|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Analysis of a mathematical model for the growth of tumors显示文摘 | Friedman A Reitich F | 1999 | J Math Biol1999，38，： | 1 |
| 3 | Evaluation of coefficients for the weighted sum of gray gases model 显示文摘 | Smith T F Shen Z F Friedman J N | 1982 | ASMEJ Heat Transfer1982，，104： | 1 |
| 4 | Efficacy and safety of low dose fluticasone propionate compared with montelukast for maintenance treatment of persistent asthma显示文摘 | MELTZER E O LOCKEY R F FRIEDMAN B F | 2002 | Mayo Clin Proc2002，77，： | 1 |
| 5 | Ego-identity status in college women显示文摘 | Marcia J E Friedman M F | 1970 | Journal of Personality1970，38，： | 1 |
| 6 | Glycyrrhizic acid alters Ka - po- sisarcom a - associated herpesvirus latency triggering p53 - medi- ated apoptosis in transformed Blymphocytes 显示文摘 | Curreli F Friedman - Kien AE | 2005 | Clin Invest2005，115，3： | 1 |
| 7 | Limitations of the motivational intensity model of attentional tuning:reply to HarmonJones,Gable,and Price显示文摘 | Friedman R.S F(o)rster J | | 0，，： | 1 |
| 8 | Desmopressin in the treat- ment of nocturia: clinical evidence and experience 显示文摘 | Friedman F M Weiss J P | 2013 | Ther Adv Urol2013，5，6： | 1 |
| 9 | Parameter identification in reaction-diffusion models 显示文摘 | Friedman A Reitich F | 1992 | Inverse Problems1992，8，： | 1 |
| 10 | Evaluation of coefficients for the weighted sum of gray gases model显示文摘 | Smith T F Shen Z F Friedman J N | 1982 | Journal of Heat Transfer1982，104，4： | 1 |
| 11 | Kinetics of acid-catalyzed hydrolysis of carbohydrate groups of potato glycoalkaloids chaconine and solanine显示文摘 | FRIEDMAN M MCDONALD G HADDON W F | 1993 | J Agric Food Chem1993，41，9： | 1 |
| 12 | NDE of damage in thick stiched composites using laser-based ultrasound with optical fibers for remote generation and detection显示文摘 | Robert F Anastasi Adam D Friedman Mark K Hinders | 1998 | Materials Evaluation1998，56，12： | 1 |
| 13 | Profilling protein expression and interactions: proximity ligation as a tool for personalized medicine显示文摘 | Blokzijl A Friedman M Ponten F | 2010 | J Intern Med2010，268，3： | 1 |
| 14 | Symptomatic Dengue infection during pregnancy and infant outcomes: a retrospective cohort study 显示文摘 | Friedman EE Dallah F Harville EW | 2014 | PLoS Negl Trop Dis2014，8，10： | 1 |
| 15 | Kinetics of cellulose pyrolysis in nitrogen and steam显示文摘 | Antal M J Friedman H L Rogers F E | 1980 | Combustion Science and Technology1980，21，： | 1 |
| 16 | Treatment of leiomyomat uterine with leuprolide acetate depot:a double-blind,placebo-controlled,multicenter study显示文摘 | Friedman AJ Hoffman DI Comite F | 1991 | Obstet Gynecol1991，77，5： | 1 |
| 17 | Diagnosrici-magingtech-miquesimthyroidcaner显示文摘 | Toriumi D Mahmood F | 1988 | Am J Surg1988，155，2： | 1 |
| 18 | 1-eV solar cells with GaInNAs active layer 显示文摘 | Friedman D J Geisz J F Kurtz S R | 1998 | J Cryst Growth1998，195，： | 1 |
| 19 | 1-eV solar cellswith GalnNAs active layer 显示文摘 | FRIEDMAN D J GEISZ J F KURTZ S R | 1998 | Journal of Crystal Growth1998，195，14： | 1 |
| 20 | Volumetric quantification of fisher grade 3 aneurysmal subarachnoid hemorrhage: A novel method to predict symptomatic vasospasm on admission computerized tomography scans显示文摘 | Friedman J A Goerss S J Meyer F B | 2002 | Journal of Neurosurgery2002，97，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员