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| 1 | Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers显示文摘Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues.The sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal muscles.When these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with HF.These detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment modalities.Therefore,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in HF.Finally,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF. | Josip Anđelo Borovac Domenico D'Amario Josko Bozic Duska Glavas | 2020 | World Journal of Cardiology2020，12，8： | 14 |
| 2 | Friction Characteristics of Mechanical Seals with Laser-textured Seal Faces显示文摘Heat generated by friction between faces of mechanica l seals is a major factor that causes deterioration of the seals and shortens th eir service life. Excessive temperature rise can greatly alter the seal geometry and vaporize the sealing fluid, resulting in friction of boundary lubrication. These effects on face seals usually lead to excessive leakage and ultimately ren der the seal inoperable. In order to maintain the reliability of seals, high fri ction and unwanted wear must be avoided. Using the laser-texturing process to produce regular micro-surface structures is a fast and convenient technique compared to some more conventional etching or erosion technique currently used by the seal industry for various grooved face seals. Indeed, by using a pulse laser, better control is obtained on the geometr y, size and pore ratio of seal rings made of metallic or ceramic materials. In t his study, seal rings are made of silicon carbide and carbon. Mating faces of th e rings are polished and only silicon carbide rings are laser-textured. The las er texturing can be controlled to produce spherical pores at selected diameters, depths and pore ratio. The textured rings are then super-polished to remove th e bulges formed on the pores rims. After this process the average pore diameter, pore depth and pore ratio reach the predetermined parameter. Some untextured ri ngs are also treated to the same surface roughness and served as a reference for comparison of the textured rings. A special test rig is used to simulate a mech anical seal system and to measure the effect of the laser texturing on friction and seal performance. Tests are performed at various rotational speeds and vario us axial loads. Compared with the conventional mechanical seals, temperature rise, friction torq ue and friction coefficient of mechanical seals with laser-textured seal faces are much lower. These preliminary results show the potential of improving fricti on performance and increasing seal life with laser-textured seal faces. | YU Xin-qi 1,2, HE Song 1, CAI Ren-ling 1 (1. Research Institute of Pressure Vessel and Process Equi pment, East China University of Science and Technology, Shanghai 200237, China 2. College of Mechanical Science and Engineering, Hebei University of Science an d Technology, Shijiazhuang 050018, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 9 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Research on Product Information Integrating and Sharing for Dynamic Colla boration显示文摘Dynamic Collaboration emerges as the new trend of n et working and collaborating work in manufacturing industry, in which product infor mation sharing among allied enterprises plays very important roles in collaborat ing product development. This thesis aims at studying the integrating, contr olling and sharing mode of product information among the heterogeneous and dispe rsed environments through Internet, and proposes the information integrating/sha ring architecture based on the Product Master Model (PMM). The following are the main contents of this thesis: 1) Research on the XML based PMM model for integration and sharing of product in formation After analyzing the requirement of the allied Enterprise for the product infor mation, the XML based product master model (XPMM) is proposed as the integrating mechanism of heterogeneous and dispersed product information. The XPMM is divid ed into some sub-models: whole-life controlling model, product defining model, conception model, design model, product structure model, machining model, q uality model, evaluating model. The character and accessing approach of XPMM is discussed in detail. 