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| 1 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 2 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 3 | Ultrasonography screening in 96, 278 unselected employees 显示文摘 | Reiners C Wegscheider K Schicha H Prevalence of thyroid disorders in the working population of Germany | 2004 | Thyroid2004，14，11： | 1 |
| 4 | Pivotal advances:high-mobility group box 1 protein-a cytokine with a role in cardiac repair显示文摘 | Germani A Limana F Capogrossi M C | 2007 | J Leukoc Biol2007，81，1： | 1 |
| 5 | A new approach to state observation of nonlinear systems with delayed output 显示文摘 | GERMANI A MANES C PEPE P | 2002 | IEEE Trans Autom Control2002，47，1： | 1 |
| 6 | Effect of sugars, lipids and type of starch on the modeand kinetics of retrogradation of concentrated com starchgels显示文摘 | GERMANI R’ CIACCO C F RODRIGUEZ-AMAYAD B | 1983 | Starch-Starke1983，35，11： | 1 |
| 7 | A new approach to state observation of nonlinear systems with delayed output显示文摘 | GERMANI A MANES C PEPE P | 2001 | IEEE Trans on Automatic Control2001，46，7： | 1 |
| 8 | Effect of sugars, lipids and type of starch on the mode and kinetics of retrogradation of concentrated corn starch gels显示文摘 | Germani R Ciacco C F | 1983 | Starch1983，35，11： | 1 |
| 9 | A new approach to state observation of nonlinear systems with delayed output 显示文摘 | Germani A Manes C Pepe P | 2002 | IEEE Transaction on Automatic Control2002，47，1： | 1 |
| 10 | Effect of Sugars,Lipids and type of starch on the mode and kinetincs of retrogradation of concentrated corn starch gels显示文摘 | Germani R Ciacco C F Rodriguez-Amaya D B | 1983 | Starch/Strke1983，35，11： | 1 |
| 11 | Patenting of research results related to genetic resources from areas beyond national jurisdiction:the crossroads of the law of the sea and intellectual property law 显示文摘 | SALPIN C GERMANI V | 2007 | Review of European Community & International Environmental Law2007，，1： | 1 |
| 12 | New model of inflation with non-minimal derivative coupling of standard model higgs boson to gravity显示文摘 | GERMANI C KEHAGIAS A | 2010 | Phys Rev Lett2010，105，01： | 1 |
| 13 | Platinum/ceria/alumina catalysts on microstructures for carbon monoxide conversion显示文摘 | GERMANI G ALPHONSE P COURTY M SCHUURMAN Y MIRODATOS C | 2005 | Catal Today2005，110，12： | 1 |
| 14 | Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit cell proliferation and differentiation显示文摘 | GERMANI LIMANA F CAPOGROSSI M C | 2005 | Circ Res2005，97，： | 1 |
| 15 | Insulin resistance and Insulin- like growth factors in children with intrauterine growth retardation显示文摘 | Cianfarani S Geremia C Germani D | 2001 | Horm Res2001，5，1： | 1 |
| 16 | DNA damage induce gamma-tubulin-RAD51 nuclear complexes in mammalian cells显示文摘 | Lesca C Germanier M RaynaudMessina B | 2005 | Oncogene2005，24，33： | 1 |
| 17 | Effect of sugars, lipids and type of starch on the mode and kinetics of retrogradation of concentrated corn starch gels 显示文摘 | Germani R Ciacco C F Rodriguez-Amaya D B | 1983 | Starch/StArke1983，35，11： | 1 |
| 18 | Hospital discharge of patients with thyroid carcinoma treated with ^131I显示文摘 | Venencia C D Germanier A G Bustos S R | 2002 | J Nucl Med2002，43，1： | 1 |
| 19 | Influence of opiate tolerance and calcium channel antagonists on the antinociceptive effects of L-arginine and N^G-nitro L-arginine显示文摘 | Contreras E Germany A C onzalez P Norris B | 1997 | Gen Pharmacol1997，28，3： | 1 |
| 20 | Effect of sugars, lipids, and type of starch on the mode and kinetics of retrogradation of concentrated corn starch gels 显示文摘 | Germani R Ciacco C F Rodriguez-Amaya D B | 1983 | Starch/Starke1983，35，11： | 1 |
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