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| 1 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 2 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 4 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 5 | Estimating the Global Public Health Implications of Electricity and Coal Consumption显示文摘 | Gohlke Julia M Thomas Reuben Woodward Alistair Campbell-Lendrum Diarmid Prüss-üstün Annette Hales Simon Portier Christopher J | 2011 | Environmental Health Perspectives2011，，6： | 2 |
| 6 | Ultrasonic attenuation in voided fibre - reinforced plastics显示文摘 | Hale J M Ashton J N | 1988 | NDT International1988，21，5： | 1 |
| 7 | Predictors of hospital outcome and intubation in COPD patients admitted to the respiratory ICU for acute hypercapnic respiratory failurel显示文摘 | Irfan Ucgun M uzaffer M etintas Hale Moral | 2008 | Respiratory Medicine2008，10，2： | 1 |
| 8 | Coherent laser radar at 2μm using solid-state lasers显示文摘 | HENDERSON S W SUNI P J M HALE C P | 1993 | IEEE Transactions on Geoscience and Remote Sensing1993，31，1： | 1 |
| 9 | Performance characterization of a hybrid STAP architecture incorporating elevation interferometry显示文摘 | Hale T Temple M Wicks M Raquet J Oxley M | 2002 | IEE Part-F2002，149，2： | 1 |
| 10 | An autophagy-enhancing drug promotes degradation of mutant alphal-antitrypsin Z and reduces hepatic fibrosis显示文摘 | Hidvegi T Ewing M Hale P | 2010 | Science2010，329，： | 1 |
| 11 | Logistic regression for geologically constrained mapping of gold potential,Baguio district显示文摘 | Carranza E J M Hale M | | 0，，03： | 1 |
| 12 | Interplay between active chromatin marks and RNA- directed DNA methylation in Arabidopsis thaliana 显示文摘 | GREENBERG M V DELERIS A HALE C J | 2013 | PLoS Genet2013，9，10： | 1 |
| 13 | Zinc alpha-2-gly- coprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer 显示文摘 | Hale L P Price D T Sanchez L M | 2001 | Clin Cancer Res2001，7，4： | 1 |
| 14 | DetaiLed polybrominated diphenyl ether(PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures显示文摘 | LA A G M J HALE R C HARVEY E | 2006 | Environ Sci Technol2006，40，： | 1 |
| 15 | A predictive GIS model for mapping potential gold and base metal mineralization in Takab area, Iran 显示文摘 | Asadi H H Hale M | 2001 | Computers & Geosciences2001，27，8： | 1 |
| 16 | Practical joint domain localized adaptive processing in homogeneous and nonhomogeneous environments显示文摘 | Adve R S Hale T E Wicks M C | 2000 | IEE Proc Radar Sonar Navigation2000，11，2： | 1 |
| 17 | Where are Porphyry Copper Deposits Spatially Localized? A Case Study in Benguet Province,Philippines显示文摘 | Carranza E G M Hale M | 2002 | Natural Resources Research2002，11，1： | 1 |
| 18 | Magnetic domain observation by electron microscopy显示文摘 | Hale M E Fuller H W Rubinstein H | 1959 | J Appl Phys1959，30，： | 1 |
| 19 | Coronary cycle flow variations' ische mic' myocardium显示文摘 | Qvizi M Kloner RA Hales SL | 1992 | Circulation1992，85，： | 1 |
| 20 | TGFβ induces morphological and molecular changes similar to human anterior subcapsular cataract显示文摘 | Lovicu F J Schulz M W Hales A M | 2002 | Br J Ophthalmol2002，86，2： | 1 |
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