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| 1 | 葛根素、齐墩果酸及其配伍对T2DM大鼠氧化应激和炎症反应的影响显示文摘目的:观察葛根素、齐墩果酸及其配伍对2型糖尿病大鼠血糖、血脂、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、糖基化终末产物(AGEs)、超敏C反应蛋白(hs-CRP)及胰腺病理组织学的影响。方法:以高糖、高脂饮食联合链脲佐菌素(30 mg.kg-1)ip法建立2型糖尿病大鼠模型,随机分为模型(M)组、二甲双胍(D)组(100 mg.kg-1.d-1)、葛根素(P)组(30 mg.kg-1.d-1)、齐墩果酸(OA)组(10 mg.kg-1.d-1)、葛根素+齐墩果酸(POA)组(40 mg.kg-1.d-1),同期设正常对照组(K)。各治疗组分别ig给予相应药物治疗。治疗前及治疗2,4,6周分别测定各组大鼠空腹血糖(FBG)及餐后2 h血糖(P2hPG),并于给药6周后,测定大鼠总胆固醇(CHOL)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),hs-CRP,血清SOD,MDA,AGEs水平,光镜下观察胰腺病理组织学变化。结果:M组大鼠FBG,P2hPG,CHOL,TG,LDL-C,hs-CRP,MDA,AGEs较K组升高,HDL-C和血清SOD水平明显下降,有统计学差异,对胰腺胰岛细胞有一定损伤。各治疗组大鼠FBG,P2hPG,CHOL,TG,LDL-C,hs-CRP,MDA,AGEs较M组降低,HDL-C和血清SOD水平增加,对胰腺胰岛细胞损伤有不同程度改善。POA组LDL-C水平较P组、OA组降低明显(P<0.05),对胰腺胰岛细胞损伤明显改善。结论:葛根素、齐墩果酸及其配伍可改善实验性2型糖尿病大鼠的糖、脂代谢,其作用机制可能与抗氧化、抑制炎症反应有关。其中葛根素配伍齐墩果酸在降低LDL-C水平、改善胰岛细胞结构方面优于单纯葛根素、齐墩果酸。 | 王会敏 田炜 喇孝瑾 高秀娟 韩婷 王亚 田震亚 Hegyi Gabriella 陈震 李继安 | 2013 | 中国实验方剂学杂志2013，19，15： | 20 |
| 2 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 3 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 4 | 荧光假单胞菌ZX对采后锦橙绿霉病的防治及其抑菌机制显示文摘【目的】采后柑橘极易受指状青霉(Penicillium digitatum)侵染而发生严重的绿霉病腐烂,生物防治因具有安全、有效、环保等特点近年来备受关注。论文旨在研究荧光假单胞菌(Pseudomonas fluorescens)ZX对采后柑橘绿霉病的防治效果,揭示P.fluorescensZX对P.digitatum可能存在的作用机制。【方法】以'北碚447'锦橙果实为试材,先分别接种20μL拮抗菌培养液、滤液(培养液离心后,上清经0.22μm滤膜过滤)、菌悬液(培养液离心后,菌体用无菌水反复洗涤并用无菌水重悬)和热杀死液(培养液高温高压灭菌),2 h后接种20μL P. digitatum孢子悬浮液(1×10~4spores/m L),所有果实于20oC、90%相对湿度环境下恒温恒湿培养8 d后,测定果实的发病率和病斑直径;制备柑橘皮培养基,进行平板抑菌试验,探索P. fluorescens ZX对P. digitatum孢子发芽情况的影响;采用两板对扣法和生物熏蒸法研究P.fluorescensZX挥发性次级代谢产物的抑菌作用;利用插入式细胞培养皿等分析P.fluorescensZX和P.digitatum之间竞争的营养物质;同时,测定P.fluorescensZX的生长曲线,利用结晶紫染色法评估P. fluorescens ZX的生物膜形成能力。【结果】P. fluorescens ZX不同处理液之间对采后锦橙绿霉病的作用效果差异显著,菌悬液抑菌效果最好,经菌悬液处理的果实,发病率和病斑直径分别仅为40.83%和1.78 cm;不论是在柑橘皮固体培养基上对峙培养还是在液体培养基中混合培养,菌悬液和原液的作用效果较好,固体平板上,相对抑制率达到了35%–45%,液体培养基中,P. digitatum孢子12 h后的发芽率不超过27%;P. fluorescens ZX产生的挥发性物质具有抑菌作用,经P. fluorescensZX熏蒸处理的锦橙果实,发病率和病斑直径都显著降低;营养竞争试验结果表明,P. fluorescens ZX能更快速有效地消耗柑橘皮培养基中的营养,并和P. digitatum竞争葡萄糖、果糖、蔗糖、天冬氨酸、苏氨酸、丝氨酸、亮氨酸、精氨酸和脯氨酸等营养物质;同时,P. fluorescens ZX生命力强,培养4 h后即进入对数生长期,约24 h后形成成熟的生物膜。【结论】P. fluorescens ZX可能通过抑制P. digitatum孢子发芽、营养与空间竞争、形成生物膜、产生抑菌物质等方式抑制P.digitatum的生长繁殖,有效防治采后锦橙绿霉病。 | 王智荣 梅小飞 杜木英 江孟遥 张洪新 汪开拓 Zsolt Zalán Ferenc Hegyi 阚建全 | 2019 | 微生物学报2019，59，5： | 12 |
