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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | Cholesteryl ester storage disease: Review of the findings in 135 reported patients with an underdiagnosed disease显示文摘 | Donna L. Bernstein Helena Hülkova Martin G. Bialer Robert J. Desnick | 2013 | Journal of Hepatology2013，，6： | 2 |
| 4 | Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein,myelin basic protein and neuron-specific enolase from glia or neurones显示文摘 | Steiner J Bielau H Bernstein HG | 2006 | J Neurol Neurosurg Psychiatry2006，77，11： | 1 |
| 5 | The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus显示文摘 | Schnitzler D Bernstein F Muller H | 1993 | J GenVirol1993，74，： | 1 |
| 6 | DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways:fail-safe protection against carcinogenesis显示文摘 | Bernstein C Bernstein H Payne CM | 2002 | Mutat Res2002，511，2： | 1 |
| 7 | Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County显示文摘 | Shimizu H Ross RK Bernstein L | 1991 | Br J Cancer1991，63，6： | 1 |
| 8 | Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis显示文摘 | Wen W H Bernstein L Lescallett J | 2000 | Cancer Res2000，60，10： | 1 |
| 9 | The health effects of non-industrial indoor air pollution 显示文摘 | BERNSTEIN J A ALEXIS N BACCHUS H | 2008 | J Allergy Clin Immunol2008，121，3： | 1 |
| 10 | Boredom and the ready-made life显示文摘 | Bernstein H E | 1975 | Sociological Research1975，，42： | 1 |
| 11 | Multicenter phase Ⅱ study of bortezomib in patients with relapsed or refractory mantle cell lymphoma显示文摘 | FISHER R I BERNSTEIN S H KAHL B S | 2006 | J Clin Oncol2006，24，： | 1 |
| 12 | Rule based expert systems for network management and operations:an introduction显示文摘 | R N Cronk P H Callan L Bernstein | 1993 | IEEE Network1993，，： | 1 |
| 13 | Ewing's sarcoma family of tumors:current management显示文摘 | Bernstein M Kovar H Paulussen M | 2006 | Oncologist2006，11，5： | 1 |
| 14 | Role of Helicobacer pylori CagA+ strains and risk of adenocarcinoma of the stomath and esophagus显示文摘 | Wu A H Crabtree J E Bernstein L | 2003 | Int J Cancer2003，103，6： | 1 |
| 15 | Agricultura'lModernization'and the Era of Structural Adjustment:Observations on Sub-Saharan Africa显示文摘 | Bernstein H | 1990 | The Journal of Peasant Studies1990，，1： | 1 |
| 16 | Laparoscopic management o{ congenital seminal vesicle cysts associated with ipsilateral renal agenesis显示文摘 | Cherullo E E Meraney A M Bernstein L H | 2002 | J Urol2002，167，3： | 1 |
| 17 | Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperldoltreated schizophrenics and a rat model of schizophrenia 显示文摘 | BERNSTEIN H G LENDECKEL U DOBROWOLNY H | 2008 | Psychoneuroendocrinology2008，33，3： | 1 |
| 18 | Active genes are tri-methylated at K4 of histone H3显示文摘 | SANTOS-ROSA H SCHNEIDER R BANNISTER A J SHERRIFF J BERNSTEIN B E | 2002 | Nature2002，419，6905： | 1 |
| 19 | Evidence for a wide extra?astrocytic distribution of S100B in human brain 显示文摘 | Steiner J Bernstein HG Bielau H | 2007 | BMC Neurosci2007，2，8： | 1 |
| 20 | Direct measurement and characterization of active photosynthesis zones inside wastewater re- mediating and biofuel producing microalgal biofilm 显示文摘 | Bernstein H C Kesaano M Moll K | 2014 | Bioresour Technol2014，156，： | 1 |
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