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| 1 | Research on the dynamics of the South China Sea opening:Evidence from analogue modeling显示文摘Independent of Indochina extrusion, the South China Sea experienced a process from passive continental rifting to marginal sea drifting. According to the fault patterns in the Beibu Gulf basin and the Pearl River Mouth basin, the continental rifting and early spreading stage from 32 to 26 Ma were controlled by extensional stress field, which shifted clockwise from southeastward to south southeastward. From 24 Ma on, the sea spread in NW-SE direction and ceased spreading at around 15.5 Ma. Integrated geological information with the assumption that the South China Sea developed along a pre-Cenozoic weakness zone, we did analogue experiments on the South China Sea evolu- tion. Experiments revealed that the pre-existing weakness zone goes roughly along the uplift zone between the present Zhu-1 and Zhu-2 depression. The pre-existing weakness zone is composed of three segments trending NNE, roughly EW and NEE, respectively. The early opening of the South China Sea is accompanied with roughly 15° clockwise rotation, while the SE sub-sea basin opened with SE extension. Tinjar fault was the western boundary of the Nansha block (Dangerous Ground), while Lupar fault was the eastern boundary of the Indochina, NW-trending rift belt known as Zengmu basin developed between above two faults due to block divergent of Indochina from Nansha. In the experiment, transtensional flower structures along NW-trending faults are seen, and slight inversion occurs along some NE-dipping faults. The existence of rigid massifs changed the orientations of some faults and rift belt, and also led to deformation concentrate around the massifs. The rifting and drifting of the South China Sea might be caused by slab pull from the proto South China Sea subducting toward Borneo and/or mantle flow caused by India-Asia collision. | SUN Zhen1,2, ZHOU Di1, ZHONG Zhihong3, XIA Bin2, QIU Xuelin1, ZENG Zuoxun4 & JIANG Jianqun5 1. CAS Key Laboratory of Marginal Sea Geology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2. CAS Key Laboratory of Marginal Sea Geology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 3. Department of Technology, Shenzhen Branch of CNOOC, Guangzhou 510240, China 4. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 5. Hainan Oil & Gas Exploration Company, Liaohe Oilfield PetroChina, Panjin 124010, China | 2006 | Science China Earth Sciences2006，49，10： | 45 |
| 2 | Effects of mixture ratio on anaerobic co-digestion with fruit and vegetable waste and food waste of China显示文摘The biochemical methane potentials for typical fruit and vegetable waste (FVW) and food waste (FW) from a northern China city were investigated,which were 0.30,0.56 m 3 CH 4/kgVS (volatile solids) with biodegradabilities of 59.3% and 83.6%,respectively.Individual anaerobic digestion testes of FVW and FW were conducted at the organic loading rate (OLR) of 3 kg VS/(m 3 ·day) using a lab-scale continuous stirred-tank reactor at 35℃.FVW could be digested stably with the biogas production rate of 2.17 m 3/(m 3 ·day) and methane production yield of 0.42 m 3 CH 4/kg VS.However,anaerobic digestion process for FW was failed due to acids accumulation.The effects of FVW:FW ratio on co-digestion stability and performance were further investigated at the same OLR.At FVW and FW mixing ratios of 2:1 and 1:1,the performance and operation of the digester were maintained stable,with no accumulation of volatile fatty acids (VFA) and ammonia.Changing the feed to a higher FW content in a ratio of FVW to FW 1:2,resulted in an increase in VFAs concentration to 1100-1200mg/L,and the methanogenesis was slightly inhibited.At the optimum mixture ratio 1:1 for co-digestion of FVW with FW,the methane production yield was 0.49 m 3 CH 4/kg VS,and the volatile solids and soluble chemical oxygen demand (sCOD) removal efficiencies were 74.9% and 96.1%,respectively. | Jia Lin Jiane Zuo Lili Gan Peng Li Fenglin Liu Kaijun Wang Lei Chen Hainan Gan | 2011 | Journal of Environmental Sciences2011，23，8： | 36 |
