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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | 抑郁治疗和急性心肌梗死后1年死亡率的相关性:TRIUMPH注册研究显示文摘在急性心肌梗死(acute myocardial infarction,AMI)患者中,抑郁症是很普遍的,并且与不良的生活质量和预后相关。尽管一些国家组织提出了筛选抑郁症的建议,但尚不清楚AMI患者的抗抑郁治疗是否与更好的预后相关。该研究的目的是确定接受抗抑郁治疗是否对患者的预后有影响。方法: | 刘莉 叶鹏 Smolderen KG Buchanan DM Gosch K Whooley MA Chan PS Vaccarino V Parashar S Shah AJ Ho PM Spertus JA | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 4 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 5 | Micro-Doppler Effect in Radar-Phenomenon,Model and Simulation Study显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，1： | 1 |
| 6 | Micro-doppler effect in radar:phenomenon,model,and simulation study显示文摘 | Chen V C Li F Y Ho S | 2006 | IEEE Transactionson Aerospace and Electronic Systems2006，42，1： | 1 |
| 7 | Controlled synthesis and application of ZnO nanoparticles, nanorods and nanospheres indye-sensitized solar cells显示文摘 | Z L S Seow A S W Wong V Thavasi R Jose S Ramakrishna G W Ho | 2009 | Nanotechnology2009，，4： | 1 |
| 8 | Leader follower formation control of underactuated autonomous under water vehicals显示文摘 | Cui R Ge S Ho B V | 2010 | Ocean Engineering2010，37，17： | 1 |
| 9 | Exploring knowledge dif- fusion among nations: A study of core technologies in fuel cells显示文摘 | Ho M H Lin V H Liu J S | 2014 | Sciemometrics2014，100，1： | 1 |
| 10 | Analysis of micro-Doppler signatures 显示文摘 | Chen V C Li F Y Ho S S | 2003 | IEEE Proceedings of Raddar Sonar and Nav- igation2003，150，4： | 1 |
| 11 | Micro-Doppler effect in radar: phenomenon,model, and simulation study 显示文摘 | Chen V C Li F Ho S S | 2006 | IEEE Trans- actions on Aerospace and Electronic Systems2006，42，1： | 1 |
| 12 | Analysis of microdoppler signatures 显示文摘 | Chen V C Li F Ho S S Wechsler H | 2003 | IEE Proceedings Radar Sonar and Navigation2003，150，4： | 1 |
| 13 | Constant-frequency hysteresis current control of grid-connected VSI without bandwidth control显示文摘 | Ho C N Cheung V S Chung H S | 2009 | IEEE Transactions on Power Electronics2009，24，11： | 1 |
| 14 | Severe systemic lupus erythematosus induced by antivira! treatment for hepatitis C显示文摘 | Ho V McLean A Terry S | 2008 | J Clin Rheumatol2008，14，3： | 1 |
| 15 | Architecture of the pulmonary veins:relevance to radiofrequency ablation显示文摘 | Ho S Y Cabrera J A Tran V H | | 0，，03： | 1 |
| 16 | A qualitative and quantitative review of antecedents of counterproductive behavior in organi zations显示文摘 | Lau V C S Au W T and Ho J M C | 2003 | Journal of Business and Psychology2003，18，1： | 1 |
| 17 | Recurrent adult Wilms tumor with extensive metastases on FDG PETCT显示文摘 | HO L QUAN V PARK S | 2008 | Clin Nucl Med2008，33，2： | 1 |
| 18 | Side population in human lungcancer cell lines and tumors is enriched with stem-like cancercells显示文摘 | Ho M M Ng A V Lam S | 2007 | Cancer Res2007，67，10： | 1 |
| 19 | Really smart bioconjugates of smart polymers and receptor proteins 显示文摘 | Ho{fman A S Stayton P S Bulmus V | 2000 | J Biomed Mater Res2000，52，4： | 1 |
| 20 | Micru-Doppler effect in radar-phe- nomenon, model and simulation study 显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Transactions on Aerospace and Electronic Systems2006，42，1： | 1 |
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