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| 1 | Exercise and gut microbiota: clinical implications for the feasibility of Tai Chi显示文摘Recent studies have shown exercise is associated with changes in the gut microbiota in humans as well as in experimental animals. Tai Chi is an exercise that integrates a martial art, deep breathing and mediation, and has various beneficial effects for health. This review summarizes current knowledge and recent literature on the association between exercise and gut microbiota, and explores the feasibility of Tai Chi for improving gut microbiota composition and function. Pub Med/MEDLINE was used to search the English literature for the keywords exercise and gut microbiota. Fourteen relevant studies were identified. In humans, exercise increases the gut microbial diversity. However, the evidence for this association is weak, as previous studies were small-scale, non-controlled studies of short duration or cross-sectional design. In animals, exercise alters the composition of gut microbiota, with some studies suggesting exercise increases the Bacteroidetes/Firmicutes ratio. However, these results are controversial, partly because host genetics and physical fitness also influence gut microbiota. Furthermore, the intensity of exercise may play a key role in how exercise affects gut microbiota. Tai Chi is a moderate-intensity exercise that improves immune function and inflammation of the gut. Tai Chi may also affect gut microbiota through vagal modulation and mediating the hypothalamic-pituitary-adrenal axis. However, no studies have investigated the association between Tai Chi and gut microbiota. Well designed studies exploring the effects of Tai Chi on gut microbiota are needed. | Hidetaka Hamasaki | 2017 | Journal of Integrative Medicine2017，15，4： | 13 |
| 2 | 红细胞的功能及血液保存显示文摘红细胞无核,糖酵解是红细胞产能的唯一途径.红细胞非常柔软且循环快,能很快通过毛细管运送氧到全身,一个细胞通过肺部毛细管只需大约千分之一秒的时间.不同种属的红细胞寿命不同,然而,猫、狗、人类通过心脏往复循环的红细胞数量事实上是相等的,约2×105.细胞死亡的信号大概来自于细胞膜的改变,如:累积的损害使膜脆性增加;抗原暴露后结合免疫球蛋白,使红细胞被巨噬细胞吞噬.红细胞能在液态保存相对较长时间.1940年代建立的血液保存方法仍在沿用.但是,由于没有侧重于红细胞在保存期的功能,所以,输血后的存活率及携氧能力均下降,因此,开展更有效的血液贮存方法是十分必要的.本文描述了红细胞的携氧作用以及评估保存红细胞携氧量的方法,讨论增加保存的红细胞较之新鲜血液(活性红细胞)有较高水平携氧量的可能性. | Naotaka Hamasaki Masaki Yamamoto 张晓寒 唐银海 | 2001 | 国外医学(输血及血液学分册)2001，24，6： | 3 |
| 3 | Causative anti-diabetic drugs and the underlying clinical factors for hypoglycemia in patients with diabetes显示文摘Recent clinical trials indicated that the intensive glycemic control do not reduce cardiovascular disease mortality among diabetic patients, challenging a significance of the strict glycemic control in diabetes management. Furthermore, retrospective analysis of the Action to Control Cardiovascular Risk in Diabetes study demonstrated a significant association betweenhypoglycemia and mortality. Here, we systematically reviewed the drug-induced hypoglycemia, and also the underlying clinical factors for hypoglycemia in patients with diabetes. The sulfonylurea use is significantly associated with severe hypoglycemia in patients with type 2 diabetes. The use of biguanide(approximately 45%-76%) and thiazolidinediones(approximately 15%-34%) are also highly associated with the development of severe hypoglycemia. In patients treated with insulin, the intensified insulin therapy is more frequently associated with severe hypoglycemia than the conventional insulin therapy and continuous subcutaneous insulin infusion. Among the underlying clinical factors for development of severe hypoglycemia, low socioeconomic status, aging, longer duration of diabetes, high Hb A1 c and low body mass index, comorbidities are precipitating factors for severe hypoglycemia. Poor cognitive and mental functions are also associated with severe hypoglycemia. | Hidekatsu Yanai Hiroki Adachi Hisayuki Katsuyama Sumie Moriyama Hidetaka Hamasaki Akahito Sako | 2015 | World Journal of Diabetes2015，6，1： | 3 |
