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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 4 | Nutrient removal using lemna mino显示文摘 | Fox J L | 1973 | J WPCF1973，45，9： | 1 |
| 5 | Rates of change of eigenvalues and eigenvectors显示文摘 | FOX R L KAPOOR M P | 1969 | AIAA Journal1969，6，： | 1 |
| 6 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 7 | Smartest review of micro-simulation models显示文摘 | ALGERS S BERNAUER E BOERO M BREHERET L DI- TARANTO C DOUGHERTY M FOX K GABARD J F | 1997 | Transport RTD1997，，3： | 1 |
| 8 | Spontaneous deletion of the methicillin resistance determinant,mecA,partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus显示文摘 | Noto M J Fox P M Archer G L | 2008 | Anti micro Agents Chemother2008，52，4： | 1 |
| 9 | Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition 显示文摘 | Beebe S J Fox P M Rec L J | 2002 | IEEE Trans on Plasma Science2002，30，1： | 1 |
| 10 | Burden and prognostic importance of subclinical cardiovascular disease in overweight and obese individual显示文摘 | INGELSSON E SULLIVAN L M FOX C S | 2007 | Circulation2007，116，： | 1 |
| 11 | Binding of silver sulfadiazine to the cellular components of pseudomonas aeruginosa显示文摘 | Medak S M Fox C L | 1973 | Biochemical Pharmacology1973，22，19： | 1 |
| 12 | Influence of transglutaminase treatment on some physico-chemical properties of milk 显示文摘 | O' Sullivan M M Kelly A L Fox P F | 2002 | Dairy Research2002，69，： | 1 |
| 13 | Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance显示文摘 | Hivert M F Sullivan L M Fox C S | 2008 | Clin Endocrinol Metab2008，93，8： | 1 |
| 14 | The microsurgieal approach to intracranial an-eurysms显示文摘 | Yasargil M G Fox J L | 1975 | Surg Neurol1975，3，1： | 1 |
| 15 | Rates of change of eigenvalues and eigenvectors 显示文摘 | R L FOX M P KAPOOR | 1968 | AIAA Journal1968，6，12： | 1 |
| 16 | Population balance modeling of aggregation and breakage in turbulent Taylor - Cou- ette flow 显示文摘 | Soos M Wang L Fox R O | 2007 | Journal of Colloid and Interface Science2007，307，2： | 1 |
| 17 | The dimensionali- ty ofcounter-productivity: Are all counterproductive behav- iors created equal显示文摘 | Spector P E Fox S Penney L M | 2006 | Journal of vocational behavior2006，68，3： | 1 |
| 18 | Evaluation of toxicosis of liposome-encapsulated cis-bis-carboxylato-trans-R, R-1, 2-diaminocyclohexzam-platinum ( Ⅱ ) in clinically normal cats显示文摘 | FOX L E TOSHACH K CALDERWOOD-MAYS M | 1999 | Ant J Vet Res1999，60，2： | 1 |
| 19 | The Di- mensionality of Counterproductivity: Are All Counterproductive Behaviors Created Equal 显示文摘 | Spector P E Fox S Penney L M Bruursema K Goh A Kessler S | 2006 | Journal of Vocational Behavior2006，，03： | 1 |
| 20 | Binding of silver sulfadiazine to the cellular components of pseudomonas aeruginosa 显示文摘 | Modak S M Fox C L | 1973 | Biochemical Pharma- cology1973，22，19： | 1 |
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