| 3 | Pollutant concentrations and pollution loads in stormwater runoff from different land uses in Chongqing显示文摘To investigate the distribution of pollutant concentrations and pollution loads in stormwater runoff in Chongqing,six typical land use types were selected and studied from August 2009 to September 2011.Statistical analysis on the distribution of pollutant concentrations in all water samples shows that pollutant concentrations fluctuate greatly in rainfall-runoff,and the concentrations of the same pollutant also vary greatly in different rainfall events.In addition,it indicates that the event mean concentrations (EMCs) of total suspended solids (TSS) and chemical oxygen demand (COD) from urban traffic roads (UTR) are significantly higher than those from residential roads (RR),commercial areas (CA),concrete roofs (CR),tile roofs (TRoof),and campus catchment areas (CCA);and the EMCs of total phosphorus (TP) and NH3-N from UTR and CA are 2.35-5 and 3 times of the class-III standard values specified in the Environmental Quality Standards for Surface Water (GB 3838-2002).The EMCs of Fe,Pb and Cd are also much higher than the class-III standard values.The analysis of pollution load producing coefficients (PLPC) reveals that the main pollution source of TSS,COD and TP is UTR.The analysis of correlations between rainfall factors and EMCs/PLPC indicates that rainfall duration is correlated with EMCs/PLPC of TSS for TRoof and TP for UTR,while rainfall intensity is correlated with EMCs/PLPC of TP for both CR and CCA.The results of this study provide a reference for better management of non-point source pollution in urban regions. | Shumin Wang Qiang He Hainan Ai Zhentao Wang Qianqian Zhang | 2013 | Journal of Environmental Sciences2013，25，3： | 33 |
| 4 | 青海贵德山坪台卡约文化墓地显示文摘贵德县下刘村山坪台卡约文化墓地是1981年7月青海省文物普查试点工作中发现的。发现时因平整土地和水电工程,部分墓葬已被破坏,随即由青海省文化局文物处和海南藏族自治州群众艺术馆共同组成清理发掘小组,配合工程进行清理发掘。小组成员有青海省文化局文物处赵生琛,海南州群众艺术馆刘青彦、王小平、石瑛等同志。自1981年10月上旬至12月上旬,共清理发掘墓葬九十座,出土文物共计六二九件。青海省文物考古队高东陆、吴平和海南藏族自治州群众艺术馆刘青彦等同志进行整理工作,由王国顺同志绘图、刘青彦同志摄影。 | Provincial Archaeological Team and Folk Art Centre of Hainan Zang (Tibetan)Autonomous Region | 1987 | 考古学报1987，，2： | 26 |
| 5 | Phosphate removal and recovery through crystallization of hydroxyapatite using xonotlite as seed crystal显示文摘Xonotlite was synthesized and tested for phosphate removal and recovery from synthetic solution in a batch mode. The effects of pH, initial calcium concentration, bicarbonate concentration on phosphate removal through crystallization were examined. The morphology and X-ray diffraction (XRD) pattern of xonotlite before and after crystallization confirmed the formation of crystalline hydroxyapatite. The results indicated that the crystallization product had a very high P content (> 10%), which is comparable to phosphate rock at the dosage of 50-200 mg xonotlite per liter, with a maximum P content of 16.7%. The kinetics of phosphate removal followed the second-order reaction equation. The phosphate removal ability increased with increasing pH. The precipitation of calcium phosphate took place when pH was higher than 7.2, whereas the crystallization occurred at pH 6.0. A high calcium concentration could promote the removal of phosphate via crystallization, while a high bicarbonate concentration also enhanced phosphate removal, through that the pH was increased and thus induced the precipitation process. When xonotlite was used to remove phosphate from wastewater, the removal effciency could reach 91.3% after 24 h reaction, with removal capacity 137 mg/g. The results indicated that xonotlite might be used as an effective crystal seed for the removal and recovery of phosphate from aqueous solution. | CHEN Xuechu, KONG Hainan, WU Deyi, WANG Xinze, LIN Yongyong School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China | 2009 | Journal of Environmental Sciences2009，21，5： | 24 |