2) Research on the mapping pattern and mapping rule of STEP/XML According to feature of XML Schema and STEP EXPRESS, the memory-constructing-t ree model is put forward as STEP/XML mapping pattern, which is constructed dynam ically according to the bottom-to-top reference relationship. Based on mapping pattern, the multi-layer XML/STEP mapping rule is discussed detailed including relation mapping, entity mapping, data type mapping, reference mapping and func tion mapping. 3) Research on the Product Information Integration and Sharing (PIIS) Architectu re Based on the XPMM, the PIIS architecture is proposed. The PIIS support the local and dispersed product information to be integrated and shared on the contro l of the XPMM. The architecture is divided into three layers :Applying-Obj ect-LayerData-Integration-Layer and STEP-Data-Layer. The kernel of the PI IS Architecture is this Data-Integration-Layer, which control the whole proces s of XPMM creating, the data approaching. The function and structure of every la yer is discussed too. | HE Wen-rui, QIN Zhong-bao, Qin Ji-feng, HE Wei-ping (Education Ministry Key Laboratory of Contemporary Design and Integrate d Manufacturing Technology, Northwestern Polytechnical University, Xi’an 710072, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 4 |
| 5 | Analysis of solar radiation variations over Nanjing region in recent 40 years显示文摘The data utilized in this analysis consisted of extraterrestrial radiation, global radiation, d iffuse radiation, direct radiation, total cloud cover and relative suns hine. The annual variations and trend were analyzed for monthly mean daily total global, direct, and diffuse radiation on a horizontal surface and for the relations between global, direct, diffuse radiation and relative sunshine, tota l cloud cover. The climatological calculation equations of global and d irect radiation are put forward. The results show that global and dir ect radiations are characterized by decrease and diffuse radiation by increase. The main causes are due to the increase of concentration of suspended particles and atmospheric turbidities rather than cloud cover var iations. | ZHANG Yunlin,QIN Boqiang,CHEN Weimin(Nanjing Institute of Geography an d Limnology, CAS, Nanjing 210008, China) | 2003 | Journal of Geographical Sciences2003，13，1： | 3 |
| 6 | T-DNA insertional mutagenesis for activation tagging in rice显示文摘 | JEONG D H AN S KANG H G | 2002 | Plant Physiol2002，130，4： | 3 |
| 7 | Impact of virus genotype on interferon treatment of patients with chronic hepatitis C: a multicenter controlled study显示文摘BACKGROUND: Some factors have been reported to besassociated with a greater likelihood of sustained viral re-sponse ( SVR) in the interferon (IFN) treatment of chronichepatitis C. The factors include HCV genotype, HCVRNA level in serum, state of liver disease, baseline bodyweight, age, sex, and race. The aim of this trial was to in-vestigate the influence of HCV genotype on the IFN treat-ment of patients with chronic hepatitis C.METHODS: The genotypes of HCV virus were determinedin the patients with chronic hepatitis C from several hospi-tals of China enrolled into the randomized, opened andcontrolled trial of Peg-IFN alpha-2a (pegasys) treatment,controlled with IFN-α-2a (roferon-A). The serum ALTlevels and HCV RNA concentrations of the patients weredetected before and at the end of treatment and during thefollow-up. The influence of HCV genotype on the IFNtreatment of patients with chronic hepatitis C was analyzedin intention-to-treat (ITT) population.RESULTS: The HCV genotypes of 202 patients were deter-mined. Of these patients, 158(78.22%) were infected withgenotype 1 HCV and 44(21.78%) with genotype non-1.The viral response at the end of treatment (ETVR) andsustained viral response (SVR) rates were 53.80% and25.32% respectively in patients with genotype 1 HCV, butthey were 61.36% and 43.18% in patients with genotypenon-1. The difference of SVR between patients with geno-type 1 HCV and those with genotype non-1 was significant(P =0.021). After being grouped by the used drugs, theETVR rates of patients infected with genotype 1 and non-1HCV were 76.83% and 80.95% in the patients treated withpegasys (P =0.686); but their SVR rates were 35.37% and66.67% (P =0. 