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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | KAI1/CD82 expression in non-small cell lung carcinoma is a novel, favorable prognostic factor: an immunohistochemical analysis显示文摘 | Higashiyama M Kadama K Yokouchi H | 1998 | Cancer1998，83，3： | 1 |
| 3 | Primary and metastatic pulmonary meningioma显示文摘 | Kodama K Doi O Higashiyama M | 1991 | Cancer1991，7，5： | 1 |
| 4 | Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid ceils显示文摘 | Okuda S Tsutsui H Shiina K Sprunck S Takeuchi H Yui R Kasahara R D HamamuraY Mizukami A S usaki D Kawano N Sakakibara T Namiki S Itoh K Otsuka K Matsuzaki M Nozaki H Kuroiwa T Nakano A Kanaoka M M Dresselhaus T Sasaki N Higashiyama T | | 0，，7236： | 1 |
| 5 | Immunohistochemically detected expression of motilityrelated protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosis 显示文摘 | Higashiyama M Doi O Kodama K | 1997 | Int J Cancer1997，74，2： | 1 |
| 6 | Natural history of pure ground-glass opacity after long-term follow-up of more than 2 years显示文摘 | Kodama K Higashiyama M Yokouchi H | 2002 | Ann Thorac Surg2002，73，： | 1 |
| 7 | Serum 1,5-anhydro- D-glucitol levels predict first-ever eardiovaseular disease : an 11-year population-based cohort study in Japan, the Suita study 显示文摘 | Watanabe M Kokubo Y Higashiyama A | 2011 | Athere- sclerosis2011，216，2： | 1 |
| 8 | KAI1/CD82 expression in non-small cell lung carcinoma is a novel favorable prognostic factor:an immunohistochemical analysis 显示文摘 | Higashiyama M Kodama K Yokouchi H | 1998 | Cancer1998，83，3： | 1 |
| 9 | Immunokinetics in severe pneumonia due to influenza virus and bacteria coinfection in mice 显示文摘 | Seki M Yanagihara K Higashiyama Y | 2004 | Eur Respir J2004，24，1： | 1 |
| 10 | Zepp,a Line-like retrotransposon accumulated in the Chlorella telomeric region显示文摘 | Higashiyama T Noutoshi Y Fujie M | 1997 | EMBOJ1997，16，12： | 1 |
| 11 | Surgery for pulmonary metastases from colorectal cancer:the importance of prethoracotomy serum carcinoembryonic antigen as an indicator of prognosis显示文摘 | Higashiyama M Kodama K Higaki N | | 0，，： | 1 |
| 12 | Differences in ehemosensitivity between primary and paired metastatic lung cancer tissues: In vitro analysis based on the collagen gel droplet embedded culture drug test (CD-DST) 显示文摘 | Higashiyama M Okami J Maeda J | 2012 | J Thorac Dis2012，4，1： | 1 |
| 13 | Influence of cathepsin D expression in lung adenocarcinoma on prognosis:possible importance of its expression in tumor cells and stromal cells,and its intracellular polarization in tumor cells显示文摘 | Higashiyama M Doi O Kodama K | 1997 | J Surg Oncol1997，65，： | 1 |
| 14 | Prognostic value of ex- pression of vascular endothelial growth factorand its flt-1 and KDR receptors in stage I non-small cell lung cancer显示文摘 | Seto T Higashiyama M Funai H | 2006 | Lung Cancer2006，53，1： | 1 |
| 15 | Diagnosis and Treatment of Small Peripheral Lung Cancer显示文摘 | Yokouchi H Kodama K Higashiyama M | 2000 | Nippon Rinsho2000，58，5： | 1 |
| 16 | Natural history of pure ground-glass opacity after long-term follow-up of more than 2 years显示文摘 | Kodama K Higashiyama M Yokouchi H | 2002 | Ann Thorac Surg2002，73，： | 1 |
| 17 | Prospective comparisons of intravitreal injections of triameinolone aeetonide and bevaeizumab for maeular oedema due to branch retinal vein occlusion 显示文摘 | Higashiyama T Sawada O Kakinoki M et at | 2013 | Acta Ophthalmol2013，91，： | 1 |
| 18 | Fractal analysis of inter- nal and peripheral textures of small peripheral bronchogenic carcino- mas in thin-section computed tomography: comparison of bronchio- loalveolar cell carcinomas with nonbronchioloalveolar cell carcinomas 显示文摘 | Kido S Kuriyama K Higashiyama M | 2003 | J Comput Assist Tomogr2003，27，1： | 1 |
| 19 | Prediction of chemotherapeutic effect on postoperative recurrence by in vitro anticancer drug sensitivity testing in non-small cell lung cancer patients 显示文摘 | Higashiyama M Oda K Okami J | 2010 | Lung Cancer2010，68，3： | 1 |
| 20 | Prognostic significance of osteopontin expression in human gastric carcinoma显示文摘 | Higashiyama M Ito T Tanaka E | 2007 | Ann Surg Oncol2007，14，12： | 1 |
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