| 6 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 7 | Genome-wide Transcription Factor Gene Prediction and their Expressional Tissue-Specificities in Maize显示文摘Transcription factors (TFs) are important regulators of gene expression. To better understand TF-encoding genes in maize (Zea mays L.), a genome-wide TF prediction was performed using the updated B73 reference genome. A total of 2 298 TF genes were identified, which can be classified into 56 families. The largest family, known as the MYB superfamily, comprises 322 MYB and MYB-related TF genes. The expression patterns of 2014 (87.64%) TF genes were examined using RNA-seq data, which resulted in the identification of a subset of TFs that are specifically expressed in particular tissues (including root, shoot, leaf, ear, tassel and kernel). Similarly, 98 kernel-specific TF genes were further analyzed, and it was observed that 29 of the kernel-specific genes were preferentially expressed in the early kernel developmental stage, while 69 of the genes were expressed in the late kernel developmental stage. Identification of these TFs, particularly the tissue-specific ones, provides important information for the understanding of development and transcriptional regulation of maize. | Yi Jiang Biao Zeng Hainan Zhao Mei Zhang Shaojun Xie Jinsheng Lai | 2012 | Journal of Integrative Plant Biology2012，54，9： | 20 |
| 8 | Metamorphosed mafic rocks with N-type MORE geochemical features in Hainan Island-Remnants of the Paleo-Tethys Oceanic Crust?显示文摘A number of metamorphosed mafic rocks occurred within the Paleozoic strata in the Chenxing and Bangxi regions at the northern side of the Changjiang-Qionghai Fault in Central Hainan Island. These metamorphosed mafic rocks are tholeiites in chemistry. They are characterized by extreme depletion of Th, Nb, Ta and LREEs, resembling the depleted N-type mid-ocean ridge basalts (MORE). Field relations suggest that the protolith of the metamorphosed mafic rocks were likely formed in Paleozoic. These metamorphosed mafic rocks with N-type MORB geochemical features were probably the remnants of the Paleo-Tethys oceanic crust. | LI Xianhua, ZHOU Hanwen, DING Shijiang, LEE Chi-yu, ZHANG Renjie, ZHANG Yeming & GE Wenchun1. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. Hainan Geological Survey, Haikou 570206, China 3. Department of Geology, Taiwan University, Taipei 106-17, China 4. Yichang Institute of Geology and Mineral Resources, Chinese Academy of Geological Sciences, Yichang 443003, China | 2000 | Chinese Science Bulletin2000，45，10： | 9 |
| 9 | Comparative Analysis of Leaf Trichomes, Epidermal Wax And Defense Enzymes Activities in Response to Puccinia horiana in Chrysanthemum and Ajania Species显示文摘White rust caused by Puccinia horiana is a destructive disease of chrysanthemum plants.To better understand the resistance mechanisms of composite species to this disease,the leaf cuticular traits,antioxidant and defensive enzymes activities of immune(Chrysanthemum makinoi var.wakasaense)and highly susceptible(Ajania shiwogiku var.kinokuniense)species were compared.Trichome density of two species was markedly different,negatively associated with plant resistance to P.horiana.Total wax load in C.makinoi var.wakasaense was two times more than that in A.shiwogiku var.kinokuniense.The wax