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| 1 | Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review显示文摘The natural history of hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT)is dismal(approximately 2-4 mo),and PVTT is reportedly found in 10%-40%of HCC patients at diagnosis.According to the Barcelona Clinic Liver Cancer(BCLC)Staging System(which is the most widely adopted HCC management guideline),sorafenib is the standard of care for advanced HCC(i.e.,BCLC stage C)and the presence of PVTT is included in this category.However,sorafenib treatment only marginally prolongs patient survival and,notably,its therapeutic efficacy is reduced in patients with PVTT.In this context,there have been diverse efforts to develop alternatives to current standard systemic chemotherapies or combination treatment options.To date,many studies on transarterial chemoembolization,3-dimensional conformal radiotherapy,hepatic arterial chemotherapy,and transarterial radioembolization report better overall survival than sorafenib therapy alone,but their outcomes need to be verified in future prospective,randomized controlled studies in order to be incorporated into current treatment guidelines.Additionally,combination strategies have been applied to treat HCC patients with PVTT,with the hope that the possible synergistic actions among different treatment modalities would provide promising results.This narrative review describes the current status of the management options for HCC with PVTT,with a focus on overall survival. | Kichang Han Jin Hyoung Kim Gi-Young Ko Dong Il Gwon Kyu-Bo Sung | 2016 | World Journal of Gastroenterology2016，22，1： | 29 |
| 2 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 3 | Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery显示文摘BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cH CC-CC) is a rare subtype of primary liver cancer consisting of both hepatocellular carcinoma (HCC)and cholangiocarcinoma (CC). Because of the rarity of this tumor its feature is poorly understood. The present study aimed to evaluate the clinicopathological features and long-term prognosis of patients with cH CC-CC after surgery and to compare with those of the patients with stage-matched HCC and CC.METHODS: The clinicopathological features of the patients who underwent surgery for cH CC-CC at our center during the period of 2001-2010 were retrospectively analyzed and compared with those of stage-matched HCC and CC patients Cancer staging was performed according to the AJCC Cancer Staging Manual (6th ed.). Overall survival and disease-free survival were compared among the groups and prognostic factors of cH CC-CC were evaluated.RESULTS: Significant differences were observed in clinico pathological features among 42 patients with cH CC-CC, 90patients with HCC and 45 patients with CC. Similar to HCC patients, cH CC-CC patients had frequent hepatitis B virus antigen positivity, microscopic vessel invasion, cirrhosis and high level of serum alpha-fetoprotein. Similar to CC patients, cH CC-CC patients showed increased bile duct invasion and decreased capsule. The 1-, 3-, and 5-year overall survival and disease free survival of patients with cH CC-CC were not significantly different from those with stage-matched patients with CC;but significantly poorer than those with HCC. In subanalysis of patients with stage II, the overall survival in patients with cH CC-CC or CC was significantly poorer than that in patients , with HCC. We did not find the difference in patients with other stages. Univariate analysis of overall and disease-free survival of patients with cH CC-CC showed that the vascular invasion and intrahepatic metastasis were the significant predictive factors.CONCLUSION: Patients with cH CC-CC showed similar clinico- pathological features as those with HCC or CC, and patients with cH CC-CC or CC had a poorer prognosis compared with those with HCC, especially at matched stage II.. | Seung Duk Lee Sang-Jae Park Sung-Sik Han Seong Hoon Kim Young-Kyu Kim Soon-Ae Lee Young Hwan Ko Eun Kyung Hong | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 11 |
