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| 1 | Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration显示文摘Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil(TEO) on hydrogen peroxide(H_2O_2)-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low(LD; 100 μmol/L) and high doses(HD;1 mmol/L) of H_2O_2 in the presence or absence of TEO(180 mg/kg). Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H_2O_2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO_2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H_2O_2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H_2O_2 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties. | Guesmi Fatma Amit K Tyagi Bellamine Houda Landoulsi Ahmed | 2016 | Biomedical and Environmental Sciences2016，29，9： | 3 |
| 2 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 3 | Investigation of Extracts from Tunisian Ethnomedicinal Plants as Antioxidants,Cytotoxins,and Antimicrobials显示文摘Objective To determine the medicinal potential of various plants and their parts extracted with different solvents. Methods The total phenolic content of acetonitrile/water(60%-40%)(ACN/W) and aqueous(W) extract fractions was determined by high-performance liquid chromatography(HPLC), and terpenic compounds were detected by gas chromatography/mass spectrometry(GC/MS). Antioxidant activity of the samples was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) assay and β-carotene bleaching method. Cell viability was investigated by thiazolyl blue tetrazolium bromide [3-(4,5-dimethylthiazol)-2-yl 2,5-diphenyltetrazolium bromide](MTT) assay. The mechanisms involved in cytotoxic activity were investigated in a murine macrophage cell line(RAW 264.7) and cancer lines. Results Our findings show that 11 plant species exhibited biological activity. In addition, moderate antibacterial activity was reported against one or more of the tested bacterial strains at two concentrations: 300 μg and 3 mg/disc. Furthermore, our data reveal that among all plants investigated, some extract and hydrophobic fractions were potent scavengers of the DPPH radical(6.78 μg/m L < EC50 < 8.55 μg/mL). Taken together, our results show that Nerium oleander(NOACN/W) and Pituranthos tortuosus(PTACN/W) were highly cytotoxic against RAW 264.7 cells with IC80 values of 0.36, and 1.55 μg/mL, respectively. In contrast, murine macrophage cell lines had low growth and were significantly sensitive to water extracts of Thymus hirtus sp. algeriensis(THW), Lavandula multifida(LMW), and ACN/W extract of Erica multiflora(EMACN/W) at doses > 400, 47.20, and 116.74 μg/m L, respectively. The current work demonstrates that RAW 264.7 cell proliferation was inhibited by samples in a dose-dependent manner. Conclusion Our findings, validated through free radical scavenging activity, agar diffusion assay, and cytotoxicity of essential oils towards cancer cells, show that ethnomedicinal plants used in this work have a novel application as a tumor suppressor. | Guesmi Fatma Ben Hadj Ahmed Sami Landoulsi Ahmed | 2017 | Biomedical and Environmental Sciences2017，30，11： | 2 |
| 4 | Select ivity of anion exchange membrane modified with polyethylene imine显示文摘 | F Guesmi Ch Hannachi B Ham rouni | 2012 | Ionics2012，18，： | 1 |
| 5 | Dysembryo plastic neuroepithelial tumors, report of 8 cases including two with unusual loealization显示文摘 | Guesmi H Houtteville J P Courtheoux P | 1999 | Neurochirurgie1999，45，19： | 1 |
| 6 | Chromium oxide species supported on silica: a representative periodic DFT model显示文摘 | Guesmi H Tielens F | 2012 | The Journal of Physical Chemistry C2012，116，1： | 1 |
| 7 | Smart wireless sensor networks for online fauhs diagnosis in induction machine 显示文摘 | GUESMI H | 2015 | Computers and Electrical Engineering2015，41，： | 1 |
| 8 | Pancreatic pseudocysts located in the liver: a systematic review of the literature显示文摘 | Guesmi F Zoghlami A Saidi Y | 2009 | Tunis Med2009，87，12： | 1 |
| 9 | Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart 显示文摘 | MOKNI M HAMLAOUI- GUESMI S AMRIi M | 2012 | Cardiovascular Toxicology2012，12，2： | 1 |
| 10 | Relevance of CT and MRIin retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological eomparison显示文摘 | Brisse HJ Guesmi M Aerts I | 2007 | Pediatr Radiol2007，37，： | 1 |
| 11 | Ultrasonic prepa- ration of cationic cotton and its application in ultrasonic natural dyeing显示文摘 | GUESMI A LADHARI N SAKLI F | 2013 | Ultrasonics sonochemistry2013，20，1： | 1 |
| 12 | New approach to solve multiobjective environmental/economic dispatch 显示文摘 | Guesmi T Abdallah H H Toumi A | 2006 | Journal ofElectricalSystems2006，2，2： | 1 |
| 13 | Control of nonlinear phenomena in DC-DC converters:Fuzzy logic approach显示文摘 | GUESMI K HAMZAOUI A ZAYTOON J | 2008 | International Journal of Circuit Theory and Applications2008，36，： | 1 |
| 14 | Hydrocadom,clasti bacteria isolated from petroleum contaminated sites in Tunisia: iso- lation, identification and characterization of the biotechnologi al po- tential显示文摘 | Mahjoubi M Jaouani A Guesmi A | 2013 | N Biotechnol2013，30，6： | 1 |
| 15 | Isolation, identification and dyeing studies of betanin on modified acrylic fabrics显示文摘 | GUESMI A HAMADI N B LADHARI N | | 0，，37： | 1 |
| 16 | Ultrasonic preparation of cationic cotton and its application in ulWasonic natural dyeing显示文摘 | Guesmi A Ladhari N Sakli F | 2013 | Ultrasonics Sonochemistry2013，20，1： | 1 |
| 17 | Shifting nonlinear phenomena in a DC-DC converter using a fuzzy logic controller显示文摘 | Guesmi K Essounbouli N Hamzaoui A | 2008 | Mathematics and Computers in Simulation2008，76，： | 1 |
| 18 | Modification of the AMX membrane surface: Temperature dependence of anion exchange equilibrium 显示文摘 | Guesmi Fatma Hannachi Chiraz | 2013 | Journal of Chemical Engineering2013，91，8： | 1 |
| 19 | Sonicator dyeing of modified acrylic fabrics with indicaxanthin natural dye显示文摘 | GUESMI A HAMADI N B LADHARI N | | 0，，42： | 1 |
| 20 | Hydrocarbonoclastic bacteria isolated from petroleum contaminated sites in Tunisia: isolation, identification and characterization of the biotechnological potential 显示文摘 | Mahjoubi M Jaouani A Guesmi A Ben Amor S Jouini A Cherif H Najjari A Boudabous A Koubaa N Cherif A | 2013 | New Biotechnol2013，30，6： | 1 |
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