composition in immune one was abundant in esters and primary alcohols.Superoxide dismutase(SOD,EC 1.15.1.1),peroxidase(POD,EC 1.11.1.7),polyphenoloxidase(PPO,EC 1.14.18.1 or EC 1.10.3.2)and phenylalanine ammonia lyase(PAL,EC 4.3.1.5)activitieswere investigated.In C.makinoi var.wakasaense,the activity of SOD and POD increased rapidly after inoculation,whichmight be non-host induced reactive oxygen species(ROS)activated antioxidant enzymes,however SOD and POD remained a low and steady level in the highly susceptible one after inoculation.Quick increase in PPO activities after inoculation was observed in both species,however it remained higher in C.makinoi var.wakasaense at the late period of inoculation.PAL in C.makinoi var.wakasaense was induced after pathogen inoculation,but not in A.shiwogiku var.kinokuniense,suggesting that these two enzymes might contribute to the resistance to P.horiana. | Yinjie Wang Jun Zeng Xiaolong Xia Yang Xu Jing Sun Jing Gu Hainan Sun Haini Lei Fadi Chen Jiafu Jiang Weiming Fang Sumei Chen | 2020 | Horticultural Plant Journal2020，6，3： | 8 |
| 10 | 美蓝染色放大电子结肠镜观察结肠息肉与组织病理学的关系显示文摘目的:研究美蓝染色后用放大电子结肠镜观察结肠息肉的微细结构类型与组织病理学的关系。方法:使用0.5%美蓝对电子结肠镜检查到有息肉的部位进行息肉及邻近的黏膜进行染色,然后用放大电子结肠镜观察。按Kudo’s标准记录正常结肠黏膜和息肉,然后行活检或息肉电切术,以便组织病理学评价。结果:本组共67人,普通电子结肠镜检查发现息肉180颗,经美蓝染色后又发现了1-3mm大小的息肉90颗,共计270颗息肉。放大结肠镜可明显提高腺瘤性病变的检出率,P<0.001。270颗病变的隐窝类型分为6种,呈Ⅱ型者2颗(0.7%);Ⅲ_s型203颗(75.2%);Ⅲ_L型49颗(18.1%),其中伴有轻、中度非典型增生者7颗;Ⅳ型11颗(4.1%),伴有轻度非典型增生者2颗、黏膜癌1颗(9.1%),Ⅴ_n共5颗(1.9%),伴有中度非典型增生者1颗,黏膜癌2颗(40%)。本组息肉均进行了电切术。结论:美蓝染色后用放大电子结肠镜可清晰地观察到结肠隐窝,其大小一致,呈圆形或椭圆形;诊断为腺瘤性息肉与病理组织学的符合率为96.7%,可明显提高息肉的检出率,并可鉴别电切息肉术后残留的基底部是否残留腺瘤组织或癌灶。 | Lu Su Hong-Zhen Pan Jing-Biao Weng Yi-Hua Xu Fang Chen Mei-Yan Hong Department of Digestive Endoscopy, The Worker’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China | 2003 | 世界华人消化杂志2003，11，8： | 8 |
| 11 | Optimization on conventional and electric air-cycle refrigeration systems of aircraft: A short-cut method and analysis显示文摘The air-cycle refrigeration system is widely used in commercial and military aircraft,and its efficiency greatly affects aircraft performance.Nowadays,this system requires a more efficient design and optimization method.In this paper,a short-cut optimization method with high efficiency and effectiveness is introduced for both conventional and electric air-cycle refrigeration systems.Based on the system characteristics,a four-layer parameter matching algorithm is designed which avoids computational difficulty caused by simultaneous equations.Fuel penalty is chosen as the objective function of optimization;design variables are reduced based on sensitivity analysis to improve optimization efficiency.The results show that the 3-variable optimization of the conventional air-cycle refrigeration system can obtain almost the same results as the traditional 6-variable optimization in that these two optimizations can both significantly reduce the fuel penalty.However,the computer running time of the 3-variable optimization is much shorter than that of the 6-variable optimization.The optimal fuel penalty of the electric air-cycle refrigeration system is lower than that of the conventional one.This study can provide reference for optimizing the aircycle refrigeration system of aircraft. | Hongsheng JIANG Sujun DONG Hainan ZHANG Fengming AI Zhiwei ZHANG Jun WANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 6 |
