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| 1 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 2 | Addition of brain infarction to the ABCD2 score ( ABCD2-I ): a collaborative analysis of unpublished data on 4574 patients 显示文摘 | Giles MF Albers GW Amarenco P | 2010 | Stroke2010，41，9： | 1 |
| 3 | Injection mixing system for boomless,target-activated herbicide spraying显示文摘 | GILLIS K P GILES D K SLAUGHTER D C | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 4 | Deranged liver blood flow patterns in the detection of liver metastases显示文摘 | Leveson S H Wiggins P H Giles G R | 1985 | Br J Surg1985，72，2： | 1 |
| 5 | A simple score (ABCD) to identify individuals at high early risk of stroke after transient isehaemic attack显示文摘 | Rothwell P M Giles M F Flossmann E | 2005 | Lancet2005，366，9479： | 1 |
| 6 | Foreland basin systems显示文摘 | Decelles P G Giles K A | 1996 | Basin Research1996，8，2： | 1 |
| 7 | Change in stroke incidence, mortality, case - fatality, severity, and risk fac- tors in Oxfordshire, UK from 1981 to 2004( Oxford Vascular Study) 显示文摘 | ROTHWELL P M COULL A J GILES M F | 2004 | Lancet2004，363，9425： | 1 |
| 8 | Phase 1 study of lowdoseprolonged xposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (dexycytidine) in hematopoietic malignancies显示文摘 | Issa J P Garcia-Manero G Giles F J | 2004 | Blood2004，103，： | 1 |
| 9 | Synthesis of the Proterozoic evolution of theMt Isa Inlier显示文摘 | Betts P G Giles D | 2006 | Australian Journal of Earth Sciences2006，53，： | 1 |
| 10 | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack显示文摘 | Rothwell P M Giles M F Flossmann E | | 0，，9479： | 1 |
| 11 | Injection mixing system for boomless, target-activated herbicide herbicide spraying显示文摘 | GILLIS K P GILES D K SLAUGHTER D C | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 12 | Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores显示文摘 | Giles M F Rothwell P M | 2010 | Stroke2010，41，4： | 1 |
| 13 | Addition of brain infarction to the ABCD2 Score (ABCD2-I):a collaborative analysis of unpublished data on 4574 patients显示文摘 | Giles MF Albers GW Amarenco P | | Stroke0，，： | 1 |
| 14 | A simple score(ABCD)to identify individuals at high early risk of stroke after transient ischaemic attack显示文摘 | Rothwell P Giles M Flossmann E | 2005 | The Lancet2005，366，9479： | 1 |
| 15 | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack显示文摘 | Rothwell P M Giles M F Flossmann E | 2005 | Lancet2005，366，： | 1 |
| 16 | Computerized patient anesthesia ecords: less time and better quality than manually produced anesthesia records显示文摘 | Deshane P Giles C | 1993 | J Clin Anesth1993，5，4： | 1 |
| 17 | Obesity and cardiovascular disease:pathophysiology,evaluation,and effect of weight loss显示文摘 | Poirier P Giles TD Bray GA | | 0，，05： | 1 |
| 18 | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack显示文摘 | Rothwell P M Giles M F Flossmann E | | 0，，： | 1 |
| 19 | Foreland basin systems显示文摘 | DeCelles P G Giles K A | 1996 | Basin Research1996，8，： | 1 |
| 20 | Addition of brain infarctionto the ABCD2 Score:a collaborative analysis of unpublished dataon 4574 patients显示文摘 | Giles MF Albers GW Amarenco P | 2010 | Stroke2010，41，9： | 1 |
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