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| 1 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Relationship between diabetes mellitus and cataract in Hungary显示文摘AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in Hungary.The effects of DM on the cataract surgical results were also in the focus of analysis.METHODS:Statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in 2015.This cross-sectional,population-based,national survey included 3523 people aged 50 years and over.Participants of the survey were examined on-site.Visual acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were examined.RESULTS:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with age.Among the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,P<0.001),DM proved to be the most independent influencing risk factor(OR=49.9%,P<0.001).The presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual acuity.CONCLUSION:DM appears to be one of the main risk factors for developing cataract.Other risk factors,such as age,sex and environment also play an influencing role.Diabetes does not seem to affect the occurrence of cataract surgical complications. | Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán Zsolt Nagy Hans Limburg János Németh | 2020 | International Journal of Ophthalmology(English edition)2020，13，5： | 2 |
| 4 | Modeling piezoelectric actuators显示文摘 | Willem L | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，4： | 1 |
| 5 | Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes/macrophage显示文摘 | Imanishi T Han DK Hofstra L | 2002 | Atherosclerosis2002，161，1： | 1 |
| 6 | Breast cancerfollowing diethylstilbestrol exposure in utero: insights from a tragedy显示文摘 | Hans O A Pagona L Dimitrios T | 2012 | European Journal of Epidemiology2012，27，1： | 1 |
| 7 | ART-KOHONEN neural network for fault diagnosis of rotating machinery显示文摘 | YANG B S HAN T AN J L | 2004 | Mechanical Systems and Signal Processing2004，18，3： | 1 |
| 8 | Efficient transformation of Actinidia arguta by reducing the strength of basal salts in the medium to alleviate callus browning显示文摘 | Han M L Gleave A P Wang T C | 2010 | Plant B iotechnology Reporter2010，4，： | 1 |
| 9 | Equivalent threshold sound pressure levels for Sennheiser HDA 200 earphone and etymotic research ER-2 insert earphone in the frequency range 125 Hz to 16 kHz 显示文摘 | HAN L A POULSEN T | 1997 | Scand Audiol1997，22，10： | 1 |
| 10 | Anti-obesity action of oolong tea 显示文摘 | Han L K Takaku T Li J | 1999 | Int J Obesity1999，23，98： | 1 |
| 11 | Microwave complex permea- bility of planar anisotropy carbonyl-iron particles显示文摘 | Han R Qiao L Wang T | 2010 | Journal of Alloys and Compounds2010，509，6： | 1 |
| 12 | Constraint-based,multidimensional data mining显示文摘 | Han J Lakshmanan L V S Ng R T | 1999 | Computer1999，32，8： | 1 |
| 13 | Static output feedback control for interval type-2 T-S fuzzy systems based on fuzzy Lyapunov functions显示文摘 | ZHAO T XIAO J HAN L | 2014 | Asian Journal of Control2014，16，6： | 1 |
| 14 | High Temperature Schottky Barrier on n - Type SrTiO3 and Its Sensitivity to Ambient Gases 显示文摘 | Kawada T Ichikawa T Han L Q | 2004 | Journal of Eleetroceramics2004，13，13： | 1 |
| 15 | Four prodator- prey models with infectious diseases 显示文摘 | HAN L T MA Z E HETHCOTE H W | 2001 | Mathl Comput Modelling2001，34，： | 1 |
| 16 | Graft interpenetrating polymer networks of urethane-modified bismaleimide and epoxy ( Ⅰ ) : Mechnical behavior and morphology 显示文摘 | Hsieh K H Han J L Yu C T | 2001 | Polymer2001，42，6： | 1 |
| 17 | Caspase family proteases and apoptosis显示文摘 | Fan T J Han L H Cong R S | 2005 | Acta Biochim Biophys Sin2005，37，11： | 1 |
| 18 | Analysis of Electro- chemical Impedance and Noise Data for Polymer Coated Metals显示文摘 | MANSFELD F HAN L T LEE C C | 1997 | Corrosion Science1997，39，2： | 1 |
| 19 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 20 | ART-KOHONEN Neural Network for Fault Diagnosis of Rotating Machinery显示文摘 | Yang B S Han T An J L | | 0，，03： | 1 |
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