| 5 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 6 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 7 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 8 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 9 | 通莲汤对胃癌MGC803细胞周期及NF-κBs信号通路的影响显示文摘目的:研究通莲汤对胃癌MGC803细胞形态、生长周期的调节作用及细胞核转录因子κB(NF-κB)信号通路的影响,以探讨该方抑制胃癌细胞增殖的机制.方法:将MGC803细胞以1×104个细胞/孔的密度接种于96孔细胞培养板,以含5%胎牛血清DMEM培养液培养,37℃,5%饱和湿度的CO2培养箱孵育,细胞贴壁24 h,分别加入浓度为25~800 mg·L-倍比梯度的通莲汤提取液,以10 ~ 160 mg·L-1倍比浓度的氟脲嘧啶为阳性对照组,孵育48 h后,倒置显微镜下观察细胞形态,MTT比色法检测细胞增殖变化,曲线拟合法计算通莲汤和氟脲嘧啶50%抑制浓度(IC50);以两者48 h IC50浓度处理细胞48 h,流式细胞技术(FCM)测定细胞周期,Western blot法测定细胞IκB激酶β(IKKβ),NF-κB,phosph-NF-κB蛋白水平.结果:通莲汤和氟脲嘧啶48 h IC50值分别为192.74 mg.L-1,23.61 mg·L-1;与空白对照组相比,通莲汤显著影响MGC803细胞周期中G2期,氟脲嘧啶显著影响MGC803细胞周期中G1期(P<0.05);通莲汤和氟脲嘧啶均能显著抑制IKKβ与NF-κB的蛋白表达.结论:通莲汤抑制MGC803细胞生长与抑制细胞于G2期,下调NF-κB通路中IKKβ,NF-κB蛋白的表达有关. | 王亚 贾永森 喇孝瑾 田炜 韩炳生 李继安 郝小惠 Hegyi Gabriella | 2013 | 中国实验方剂学杂志2013，19，22： | 6 |
| 10 | 代平颗粒对2型糖尿病大鼠血糖、血脂水平及骨骼肌Glut4 mRNA,IRS-1 mRNA表达的影响显示文摘目的:观察中药代平颗粒对2型糖尿病大鼠骨骼肌葡萄糖转运蛋白4(Glut4)、胰岛素受体底物1(IRS-1)基因表达的影响,初步探讨其降低血糖的分子机制。方法:雄性SD大鼠分为正常对照组(8只,普通饲料),其余大鼠采用高脂饲料喂养联合链脲佐菌素(STZ)尾静脉注射的方法造成2型糖尿病成膜大鼠(32只),分为模型组(M)、二甲双胍组(Met)、代平颗粒低剂量组(DL),代平颗粒高剂量组(DH),每组8只。经药物干预4周后检测各组大鼠空腹血糖(FBG)、血脂、空腹胰岛素(FINS)并计算胰岛素敏感指数(ISI),采用实时荧光定量PCR技术检测大鼠骨骼肌Glut4 mRNA,IRS-1 mRNA表达水平。结果:给药后4周,与M组FBG:(20.55±5.50)mmol·L-1,ISI:(-6.05±0.29)比较,Met组FBG(14.75±3.90)mmol·L-1和DH组FBG(11.21±2.95)mmol·L-1均显著下降(P<0.01),Met组ISI(-5.37±0.38)和DH组ISI(-5.38±0.37)均显著升高(P<0.01);M组Glut4 mRNA(0.63±0.13)和IRS-1 mRNA(0.68±0.17)表达量分别为N组的63.3%,67.8%(P<0.01);与M组比较,Met组Glut4 mRNA(0.95±0.19)表达量升高了31%(P<0.01),IRS-1 mRNA(0.88±0.24)表达量无显著升高,DH组Glut4 mRNA(1.19±0.15)和IRS-1 mRNA(1.24±0.22)表达量,分别升高了88.9%,82.4%(P<0.01)。结论:代平颗粒具有降低2型糖尿病大鼠FBG效果,其作用机制之一与增加组织胰岛素敏感性,上调2型糖尿病大鼠骨骼肌中Glut4 mRNA和IRS-1 mRNA的表达,促进骨骼肌对葡萄糖的摄取和利用有关。 | 张艳萍 郭志义 吴范武 Hegyi Gabriella 刘志霞 高秀娟 喇孝谨 柳月娟 崔鹏 李继安 | 2012 | 中国实验方剂学杂志2012，18，13： | 6 |
