate ratio was lower in the RPG group.Gene expression analysis indicated that RPG supplementation tended to upregulate the expression of Na^(+)/H^(+)hydrogen exchanger 3(NHE3)(P=0.076).RPG supplementation downregulated the expression of genes involved in self-rehabilitation such as matrix metalloproteinase 1(MMP1),MMP3,MMP9 and MMP13.Additionally,the mRNA expression of genes involved in immunity including Toll-like receptors(TLR4,TLR6 and TLR7)and proinflammatory cytokines(immune interferon gamma[IFNG]and interleukins interleukin 17 A[IL7 F],IL17 A,IL22),was downregulated by RPG supplementation.Nonetheless,no differences existed in the bacterial copy number and beta diversity between the 2 groups.Overall,supplementation with RPG would probably cause a shift towards propionate production in the cecal digesta,and promote the immune homeostasis of the cecal mucosa in transition dairy cows.Our results extended the basic understanding of RPG supplementation and utilization in transition dairy cows in terms of host microbe interplay in the cecum. | Xiaoli Zhang Xiaopeng Li Jian Wu Jinzhen Jiao Zhixiong He Zhiliang Tan Xuefeng Han | 2021 | Animal Nutrition2021，，4： | 4 |
| 16 | Effect of bio-column composed of aged refuse on methane abatement-A novel configuration of biological oxidation in refuse landfill显示文摘An experimental bio-column composed of aged refuse was installed around the exhaust pipe as a new way to mitigate methane in refuse landfill.One of the objectives of this work was to assess the effect of aged refuse thickness in bio-column on reducing CH 4 emissions.Over the study period,methane oxidation was observed at various thicknesses,5 cm (small size),10 cm (middle size) and 15 cm (large size),representing one to three times of pipeline diameters.The middle and large size both showed over 90% methane conversion,and the highest methane conversion rate of above 95% occurred in the middle-size column cell.Michaelis-Menten equation addressed the methanotrophs diffusion in different layers of the bio-columns.Maximum methanotrophic activity (V max) measured at the three thicknesses ranged from 6.4 × 10 3 to 15.6 × 10 3 units,and the half-saturation value (K M) ranged from 0.85% to 1.67%.Both the highest V max and K M were observed at the middle-size of the bio-column,as well as the largest methanotrophs population,suggesting a significant efficiency of methane mitigation happened in the optimum zone with greatest affinity and methanotrophic bacteria activities.Therefore,bio-column is a potential style for methane abatement in landfill,and the aged refuse both naturally formed and artificially placed in the column plays a critical role in CH 4 emission. | Dan Han Youcai Zhao Binjie Xue Xiaoli Chai | 2010 | Journal of Environmental Sciences2010，22，5： | 4 |
| 17 | Quantifying the effectiveness of SiO_2/Au light trapping nanoshells for thin film poly-Si solar cells显示文摘In order to enhance light absorption of thin film poly-crystalline silicon(TF poly-Si)solar cells over a broad spectral range, and quantify the effectiveness of nanoshell light trapping structure over the full solar spectrum in theory,the effective photon trapping flux(EPTF)and effective photon trapping efficiency(EPTE)were firstly proposed by considering both the external quantum efficiency of TF poly-Si solar cell and scattering properties of light trapping structures.The EPTF,EPTE and scattering spectrum exhibit different behaviors depending on the geometric size and density of nanoshells that form the light trapping layer.With an optimum size and density of SiO2/Au nanoshell light trapping layer,the EPTE could reach up to 40%due to the enhancement of light trapping over a broad spectral range,especially from 500 to 800 nm. | BAI YiMing 1 ,WANG Jun 2 ,CHEN NuoFu 1,3 ,YAO JianXi 1 ,YIN ZhiGang 3 ,ZHANG Han 3 , ZHANG XingWang 3 ,HUANG TianMao 3 ,WANG YanShuo 3 &YANG XiaoLi 3 1School of Renewable Energy Engineering,North China Electric Power University,Beijing 102206,China 2 National Engineering Research Center for Optoelectronic Devices,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China 3 Key Laboratory of Semiconductor Materials Science,Institute of Semiconductors, Chinese Academy of Sciences,PO Box 912,Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，8： | 4 |
