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| 1 | Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase显示文摘Ribonucleotide reductase(RNR), the rate-limitingenzyme in DNA synthesis, catalyzes reduction of thedifferent ribonucleotides to their corresponding deoxyri-bonucleotides. The crucial role of RNR in DNA synthesishas made it an important target for the development ofantiviral and anticancer drugs. Taking account of the re-cent developments in this field of research, this reviewfocuses on the role of thioredoxin and glutaredoxin sys-tems in the redox reactions of the RNR catalysis. | Rajib Sengupta Arne Holmgren | 2014 | World Journal of Biological Chemistry2014，5，1： | 6 |
| 2 | Effects of Carbon Content and Solidification Rate on the Thermal Conductivity of Grey Cast Iron显示文摘The thermal conductivity/diffusivity of pearlitic grey irons with various carbon contents was investi- gated by the laser flash method. The materials were cast in controlled thermal environments producing three dissimilar cooling rates. The cooling rates together with the carbon content largely influence the thermal conductivity of grey iron. Linear relationships exist between the thermal conductivity and the carbon content, the carbon equivalent, and the fraction of the former primary solidified austenite transformed into pearlite. The results show that the optimal thermal transport properties are obtained at medium cooling rates. Equa- tions are given for the thermal conductivity of pearlite, solidified as pre-eutectic austenite, and the eutectic of grey iron. The thermal conductivity of pearlitic grey iron is modelled at both room temperature and elevated temperatures with good accuracy. | Daniel Holmgren Attila Diószegi Ingvar L. Svensson | 2008 | Tsinghua Science and Technology2008，13，2： | 5 |
| 3 | Effects of carbon content and solidification rate on thermal conductivity of grey cast iron显示文摘The thermal conductivity or diffusivity of pearlitic grey irons with various carbon contents is investigated by the laser flash method. The materials are cast in controlled thermal environments and produced in three dissimilar cooling rates. The cooling rate together with the carbon content largely influence the thermal conductivity of grey iron. Linear relationships exist between the thermal conductivity and the carbon content,the carbon equivalent and the fraction of former primary solidified austenite transformed into pearlite. The work shows that optimal thermal transport properties are obtained at medium cooling rates. Equations describing the thermal conductivity of pearlite,solidified as pre-eutectic austenite,and the eutectic of grey iron are derived. The thermal conductivity of pearlitic grey iron is modeled at both room temperature and elevated temperature with good accuracy. | Daniel Holmgren Attila Diószegi Ingvar L.Svensson | 2007 | China Foundry2007，4，3： | 5 |
| 4 | Selenium and the Thioredoxin and Glutaredoxin Systems显示文摘Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FADcontaining enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation. Selenite, selenodiglutathione (GS-Se-SG) and selenocystine are efficiently reduced by thioredoxins and also directly by NADPH and mammalian TR but not by the E. coli enzyme. Incubation of selenite or GS-Se-SG with the Trx system or with mammalian TR results in a rapid formation of selenide, which by redox cycling with oxygen may cause a large non-stoichiometric oxidation of NADPH. Selenocystine is efficiently reduced into two molecules of the selenol amino acid selenocysteine by mammalian TR with a Km-value (6μmol·L-1 ) and a high turnover number (kcat, 3200 min-1) almost identical to the natural substrate Trx-S2. TR also directly reduces lipid hydroperoxides and this peroxidase reaction is strongly stimulated by the presence of catalytic amounts of free selenocysteine. Glutaredoxin (Grx) which catalyzes GSH dependent disulfide reduction also via a redox-active disulfide and Trx are both efficient electron donors to the hut-nan plasrna glutathione peroxidase providing a mechanism by which human plasma glutathione peroxidase may reduce hydroperoxides in an environment almost free from glutathione. Selenate is reduced by Grx and Trx in the presence of GSH. The DNA-binding of the transcription factor AP-1 is strongly inhibited by GS-Se-SG and selenite. Furtherrnore, selenide formed by TR-mediated reduction of selenite and GS-Se-SG inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron. Mammalian TR with two subunits of 57 kDa has recently been cloned and shown to be homologous to glutathione reductase. The rat enzyme contains a selenocysteine residue in a unique Cterminal position and a conserved SEClS sequence directing insertion of the selenocysteine. The discovery of selenocysteine in mammalian TR may explain the broad substrate specificity of the enzyme and the requirement of seleflium for cell | MIKAEL BJORNSTEDT SUSHIL KUMAR LINDA BJ■RKHEM GIANNIS SPYROU AND ARNE HOLMGREN(The Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 77 Stockholm, Sweden Department of Bioscience, | 1997 | Biomedical and Environmental Sciences1997，10，2： | 4 |
