|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulation of NF-κB signaling by the A20 deubiquitinase显示文摘NF-κ B 抄写因素是煽动性、天生的有免疫力的发信号小径的一个中央调停人。NF-κ 的激活; B 被哪个的关键发信号的分子的连接 K63 的 polyubiquitination 完成接着激活 Iκ 的成员 kinase 建筑群; B kinase (IKK ) 。Ubiquitination 是一个高度有活力的过程并且被 deubiquitinases 平衡劈开 polyubiquitin 链并且终止下游地发信号的事件。A20 deubiquitinase 是 NF-κ 的一个批评否定管理者; B 和发炎,后来 A20 缺乏的老鼠开发不受管束、自发的多器官发炎。而且,在 A20 genomic 地点的特定的多型性预先安排人到自体免疫的疾病。最近的研究也显示 A20 是在 B 房间淋巴瘤被使失去活性的重要肿瘤 suppressor。因此,指向 A20 可以为自体免疫的疾病和淋巴瘤形成新奇治疗的基础。 | Noula Shembade Edward W Harhaj | 2012 | Cellular & Molecular Immunology2012，9，2： | 22 |
| 2 | Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses显示文摘 | Renfang Mao Riyun Yang Xia Chen Edward W Harhaj Xiaoying Wang Yihui Fan | 2017 | Cellular & Molecular Immunology2017，14，5： | 3 |
| 3 | Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses显示文摘被 oncogenic 病毒与感染在 15% 人的癌症和 20% 之间联系。包括 HPV, HBV, HCV 和 HTLV-1, Oncogenic 病毒指向线粒体影响房间增长和幸存。Oncogenic 病毒的基因产品也触发能得到氧化 DNA 损坏并且加强的反应的氧种类的生产 oncogenic 主人发信号小径。病毒的 oncogenes 可以也破坏象 mitophagy 和新陈代谢的改编小径那样的线粒体质量控制机制支持病毒复制。这里,我们将在病毒的 oncogenesis 在 mitophagy 和新陈代谢的改编和他们的角色的病毒的规定上考察最近的进步。 | Young Bong CHOI Edward William HARHAJ | 2014 | Frontiers in Biology2014，9，6： | 2 |
| 4 | The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling显示文摘 | Soratree Charoenthongtrakul Linlin Gao Edward W Harhaj | 2012 | Cellular & Molecular Immunology2012，9，6： | 2 |
| 5 | VEGF activation of protein kinase C stimu- lates occludin phosphorylation and contributes to endothelial permeability显示文摘 | Harhaj NS Felinski EA Wolpert EB Stmdstrom JM Gardner TW Antonetti DA | 2006 | Invest Ophthalmol Vis Sci2006，47，11： | 1 |
| 6 | Regulation of tight junctions and loss of barrier function in pathophysiology显示文摘 | Harhaj NS Antonetti DA | 2004 | Int J Biochem Cell Biol2004，36，7： | 1 |
| 7 | Regulation of NF-κB by deuhiquiti-nases显示文摘 | Harhaj EW Dixit VM | 2012 | Immunol Rev2012，246，1： | 1 |
| 8 | Role of post-translational modifications of HTLV-1 Tax in NF-κB activation显示文摘Human T-cell leukemia virus type 1(HTLV-1),the first human retrovirus discovered,is the etiological agent of adult-T-cell leukemia/lymphoma.The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB(NF-κB).Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T cells.In this review,we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation,with an emphasis on post-translational modifications of Tax. | Noula Shembade Edward W Harhaj | 2010 | World Journal of Biological Chemistry2010，1，1： | 1 |
| 9 | Regulation of tight junctions and loss of barrier function in pathophysiology显示文摘 | Nicole S Harhaj David A Antonetti | 2003 | International Journal of Biochemistry and Cell Biology2003，，7： | 1 |
| 10 | VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability显示文摘 | Harhaj NS Felinski EA Wolpert EB | 2006 | Invest Ophthalmol Vis Sci2006，47，11： | 1 |
| 11 | Human T cell leukemia virus type 1 - induce disease: pathway to cancer and neurodegeneration 显示文摘 | Barmark K Harhaj E Grant C | 2003 | Virology2003，308，1： | 1 |
| 12 | Inhibition of NF-kappaBsignaling by A20 through disruption of ubiquitin enzymecomplexes 显示文摘 | Shembade N Ma A Harhaj EW | 2010 | Science2010，327，： | 1 |
| 13 | Regulation of tight junctions and loss of barrier function in pathophysiology 显示文摘 | Harhaj NS Antonetti DA | 2004 | Int J Biochem Cell Biol2004，36，7： | 1 |
| 14 | Regulation of tight junctions and loss of barrier function in pathophysiology显示文摘 | HARHAJ N S ANTONETTI D A | 2004 | The International Journal of Biochemistry & Cell Biology2004，36，： | 1 |
| 15 | Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway显示文摘 | Harhaj EW Harhaj NS Grant C | 2005 | Virology2005，333，1： | 1 |
| 16 | Regulation of tight junctions and loss of barrier function in pathophysiology 显示文摘 | Harhaj NS Antonetti DA | 2004 | Inter- national Journal of Biochemistry & Cell Biology2004，36，7： | 1 |
| 17 | Regulation of tight junctions and loss of barrier function in pathophysiology 显示文摘 | Harhaj NS Antonetti DA | 2004 | Int J Biochem Cell Biol2004，36，7： | 1 |
| 18 | Regulation of tight junctions and loss of barrier function in pathophysiology显示文摘 | Harhaj N S Antonetti D A | 2004 | Int J Biochem Cell Biol2004，36，7： | 1 |
| 19 | A20 inhibition of NFKB and inflammation 显示文摘 | Shembade N Harhaj E | 2010 | Cell Cycle2010，9，13： | 1 |
| 20 | Mechanisms of persistent NF-kappaB activation by HTLV-Ⅰ tax显示文摘 | Harhaj E W Harhaj N S | 2005 | IU BMB Life2005，57，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员