| 18 | Camptothecin-based nanodrug delivery systems显示文摘The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer,rectal and colon cancer,liver cancer,and lung cancer.Camptothecin-based drugs inhibit topoisomerase 1(Topo 1),leading to destruction of DNA,and are currently being used as important chemotherapeutic agents in clinical antitumor treatment.However,the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site.In addition,low bioavailability,poor water solubility,and other shortcomings hinder their anticancer activity.Different from traditional pharmaceutical preparations,nanotechnology-dependent nanopharmaceutical preparations have become one of the main strategies for different countries worldwide to overcome drug development problems.In this review,we summarized the current hotspots and discussed a variety of camptothecin-based nanodrugs for cancer therapy.We hope that through this review,more efficient drug delivery systems could be designed with potential applications in clinical cancer therapy. | Yan Wen Yingze Wang Xiaoli Liu Wei Zhang Xinhe Xiong Zhongxiao Han Xingjie Liang | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 19 | High-resolution structure-from-motion models covering 160 km-long surface ruptures of the 2021 M_(W)7.4 Madoi earthquake in northern Qinghai-Tibetan Plateau显示文摘The May 222021 M_(W)7.4 Madoi,Qinghai,China earthquake presented a rare opportunity to apply the modern unmanned aerial vehicle(UAV)photography method in extreme altitude and weather conditions to image surface ruptures and near-field effects of earthquake-related surface deformations in the remote Tibet.High-resolution aerial photographs were acquired in the days immediately following the mainshock.The complex surface rupture patterns associated with this event were covered comprehensively at 3-6 cm resolution.This effort represents the first time that an earthquake rupture in the interior of the Qinghai-Tibetan Plateau has been fully and systematically captured by such high-resolution imagery,with an unprecedented level of detail,over its entire length.The dataset has proven valuable in documenting subtle and transient rupture features,such as the significant mole-tracks and opening fissures,which were ubiquitous coseismically but degraded during the subsequent summer storm season.Such high-quality imagery also helps to document with high fidelity the fractures of the surface rupture zone(supplements of this paper),the pattern related to how the faults ruptured to the ground surface,and the distribution of off-fault damage.In combination with other ground-based mapping efforts,the data will be analyzed in the following months to better understand the mechanics of earthquake rupture related to the fault zone rheology,rupture dynamics,and frictional properties along with the fault interface. | Jing Liu-Zeng Wenqian Yao Xiaoli Liu Yanxiu Shao Wenxin Wang Longfei Han Yan Wang Xianyang Zeng Jinyang Li Zijun Wang Zhijun Liu Hongwei Tu | 2022 | Earthquake Research Advances2022，2，2： | 3 |
| 20 | Synthesis and Diameter-dependent Thermal Conductivity of InAs Nanowires显示文摘In this work, we synthesized high-quality In As nanowires by a convenient chemical vapor deposition method,and developed a simple laser heating method to measure the thermal conductivity of a single In As nanowire in air. During the measurement, a focused laser was used to heat one end of a freely suspended nanowire, with its other end embedded into a carbon conductive adhesive. In order to obtain the thermal conductivity of In As nanowires, the heat loss in the heat transfer process was estimated, which includes the heat loss through air conduction, the heat convection, and the radiation loss. The absorption ratio of the laser power in the In As nanowire was calculated. The result shows that the thermal conductivity of In As nanowires monotonically increases from 6.4 W m-1K-1to 10.5 W m-1K-1with diameters increasing from 100 nm to 190 nm, which is ascribed to the enhanced phonon-boundary scattering. | Pinyun Ren Xiaoli Zhu Jinyun Han Jinyou Xu Liang Ma Honglai Li Xiujuan Zhuang Hong Zhou Qinglin Zhang Minggang Xia Anlian Pan | 2014 | Nano-Micro Letters2014，6，4： | 2 |
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