| 4 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 5 | Increased liver markers are associated with higher risk of type 2 diabetes显示文摘AIM: To investigate the association between liver markers and the risk of type 2 diabetes(T2DM) and impaired fasting glucose(IFG).METHODS: A total of 8863 participants(3408 men and 5455 women) over 30 years of age were analyzed from the fifth Korean National Health and Nutrition Examination Survey(2010-2011). The associations of serum liver markers such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), AST/ALT, and gamma-glutamyltransferase(GGT) with T2 DM and IFG were analyzed using logistic regression models. Participants were divided into sex-specific quartiles on the basis of liver markers.RESULTS: The prevalence of T2 DM and IFG were 11.3% and 18.3%. Increasing quartiles of ALT and GGT were positively and AST/ALT were negatively correlated with T2 DM and IFG. Analysis of the liver marker combinations showed that if any two or more markers were in the highest risk quartile, the risks of both T2 DM and IFG increased significantly. The risk was greatest when the highest ALT and GGT and lowest AST/ALT quartile were combined, with the riskof T2 DM at 3.21(95%CI: 1.829-5.622, P < 0.001) in men and 4.60(95%CI: 3.217-6.582, P < 0.001) in women. Men and women with the highest AST and ALT and lowest AST/ALT quartile had a 1.99 and 2.40 times increased risk of IFG.CONCLUSION: Higher levels of GGT and ALT and lower AST/ALT within the physiological range are independent, additive risk factors of T2 DM and IFG. | Sun-Hye Ko Myong Ki Baeg Kyung-Do Han Seung-Hyun Ko Yu-Bae Ahn | 2015 | World Journal of Gastroenterology2015，21，24： | 8 |
| 6 | Mechanical properties and corrosion resistance of low rigidity quaternary titanium alloy for biomedical applications显示文摘Electrochemical corrosion of Ti-35Nb-5Ta-7Zr alloy fabricated by arc melting and heat treatment process was studied in 0.9% NaCl at(37±1) ℃.Phase and microstructure of the fabricated alloy were investigated using X-ray diffractometer and scanning electron microscope.Mechanical properties such as yield strength and elastic modulus of the alloy were determined by tensile test.Potentiodynamic polarization technique and impedance spectroscopy were employed to study the corrosion behavior.The results of the study were compared with those obtained for Ti-6Al-4V commercial alloy.The result of the study supports feasibility of Ti-35Nb-5Ta-7Zr alloy for implant applications. | Han-Cheol CHOE Viswanat han S.SAJI Yeong-Mu KO | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 4 |
| 7 | Mitochondria as therapeutic targets for cancer stem cells显示文摘Cancer stem cells(CSCs) are maintained by theirsomatic stem cells and are responsible for tumor initiation, chemoresistance, and metastasis. Evidence for the CSCs existence has been reported for a number of human cancers. The CSC mitochondria have been shown recently to be an important target for cancer treatment, but clinical significance of CSCs and their mitochondria properties remain unclear. Mitochondriatargeted agents are considerably more effective compared to other agents in triggering apoptosis of CSCs, as well as general cancer cells, via mitochondrial dysfunction. Mitochondrial metabolism is altered in cancer cells because of their reliance on glycolytic intermediates, which are normally destined for oxidative phosphorylation. Therefore, inhibiting cancer-specific modifications in mitochondrial metabolism, increasing reactive oxygen species production, or stimulating mitochondrial permeabilization transition could be promising new therapeutic strategies to activate cell death in CSCs as well, as in general cancer cells. This review analyzed mitochondrial function and its potential as a therapeutic target to induce cell death in CSCs. Furthermore, combined treatment with mitochondriatargeted drugs will be a promising strategy for the treatment of relapsed and refractory cancer. | In Sung Song Jeong Yu Jeong Seung Hun Jeong Hyoung Kyu Kim Kyung Soo Ko Byoung Doo Rhee Nari Kim Jin Han | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 8 | Inhibitory effect of different Dendrobium species on LPS-induced inflammation in macrophages via suppression of MAPK pathways显示文摘Dendrobii Caulis(DC), named ‘Shihu' in Chinese, is a precious herb in traditional Chinese medicine. It is widely used to nourish stomach, enhance body fluid production, tonify 'Yin' and reduce heat. More than thirty Dendrobium species are used as folk medicine. Some compounds from DC exhibit inhibitory effects on macrophage inflammation. In the present study, we compared the anti-inflammatory effects among eight Dendrobium species. The results provided evidences to support Dendrobium as folk medicine, which exerted its medicinal function partially by its inhibitory effects on inflammation. To investigate the anti-inflammatory effect of Dendrobium species, mouse macrophage cell line RAW264.7 was activated by lipopolysaccharide. The nitric oxide(NO) level was measured using Griess reagent while the pro-inflammatory cytokines were tested by ELISA. The protein expressions of inducible NO synthase(iNOS), cyclooxygenase-2(COX-2) and