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| 1 | Weight gain following breast cancer diagnosis: Implication and proposed mechanisms显示文摘Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes andpharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged. | Grace Makari-Judson Barry Braun D Joseph Jerry Wilson C Mertens | 2014 | World Journal of Clinical Oncology2014，5，3： | 8 |
| 2 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 3 | 天然气自热重整模块化流化床膜反应器的测试显示文摘针对燃料电池等行业对分布式高纯度氢气的需求,研发了一种新型模块化流化床膜反应器用于中小规模天然气水蒸汽自热重整制氢。在一个天然气制氢测试平台上对该反应器进行了中试研究,测试了空气引入方式对床层温度均匀性的影响,钯膜组件及催化剂的工作性能,并将反应器尾气成分与平衡态最小自由能模型预测的结果进行了比较。测试结果表明该新型模块化流化床膜反应器适于天然气自热重整制氢。 | 解东来 Adris A M Lim C J Grace J R | 2009 | 太阳能学报2009，30，5： | 6 |
| 4 | 二维导流管喷动床的流动特征显示文摘带导流管的二维喷动床(2-DSBDP)是传统喷动床的改进型式,矩形床内设置的与床同厚的垂直导流管可以控制固体颗粒的循环速率, 同时使下行区中的气固移动床维持平推流. 本文实验测定了不同表观气速、床层高度、固体颗粒与气体入口尺寸时, 二维导流管喷动床的床压降及相应的空隙率,藉以阐述2-DSBDP的流动特征. | 罗保林 Freitas L A P Lim C J Grace J R | 2000 | 化工冶金2000，21，4： | 5 |
| 5 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 6 | Hydrodynamics of spouted and spout-fluidized beds at high temperature 显示文摘 | Ye B Lim C J Grace J R | 1992 | The Canadian Journal of Chemical Engineering1992，70，5： | 2 |
| 7 | Physico-chemical screening of phosphate-removing substrates for use in constructed wetland systems 显示文摘 | DRIZO A FROST C A GRACE J | 1999 | Water Research1999，33，17： | 1 |
| 8 | Significance analysis of microarrays (SAM) offers clues to differences between the genomes of adult philadelphia positive ALL and the lymphoid blast transformation of CML 显示文摘 | Grace C Nacheva EP | 2012 | Cancer Inform2012，11，： | 1 |
| 9 | The effect of cop- per and cadmium on 65 - zinc absorption in zinc - defi- cient and zinc supplemented rats 显示文摘 | Evans G W Grace C I and Hahn C | 1974 | Bioinorg Chem1974，3，11： | 1 |
| 10 | Influence of nitrogen fertiliser application and timing on greenhouse gas emissions from a lychee (Litchi chinensis)orchard in humid subtropical Australia显示文摘 | Rowlings D W Grace P R Scheer C et d | 2013 | Agr Ecosyst Environ2013，179，1： | 1 |
| 11 | Biomass gasification in a circulating fluidized bed显示文摘 | Li X T Grace J R Lim C J | | 0，，02： | 1 |
| 12 | Sequence and spacing of TATA box elements are critical for accurate initiation from the β-phaseolin promoter显示文摘 | GRACE M L CHANDRASEKHARAN M B HALL T C CROWE A J | 2004 | Biological Chemistry2004，279，： | 1 |
| 13 | Broadband Communications from a High-altitude Platform:the European HeliNet Programme显示文摘 | Thornton J Grace D Spillard C | 2001 | Electronics & Communication Engineering Journal2001，6，： | 1 |
| 14 | High Altitude Platforms for Wireless Communications显示文摘 | TOZER T C GRACE D | 2001 | Electronics & Communication Engineering Journal2001，13，3： | 1 |
| 15 | Particle velocity profiles in a circulating fluidized bed riser of square cross-section显示文摘 | Zhou J Grace J R Lim C J | 1995 | Chemical Engineering Science1995，50，2： | 1 |
| 16 | Mierostruetural aspects of the behavior of circulating fluidized beds显示文摘 | Brereton C M H Grace J R | 1993 | Chemical Engineer-ing Science1993，48，14： | 1 |
| 17 | NOD-Like Receptors:Role in Innate Immunity and Inflammatory Disease显示文摘 | Grace C Michael H.Shaw Yun-Gik | | 0，，： | 1 |
| 18 | Equilibrium modeling of gasification:a free energy minimization approach and its application to a circulating fluidized bed coal gasifier显示文摘 | LI X GRACE J R LIM C J | | 0，，02： | 1 |
| 19 | High-altitude platforms for wireless commu- nications显示文摘 | TOZER T C GRACE D | 2001 | Electronic & Communications Engineering Journal2001，13，3： | 1 |
| 20 | The effect of CaO sintering on cyclic CO2 capture in energy systems显示文摘 | Sun P Grace J R Lim C J | 2007 | AIChE Journal2007，53，9： | 1 |
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