| 12 | A new sorbent that simultaneously sequesters multiple classes ofpollutants from water: Surfactant modified zeolite显示文摘A zeolite (ZFA) was synthesized from coal fly ash and then modified using hexadecyltrimethylammonium. The surfactant modified ZFA (SMZFA) was evaluated for its versatility to sequester multiple classes of pollutants from water. The target pollutants include ionic inorganic pollutants (ammonium and phosphate), ionic organic pollutants (methylene blue and humic acid), ionizable organic pollutants (bisphenol A,-chlorophenol and phenol, with different pKa), and electrically neutral or-ganic pollutants (aniline, nitrobenzene, and naphthalene, with different hydrophobicity). The SMZFA showed high potential for the retention of ammonium and phosphate, being comparable with ZFA. While the negative charge in the internal pores of zeolite was responsible for the retention of ammonium, the oxides of CaO, Al2O3and Fe2O3in the non-zeolite fraction, which originated from coal fly ash but received modification during zeolite synthesis, accounted for the removal of phosphate. Results also showed that while ZFA had little affinity for humic acid, the ionizable, and the electrically neutral organic compounds, SMZFA exhibited greatly enhanced adsorption capacity. Thus, the surfactant modified external surface, which formed a bilayer micelle of zeolite, imparts a hydrophobic characteristic that enables the uptake of the organic pollutants. We showed that SMZFA is a promising versatile sorbent for water treatment. | XIE Qiang XIE Jie CHI LiNa LI ChunJie WU DeYi ZHANG ZhenJia KONG HaiNan | 2013 | Science China(Technological Sciences)2013，56，7： | 5 |
| 13 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 14 | Molecular modeling and spectroscopic studies on the binding of guaiacol to human immunoglobulin显示文摘The fluorogenic property of guaiacol was exploited for the first time to analyze the interaction with target protein as a probe by molecular modeling, fluorescence, circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy. Molecular docking was performed to reveal the possible binding mode or mechanism and suggested that guaiacol can strongly bind to human immu- noglobulin (HIgG). It is considered that guaiacol binds to HIgG mainly by a hydrophobic interaction and there are two hydrogen bond interactions between the drug and the residues LEU 80 and ASP 65, which is in good agreement with the results from the experimental thermodynamic parameters (the enthalpy change △H0 and the entropy change △S0 were calculated to be 65.55 kJ·mol-1 and 132.95 J·mol-1·K-1 according to the Vant’ Hoff equation). Data obtained by the fluorescence spectroscopy indicated that binding of guaiacol with HIgG leads to dramatic enhancement in the fluorescence emission intensity along with significant occurrence of efficient Frster resonance energy transfer (FRET) from the residue of HIgG to the protein bound guaiacol. From the low value of fluorescence anisotropy (r = 0.06), it is argued that the probe molecule is located in the motionally unrestricted environment of the protein. The alterations of protein’s secondary structure in the presence of guaiacol in aqueous solution were quantitatively calculated by the evidences from FT-IR and CD spectroscopes. | HE Wenying1,2, YAO Xiaojun1, LIU Pengjun2, GAO Zhenxia2 & HU Zhide1 1. Department of Chemistry, Lanzhou University, Lanzhou 730000, China 2. Department of Chemistry, Hainan Normal University, Hainan 571158, China | 2006 | Science China Chemistry2006，49，6： | 5 |
| 15 | FEEDING HABITS OF HAINAN ELDI'S DEER显示文摘Hainan eldi’s deer is a precious species of deer in the tropic zone,it is regardedas the first—class animal under protection in China.Based on all-year-round observation on thedeer’s feeding habit in the reserve from 1985 to 1988,we discovered that Hainan eldi’s deer is aeuryphangous herbivore.They take various herbs as their main food and have fairly strongselectivity for woody plants,especially tending to eat the tender parts of plants and some fruits andflowers.Like other species of deer,they also like to lick the alkaline soil.This paper reports the re-search and evaluation on the feeding and choosing food characteristics of Hainan eldi’s deer,and onthe palatability of the main plants in the reserve. | Yuan Xicai Liu Xiaoming Wang JunSouth China Institute of Endangered AnimalsFu GuoaiThe Forestry Bureau of Hainan ProvinceLi ShanyuanThe Datian Reserve of Hainan Province | 1991 | Journal of Northeast Forestry University1991，2，1： | 5 |