mitogen-activated protein kinases(MAPKs) phosphorylation were evaluated by Western blotting analysis. Among the eight Dendrobium species, both water extracts of D. thyrsiflorum B.S.Williams(DTW) and D. chrysotoxum Lindl(DCHW) showed most significant inhibitory effects on NO production in a concentration-dependent manner. DTW also significantly reduced TNF-α, MCP-1, and IL-6 production. Further investigations showed that DTW suppressed iNOS and COX-2 expression as well as ERK and JNK phosphorylation, suggesting that the inhibitory effects of DTW on LPS-induced macrophage inflammation was through the suppression of MAPK pathways. In conclusion, D. thyrsiflorum B.S.Williams was demonstrated to have potential to be used as alternative or adjuvant therapy for inflammation. | ZENG Qiang Chun-Hay Ko Wing-Sum Siu LI Kai-Kai Chun-Wai Wong HAN Xiao-Qiang YANG Liu Clara Bik-San Lau HU Jiang-Miao Ping-Chung Leung | 2018 | Chinese Journal of Natural Medicines2018，16，7： | 4 |
| 9 | Assessment of cystic renal masses based on Bosniak classification: Comparison of CT and contrast-enhanced US显示文摘 | Byung Kwan Park Bohyun Kim Seung Hyup Kim Kyungran Ko Hyun Moo Lee Han Yong Choi | 2006 | European Journal of Radiology2006，，2： | 3 |
| 10 | Undiagnosed Borrmann type Ⅱ gastric cancer due to necrosis and regenerative epithelium显示文摘Endoscopic biopsy is essential to the proper diagnosis and treatment of gastric cancer.Unfortunately,the results of endoscopic biopsy are not always the same as what is expected based on gross endoscopic findings.The results of endoscopic biopsy can be negative for malignancy in Borrmann typeⅣadvanced gastric cancer(AGCa)or gastric lymphoma.However,in the case of typeⅡAGCa,repeated biopsies negative for malignancy have not been reported.A 49-year-old male patient underwent esophagogastroduodenoscopy three times due to large gastric ulcer suspected to be Borrmann typeⅡcancer.However,three repeat endoscopic biopsies with multiple specimens showed necrosis and superficial regenerative epithelium without malignant findings.The patient underwent laparoscopic distal gastrectomy with D2 lymph node dissection.The surgical specimen revealed that the mucosal layer was completely replaced with regenerative epithelium without cancer cells. | Joon Hur Jae Hyuck Chang Byung Kee Kim Hoon Young Ko Jong Hwan Lee Soo Jeong Kim Mi Ae Song Tae Ho Kim Chang Whan Kim Sok Won Han | 2014 | World Journal of Gastroenterology2014，20，28： | 2 |
| 11 | Optimum condition by mechanical characteristic evaluation in friction stir welding for 5083-O Al alloy显示文摘The mechanical characteristies for friction stir welding (FSW) of 5083-O Al alloy were evaluated. The results show that in FSW at 800 r/min and 124 mm/min, a weld defect is observed at the start point. However, the button shape at the end point is good and the stir zone has a soft appearance. At 267 mm/min, a void occurs at the button. A slight weld defect and rough stir zone are seen both at the start and end points at 342 mm/min. Moreover, at the bottom, a tunnel-type void is observed from an early stage to the end point, and at 1 800 r/min, a weld defect can be found from an early stage to the end point. These defects are rough with imperfect joining due to excessive rotation speed and high physical force. Weld fractures relative to rotational and travel speeds are observed at the stir zone. The optimum FSW conditions are a welding speed of 124 mm/min and a rotational speed of 800 r/min. | Min-Su HAN Seung-Jun LEE Jae-Cheul PARK Seok-Cheol KO Yong-Bin WOO Seong-Jong KIM | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 12 | Modeling and implementation of tandem polymer solar cells using wide-bandgap front cells显示文摘Tandem device architectures offer a route to greatly increase the maximum possible power conversion efficiencies(PCEs)of polymer solar cells,however,the complexity of tandem cell device fabrication(such as selecting bandgaps of the front and back cells,current matching,thickness,and recombination layer optimization)often result in lower PCEs than are observed in single-junction devices.In this study,we analyze the influence of front cell and back cell bandgaps and use transfer matrix modeling to rationally design and optimize effective tandem solar cell structures before actual device fabrication.Our approach allows us to estimate tandem device parameters based on known absorption coefficients and open-circuit voltages of different active layer materials and design devices without wasting valuable time and materials.Using this approach,we have investigated a series of wide bandgap,high voltage photovoltaic polymers as front cells in tandem devices with PTB7-Th as a back cell.In this way,we have been able to demonstrate tandem devices with PCE of up to 12.8%with minimal consumption of valuable photoactive materials in tandem device optimization.This value represents one of the highest PCE values to date for fullerene-based tandem solar cells. | Seo-Jin Ko Hyosung Choi Quoc Viet Hoang Chang Eun Song Pierre-Olivier Morin Jungwoo Heo Mario Leclerc Sung Cheol Yoon Han Young Woo Won Suk Shin Bright Walker Jin Young Kim | 2020 | Carbon Energy2020，2，1： | 2 |