| 11 | 荧光假单胞菌ZX对葡萄采后灰霉病的防治显示文摘研究荧光假单胞菌(Pseudomonas fluorescens)ZX对葡萄采后灰霉病的防治效果。以“巨峰”葡萄为试材,测定P.fluorescens ZX的控病效果和生长动态,在离体条件下通过孢子萌发观察、挥发性物质抑菌测试、扫描电镜探究其对灰葡萄孢霉(Botrytis cinerea)的防治。结果表明,使用P.fluorescens ZX处理,葡萄果实的发病率仅为24.8%,明显低于对照组(发病率64.67%),病斑直径最小,可以明显抑制B.cinerea孢子萌发、芽管伸长。P.fluorescens ZX产生的挥发性物质具有较强的抑菌效果,并且能对B.cinerea有重寄生作用,破坏菌丝的正常形态。另外,无论是浸泡还是接种处理,P.fluorescens ZX都能在葡萄果实上快速地定殖生长。由此表明,P.fluorescens ZX通过抑制B.cinerea生长来控制葡萄采后灰霉病,为果实采后防腐保鲜提供一种新的选择。 | 魏雪 江孟遥 钟涛 张曼 王智荣 ZSOLT Zalan FERENC Hegyi KRISZTINA Takacs 杜木英 | 2021 | 食品工业科技2021，42，22： | 6 |
| 12 | 不同非酿酒酵母与酿酒酵母混合发酵对脆红李酒品质的影响显示文摘分别采用热带假丝酵母(Candida tropicalis)、东方伊萨酵母(Issatchenkio orientalis)、美极梅奇酵母(Metschnikowia pulcherrima)、葡萄汁有孢汉逊酵母(Hanseniaspora uvarum)与商业酿酒酵母(Saccharomyces cerevisiae)D254混合发酵脆红李酒,比较其在发酵速率、理化指标、有机酸和挥发性成分的差异,并进行感官评价分析,以期为提升脆红李酒品质提供依据。结果表明,与S.cerevisiae单独发酵(10 d)相比,混合发酵延缓了发酵进程(12~13 d)。不同脆红李酒的理化指标均符合国标,混合发酵后酒样中苹果酸、乳酸和乙酸含量显著降低(P<0.05),有利于果酒风味平衡协调。香气成分结合主成分分析表明,Mp-Sc混合发酵香气组分优于其他酒样,其中辛酸乙酯、癸酸乙酯、月桂酸乙酯、芳樟醇显著提高且香气活度值>1,能够增强酒体果香、花香。感官评价结果也表明Mp-Sc混合发酵的果香味和花香味较为浓郁。综上,Mp-Sc混合发酵更适合应用于脆红李酒酿造,有利于增加香气复杂性,提升品质。 | 张曼 钟涛 魏雪 阚建全 武运 FERENC Hegyi 杜木英 | 2021 | 食品与发酵工业2021，47，12： | 6 |
| 13 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 14 | 方竹笋膳食纤维作为益生元对乳酸菌生长的影响显示文摘为了探究竹笋膳食纤维(bamboo shoot dietary fiber,BSDF)作为益生元对乳酸菌生长的影响,以常见益生元菊粉为对照,检测了BSDF在模拟胃肠液中的抗消化性,以及对乳酸菌L1(Lactobacillus fermentum)、L2(Lactobacillus plantaum)生长过程中pH值、总酸含量和生长曲线的影响。结果表明,BSDF中总膳食纤维、不溶性膳食纤维、可溶性膳食纤维含量分别为64.90%、58.12%、6.78%,相对含量较高的单糖有葡萄糖(39.72%)、阿拉伯糖(12.77%)、木糖(12.69%)。BSDF在胃肠液中具有一定的抗消化性,模拟消化6 h后,BSDF在人工胃液(pH=3.5)和人工肠液(pH=7)的水解率分别为15.54%、31.08%,均低于菊粉对照组。对于乳酸菌L1,随着BSDF添加量的增加,培养基中的菌群浓度不断增加,BSDF相比于菊粉更有利于乳酸菌L1生长。对于乳酸菌L2,随着BSDF添加量的增加,总酸含量逐渐增大,乳酸菌的益生效应也随之增强。该研究可为BSDF作为益生元的开发利用提供理论参考。 | 赵泓舟 杜木英 ZALAN Zsolt HEGYI Ferenc 吴良如 张同芳 郑炯 | 2022 | 食品与发酵工业2022，48，6： | 5 |
