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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Arterial stiffness and risk of cor onary heart disease and stroke: the Rotter-dam Study 显示文摘 | MATTACE RASO F U VAN DER CAMMEN T J HOFMAN A | 2006 | Circulation2006，113，： | 1 |
| 3 | A practical approach to obtain primary drainagecapillary pressure curves from NMR core and log data显示文摘 | HOFMAN J P LOOYESTIJN W J SLIJKERMAN W F | 2001 | Petrophysics2001，42，4： | 1 |
| 4 | Arterial stiffness and risk of coronary heart disease and stroke:the rotterdam study显示文摘 | Mattace-Raso F U van der Cammen T J Hofman A | 2006 | Circulation2006，113，： | 1 |
| 5 | Ripening and quality responses of avocado,custard apple,mango and papaya fruit to 1-methylcyclopropene显示文摘 | Hofman P J Jobin-Décor M Meiburg G F | 2001 | Australian Journal of Experimental Agriculture2001，41，4： | 1 |
| 6 | Circulating antibody against tumornecrosis factor-alpha protectsrat brain from reperfusion injury显示文摘 | Lavine S D Hofman F N Zlokovic B V | 1998 | J Cereb Blood Flow Metab1998，18，1： | 1 |
| 7 | Ripening and quality responses of avocado, custardapple, mango and papaya fruit tol-MCP显示文摘 | Hofman P J Jobin D M Meiburg G F | 2001 | Australian Journal of Experiment Agriculture2001，41，： | 1 |
| 8 | Low temperature conditioning before cold disinfestation improves 'Hass' avocado fruit quality显示文摘 | Hofman P J Stubbings B A Adkins M F | 2003 | Postharvest Biology and Technology2003，28，1： | 1 |
| 9 | Premature birth and later insulin resistance 显示文摘 | Hofman PL Regan F Jackson WE | 2004 | N Engl J Med2004，351，21： | 1 |
| 10 | Arterial stiffness and risk of coronary heart disease and stroke;the rotterdam study显示文摘 | Mattace-Raso F U van der Cammen T J Hofman A | 2006 | Circulation2006，113，5： | 1 |
| 11 | Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury 显示文摘 | LAVINE S D HOFMAN F M ZLOKOVIC B V | 1998 | J Cereb Blood Flow Matab1998，18，1： | 1 |
| 12 | TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin - treated patients with familial hyper- cholesterolemia 显示文摘 | Mohrschladt MF van der Smart -de Beer F Hofman MK | 2005 | Eur J Hum Genet2005，13，： | 1 |
| 13 | GDF5 single nucleotide polymorr phism rs143383 is associated with lumbar disc degeneration inNorthern European women显示文摘 | Williams F M Popham M Hart D J de Schepper E Bierma Zeinstra S Hofman A | 2011 | Arthritis Rheum2011，63，： | 1 |
| 14 | Absence of a prominent Th2 cytokine response in human tuberculosis显示文摘 | Lin Y Zhang M Hofman F M | 1996 | Infect Immun1996，64，6： | 1 |
| 15 | Cell cycle phase-specific survival of CD95 ligand-challenged Jurkat cells:upregulation of heatshock response显示文摘 | Parr T B Hofman F M Kiener P A | 2001 | Cell Immunol2001，211，： | 1 |
| 16 | Sensitive salivary estradiol for monitoring ovarian function显示文摘 | WORTHMAN C M STALLINGS J F HOFMAN L F | | 0，，： | 1 |
| 17 | Thoron Exposure to Man: A Negligible Issue? 显示文摘 | Steinhausler F Hofman W Lettner H | 1994 | Radia Prot Dosim1994，56，： | 1 |
| 18 | Lack of blood- brain barrier properties in microvessels of the prelami- nar optic nerve head 显示文摘 | Hofman P Hoyng P Vanderwerf F | 2001 | Invest Ophthalmol Vis Sci2001，42，5： | 1 |
| 19 | Decreased selenium levels in acute myocardial infraction显示文摘 | Kok F J Hofman A Witteman J C | 1989 | Journal of the American Medical Association1989，261，： | 1 |
| 20 | Phase II study of induction chemotherapy in patients with stage IIIB NSCLC显示文摘 | C Pitz A Brutel de la Riviere F van Beek N Schlosser P Hofman H Dik J Kersbergen B Biesma F Schramel | 2000 | Lung Cancer2000，，1： | 1 |
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