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| 1 | 雷公藤红素阻断全反式维甲酸导致的白血病细胞与内皮细胞黏附显示文摘目的:全反式维甲酸(all-trans retinoic acid,ATRA)治疗急性早幼粒细胞白血病,引起白血病细胞与内皮细胞之间黏附增加,是发生维甲酸综合征的重要原因。本文观察雷公藤红素对这种黏附增加的影响。方法:用流式细胞术检测雷公藤红素对急性早幼粒细胞白血病细胞系NB4和人脐静脉内皮细胞(humanumbilical vascular endothelial cell,HUVEC)在ATRA刺激下表达黏附分子的影响。用细胞黏附功能实验,检测雷公藤红素对ATRA导致的上述两种细胞之间黏附增加的影响。结果:ATRA能引起NB4细胞表面细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)表达增加,但可被雷公藤红素明显抑制(P<0.01)。NB4细胞上清液能刺激HUVEC表达ICAM-1(P<0.05);而被ATRA处理过的NB4细胞上清液能明显刺激HUVEC表达选择素E(E-selectin)、血管细胞黏附分子-1(vascular cell adhesion molecule-1,VCAM-1)和ICAM-1等黏附分子(P<0.01),雷公藤红素对其抑制率分别达25.3%、42.4%和61.0%。ATRA导致上述两种细胞之间黏附增加,雷公藤红素对其完全抑制。结论:雷公藤红素能抑制ATRA导致的白血病细胞与内皮细胞黏附,有可能用于维甲酸综合征的治疗。 | 徐莉敏 张登海 杨春欣 刘旭辉 Geroges UZAN 秦万章 | 2007 | 中西医结合学报2007，5，3： | 11 |
| 2 | Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants——China,May 21,2021-February 28,2022显示文摘Summary What is already known about this topic?Compared with the international mRNA and adenovirus-vectored coronavirus disease 2019(COVID-19)vaccines,there is less real-world research data about breakthrough cases in people vaccinated with China-made COVID-19 vaccines.Analyses of clinical outcomes of breakthrough cases will be an important supplement to the clinical trial efficacy and observational effectiveness data of China-made COVID-19 vaccines. | Mingshuang Li Qianqian Liu Dan Wu Lin Tang Xiaoqi Wang Tingting Yan Zhijie An Zundong Yin Geroge F.Gao Fuzhen Wang Hui Zheng | 2022 | China CDC weekly2022，4，14： | 10 |
| 3 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 4 | 雷公藤红素对ATRA诱导白血病细胞分化成熟的影响显示文摘目的观察雷公藤红素对ATRA诱导白血病细胞分化成熟的影响。方法用细胞形态学、生化指标、分子标志等指标,观察雷公藤红素和/或ATRA不同处理组NB4分化情况。结果与对照组相比,ATRA诱导后,NB4细胞呈现中性粒细胞分叶核形态;NBT还原能力明显增加;分化抗原CD13和CD33表达下降,而CD11b和CD15表达增加。雷公藤红素与ATRA联合应用,结果与ATRA处理组相似。结论雷公藤红素不影响ATRA诱导NB4细胞分化成熟作用,提示雷公藤红素作为分化综合征的治疗和预防药物值得进一步研究。 | 徐莉敏 张登海 杨春欣 彭彬 曹帆帆 Geroges UZAN | 2010 | 同济大学学报(医学版)2010，31，3： | 3 |
| 5 | 静脉溃疡病人愈合后皮肤结构变化的远期随访(英文)显示文摘目的 观察静脉溃疡患者愈合后皮肤超声结构的变化 ,探讨创面愈合质量。方法 应用皮肤超声仪检测静脉溃疡病人愈合后瘢痕表皮及真皮的厚度 ,分析真皮中低回声区像素 (LEPs)。结果 与正常皮肤比较 ,静脉溃疡愈合后瘢痕的平均表皮厚度显著增加 (P <0 0 1) ,平均真皮厚度显著降低 (P <0 0 1) ,而真皮中LEPs的数量及分布均无明显变化。皮肤的回声参数与创面愈合时间、创面大小、创面存在时间及病人年龄均无显著相关性。结论 静脉溃疡患者创面愈合后 ,真皮中液体的数量及分布无显著改变 。 | 杨银辉 贾赤宇 Geroge W Cherry 付小兵 黎君友 | 2002 | Chinese Medical Journal2002，，12： | 2 |
| 6 | Slack resource and the performance of private- ly held firms 显示文摘 | Geroge G | 2005 | Academy of Management Journal2005，48，： | 1 |
| 7 | Returns to Investment in Education : A Global Update 显示文摘 | Geroge Psacharoopoulos | 1994 | World Development1994，22，9： | 1 |
| 8 | Improving productivity in the dental practice:a starting point 显示文摘 | Geroge RJ | 1996 | N Z Dent1996，92，409： | 1 |
| 9 | The fern understory as an ecological filter: Emergence and establishment of canopy tree seedings显示文摘 | Geroge L O Bazzaz F A | 1999 | Ecology1999，80，： | 1 |
| 10 | Indium-111 labelled ltmphocytes: isotope distribution and cell division显示文摘 | KUYAMA J MCCORMACK A GEROGE AJ | 1997 | Eur J Nucl Med1997，24，： | 1 |
| 11 | Human neural tube de- fects : developmental biology epidemiology, and geneties 显示文摘 | Detrait ER Geroge TM Etehevers HC | 2005 | Neuro- toxieology and Teratology2005，27，3： | 1 |
| 12 | Coadministration of grapefruit juice increases tacrolimus levels in liver transplant recipients 显示文摘 | WESTVEER M K FARQYHAR M L GEROGE P | 1996 | Ann Meet Am Soc Transplant Physitiaras1996，202，： | 1 |
| 13 | An experimental laboratory facility for studying shock-induced liquefaction显示文摘 | Veyera Geroge E Charlie Wayne A | 1990 | Geotechnical Testing Journal1990，13，4： | 1 |
| 14 | New sintered high temperature Sm-Co base permanent magnet materials 显示文摘 | Liu S Yang J Geroge G Edward Kuhl | 1999 | IEEE Trans Magn1999，35，5： | 1 |
| 15 | Quantity and quality of virus-specific CD8 cell response:relevance to the design of a therapeutic vaccine for chronic HBV infection显示文摘 | Bertoletti | 2001 | Mol Immunol2001，38，6： | 1 |
| 16 | 1-Formylpiperazine and related compounds 显示文摘 | Bruce WH Morris F Geroge RS | 1955 | J Am Chem Soc1955，77，： | 1 |
| 17 | A review on interface modification and characterization of natural fiber reinforced plastic composites 显示文摘 | GEROGE J SREELALA M S THOMAS | 2001 | Polymer Engineering and Science2001，41，9： | 1 |
| 18 | Derrida and the Marxian promise显示文摘 | Geroge Salemohamed | 1995 | Economy and Society1995，24，3： | 1 |
| 19 | 显示文摘 | Geroge J Sreekala M Thomass S | 2001 | Polym Eng Sci2001，41，9： | 1 |
| 20 | Colorectal carcinoma associated with serrated adenoma-prevalence,histological features and Prognosis 显示文摘 | Geroge SM Jernvail P | 2001 | J Pathol2001，193，3： | 1 |
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