| 16 | Construction of a metabolomics profile of arsenic trioxide effect in gastric carcinoma cell line SGC7901显示文摘砷三氧化物(ATO ) 为对待尖锐 promyelocytic 白血病是高度有效的。它也为治疗稳固的肿瘤保持诺言,包括胃的癌。然而,到稳固的肿瘤的 ATO 的有效性的分子的机制仍然糟糕被理解。在这研究,我们 chosed 是的胃的癌一个例子并且试着通过 metabolomics 揭示 antitumor 机制。胃的癌房间线 SGC7901 为 6, 12,和 24 h 与 ATO 被对待。全球代谢物侧面被 metabolomics 分析用气体监视层析(GC )/mass spectrometry (MS ) 和液体层析 /MS/MS。281 的一个总数证明代谢物可靠地被检测。生物信息学分析证明那 glycerophospholipid 合成,一个碳合成,和谷胱甘肽合成戏剧性地被影响。被影响了的另外的细胞的功能 / 小径包括了煽动性的反应,菸碱腺嘌 dinucleotide (NAD +), 和 polyamine 生合成小径。在有以前的 transcriptomics 和 proteomics 数据的联合,从这研究的 metabolomics 数据能为 ATO 处理的特定的 antitumor 机制的理解用作珍贵资源。 | Ziqing Chen Hainan Zhang Lina Yang Hewei Jiang Shujuan Guo Yang Li Shengce Tao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 17 | The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease显示文摘In recent years,many studies have investigated the correlations between Parkinson's disease(PD)and vitamin D status,but the conclusion remains elusive.The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor(VDR)gene polymorphisms from PubMed,Web of Science,Cochrane Library,and Embase databases.We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity.Furthermore,higher vitamin D concentrations are linked to better cognitive function and mood in PD patients.Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent,but the Fokl(C/M)polymorphism is significantly linked with PD.The occurrence of Fokl(CT)gene polymorphism may influence the risk,severity,and cognitive ability of PD patients,while also possibly influencing the effect of Vitamin D3 supplementation in PD patients.In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission,interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future. | Lingling Lv Xuling Tan Xinke Peng Rongrong Bai Qile Xiao Ting Zou Jieqiong Tan Hainan Zhang Chunyu Wang | 2020 | Translational Neurodegeneration2020，9，3： | 5 |
| 18 | Behavior features of heavy metals in the Haikou Bay waters显示文摘Dissolved Cu, Ph, Zn and Cd in the Haikou Bay waters were measured to be respectively in the range concentrations of 0.47-1.16 μg/dm^3, 0. 94-- 2. 36μg/dm^3, 1.28-4.83 μg/dm^3 and 0. 005-0.072μg/dm^3; with respectively average values of 0.78μg/dm^3, 1.36μg/dm^3, 3.14 g/dm^3 and 0. 03 μg/dm^3. Dissolved Cu and Zn concentrations are relatively high at the stations near the Longkun Road Outfall for domestic sewage, the Xiuying Outfall for industry waste water and the Haidian Island Estuary, but dissolved Pb and Cd concentrations are low in these stations. The values in Other stations are comparatively homogenous. Vertical dissolved Cu, Pb and Zn concentrations at the bottom layer are higher than at the surface layer, but dissolved Cd concentration appears to be on the opposite. The measurement results of Cu, Pb, Zn and Cd in suspended particle show that particulate matters in the Haikou Bay seawater play a role in purifying heavy metals. The study on strong complexed form and non-liable form of dissolved copper show that the ratio of strong complexed form and dissolved form is about 85%, and non-liable form is very low with a value lower than 5 nmol/dm^3. Therefore, copper in the Haikou Bay seawater cannot cause influence on marine organisms. | Chen Chunhua Wang Zhengfang and Lu Haiyan 1. Marine Exploitation Plan and Design Research Institute of Hainan Province, Haikou 570203, China 2. Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China (Received July 12, 1996 | 1999 | Acta Oceanologica Sinica1999，18，2： | 4 |