| 15 | 葛根素和黄芪甲苷及其配伍对T2DM大鼠的影响显示文摘①目的观察葛根素、黄芪甲苷及其配伍对2型糖尿病大鼠血糖、血脂、超敏C反应蛋白(hs-CRP)及胰腺病理组织学的影响,初步探讨其作用机制。②方法以高糖、高脂饮食+链脲佐菌素腹腔注射法建立2型糖尿病大鼠模型,随机分为模型组、二甲双胍组、葛根素组、黄芪甲苷组、葛根素+黄芪甲苷组。治疗前及治疗2、4、6周分别测定各组大鼠空腹血糖(FBG)及餐后2小时血糖(P2hPG),并于给药6周后,测定大鼠CHOL、TG、HDL-C、LDL-C、hs-CRP含量,光镜下观察胰腺病理组织学变化。③结果各治疗组大鼠FBG、P2hPG、CHOL、TG、LDL-C、hs-CRP较M组降低,HDL-C含量增加,对胰腺胰岛细胞损伤有不同程度改善。PA组LDL-C水平较P组、A组降低明显(P<0.05),对胰腺胰岛细胞损伤明显改善。④结论葛根素、黄芪甲苷及其配伍可改善实验性2型糖尿病大鼠的糖、脂代谢,其作用机制可能抑制炎症反应有关。其中葛根素配伍黄芪甲苷在降低LDL-C水平、改善胰岛细胞结构方面优于单纯葛根素、黄芪甲苷。 | 田震亚 王会敏 田炜 喇孝瑾 高秀娟 韩婷 王亚 Hegyi Gabriella 陈震 李继安 | 2013 | 河北联合大学学报(医学版)2013，15，4： | 4 |
| 16 | 荧光假单胞菌对采后锦橙青霉病的防治和贮藏品质的影响显示文摘以'北碚447'锦橙果实为实验材料,研究了荧光假单胞菌(Pseudomonas fluorescens)对采后锦橙青霉病的防治效果和贮藏品质及感官品质的影响。利用P. fluorescens不同浓度菌悬液和各种处理液分别进行离体和活体实验。离体实验结果表明,1×10~8CFU/mL菌悬液在混合固体培养基上和意大利青霉孢子共同培养时,能完全抑制其生长繁殖,对峙培养时,相对抑菌率高达(52. 59±1. 59)%;在马铃薯葡萄糖液体培养基中意大利青霉孢子12 h后的萌发率和芽管长度分别为(0. 67±0. 47)%和(2. 25±0. 25)μm。活体实验结果表明,P. fluorescens菌悬液抑菌效果最好,且其浓度越高,防治效果越好,浓度为1×10~9CFU/mL时,果实的发病率和病斑直径仅为(49. 17±1. 18)%和(2. 72±0. 09) cm; 4℃下培养16 d,20℃下培养8 d,P. fluorescens在果实伤口处的活菌数分别增长了28倍和34倍;和对照相比,P. fluorescens能显著提高果实几丁质酶和β-1,3-葡聚糖酶的活性,有效增强果实的抗病性;经P. fluorescens菌悬液保鲜的果实,病情指数显著降低,且感官品质和对照差别较小,表明该P. fluorescens试验菌株在锦橙采后病害上具有极高的生物防治潜力。 | 王智荣 江孟遥 杜木英 汪开拓 Zsolt Zalán Ferenc Hegyi 阚建全 | 2018 | 食品与发酵工业2018，44，11： | 4 |
| 17 | Tonglian Decoction(通莲汤)Arrests the Cell Cycle in S-phase by Targeting the Nuclear Factor-Kappa B Signal Pathway in Esophageal Carcinoma Eca109 Cells显示文摘Objective:To investigate the anti-tumor activity and molecular mechanism of Tonglian Decoction(通莲汤,TLD) on esophageal carcinoma Eca109 cells.Methods:Eca109 cells were treated with TLD and its separated formulae,including the clearing-heat and detoxification formula(Q),activating-blood and promoting-qi formula(H) and nourishing-yin and blood formula(Z).Cell proliferation was measured using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay,cell morphology was observed using a microscope,the cell cycle was measured using flow cytometry and the activity of the nuclear factor-kappa B(NF-κB) signal pathway was detected by Western blot.Results:The half maximal inhibitory concentrations of TLD,Q and H were 386,771 and 729 mg/L,respectively.TLD,Q and H significantly inhibited cell proliferation,with 69.43%,60.84%and 61.90%of treated cells in the