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| 1 | The role of endoscopy in the management of hereditary diffuse gastric cancer syndrome显示文摘Hereditary diffuse gastric cancer(HDGC) syndrome is an inherited cancer risk syndrome associated with path-ogenic germline CDH1 variants. Given the high risk for developing diffuse gastric cancer, CDH1 carriers are recommended to undergo prophylactic total gastrectomy for cancer risk reduction. Current guidelines recommend upper endoscopy in CDH1 carriers prior to surgery and then annually for individuals deferring prophylactic total gastrectomy.Management of individuals from HDGC families without CDH1 pathogenic variants remains less clear, and management of families with CDH1 pathogenic variants in the absence of a family history of gastric cancer is particularly problematic at present. Despite adherence to surveillance protocols, endoscopic detection of cancer foci in HDGC is suboptimal and imperfect for facilitating decision-making. Alternative endoscopic modalities, such as chromoendoscopy,endoscopic ultrasound, and other non-white light methods have been utilized,but are of limited utility to further improve cancer detection and risk stratification in HDGC. Herein, we review what is known and what remains unclear about endoscopic surveillance for HDGC, among individuals with and without germline CDH1 pathogenic variants. Ultimately, the use of endoscopy in the management of HDGC remains a challenging arena, but one in which further research to improve surveillance is crucial. | Shria Kumar Jessica M Long Gregory G Ginsberg Bryson W Katona | 2019 | World Journal of Gastroenterology2019，25，23： | 2 |
| 2 | Genetic polymorphism in cy- tochrome P450 2D6 (CYP2D6) :population distribution of CYP2D6 ac- tivity显示文摘 | Neafsey P Ginsberg G Hattis D | 2009 | J Toxicol Environ Health B Crit Rev2009，12，5： | 1 |
| 3 | The T pouch: an orthotopic ileal neobladder incorporating a serosal lined ileal antireflux technique显示文摘 | Stein JP Lieskovsky G Ginsberg DA | 1998 | J Urol1998，159，6： | 1 |
| 4 | Brief report:a scale for rating conversational impairment in autism spectrum disorder显示文摘 | de Villiers J Fine J Ginsberg G | 2007 | J Autism Dev Disord2007，37，7： | 1 |
| 5 | Genetic polymorphism in paraoxonase 1 (PON1) : Population distribution of PON1 ac- tivity显示文摘 | Ginsberg G Neafsey P Hattis D | 2009 | Toxicol Environ Health B Crit Rev2009，12，： | 1 |
| 6 | Further evidence that insulin resistance exists in patients with chemical diabetes显示文摘 | GINSBERG H OLEFSKY J M | 1974 | Diabetes1974，23，7： | 1 |
| 7 | Small-cell lung cancer 显示文摘 | Simon G Ginsberg R J Ruckdeschel JC | 2001 | Chest Surg Clin N Am2001，11，1： | 1 |
| 8 | Percutaneous lumbar dis- cectomy using a as new aspiration probe 显示文摘 | Onik G Helms CA Ginsberg L | 1985 | AJNR Am J1985，6，2： | 1 |
| 9 | Pharmacokinetics of remifentanil in anesthe tized pediatric patients undergoing elective surgery or diagnostic procedures显示文摘 | Ross A K Davis P J Dear Gd G L Ginsberg B McGowan F X Stiller R D | 2001 | Anesth Analg2001，93，： | 1 |
| 10 | Percutaneous lumbar discectomy using a as new aspiration probe显示文摘 | Onik G Helms CA Ginsberg L | 1985 | AJNR Am J1985，6，： | 1 |
| 11 | Single port access adrenaleetomy显示文摘 | Castellucci S A Curcillo P G Ginsberg P C | 2008 | J Endourol2008，22，8： | 1 |
| 12 | Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults; implications for assessing children's risks from environmental agents 显示文摘 | Ginsberg G Hattis D Russ A Sonawane B | 2004 | J Toxicol Environ Health A2004，67，4： | 1 |
| 13 | Endoscopic management of gastroin- testinal stromal tumors显示文摘 | Chandrasekhara V Ginsberg G G | 2011 | Curt Gastroenterol Rep2011，13，6： | 1 |
| 14 | Primary prevention of cardiovascular diabetes in people with diabetes mellitus a scientific statement from the American Heart Association and the American Diabetes Association显示文摘 | Buse J B Ginsberg H N Bakris G L | | 0，，01： | 1 |
| 15 | Antigenic and genetic char- acteristics of swine - origin 2009 A( H1N1 ) influenza viruses cir- culating in humans 显示文摘 | Garten R J Davis C T Russell C A Shu B Lindstrom S Balish A Sessions W M Xu X Skepner E Deyde V Okomo - Adhi- ambo M Gubareva L Barnes J Smith C B Emery S L Hillman M J Rivailler P Smagala J de Graaf M Burke D F Fouchier R A Pappas E Alpuche - Aranda C M Lopez - Gatell H Ohvera H Lopez I Myers C A Faix D Blair P J Yu C Keene K M Dotson P D Jr Boxrud D Sambol A R Abid S H St George K Bannerman T Moore A L Stringer D J Blevins P Demmler - Harrison G J Ginsberg M Kriner P Waterman S Smole S Guevara H F Belongia E A Clark P A Beatrice S T Donis R Katz J Finelli L Bridges C B Shaw M Jernigan D B Uyeki T M Smith D J Klimov A I Cox N J | 2009 | Science2009，325，5937： | 1 |
| 16 | Polymor- phism in the DNA repair enzyme XRCC1 : utility of current database and implications for human health risk assessment 显示文摘 | Ginsberg G Angle K Guyton K | 2011 | Murat Res2011，727，12： | 1 |
| 17 | Gastric polyps: relationship of size and histology to cancer risk显示文摘 | Ginsberg C G AL - Kawas FH Fleischer DE | 1996 | Am J Gastroenterol1996，91，： | 1 |
| 18 | Automatic detection of small lung nodules on CT utilizing a local density maximum algorithm 显示文摘 | Zhao B Gamsu G Ginsberg M | 2003 | Journal of Applied Clinical Medical Physics (S1526-9914)2003，4，3： | 1 |
| 19 | New ways to ventilate newborn in acute respiratory failure显示文摘 | MEGETTIGAN M E ADOLPH V R GINSBERG H G | 1998 | Pediatr Clin North Am1998，45，： | 1 |
| 20 | A phase Ⅱ study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromlboembolism after hip or knee replacement显示文摘 | Agnelli G Haas S Ginsberg JS | 2007 | J Thromb Haemost2007，5，4： | 1 |
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