| 19 | U-Pb dating of zircon from the bed parallel anatectic granitic intrusion in the Baoban group in Hainan Island and the tectonic implication显示文摘The petrological and geochemical features of the bed parallel granitic intrusion in the Pre-Cambrian Baoban group in Hainan Island attest to the anatexis origin of the granites. U-Pb dating analyses of zircons from the anatectic granite and the biotite two-feldspar gneiss in the Baoban group, using SHRIMP II in the Beijing Ion-probe Center, acquire 206Pb/238U ages of 368±3.5 Ma (of granite, 95% confidence level, MSDW=1.23) and 362.9±6.1 Ma (of gneiss, 95% confidence level, MSDW = 2.04) respectively. The two late Devonian ages indicate consistently a tectonic- thermal event experienced in Hainan Island, and are the first discovered record of the Devonian geological process in the district. This event possibly resulted from the deep ther-mal-dynamic process when the Gondwana continent began to break up in the Devonian period. | DING Shijiang1, HU Jianmin2, SONG Biao3,4, CHEN Mulun1, XIE Shengzhou1 & FAN Yuan1 1. Geological Surveying Institute of Hainan, Haikou 570206, China 2. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China 3. Beijing Center of SHRIMP, Beijing 100037, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，12： | 4 |
| 20 | The involvement of PybZIPa in light-induced anthocyanin accumulation via the activation of PyUFGT through binding to tandem G-boxes in its promoter显示文摘To gain insight into how anthocyanin biosynthesis is controlled by light in fruit,transcriptome and metabolome analyses were performed in the Chinese sand pear cultivar“Mantianhong”(Pyrus pyrifolia)after bagging and bag removal.We investigated transcriptional and metabolic changes and gene-metabolite correlation networks.Correlation tests of anthocyanin content and transcriptional changes revealed that 1,530 transcripts were strongly correlated with 15 anthocyanin derivatives(R2>0.9,P-value<0.05),with the top 130 transcripts categorized as being associated with flavonoid metabolism,transcriptional regulation,and light signaling.The connection network revealed a new photosensitive transcription factor,PybZIPa,that might play an important role during light-induced anthocyanin accumulation.The overexpression of PybZIPa promoted anthocyanin accumulation in pear and strawberry fruit as well as tobacco leaves.Dual luciferase and Y1H assays further verified that PybZIPa directly activated the expression of PyUFGT by binding to tandem G-box motifs in the promoter,which was key to differential anthocyanin accumulation in debagged pear skin,and the number of G-box motifs affected the transcriptional activation of PyUFGT by PybZIPa.The results indicate that the light-induced anthocyanin biosynthesis regulatory mechanism in pear differs from that described in previous reports suggesting that a bZIP family member co-regulates anthocyanin biosynthesis with other transcription factors in apple and Arabidopsis.It was found that,in response to light,PybZIPa promoted anthocyanin biosynthesis by regulating important transcription factors(PyMYB114,PyMYB10,and PyBBX22)as well as structural genes(PyUFGT)via binding to G-boxes within promoters.This activation was amplified by the self-binding of PybZIPa to activate its own promoter.Overall,we demonstrate the utility of a multiomics integrative approach for discovering new functional genes and pathways underlying light-induced anthocyanin biosynthesis. | Hainan Liu Jun Su Yangfan Zhu Gaifang Yao Andrew C.Allan Charles Ampomah-Dwamena Qun Shu Kui Lin-Wang Shaoling Zhang Jun Wu | 2019 | Horticulture Research2019，6，1： | 3 |
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