G1 phase of the cell cycle.The percentage of cells in S phase increased significantly after treatment with TLD,Q,and H compared with the control group(P<0.05),and TLD showed the strongest effect.Z had no influence on the cell cycle compared with the control group(P>0.05).Western blot detection indicated slight differences in the inhibition of the NF- k B pathway by the different formulae.TLD formula strongly inhibited IKKβ,NF-κB,interleukin-6 and tumor necrosis factor-α expression compared with the control group.Conclusions:TLD inhibited Eca109 cell proliferation by arresting cells in S phase.The possible mechanism might be related to inhibiting the NF- κB transduction cascade.The combination of the herbs found in the three separate formulae,H,Q and Z,work synergistically in TLD to produce the inhibitory effects of TLD treatment on Eca109 proliferation. | 贾永森 胡雪琴 李继安 Andras Szasz Gabriella Hegyi 韩炳生 | 2016 | Chinese Journal of Integrative Medicine2016，22，5： | 3 |
| 18 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 19 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 20 | Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis显示文摘BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major concern.AIM To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB patients.METHODS We searched three databases from inception through October 19th,2020.Randomized controlled trials(RCTs)and observational cohort studies were eligible.Studies compared patients with NVUGIB receiving PTAE to those who did not get PTAE.Investigated outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)stay.In the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention group.PTAE was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control groups.Patients who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in NVUGIB.However,further RCTs are needed to have a higher level of evidence. | Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa Szabolcs Kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
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