01). The viral relapse rate of genotype 1HCV (55.56%) was significantly higher than that of geno-type non-1 HCV (23.53%) (P=0.02). In roferon-A group,the ETVR and SVR rates of patients with genotype 1 HCVwere 28.95% and 14.47% respectively, which were lowerbut not more significant than those of patients with geno-type non-1 HCV (43.48% and 21.74%). Moreover, the vi-ral relapse rate of genotype 1 HCV (72.73%) was higherbut not more significant than that of genotype non-1 HCV(50.00%) (P=0.21).CONCLUSION: HCV genotype could affect the efficacies,mainly sustained responses, of IFN treatment in patientswith chronic hepatitis C, and the effects of IFN are relatedto drugs and therapeutic course. | Yao Xie, Dao-Zhen Xu, Zhi-Meng Lu, Kang-Xian Luo, Ji-Dong Jia, Yu-Ming Wang,Gui-Zhen Zhao, Shu-Lin Zhang and Da-Zhi Zhang Department of Infeetious Diseases , Beijing Ditan Hos-pital, Beijing 100011 , China Department of Infec-tious Diseases, Ruijin Hospital, Shanghai 200025, China De-partment of Infectious Diseases, Naifang Hospital, First Military Medical U-niversity, Guangzhou 510515, China (Luo KX) Center of Liver Disease,Beijing Friendship Hospital, Beijing 100050, China (Jia J D ) Institute ofInfectious Disease, Southwest Hospital, Third Military Medical University,Chongqing 410032, China Department of Infectious Disea-ses, Second Hospital, China Medical University, Shenyang 110004, China Department of Infectious Diseases, First Hospital, Xi’ an Jiao-tong University, Xi’ an 710061 , China ) Liver Disease Centerof Chongqing, Second Hospital, Chongqing Medical University,Chongqing 410010, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 2 |
| 8 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 9 | Effect of carbon nanotube addition on tribological behavior of UHMWPE显示文摘 | Zoo Y S An J W Lim D P | 2004 | Tribology Letters2004，16，： | 1 |
| 10 | Histone deacetylase activities are required for innate immune cell control of Thl but not Th2 effector cell function显示文摘 | Brogdon J L Xu Y Szabo S J An S Buxton F Cohen D | 2007 | Blood2007，109，： | 1 |
| 11 | Dengue-specific CD8^+ T cells have both protective and pathogenic roles in dengue virus infection 显示文摘 | An J Zhou D S Zhang J L | 2004 | Immtmol Lett2004，95，： | 1 |
| 12 | Rare pathological variants and presentations of primary central nervous system lymphomas显示文摘 | Da Silva AN Lopes MB Schiff D | 2006 | Neurosurg Focus2006，1521，5： | 1 |
| 13 | Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with ciplatin 显示文摘 | Cemazar M Miklavcic D An D | 1999 | Br J Cancer1999，79，910： | 1 |
| 14 | A randomized, double-blind conparison of lumber epidural and intravenous fentanvl infusion for post-thoracotomy pain relief: analgesic,pharmacokinetic and respiratory effects显示文摘 | Sandler AN Panos L Stringer D el al | 1992 | Anesthesiology1992，77，： | 1 |
| 15 | Generation of a flanking sequence-tag database for activation-tagging lines in japonica rice显示文摘 | JEONG D H AN S Y PARK S | 2006 | The Plant Journal2006，45，1： | 1 |
| 16 | Smoking and the risk of endometrial cancer: Results from the Nurses' Health Study显示文摘 | Viswanathan AN Feskanich D De Vivo I | 2005 | Int J Cancer2005，114，： | 1 |
| 17 | Success: A Next-Genera- tion Hybrid WDM/TDM Optical Access Network Architecture 显示文摘 | AN Fu-Tai KIM K S GUTIERREZ D | 2004 | Journal of Light wave Technology2004，22，11： | 1 |
| 18 | poly(lactic acid) nanocomposites: Comparison of their properties with montmorillonite and synthetic mica (Ⅱ) 显示文摘 | CHANG J H AN Y U CHO D H | 2003 | Polymer2003，44，13： | 1 |
| 19 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 20 | Proteomic analysis of the protective effects of Platycodi Radix in liver of chronically alco- holic rats显示文摘 | An J H Kim D S Lee D S | 2009 | J Med Food2009，12，6： | 1 |
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