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79篇 您的检索式:作者名="Gillessen"
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1Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma显示文摘AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible.Hans-Udo Kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen 2009World Journal of Gastroenterology2009,15,40:8
2显示文摘Scandella E Men Y Gillessen S 2002Blood2002,100,4:1
3Metastatic hone pain treatment options with an emphasis on bisphosphonates 显示文摘von - Moos R Strasser F Gillessen S 2008Support Care Cancer2008,16,10:1
4Efects of propofol on N-methyl-D-aspartatereceptor-mediated calcium increase in cultured rat cerebrocorticalneurons显示文摘Grasshoff C Gillessen T 2005Eur J Anaesthesiol2005,22,6:1
5Excitatory amino acid neurotoxitcity显示文摘Gillessen T Budd Sl Lipton SA 2002Adv Exp Med Biol2002,513,:1
6Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand显示文摘Mach N Gillessen S Wilson B 2000Cancer Res2000,60,:1
7Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells显示文摘 Men Y Gillessen S 2002Blood2002,100,:1
8Mitochondrial permea-bility transition can be directly monitored in living neurons显示文摘Gillessen T Grasshoff C Szinicz L 2002Biomed Pharmacother2002,56,4:1
9Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells 显示文摘Scandella E Men Y Gillessen S 2002Blood2002,100,4:1
10Efects of propofol on N-methyl-D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons显示文摘Grasshoff C Gillessen T 2005Eur J Anaesthesiol2005,22,6:1
11Prosta- glandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells 显示文摘SCANDELLA E MEN Y GILLESSEN S 2002Blood2002,100,4:1
12Activity of pemetrexed against brain metastases in a patient with adenocarcinoma of the lung显示文摘Omlin A D 'addario G Gillessen S 2009Lung Cancer2009,65,3:1
13Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy显示文摘Omlin A Pezaro C Gillessen SS 2014Ther Adv Urol2014,6,1:1
14Intermediate states in the precipitation of hydroxyapatite显示文摘Eanes E D Gillessen I H Posner A S 1965Nature1965,208,5008:1
15Gastric cancer in pregnancy:do pregnancy,age or female sexalter the prognosis?Case reports and review显示文摘Jaspers VK Gillessen A Quakernack K 1999Eur J Obstet Gynecol Reprod Biol1999,87,:1
16Activity of pemetrexed against brain metastases in a patient with adenocarcinoma of the lung显示文摘Omlin A D'Addario G Gillessen S 2009Lung Cancer2009,65,3:1
17Excitatory amino acid neurotoxicity显示文摘Gillessen T Budd SL Lipton SA 2002Adv Exp Med Biol2002,513,:1
18CDld-restricted T cells regulate dendritic cell function and antitumor mmunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion 显示文摘Gillessen S Naumov YN Nieuwenhuis EES 2003Proc Natl Acad Sci U S A2003,100,15:1
19Gastric Cancer in Pregnancy: Do Pregnancy,Age or Female Sex Aher Prognosis? Case Reports and Reriew显示文摘Jaspers V K Gillessen A 1999Eur J obster Gynecol Reprod Biol1999,871,:1
20The effect of acetylcholinesterase- inhibition on depolarization-induced GABA release from rat striatal slices 显示文摘GRASSHOFF C GILLESSEN T THIERMANN H 2003Toxicol2003,184,23:1
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