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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 3 | Proteolytic cascade enzymes increase in focal cerebral ischemia in rat显示文摘 | Rosenberg GA Navratil M Barone F | 1996 | Journal of Cerebral Blood Flow and Metabolism1996，16，： | 2 |
| 4 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 5 | The influence of age, relative weight, smoking, and alcohol intake on the reproducibility of a dietary questionnaire 显示文摘 | Colditz GA Willett WC Stampfer M J | 1987 | Int J Epidemiol1987，16，3： | 1 |
| 6 | Congenital choledochal cyst:video-guided laparoscopic treatment显示文摘 | Cerofolini A Rebonato M Bergamaschi G Ferrari C Chiappetta A | 1995 | Surg Laparosc Endosc1995，5，： | 1 |
| 7 | Collagenase-induced intracerebral hemorrhage in rats显示文摘 | Mun-Bryce S Westey M | 1990 | Stroke1990，21，： | 1 |
| 8 | Characterization and kinetic study of carbon-based briquettes for the reduction of NO 显示文摘 | Boyano A Ga'lvez M E La'zaro M J | 2006 | Carbon2006，44，： | 1 |
| 9 | Contrast Induced Nephropathy after Angiography显示文摘 | Stouffer GA Aqrawal M | 2002 | Am J Med Sci2002，323，5： | 1 |
| 10 | Lowest effective trasdermal 17β-estradiol dose for relief of hot flushes in postmenopausal women: a randomized controlled trial 显示文摘 | Bachmann GA Schaefers M Uddin A | 2007 | Obstet Gynecol2007，110，： | 1 |
| 11 | A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling显示文摘 | Rodrigues GA Falasca M Zhang Z | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 12 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 13 | Collagenase-indused intracerebral hemorrhage in rats 显示文摘 | Rosenberg GA Mun-Bryce S Wesley M | 1999 | Stroke1999，21，： | 1 |
| 14 | Collagenase-induced Intracerebral Hemorrhage in Rats显示文摘 | ROSENBERG GA MUN-BRYCE BS WESLEY M | 1990 | Stroke(S0039-2499)1990，21，5： | 1 |
| 15 | Effect of graded doses of ionizing radiation on the human testis显示文摘 | Rowley M J Leach DR Warner GA | 1974 | Radiat Res1974，59，3： | 1 |
| 16 | Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome显示文摘 | Diaz GA Banikazemi M Oishi K | 1999 | Nat Genet1999，22，3： | 1 |
| 17 | Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat显示文摘 | Rosenberg GA Navratil M | 1997 | Neurology1997，48，： | 1 |
| 18 | Meningiomas of the tentorial notch: Surgical anatomy and management显示文摘 | Samii M Carvalho GA Tatagiba M | 1996 | J Neurosurg1996，84，： | 1 |
| 19 | Comparison of accidental and nonaccidental traumatic head iniury in children on noncontrast computed tomography显示文摘 | Tung GA Kumar M Richardson RC | 2006 | Pediatrics2006，118，2： | 1 |
| 20 | miR- 15 and miR-16 induce apoptosis by targeting BCL2 显示文摘 | Cimmino A Calin GA Fabbri M etal | 2005 | Proc Natl Acad Sci USA2005，102，13： | 1 |
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