| 4 | Daily physical activity and type 2 diabetes: A review显示文摘Physical activity improves glycemic control and reduces the risk of cardiovascular disease(CVD) and mortality in patients with type 2 diabetes(T2D). Moderate to vigorous physical activity is recommended to manage T2D; however, patients with T2D can be physically weak, making it difficult to engage in the recommended levels of physical activity. Daily physical activity includes various activities performed during both occupational and leisure time such as walking, gardening, and housework that type 2 diabetic patients should be able to perform without considerable physical burden. This review focuses on the association between daily physical activity and T2D. Walking was the most common form of daily physical activity, with numerous studies demonstrating its beneficial effects on reducing the risk of T2D, CVD, and mortality. Walking for at least 30 min per day was shown to reduce the risk of T2D by approximately 50%. Additionally, walking was associated with a reduction in mortality. In contrast, evidence was extremely limited regarding other daily physical activities such as gardening and housework in patients with T2D. Recent studies have suggested daily physical activity, including non-exercise activity thermogenesis, to be favorably associated with metabolic risks and mortality. However, well-designed longitudinal studies are warranted to elucidate its effects on overall health. | Hidetaka Hamasaki | 2016 | World Journal of Diabetes2016，7，12： | 3 |
| 5 | Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma显示文摘 | Kiyoshi Migita Seiji Miyazoe Yumi Maeda Manabu Daikoku Seigo Abiru Tshihito Ueki Koji Yano Shinya Nagaoka Takehiro Matsumoto Kazuhiko Nakao Keisuke Hamasaki Hiroshi Yatsuhashi Hiromi Ishibashi Katsumi Eguchi | 2004 | Journal of Hepatology2004，，4： | 3 |
| 6 | Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus显示文摘 | Seiji Miyazoe Keisuke Hamasaki Keisuke Nakata Yuji Kajiya Kayo Kitajima Kazuhiko Nakao Manabu Daikoku Hiroshi Yatsuhashi Michiaki Koga Michitami Yano Katsumi Eguchi | 2002 | The American Journal of Gastroenterology2002，，8： | 3 |
| 7 | Sulfonylurea and glinide reduce insulin content, functional expression of K ATP channels, and accelerate apoptotic β-cell death in the chronic phase显示文摘 | Akira Takahashi Kazuaki Nagashima Akihiro Hamasaki Naomitsu Kuwamura Yukiko Kawasaki Hiroki Ikeda Yuichiro Yamada Nobuya Inagaki Yutaka Seino | 2007 | Diabetes Research and Clinical Practice2007，，3： | 2 |
| 8 | Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction显示文摘 | Yasuhiko Sakata Daisaku Nakatani Masahiko Shimizu Shinichiro Suna Masaya Usami Sen Matsumoto Masahiko Hara Satoru Sumitsuji Shigeo Kawano Katsuomi Iwakura Toshimitsu Hamasaki Hiroshi Sato Shinsuke Nanto Masatsugu Hori Issei Komuro | 2011 | Journal of Cardiology2011，，： | 2 |
| 9 | Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction显示文摘 | Al Suwaidi J Hamasaki S Higano ST | 2000 | Circulation2000，101，： | 1 |
| 10 | Cyelosporine and steroid therapy in children with steroid-resistant nephrotie syndrome显示文摘 | Hamasaki Y Yoshikawa N Hattori S | 2009 | Pediatr Nephrol2009，24，11： | 1 |
| 11 | Advanced multi- channel audio systems with superior impression of presence and reality 显示文摘 | K Hamasaki K Hiyama | 2004 | AES ll6th Convention Berlin Germany2004，6053，： | 1 |
| 12 | Activated protein C anticoagu- lant system dysfunction and thrombophilia in Asia显示文摘 | Hamasaki N Kuma H Tsuda H | 2013 | Ann Lab Med2013，33，1： | 1 |
| 13 | Study on the reproduction and development of the swimming crab, Portunus trituberculatus 显示文摘 | Hamasaki K | 1996 | Special Scientific Report of Japan Sea-Farming Association1996，8，： | 1 |
| 14 | Apoptosis and cycle asaociated gene expression profiling of histiocytic necrotizing lymphadenitis显示文摘 | Ohshima K Karub K Hamasaki M | | Eur J Haematol0，72，5： | 1 |
| 15 | A 3 - di-mensional computed tomographic procedure for planning retrosigrnoid craniotomy 显示文摘 | HAMASAKI T MORIOKA M NAKAMURA H | 2009 | Neurosurgery2009，64，52： | 1 |
| 16 | Variability in toxicity of the dinoflagellate Alexandrium tamarense isolated from Hiroshima Bay,western Japan,as a reflection of changing environmental conditions显示文摘 | Hamasaki K Horie M Tokimitsu A | 2001 | J Plank Res2001，23，： | 1 |
| 17 | Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase - dependent and - independent apoptosis 显示文摘 | Ishitsuka K Hideshima T Hamasaki M | 2005 | Blood2005，106，5： | 1 |
| 18 | Preparation of TiO2 hollow-fibers using suprarnolecular assemblies 显示文摘 | KOBAYASHI S HANABUSA K HAMASAKI N | 2000 | Chemistry of Materials2000，12，6： | 1 |
| 19 | Important points for newly revised Japanese pediatric guideline for treatment and management of asthma (JPGL) 2012显示文摘 | Hamasaki Y | | 0，，06： | 1 |
| 20 | Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction 显示文摘 | Suwaidi JA Hamasaki S Higano ST | 2000 | Circulation2000，101，9： | 1 |
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