| 5 | Angiostatin:a novel angiogenesis inhibitor that mediates the suppression of metastasis by a Lewis lung carcinoma显示文摘 | O Reilly MS Holmgren L Shing Y | 1994 | Cell1994，79，2： | 2 |
| 6 | Effect of phosphate on heterogeneous Fenton oxidation of catechol by nano-Fe_(3)O_(4):Inhibitor or stabilizer?显示文摘The effect of phosphate on adsorption and oxidation of catechol, 1,2-dihydroxybenzene,in a heterogeneous Fenton system was investigated. In situ attenuated total reflectance infrared spectroscopy(ATR-FTIR) was used to monitor the surface speciation at the nano-Fe_3O_4 catalyst surface. The presence of phosphate decreased the removal rate of catechol and the abatement of dissolved organic compounds, as well as the decomposition of H_2O_2. This effect of phosphate was mainly due to its strong reaction with surface sites on the iron oxide catalyst. At neutral and acid pH, phosphate could displace the adsorbed catechol from the surface of catalyst and also could compete for surface sites with H_2O_2. In situ IR spectra indicated the formation of iron phosphate precipitation at the catalyst surface. The iron phosphate surface species may affect the amount of iron atoms taking part in the catalytic decomposition of H_2O_2 and formation of hydroxyl radicals,and inhibit the catalytic ability of Fe_3O_4 catalyst. Therefore, phosphate ions worked as stabilizer and inhibitor in a heterogeneous Fenton reaction at the same time, in effect leading to an increase in oxidation efficiency in this study. However, before use of phosphate as p H buffer or H_2O_2 stabilizer in a heterogeneous Fenton system, the possible inhibitory effect of phosphate on the actual removal of organic pollutants should be fully considered. | Xiaofang Yang Jie He Zhongxi Sun Allan Holmgren Dongsheng Wang | 2016 | Journal of Environmental Sciences2016，28，1： | 2 |
| 7 | Thioredoxin structure mechanism:Conformational changes on oxidation of the active-site sulfhydryls to a disulfide 显示文摘 | Holmgren A | 1995 | Structure1995，3，3： | 2 |
| 8 | El Ni?o as a Window of Opportunity for the Restoration of Degraded Arid Ecosystems显示文摘 | Milena Holmgren Marten Scheffer | 2001 | Ecosystems2001，，2： | 2 |
| 9 | Prevalence of the fragile-X syndrome in mentally retarded boys in a Swedish county显示文摘 | Gustavson KH Blomquist HK Holmgren G | 1986 | Am J Med Genet1986，23，12： | 2 |
| 10 | An active ingredient of cat's claw water extracts identification and efficacy of quinic acid 显示文摘 | Sheng Y Akesson C Holmgren K | 2005 | J Ethnopharmacol2005，96，3： | 1 |
| 11 | Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin,cholera toxin B subunit and CpG DNA显示文摘 | Holmgren J Adamsson J anjuère F | 2005 | Immunol Lett2005，97，2： | 1 |
| 12 | Physiological functions of thioredoxin and thioredoxin reductase显示文摘 | Arner ES Holmgren A | 2000 | Eur J Biochem2000，267，20： | 1 |
| 13 | The effects of an occlusal splint on the electromyographic activities of the temporal and masseter muscles during maximal clenching in patients with a habit of nocturnal bruxism and signs and symptoms of craniomandibular disorders 显示文摘 | Holmgren K Sheikholeslam A Riise C | 1990 | J Oral Rehabil1990，17，5： | 1 |
| 14 | Antiangiogenis restricted tumor dormancy显示文摘 | Holmgren L | 1996 | Cancer Metastasis Rev1996，15，2： | 1 |
| 15 | A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection显示文摘 | Harandi A M Eriksson K Holmgren J | 2003 | J Virol2003，77，2： | 1 |
| 16 | Self- Forgiveness and Responsible Moral Agency 显示文摘 | Holmgren M R | 1998 | The Journal of Value Inquiry1998，，32： | 1 |
| 17 | The thioredoxin system in cancer显示文摘 | Arner ES Holmgren A | 2006 | Semin Cancer Biol2006，16，6： | 1 |
| 18 | Recent advances in mucosal vaccines and adjuvants显示文摘 | Eriksson K Holmgren J | 2002 | Immunotherapy2002，14，： | 1 |
| 19 | Trace element variation in Speleothem aragonite: Potential for palaeoenvironmental reconstruction显示文摘 | Finch A A Shaw P A Weedon G P Holmgren K | 2001 | Earth and Planetary Science Letters2001，186，： | 1 |
| 20 | Distribution of PACAP (pituitary adenylate cyclase-activating polypeptide)-like and helospectin-like peptides in the teleost gut 显示文摘 | Olsson C Holmgren S | 1994 | Cell Tissue Res1994，277，3： | 1 |
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