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| 1 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Laurent Sandrin Bertrand Fourquet Jean-Michel Hasquenoph Sylvain Yon Céline Fournier Frédéric Mal Christos Christidis Marianne Ziol Bruno Poulet Farad Kazemi Michel Beaugrand Robert Palau | 2003 | Ultrasound in Medicine & Biology2003，，12： | 3 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Transcatheter Arterial Embolization of Splenic Artery Aneurysms and Pseudoaneurysms: Short- and Long-Term Results显示文摘 | Romaric Loffroy Boris Guiu Jean-Pierre Cercueil C?me Lepage Nicolas Cheynel Eric Steinmetz Frédéric Ricolfi Denis Krausé | 2008 | Annals of Vascular Surgery2008，，5： | 2 |
| 4 | 钾通道J亚家族成员5基因嵌合导致双侧肾上腺皮质增生进而引起的早期原发性醛固酮增多症显示文摘钾通道J亚家族成员5(potassium voltage-gated channel subfamily J member 5,KCNJ5)的体细胞变异最易导致原发性醛固酮增多症(primary aldosteronism,PA),有部分患者因KCNJ5钾通道基因的生殖细胞突变而患该病[家族性醛固酮增多症Ⅲ型(familial hyperaldosteronismⅢ,FH-Ⅲ)]。方法:1998年,美国国立卫生研究院临床中心发现一名11岁的白人男孩,患有早期严重高血压。 | Maria AG Suzuki M Berthon A Kamilaris C Demidowich A Lack J Zilbermint M Hannah-Shmouni F Faucz FR Stratakis CA 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 5 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 6 | Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva:The role of dosimetric and clinical factors显示文摘 | Beetz I Schilstra C Burlage FR | 2012 | Radiother Oncol2012，105，1： | 1 |
| 7 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 8 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 9 | Sc FOS a prebiotic for synbiotic associations:Recent studies in humans显示文摘 | Céline H Anne W Frédérique R | 2010 | Nutrafoods2010，9，1： | 1 |
| 10 | Quality control in rehabilitation of patients with visual impairment: evaluation of use and benefits of optic and elec- tronic devices 显示文摘 | Fr hlich S J Lackerbauer C A | 2006 | Ophthalmologe2006，103，12： | 1 |
| 11 | TGF-beta expression during rat pregnancy and activity on decidual cell survival显示文摘 | Shooner C Caron PL Fr chette-Frigon G | 2005 | Reprod Biol Endocrinol2005，31，3： | 1 |
| 12 | Controlled free-radical polymerization显示文摘 | Bosman A W Fréchet J M J Hawker C J | 2001 | Polym Mater Sci Eng2001，84，： | 1 |
| 13 | Age-related differences on event-related potentials and brain rhythm oscillations during working memory activation显示文摘 | Missonnier P Herrmann FR Rodriguez C | 2011 | J Neural Transm2011，118，6： | 1 |
| 14 | Folate content in frozen vegetarian ready meals and folate retention after different reheating methods显示文摘 | Johansson M Furuhagen C Frlich W | 2008 | Swiss Society of Food Science and Technology2008，41，： | 1 |
| 15 | Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process显示文摘 | Aude Autissier Catherine Le Visage Cécile Pouzet Frédéric Chaubet Didier Letourneur | 2010 | Acta Biomaterialia2010，，9： | 1 |
| 16 | Molecular profiling of ADAM12 in human bladder cancer显示文摘 | Fr(o)hlich C Albrechtsen R Dyrskj(o)t L | 2006 | Clin Cancer Res2006，12，24： | 1 |
| 17 | Hyperfractionation in carcinoma of the cervix: tumor control and late bowel complications显示文摘 | Viswanathan FR Varghese C Peedieayil R | 1999 | Int J Radiat Oncol Biol Phys1999，45，3： | 1 |
| 18 | Health risk assessment of dioxin emissions from municipal waste incinerators:the Neerlandquarter(Wilrijk,Belgium)显示文摘 | Nouwen J Cornelis C De Fré R | | Chemosphere0，，： | 1 |
| 19 | Cytomegalovirus immune evasion显示文摘 | Powers C DeFilippis V Malouli D Früh K | 2008 | Curr Top Microbiol Immunol2008，325，： | 1 |
| 20 | Role of caveolins in body weight and insulin resistance regulation显示文摘 | Frühbeck G López M Diéguez C | 2007 | Trends Endocrinol Metab2007，18，5： | 1 |
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