| 13 | The Significance of Blood Pressure Variability for the Development of Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Youngchai Ko Jung Hyun Park Mi Hwa Yang Sang-Bae Ko Moon-Ku Han Chang Wan Oh JiSung Lee Juneyoung Lee Hee-Joon Bae | 2010 | Stroke2010，，11： | 2 |
| 14 | Impact of patient education with cartoon visual aids on the quality of bowel preparation for colonoscopy显示文摘 | Jae Woong Tae Jong Chan Lee Su Jin Hong Jae Pil Han Yun Hee Lee Jong Ho Chung Hyung Geun Yoon Bong Min Ko Joo Young Cho Joon Seong Lee Moon Sung Lee | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 15 | MYB46-Mediated Transcriptional Regulation of Secondary Wall Biosynthesis显示文摘Formation of secondary wall requires coordinated transcriptional regulation of the genes involved in the biosynthesis of major secondary wall components (e.g.cellulose,hemicellulose,and lignin).Even though many aspects of plant biology have been extensively elucidated using various model species,our current understanding of secondary wall formation is limited. | Jae-Heung Ko Won-Chan Kim Joo-Yeol Kim Sung-Ju Ahn Kyung-Hwan Han | 2012 | Molecular Plant2012，5，5： | 2 |
| 16 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 17 | Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins显示文摘 | Dohoon Kim Chun-Hyung Kim Jung-Il Moon Young-Gie Chung Mi-Yoon Chang Baek-Soo Han Sanghyeok Ko Eungi Yang Kwang Yul Cha Robert Lanza Kwang-Soo Kim | 2009 | Cell Stem Cell2009，，6： | 2 |
| 18 | A movie recommendation algorithm based on genre correlations显示文摘 | Sang-Min Choi Sang-Ki Ko Yo-Sub Han | 2012 | Expert Systems With Applications2012，，9： | 2 |
| 19 | A molecular framework for seasonal growth-dormancy regulation in perennial plants显示文摘The timing of the onset and release of dormancy impacts the survival,productivity and spatial distribution of temperate horticultural and forestry perennials and is mediated by at least three main regulatory programs involving signal perception and processing by phytochromes(PHYs)and PHY-interacting transcription factors(PIFs).PIF4 functions as a key regulator of plant growth in response to both external and internal signals.In poplar,the expression of PIF4 and PIF3-LIKE1 is upregulated in response to short days,while PHYA and PHYB are not regulated at the transcriptional level.Integration of light and environmental signals is achieved by gating the expression and transcriptional activity of PIF4.During this annual cycle,auxin promotes the degradation of Aux/IAA transcriptional repressors through the SKP–Cullin-F–boxTIR1 complex,relieving the repression of auxin-responsive genes by allowing auxin response factors(ARFs)to activate the transcription of auxin-responsive genes involved in growth responses.Analyses of transcriptome changes during dormancy transitions have identified MADS-box transcription factors associated with endodormancy induction.Previous studies show that poplar dormancy-associated MADS-box(DAM)genes PtMADS7 and PtMADS21 are differentially regulated during the growth-dormancy cycle.Endodormancy may be regulated by internal factors,which are specifically localized in buds.PtMADS7/PtMADS21 may function as an internal regulator in poplar.The control of flowering time shares certain regulatory hierarchies with control of the dormancy/growth cycle.However,the particularities of different stages of the dormancy/growth cycle warrant comprehensive approaches to identify the causative genes for the entire cycle.A growing body of knowledge also indicates epigenetic regulation plays a role in these processes in perennial horticultural and forestry plants.The increased knowledge contributes to better understanding of the dormancy process and consequently to precise manipulation of dormancy-related horticultural traits,such as flowering time. | Donghwan Shim Jae-Heung Ko Won-Chan Kim Qijun Wang Daniel E Keathley Kyung-Hwan Han | 2014 | Horticulture Research2014，1，1： | 2 |
| 20 | Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats显示文摘 | Ko GJ Kang YS Han SY | 2008 | Nephrol Dial Transplant2008，23，9： | 1 |
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