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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Male systemic lupus erythemato- sus in a Latin-American inception cohort of 1214 patients显示文摘 | Garcia MA Marcos JC Marcos AI | 2005 | Lupus2005，14，12： | 1 |
| 3 | Ad- juvant hormonal therapy in perimenopausal patients显示文摘 | Pinto Marn A Ballesteros Garcia AI Izarzugaza Per6n Y | 2011 | Adv T- her2011，28，6： | 1 |
| 4 | Poor ad- herence todietinhemodi anlysis: roIeof anxiety and depression sym Ptoms 显示文摘 | Garcia vaIderrama FW Fajardo C Guevar aR et aI | 2002 | nefroIogia2002，22，3： | 1 |
| 5 | PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation显示文摘 | Lamadrid AI Garcia O Delbos M | 2007 | J Radiat Res (Tokyo)2007，48，1： | 1 |
| 6 | Doubleblind,placebo-controlled study of Alternaria alternata immunotherapy:clinical efficacy and safety显示文摘 | Tabar AI Lizaso MT Garcia BE | 2008 | Pediatr Allergy Immunol2008，19，： | 1 |
| 7 | Double-blind, placebo-controlled study of Alternaria alternata immunotherapy: Clinical efficacy and safety显示文摘 | Tabar AI Lizaso MT Garcia BE Gomez B Echechipia S Aldunate MT | 2008 | Pediatr Allergy Immunol2008，19，1： | 1 |
| 8 | Lack Of association be- tween the MTHFR C677T variant and migraine with aura in an older population:Could selective survival play a role? 显示文摘 | Scher AI Eiriksdottir G Garcia M | 2013 | Cepha- lalgia2013，33，5： | 1 |
| 9 | Multiple infection,recombination and genomic relationships among begomovirus isolates found in cotton and other plants in Pakistan显示文摘 | Sanz AI Fraile A Garcia FA | | 0，，07： | 1 |
| 10 | Male systemic lu- pus erythematosus in a Latin-American inception cohort of 1214 patients显示文摘 | Garcia MA Marcos JC Marcos AI | 2005 | Lupus2005，14，12： | 1 |
| 11 | Double-blind placebo-controlled study of Ahernaria ahernata immunotherapy clinical efficacy and safety显示文摘 | TABAR AI LIZASO MT GARCIA BE | 2008 | Pediatr Allergy Immunol2008，19，1： | 1 |
| 12 | Kainate receptor activation induces mixed lineage kinase - mediated cellular signaling cascades via post - synaptic density protein 95 显示文摘 | Savinainen A Garcia EP Dorow D et aI | 2001 | J Bioi Chern2001，276，11： | 1 |
| 13 | Double-blind comparativestudy of cluster and conventional immunotherapy schedules with Dematophagoides pteronyssinus 显示文摘 | Tabar AI Echechipia S Garcia BE | 2005 | J Allergy Clin Immunol2005，116，1： | 1 |
| 14 | PCR identification of beef, sheep, goat and pork in raw and heat-treated meat mixtures显示文摘 | Rodriguez MA Garcia T Gonzale I et aI | 2004 | J of Food Protection2004，67，： | 1 |
| 15 | Kinetics of phospha- tase activity in organic wastes显示文摘 | Garcia C Herndndez T Costa F et aI | 1993 | Soil Biology and Biochem- istry1993，25，5： | 1 |
| 16 | Risk factors associated with arterial switch operation for transposition of the great arteries显示文摘 | Garcia Hernandez JA Montero Valladares C Martinez Lopez AI | 2005 | Rev Esp Cardiol2005，58，7： | 1 |
| 17 | Allogeneic peripheral blood stem cell transplantation(PBSCT)from HLA-identical sibling donors in children with hematological diseases:a single center pilot study显示文摘 | Benito AI Gonzalez-Vicent M Garcia F | 2001 | Bone Marrow Transplant2001，28，6： | 1 |
| 18 | Influence of concentric left ventricular remodeling on early mortality after aortic valve replacement显示文摘 | Duncan AI Lowe BS Garcia MJ | 2008 | Ann Thorac Surg2008，85，6： | 1 |
| 19 | Characterization of the most odor-active compounds of Iberian ham headspace显示文摘 | Carrapiso AI Ventanas J Garcia C | 2002 | J Agric Food Chem2002，50，： | 1 |
| 20 | HPV geno- typing from invasive cervical cancer in Chile显示文摘 | Roa JC Garcia P Gomez J et aI | 2009 | Intemational Journal of Gynecology and Obstetrics2009，105，2： | 1 |
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