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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 3 | MicroRNA expression patterns to differentiate pancreatic ad from normal pancreas and chronic pancreatitis 显示文摘 | Bloomston M Frankel WL Petrocca F | 2007 | JAMA2007，297，： | 1 |
| 4 | Accounting valuation, market expectation and cross-sectional stock returns显示文摘 | Frankel R Charles M C Lee | 1998 | The Journal of Accounting and Economics1998，25，1： | 1 |
| 5 | Historical de velopment of glycidyl azide polymer显示文摘 | Frankel M B Grant L R Flanagen J E | 1992 | Journal of Pro- pulsion and Power1992，8，3： | 1 |
| 6 | Posterior occip- itocervical (C0-3) fusion using polyaxial ceipital condyle t cervical spine screw and rod fixation: a radiographic and cadaveric analysis 显示文摘 | Frankel BM Hanley M Vandergrif/ A | 2010 | J Neurosurg Spine2010，12，5： | 1 |
| 7 | MicroRNA expression pattems to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis显示文摘 | Bloomston M Frankel WL Petrocca F | | 0，，： | 1 |
| 8 | The Relation between Auditors' Fees for Nonandit Services and Earnings Management 显示文摘 | Frankel R M Johnson M F Nelson K K | 2002 | The Accounting Review2002，77，： | 1 |
| 9 | Rock magnetic criteria for the detection of biogenic magnetite 显示文摘 | MOSKOWITZ B M FRANKEL R B BAZYLINSKI D A | 1993 | Earth and Planetary Science Letters1993，120，： | 1 |
| 10 | MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis 显示文摘 | Bloomston M Frankel WL Petrocca F | 2007 | JA- MA2007，297，17： | 1 |
| 11 | Magnetic microstructure of magnetotactic bacteria by electron holography显示文摘 | Dunin R E McCartney M R Frankel R B | 1998 | Science1998，282，： | 1 |
| 12 | MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival显示文摘 | Dillhoff M Liu J Frankel W | 2008 | J Gastrointest Surg2008，12，12： | 1 |
| 13 | Enhancing clinician communication skills in a large healthcare organization:A longitudinal case study 显示文摘 | Stein T Frankel R M Krupat E | 2005 | Patient Educ Couns2005，58，1： | 1 |
| 14 | Comparison of residual stresses in Ti - 6AL- 4V and Ti - 6AL- 2Sn - 4Zr-2Mo linear friction welds 显示文摘 | Frankel P Preussl M Steuwer A | 2009 | Materials Science and Technology2009，25，5： | 1 |
| 15 | Discretionary disclosure and external financing显示文摘 | Frankel R McNichols M Wilson G P | 1995 | Accounting Review1995，70，1： | 1 |
| 16 | Intragenic recombination in a flagellin gene:characterization of the H1-j gene of Salmonella typhi显示文摘 | FRANKEL G NEWTON S M SCHOOLNIK G K | 1989 | EMBO J1989，8，： | 1 |
| 17 | Historical development of glycidyl azide polymer显示文摘 | Frankel M B Grant L R Flanagan J E | 1992 | Propulsion and Power1992，8，3： | 1 |
| 18 | Getting the Most Out of the Clinical Encounter:The Four Habits Model显示文摘 | Frankel R M Stein T | 1999 | J Perm J1999，3，3： | 1 |
| 19 | Magnetite and magnetotaxis in algae 显示文摘 | Torres de Araujo F F Pires M A Frankel R B | 1986 | Biophysics J1986，50，： | 1 |
| 20 | Effect of tumor necrosis factor α and intercelluar adhesion molecule-1 expression on immunogenicity of murine liver cells in mice显示文摘 | Bumgardner GL Li J Apte S Heininger M Frankel WL | 1998 | Hepatology1998，28，2： | 1 |
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